Studies in Natural Products Chemistry
- 1st Edition, Volume 71 - September 22, 2021
- Editor: Atta-ur Rahman
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 9 1 0 9 5 - 8
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 1 0 9 6 - 5
Studies in Natural Products Chemistry, Volume 71 covers the synthesis, testing and recording of the medicinal properties of natural products, providing cutting-edge accounts… Read more
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Request a sales quoteStudies in Natural Products Chemistry, Volume 71 covers the synthesis, testing and recording of the medicinal properties of natural products, providing cutting-edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry.
Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects, hence users will find the detailed information in this book to be a great resource on the topics covered.
- Focuses on the chemistry of bioactive natural products
- Contains contributions by leading authorities in the field
- Presents sources of new pharmacophores
Natural product chemists working in academia and industry. Medicinal chemists and pharmacologists in academia and industry
- Cover image
- Title page
- Table of Contents
- Studies in Natural Products Chemistry
- Copyright
- Contributors
- Preface
- Chapter 1. Recent advances in molecular mechanisms of anticancer natural products that target mitochondrial bioenergetics
- Introduction
- Mitochondrial function: an overview
- Targeting oxidative phosphorylation of cancer cells with natural products
- Modulation of PDH/PDK axis in cancer cells by natural products
- Modulation of mitochondrial calcium uptake by natural products
- Natural products that induce bioenergetics disruption by cardiolipin interaction in cancer cells
- Targeting the mitochondrial quality control of cancer cells with natural products
- Selective action of mitochondria-affecting natural products on cancer stem cells
- Determinants of selectivity of anticancer natural products
- Mitochondrial drug delivery systems for natural products
- Conclusion
- Chapter 2. Plant-derived small molecule inhibitors as modulators of EMT pathway in cancer chemoprevention
- Introduction
- Hedgehog signaling and EMT
- Natural products impede the hedgehog signaling in cancer
- Wnt/beta-catenin signaling and EMT
- Transforming growth factor-β1 signaling and EMT
- Natural products impede the TGF-β1 signaling in cancer
- Conclusion
- Chapter 3. Bioactive polysaccharides and their derivatives from microalgae: biosynthesis, applications, and challenges
- Introduction
- Isolation and screening of polysaccharides
- Biosynthesis and biological activities of polysaccharides
- Challenges and future perspectives
- Chapter 4. Metabolites produced by macro- and microalgae as plant biostimulants
- Introduction
- Biocompounds of algae and microalgae origin
- Seaweeds and microalgae as sources of polysaccharides and oligosaccharides
- (Poly)phenol compounds and antioxidant activity
- Algae and microalgae as sources of biopesticide compounds
- Perspective for biostimulant development from macro- and microalgae: nanotechnology and natural polymers
- Conclusion
- Chapter 5. Marine collagen
- Introduction
- Collagen
- Collagen types
- Molecular structure of collagens
- Marine collagens
- Characterization methods of marine collagens
- Conclusion
- Abbreviations
- Chapter 6. Fenugreek (Trigonella foenum-graecum L.) seed: promising source of nutraceutical
- Introduction
- Fenugreek bioactive compounds and their mechanisms of action against diabetes mellitus
- Nutraceutical effects of fenugreek seed extracts on diseases
- Nutraceutical effects of fenugreek seed/extract on cell disorders
- Safety and side effects of fenugreek seeds
- Conclusion
- Abbreviations
- Chapter 7. Importance of quinazoline and quinazolinone derivatives in medicinal chemistry
- Introduction
- Conclusion
- Chapter 8. Plant secondary metabolites for preferential targeting among various stressors of metabolic syndrome
- Introduction
- PSMs: antinutrients to nutraceuticals
- Various stressors of MetS comorbidities and preferential targets of PSMs
- Significance of PSMs against MetS stressors
- Conclusion
- Abbreviations
- Chapter 9. Flavonoids of Passiflora: isolation, structure elucidation, and biotechnological application
- Historical background and importance of the genus Passiflora
- Botanical features of Passiflora
- Ethnobotanical uses and biological activities of flavonoids of Passiflora
- The biosynthetic pathway of C-glycosyl flavonoids
- Selected species of Passiflora and their flavonoids
- Isolation techniques of flavonoids
- Structure identification: UV, MS, NMR hyphenated techniques
- Biotechnological approach to the in vitro production of flavonoids
- Conclusions and prospects
- Chapter 10. Recent developments on the synthesis of functionalized carbohydrate/sugar derivatives involving the transition metal–catalyzed C–H activation/C–H functionalization
- Introduction
- Functionalization of carbohydrates via directing group–aided C–H activation/functionalization
- Functionalization of carbohydrates via direct C–H activation/functionalization
- Functionalization of carbohydrates involving carbene insertion into C–H bond
- Functionalization of carbohydrates via C–H amination involving carbamate-protected carbohydrates
- Functionalization of carbohydrates via cross-coupling, allylic- and anomeric C–H functionalization and related strategies
- Concluding remarks
- Chapter 11. Asymmetric synthesis of butyrolactones by aldol reactions
- Introduction
- Application of aldol reaction to the asymmetric synthesis of γ-butyrolactones
- Summary and outlook
- Index
- No. of pages: 450
- Language: English
- Edition: 1
- Volume: 71
- Published: September 22, 2021
- Imprint: Elsevier
- Hardback ISBN: 9780323910958
- eBook ISBN: 9780323910965
AR
Atta-ur Rahman
Atta-ur-Rahman, Professor Emeritus, International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Pakistan, was the Pakistan Federal Minister for Science and Technology (2000-2002), Federal Minister of Education (2002), and Chairman of the Higher Education Commission with the status of a Federal Minister from 2002-2008. He is a Fellow of the Royal Society of London (FRS) and an UNESCO Science Laureate. He is a leading scientist with more than 1283 publications in several fields of organic chemistry.
Affiliations and expertise
Professor Emeritus, International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, PakistanRead Studies in Natural Products Chemistry on ScienceDirect