Studies in Natural Products Chemistry
Stereoselective Synthesis
- 1st Edition, Volume 14 - January 1, 1994
- Imprint: Elsevier
- Editor: Atta-ur-Rahman
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 4 - 8 1 7 8 0 - 8
- eBook ISBN:9 7 8 - 1 - 4 8 3 1 - 6 3 5 3 - 6
Studies in Natural Products Chemistry, Volume 14: Stereoselective Synthesis, Part I is a collection of discourses on the stereoselective synthesis of the anticancer anthrucycline… Read more
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Request a sales quoteStudies in Natural Products Chemistry, Volume 14: Stereoselective Synthesis, Part I is a collection of discourses on the stereoselective synthesis of the anticancer anthrucycline antibiotics; tetramic acid antibiotics; 3-and 4-deoxyhexoses; polysaccharides; levoglucosenone as precursor to natural products; synthesis of oligoribonucleotides; and oxidation of guaiazulene. This volume deals with a broad range of natural products focusing on the synthesis of antibiotics and anticancer agents — anthracyclines, tetramic acid, taxodione, vinblastine, and vincristine. These aforementioned drugs are used for the treatment of cancer (anthracyclines) and Hodgkin's disease and childhood acute leukemia (vinblastine and vincristine). The importance of the latest developments in the stereocontrolled synthesis of polysaccharides is discussed as polysaccharides play a fundamental role in cell life and have many technical applications. The synthesis of bioactive carbohydrates 3- and 4-deoxy-hexoses is compared with the more occurring deoxyhexoses in nature such as the 2-deoxy, 6-deoxy, and 2,6-dideoxy-hexoses, because the former are rare compounds and useful tools in the study of biological and biochemical properties of mono- and oligosaccharides, glycoproteins, and antibiotics. Alkaloids derived from Apocynaceae are known for their medicinal properties; hence the synthetic approaches to vinblastine and vincristine are discussed. Because of the minute amounts available from herbal sources, efforts toward their chemical synthesis are given more reference. This book can be a useful reference for the organic chemists. Chemical researchers, pharmaceutical scientists, and professionals of bioorganic chemistry will likewise gain a lot from this collection.
Foreword
Preface
Contributors
Stereoselective Syntheses of Doxorubicin and Related Compounds
Total Synthesis of Nogalamycin Congeners and Their Related Compounds
Synthesis of the Tetramic Acid Antibiotics
The Syntheses of 3-And 4-Deoxy-Hexoses
Recent Developments In the Synthesis of Polysaccharides and Stereospecificity of Glycosylation Reactions
Levoglucosenone: A Versatile Carbohydrate Precursor for the Synthesis of Natural Products
Chemical Synthesis of Branched Oligoribonucleotides and Their Related Compounds
Oxidation Products of Guaiazulene and Other Azulenic Hydrocarbons
Syntheses of Hydroazulene Sesquiterpenes Via Rearrangement of Substituted Hydronaphthalene Precursors
A Chapter In Thujone Chemistry - from Waste By-Product to Natural Products and Related Compounds
The Total Synthesis of Eudesm-11-En-4-Ols
Asymmetric Synthesis Using Chiral Acetals from C2-Symmetric Diols and Its Application to Natural Product Synthesis
Asymmetric Synthesis of Some Natural Spiro Compounds Utilizing Chiral Sulfoxide Auxiliary
Asymmetric Construction of Versatile Chiral Building Blocks and Their Application to the Syntheses of Natural Products
Cationic Cyclopentannelation Reactions
Chiral Construction of Quaternary Carbons Through Additionelimination Process: Application to the Natural Product Syntheses
Organic Synthesis Using Hydrogen Atom Abstraction Reactions
Taxodione Synthetic Studies
Synthetic Studies In the Field of Indole Alkaloids. Part 2
Stereoselectivity In Synthesis and Biosynthesis of Lupine and Nitraria Alkaloids
Biomimetic Synthesis of Benzo [C] Phenanthridine Alkaloids from Protoberberines
Synthetic Approaches to Vinblastine and Vincristine - Anticancer Alkaloids of Catharanthus Roseus
Subject Index
- Edition: 1
- Volume: 14
- Published: January 1, 1994
- No. of pages (eBook): 938
- Imprint: Elsevier
- Language: English
- Hardback ISBN: 9780444817808
- eBook ISBN: 9781483163536
A
Atta-ur-Rahman
Renowned scientist Dr. Atta-ur-Rahman was appointed as the chairman of United Nations’ committee on Science, Technology and Innovation in March 2016. Formerly Professor Emeritus, International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Pakistan, he was Pakistan Federal Minister for Science and Technology (2000-2002), Federal Minister of Education (2002), and Chairman of the Higher Education Commission with the status of a Federal Minister from 2002-2008. He is a Fellow of the Royal Society of London (FRS) and an UNESCO Science Laureate. A leading scientist, he also has over 930 publications to his name in several fields of organic chemistry.
Affiliations and expertise
Associate Professor, Institute of Geography, Urban and Regional Planning, University of Peshawar, Pakistan and Chairman of the United Nations’ committee on Science, Technology and Innovation, PakistanRead Studies in Natural Products Chemistry on ScienceDirect