Skip to main content
Elsevier

Structure, Function, and Regulation of G Protein-Coupled Receptors Part B

  • 1st Edition, Volume 750 - June 1, 2027
  • Latest edition
  • Editors: Arun K. Shukla, Anna Pyle, David Christianson, Karen N. Allen
  • Language: English

G protein-coupled receptors constitute one of the largest classes of cell surface receptors in the human genome and drug targets for approximately one third of the currently… Read more

Description

G protein-coupled receptors constitute one of the largest classes of cell surface receptors in the human genome and drug targets for approximately one third of the currently prescribed medicines. The has been a tremendous advance in understanding the activation, signaling, and regulation of these receptors over the past couple of years using cellular, biochemical, structural, and pharmacological approaches. These two volumes of Methods in Enzymology cover these recent advances in the form of short overview of the key topics as well as step-by-step protocols developed to probe the functional attributes of these versatile receptors.

Key features

  • Contributions by the leaders in the field of GPCR biology
  • Focus on recently developed and broadly applicable methods and advances
  • Chapters are based on most recent advances in the field with futuristic outlook

Readership

Anyone involved in research focused on G protein-couples receptors (GPCRs) would find these volumes highly valuable and these will particularly appeal to the researchers involved in cutting-edge research and development on GPCRs

Table of contents

1. TBD
Leonidas Tsiokas

2. Exploring Large-Scale Dynamics of GPCR Signalling Proteins Using Coarse-Grained Molecular Dynamics
Özge Şensoy, Zeynep Nur Cinviz and Giulia Morra

3. TBD
Marián Castro

4. TBD
Prashen Chelikani

5. TBD
Mette Marie Rosenkilde

6. A fluorogenic method to detect GPCR expression and lysosomal downregulation
Braden T. Lobingier and Hayden Adoff

7. TBD
Elizabeth Johnstone

8. TBD
Alejandra Tomas

9. TBD
Valentin Borshchevski

10. TBD2
Valentin Borshchevski

11. TBD
Terry Hébert and Dulce Carillo Valenzuela

12. TBD
Séverine Morisset-Lopez

13. TBD
Prem N. Yadav

14. TBD
Tao Che

15. TBD
Asuka Inoue

16. TBD
Ajith Karunarathne

17. TBD
Irina Tikhonova

18. TBD
Philippe Rondard

19. TBD
Natasha Grimsey

20. TBD
Norbert Straeter, Manuel Jankovic, Robin Schick and Tobias Langenhan

21. TBD
Marcel Bermúdez

22. TBD
Rob Leurs and H.F. Vischer

Product details

  • Edition: 1
  • Latest edition
  • Volume: 750
  • Published: June 1, 2027
  • Language: English

About the editors

Arun K. Shukla

Serial Volume Editor
Dr. Arun K. Shukla is a world leader in the field of GPCR biology and he is currently a Professor in the Department of Biological Sciences and Bioengineering at the Institute of Technology, Kanpur in India. Dr. Shukla’s research program is focused on understanding the structure, function and regulation of G protein-coupled receptors with a long-term of designing novel therapeutics with minimized side-effects.
Affiliations and expertise
Professor, Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur, India

David Christianson

Serial Editor

After completing studies for the A.B., A.M., and Ph.D. degrees in chemistry at Harvard University, David W. Christianson joined the faculty of the University of Pennsylvania, where he is currently the Roy and Diana Vagelos Professor in Chemistry and Chemical Biology. At Penn, Christianson’s research focuses on the structural and chemical biology of the zinc-dependent histone deacetylases as well as enzymes of terpene biosynthesis. His research accomplishments have been recognized by several awards, including the Pfizer Award in Enzyme Chemistry and the Repligen Award in Chemistry of Biological Processes from the American Chemical Society, a Guggenheim Fellowship, and the Elizabeth S. and Richard M. Cashin Fellowship from the Radcliffe Institute for Advanced Study at Harvard University. Christianson is also a dedicated classroom teacher, and his accomplishments in this regard have been recognized by the Lindback Award for Distinguished Teaching at Penn and a Rhodes Trust Inspirational Educator Award from Oxford University. Christianson has also held visiting professorships in the Department of Biochemistry at Cambridge University and the Department of Chemistry and Chemical Biology at Harvard University. Christianson has served with Prof. Anna Pyle as Co-Editor-in-Chief of Methods in Enzymology since 2015.

Affiliations and expertise
Roy and Diana Vagelos Professor in Chemistry and Chemical Biology, Department of Chemistry and Chemical Biology, University of Pennsylvania, Philadelphia, USA

Karen N. Allen

Serial Editor
Dr. Karen N. Allen works at the Department of Chemistry of the Boston University, the Metcalf Center for Science and Engineering
Affiliations and expertise
Department of Chemistry, Metcalf Center for Science and Engineering, Boston University, Boston, MA, USA