Studies in Natural Products Chemistry
- 1st Edition, Volume 38 - December 24, 2013
- Editor: Atta-ur- Rahman
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 4 - 5 9 5 3 0 - 0
- Paperback ISBN:9 7 8 - 0 - 4 4 4 - 6 0 2 3 9 - 8
- eBook ISBN:9 7 8 - 0 - 4 4 4 - 5 9 5 3 8 - 6
Natural products present in the plant and animal kingdom offer a huge diversity of chemical structures which are the result of biosynthetic processes that have been modulated ov… Read more
Natural products present in the plant and animal kingdom offer a huge diversity of chemical structures which are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate, and then determine the structures and biological activity of natural products rapidly, thus opening up exciting new opportunities in the field of new drug development to the pharmaceutical industry. The series also covers the synthesis or testing and recording of the medicinal properties of natural products.
- Describes the chemistry of bioactive natural products
- Contains contributions by leading authorities in the field
- A valuable resource for natural product and medicinal chemistry
Natural product chemists, medicinal chemists, pharmacologists as well as researchers, particularly those in academia and in the pharmaceutical industry
Contributors
Preface
Studies in Natural Products Chemistry edited by Atta-ur-Rahman
Chapter 1 Phytoestrogens: “Estrogene-Like” Phytochemicals
Introduction
Phytoestrogens
Absorption and Bioavailability of Phytoestrogens
Phytoestrogens “Estrogen-Like” Activities
Health and Phytoestrogens
Dietary Supplements
Safety Aspects
Conclusion
Chapter 2 The Discovery and Synthesis of Brevisamide
Introduction
Total Syntheses of Brevisamide
Formal Total Syntheses of Brevisamide
Biosynthesis of Brevisamide
Summary
Chapter 3 Recent Asymmetric Syntheses of Tetrahydroisoquinolines Using “Named” and Some Other Newer Methods
Asymmetric Bischler–Napieralski Cyclization–Reduction Syntheses
Asymmetric Pomeranz–Fritsch and Related Reactions
Asymmetric Pictet–Spengler Syntheses
Metal-Catalyzed Cyclizations
Conclusions
Chapter 4 1-Methoxy-Canthin-6-One and Related β-Carbolines: From Natural Compound to Synthesis and Biological Activities
Introduction
1-Methoxy-Canthin-6-One: Extraction from Natural Source
1-Methoxy-Canthin-6-One: Synthetic Procedures
Biological Properties of 1-Methoxy-Canthin-6-One and Related β-Carbolines
Conclusion
Chapter 5 Fern Acylphloroglucinols: Structure, Location, and Biological Effects
Introduction
Structural Features of Fern Acylphloroglucinols
Acylphloroglucinols from Dryopteris and Related Genera
Monomers
Dimers and Polymers
Terpenylated Acylphloroglucinols
Elaphoglossum Acylphloroglucinols
Phytochemical and Botanical Considerations
Improvement of Detection and Isolation Procedures
Final Remarks
Chapter 6 Mitogen-Activated Protein Kinase and Natural Phenolic Compounds in Cardiovascular Remodeling
Introduction
Cardiac Remodeling
Vascular Remodeling
MAPK Pathways
ERK Subfamily
p38 Subfamily
c-Jun Kinase
Upstream Activators of MAPK Families, GPCR and Small G-Proteins
Angiotensin Receptors
Epidermal Growth Factor Receptor
Endothelin System
Mitochondrial ROS Production and MAPK Pathway
NADPH and MAPK Pathway
Phenolic Compounds as New Therapeutic Agents for Targeting MAPKs
Conclusion
Chapter 7 Chemistry and Biological Activity of Diterpenoid Alkaloids
Introduction
Results and Discussion
Material and Methods
Chapter 8 Novel Plant-Derived Biomedical Agents and Their Biosynthetic Origin
Introduction
Chapter 9 Histone Deacetylases as Cancer Chemoprevention Targets for Natural Products
Introduction
The Role of HDACs in Carcinogenesis
HDACi from Natural Sources
The Role of Sirtuins in Carcinogenesis
Modulators of Sirtuins from Natural Sources
Biological Assays
Chapter 10 Natural Products: Strategic Tools for Modulation of Biofilm Formation
Introduction
Surface Active Natural Products
Natural Products in Biofilm Regulation Mechanisms
Microbial Natural Products
Marine Organisms
Plants
Animals
Conclusion
Chapter 11 Medicinal Herbs and Plant Extracts for Influenza: Bioactivity, Mechanism of Anti-influenza Effects, and Modulation of Immune Responses
Introduction
Bioactivity
Mechanisms of Antiviral Effects Against Influenza
Modulation of Immune Responses
Conclusion
Chapter 12 Bioactive Compounds from Marine Gorgonian Corals
Introduction
Bioactive Compounds from Marine Gorgonians
Conclusion
Acknowledgments
Chapter 13 Natural Herbicides as a Safer and More Environmentally Friendly Approach to Weed Control: A Review of the Literature Since 2000
Introduction
Agriculture and Weeds
Agricultural Uses
Nonagricultural Uses
Conclusions
Chapter 14 Recent Approaches Towards Selected Lamiaceae Plants for Their Prospective Use in Neuroprotection
Introduction
Rosmarinus officinalis L.
