Studies in Natural Products Chemistry

Chapter 1: Pharmacology and Structure-Activity Relationship of Natural Products With Psychoactive Effects From Salvia divinorum, Mitragyna speciosa, and Ayahuasca

• Abstract
• Introduction
• Psychoactive Principle and Related Pharmacology of S. divinorum, M. speciosa, and Ayahuasca
• Structure-Activity Relationship of Salvinorin A, Mitragynine, and DMT

Chapter 2: Recent Developments on the Synthesis and Applications of Betulin and Betulinic Acid Derivatives as Therapeutic Agents

• Abstract
• Introduction
• Functionalization at the C₂₈ Position
• Functionalization at the C₂₀ Alkene Site
• Functionalization of the A-Ring
• Functionalization of the E-Ring
• Acknowledgements

Chapter 3: Synthetic Approaches to the Naturally Occurring Anticancer Amaryllidaceae Alkaloids trans-dihydrolycoricidine and trans-dihydronarciclasine

• Abstract
• Introduction
• Synthetic Structure-Activity Studies: Illumination of the Anticancer Amaryllidaceae Pharmacophore
• Summary of Strategies Toward the Total Synthesis of trans-dihydrolycoricidine 3
• Summary of Strategies Toward the Total Synthesis of trans-dihydronarciclasine 6
• Conclusions

Chapter 4: Total Synthesis of Schisandra Nortriterpenoids: History, Progress, and Perspective

• Abstract
• Introduction
• Synthesis of Schisandra Nortriterpenoids
• Concluding Remarks

Chapter 5: Chemical Synthesis of Meridianins and Related Derivatives

• Abstract
• Introduction
• Synthesis of Meridianins
• 2000–2005
• 2006–2010
• 2011–2016
• Conclusion
• Acknowledgments

Chapter 6: Biologically Active Isothiocyanates: Protecting Plants and Healing Humans

• Abstract
• Introduction
• General Synthetic Methods
• Biologically Active ITCs
• Conclusions
• Acknowledgements

Chapter 7: Curcumin, a Multitarget Phytochemical: Challenges and Perspectives

• Abstract
• Introduction
• Curcumin Molecular Features
• Antitumor Activity
• Curcumin Antioxidant Activity
• Curcumin Anti-HIV
• Antifungal Activity
• Curcumin Analogs
• Nanotechnological Approaches to Curcumin Delivery
• Concluding Remarks

Chapter 8: Bioactive Coumarins and Xanthones From Calophyllum Genus and Analysis of Their Druglikeness and Toxicological Properties

• Abstract
• Introduction
• Botanical Background of Calophyllum Genus
• Chemistry of Calophyllum Genus
• Chemoinformatics and Toxicoinformatics in Natural Products and Drug Discovery
• Molecular Properties of Coumarins and Xanthones From Calophyllum Species
• Conclusions
• Acknowledgments
• Appendix

Chapter 9: Structure and Biological Functions of d-Glucans and Their Applications

• Abstract
• Introduction
• Relationship Between Glucan Structure and Immunomodulatory Activity
• Relationship Between Glucan Structure and Antioxidant Activity
• Commercial Glucans: Technology Applications and Health Benefits
• Applications of Glucans in Food Products
• Applications of Glucans in Cosmetics
• Potential Applications of Glucans in the Pharmaceutical and Medical Sectors
• Applications of Glucans in Other Sectors
• Advances and Future Perspectives of Glucans

Chapter 10: Chemistry, Bioactivity, and the Structure-Activity Relationship of Cephalotaxine-Type Alkaloids From Cephalotaxus sp.

• Abstract
• Introduction
• Chemistry
• Bioactivity
• Synthesis
• Concluding Remarks
• Acknowledgments

Chapter 11: Analysis of the Protein Binding Sites for Thiamin and Its Derivatives to Elucidate the Molecular Mechanisms of the Noncoenzyme Action of Thiamin (Vitamin B1)

• Abstract
• Introduction
• Overview of the Naturally Occurring Thiamin Compounds and Their Metabolism
• Pharmacological Forms of Thiamin and Their Target Proteins and Pathways
• Thiamin Antagonists
• Noncanonical Thiamin-Binding Proteins
• Analysis of Protein Binding Sites for Thiamin and Derivatives
• Conclusions
• Acknowledgment