Structure and Metabolic Mechanisms
- 1st Edition - January 1, 1977
- Imprint: Academic Press
- Editor: Walter Lovenberg
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 4 5 6 0 0 3 - 1
- Paperback ISBN:9 7 8 - 0 - 1 2 - 4 1 4 6 3 3 - 4
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 1 4 9 5 2 - 5
Iron-Sulfur Proteins, Volume III: Structure and Metabolic Mechanisms focuses on numerous advances that have been made in the vital role of iron-sulfur proteins in biologica… Read more
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Request a sales quoteIron-Sulfur Proteins, Volume III: Structure and Metabolic Mechanisms focuses on numerous advances that have been made in the vital role of iron-sulfur proteins in biological processes. Of the 10 chapters in this book, five chapters present advances in biochemical areas and the other five chapters discuss some of the elegant physical studies made.
This book begins with a description of the nitrogenase gene and the molecular mechanism of this complex enzyme. It then centers on the role of iron-sulfur proteins in mammalian mitochondrial function, as well as on the mechanism of biosynthesis and the function of these proteins in formate metabolism. Different approaches that have yielded advances in the understanding of the iron-sulfur clusters are also shown. This book also gives an in-depth discussion on the theoretical aspects of the redox properties of iron-sulfur proteins.
List of ContributorsPrefaceContents of Other Volumes1. Nitrogenase-Derepressed Mutants of Klebsiella pneumoniae I. Introduction II. Glutamine Synthetase as Regulatory Protein III. Nitrogenase-Derepressed Mutants IV. Discussion and Summary References2. Current Topics and Problems in the Enzymology of Nitrogenase I. Introduction II. Composition and Structure of Nitrogenase Protein Components III. Interaction of MgATP and the Fe Protein IV. Sequence of Electron Transfers between Nitrogenase Components V. Structural and Mechanistic Hypotheses References3. Iron-Sulfur Centers of the Mitochondrial Electron Transfer System—Recent Developments I. Introduction II. Iron-Sulfur Centers of the Mitochondrial Electron Transfer System III. Relation of Iron-Sulfur Centers to Energy Conservation IV. Outlook References4. Biosynthesis of Iron-Sulfur Proteins I. Introduction II. Bacterial Protein Synthesis III. Regulation of Synthesis of Ferredoxin IV. Conversion of Apoferredoxin to Holo- or Native Ferredoxin V. Synthesis of Specific Proteins in Vitro VI. Immunological Studies with Clostridial Ferredoxin VII. Enzymatic Assays for Ferredoxin VIII. Synthesis of Clostridial Ferredoxin or Apoferredoxin in Vitro References5. Role of Iron-Sulfur Proteins in Formate Metabolism I. Introduction II. Role of Formate in Metabolism III. Ferredoxin and Formate Metabolism IV. Formate Dehydrogenases and Formate Metabolism V. Concluding Remarks References6. X-Ray Analysis of High-Potential Iron-Sulfur Proteins and Ferredoxins I. Introduction II. Fe4S4* Active Centers and the Three-State Hypothesis III. Comparison of the Protein-Bound and Synthetic Fe4S4* Clusters IV. Characteristic Features of the Cluster Binding Cavities V. Analysis of Reduced versus Oxidized HiPIP VI. Conclusions and Review References7. Synthetic Analogues of the Active Sites of Iron-Sulfur Proteins I. Introduction II. Synthesis and Structures of 1-Fe, 2-Fe, and 4-Fe Active-Site Analogues III. Physical Properties of Analogues IV. Chemical Reactivity of Analogues V. Iron-Sulfur Units as Redox Centers VI. Perspectives and Conclusions References8. Evidence from Mössbauer Spectroscopy and Magnetic Resonance on the Active Centers of the Iron-Sulfur Proteins I. Introduction II. Spectroscopy of the Active Center III. Proteins with 1 Fe Centers IV. Proteins with 2 Fe-2 S* Centers V. Proteins with 4 Fe-4 S* Centers VI. Conclusions References9. Redox Mechanisms of Iron-Sulfur Proteins I. Introduction II. Recent Development in Simple Redox Chemistry III. Redox Dynamics of Structurally Characterized Iron-Sulfur Proteins IV. Survey of the Redox Behavior of Structurally Less Characterized Iron-Sulfur Proteins References10. Recent Mössbauer Results of Some Iron-Sulfur Proteins and Model Complexes I. Introduction II. Rubredoxin III. The MoFe Protein of Nitrogenase IV. Model Compounds for Rubredoxin and 4 Fe-4 S* Clusters ReferencesAuthor IndexSubject Index
- Edition: 1
- Published: January 1, 1977
- No. of pages (eBook): 460
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780124560031
- Paperback ISBN: 9780124146334
- eBook ISBN: 9780323149525
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