Studies in Natural Products Chemistry

1st Edition - February 4, 2021

Editor: Atta-ur Rahman

Hardback ISBN:

9 7 8 - 0 - 1 2 - 8 1 9 4 8 5 - 0

eBook ISBN:

9 7 8 - 0 - 1 2 - 8 1 9 4 8 6 - 7

eBook ISBN:

9 7 8 - 0 - 3 2 3 - 8 9 8 0 7 - 2

Studies in Natural Products Chemistry, Volume 68, covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting-edge accounts… Read more

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Studies in Natural Products Chemistry, Volume 68, covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting-edge accounts surrounding developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products and their exciting developments in phytochemistry. As natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects, their uses in new drug developments in the pharmaceutical industry has become increasingly important.

With rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, the ability to rapidly isolate and determine the structures and biological activity of natural products has created opportunities for future drug therapies and uses.

Cover image
Title page
Table of Contents
Copyright
Contributors
Preface
Chapter 1: Studies of pentacyclic triterpenoids structures and antidiabetic properties of Myrianthus genus
Abstract
Introduction
Biosynthesis of triterpenoids
Structures of triterpenes isolated from M. arboreus
Extraction and isolation of triterpenoids
Structural elucidation of triterpenoids by spectroscopic methods
Antidiabetic activities of M. arboreus
Concluding remark
Chapter 2: Limonoids and other secondary metabolites of Azadirachta indica (neem) and Azadirachta indica var. siamensis (Siamese neem), and their bioactivities
Abstract
Introduction
Materials and methods
Limonoids and other secondary metabolites of Azadirachta indica (AI) and Azadiracta indica var. siamensis (AIS)
Structural features of limonoids and other secondary metabolites of Azadirachta indica (AI) and Azadiracta indica var. siamensis (AIS)
Bioactivities of limonoids and other secondary metabolites of Azadirachta indica (AI) and Azadiracta indica var. siamensis (AIS)
Conclusions
Chapter 3: Steroidal sapogenins from genus Trillium: Chemistry, synthesis, and opportunities in neuro-active steroids designing
Abstract
Introduction
Steroidal saponins from Trillium genus
Biosynthesis of steroidal saponins
Functions of steroidal saponins
Virtual screening of sapogenin with GABAA receptor
Experimental
Conclusion
Chapter 4: Biological activity and 13C NMR spectral data of skeleton type C20 quassinoids (1985–2019)
Abstract
Introduction
Description and 13C NMR data of C20 skeletal-type quassinoids
Biological activities
Concluding remarks
Aknowledgments
Chapter 5: Carotenoid isomers: A systematic review of the analysis, biological activity, physicochemical property, and methods for isomerization
Abstract
Introduction
General procedure for the analysis of carotenoid isomers
Effect of E/Z-isomerization on bioavailability and biological activity of carotenoids
Effect of E/Z-isomerization on physicochemical properties of carotenoids
Methods for E/Z-isomerization of carotenoids
Utilization of carotenoid Z-isomerization technique: Future directions
Chapter 6: Methods, characteristics, variance, and genetics of pine oleoresin components, and their potential for renewable and sustainable energy
Abstract
Introduction
The composition of pine oleoresin
The genetics of composition of pine oleoresin
The potential for renewable and sustainable energy
Chapter 7: Biologically active compounds from Lamiaceae family: Central nervous system effects
Abstract
Introduction
Ethnomedicine
Lamiaceae family
Bioactivities of extracts from Lamiaceae species on CNS
Lamiaceae compounds with CNS activity
Concluding remarks
Chapter 8: The chemical constituents and biological activities of Cnidoscolus chayamansa McVaugh, a Mexican medicinal species, and plant cell cultures for the production of bioactive secondary metabolites
Abstract
Introduction
Chapter 9: Developments in extraction, purification, and structural elucidation of proanthocyanidins (2000–2019)
Abstract
Introduction
Extraction of free proanthocyanidins
Extraction of bound proanthocyanidins
Purification of proanthocyanidins
Structural identification of proanthocyanidins
Concluding remarks
Acknowledgments
Chapter 10: A review on xanthone derivatives with antiinflammatory effects and their structure–activity relationship
Abstract
Introduction
Antiinflammatory assay
Xanthones with antiinflammatory activity
Conclusion and future perspectives
Acknowledgment
Chapter 11: Biotransformation in the production of secondary metabolites
Abstract
Introduction
Secondary metabolites
Plant metabolic pathways
Techniques for increasing the secondary metabolites
Optimization conditions of the biotransformation reactions
The chemistry techniques used to separate and identify secondary metabolites
Conclusions
Chapter 12: The role of natural and nature-based compounds against Chikungunya and Mayaro alphaviruses and their vectors
Abstract
Introduction
Chikungunya virus (CHIKV)
Mayaro virus (MAYV)
Medicinal chemistry of CHIKV and MAYV
Final considerations
Index