Scutellaria baicalensis Georgi
Salvia L.
Conclusion
Chapter 15 Phytochemicals
Introduction
An Ancient Scourge: Tuberculosis
The Next Catastrophe: TB Tsunami
The Culprit: Mtb
Current Drugs
Need for Alternative and Integrative Forms of Treatment
Drug Targets of Current Drugs
Structure–Activity Relationships
Synergism
Conclusion
Index
- Edition: 1
- Volume: 38
- Published: December 24, 2013
- Language: English
AR
Atta-ur- Rahman
Atta-ur-Rahman, FRS, D.Phil., TI, SI HI, NI, is a leading scientist and scholar in the field of organic chemistry from Pakistan, especially renowned for his research in the various areas relating to natural product chemistry. With over 909 publications in the field of his expertise including 116 books largely published by leading publishers in Europe and USA and 27 patents, he is also credited for reviving the higher education and research practices in Pakistan.
Prof. Rahman was elected as Fellow of Royal Society (London) in July 2006 thereby becoming one of the 4 scientists from the Muslim world to have ever won this honor in the last 350 years when the Royal Society was established. He is also the only scientist from the Muslim world to have been conferred the UNESCO Science Prize in 1999.[11] He has been conferred honorary doctorate degrees by many universities including the degree of Doctor of Science (Sc.D.) by Cambridge University (UK) (1987) and an Honorary degree of Doctor of Education by Coventry University UK in November 2007. He was elected Honorary Life Fellow of Kings College, Cambridge University, UK in 2007. Prof. Atta-ur-Rahman was conferred the TWAS Prize for Institution Building in Durban, South Africa in October 2009 in recognition of his contributions for bringing about revolutionary changes in the higher education sector in Pakistan. He was awarded the Engro Excellence Award in Science & Technology 2011 for meritorious contributions.
He is President of Network of Academies of Sciences of Islamic Countries (NASIC) and the Vice-President (Central & South Asia) of the Academy of Sciences for the Developing World (TWAS) Council, and Foreign Fellow of Korean Academy of Sciences. Prof. Atta-ur-Rahman was the President of the Pakistan Academy of Sciences (2003–06), and was again elected President of Pakistan Academy of Sciences in January 2011.
He was the Federal Minister for Science and Technology (14 March 2000 – 20 November 2002), Federal Minister of Education (2002) and Chairman of the Higher Education Commission with the status of a Federal Minister from 2002-2008. The Austrian government also honoured him with its highest civil award ("Das Große Goldene Ehrenzeichen am Bande", 2007) in recognition of his eminent contributions.
Prof. Atta-ur-Rahman was the Coordinator General of COMSTECH, an OIC Ministerial Committee comprising the 57 Ministers of Science & Technology from 57 OIC member countries during 1996-2012. He is also the Patron of International Centre of Chemical and Biological Sciences (which comprises a number of institutes, including the Hussain Ebrahim Jamal Research Institute of Chemistry and the Dr. Panjwani Center of Molecular Medicine and Drug Development) at Karachi University.
He established a research center on Genomics in Karachi University. In recognition of the eminent contributions of Prof. Atta-ur-Rahman, a number of institutions have been named after him within and outside Pakistan. These include a natural product chemistry institute (Atta-ur-Rahman Research Institute of Natural Product Discovery, RiND) at the University of Technology Mara in Malaysia, Atta-ur-Rahman School of Applied Biosciences at National University of Science & Technology in Islamabad, and Dr. Atta-ur-Rahman Building at the International Centre for Chemical and Biological Sciences, University of Karachi. The Academy of Sciences in the Developing World (TWAS) based in Trieste, Italy has introduced a Dr. Atta-ur-Rahman Prize in Chemistry to a scientist from the developing world each year. The Prize carries a cash award of $ 5,000 and a Certificate.
Affiliations and expertise
University of Karachi, PakistanRead Studies in Natural Products Chemistry on ScienceDirect