Stromal Signaling in Cancer
- 1st Edition, Volume 154 - April 20, 2022
- Editors: Peggi Angel, Michael Ostrowski
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 8 5 4 2 3 - 8
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 5 4 2 4 - 5
Stromal Signaling in Cancer, Volume 154 in the Advances in Cancer Research series, highlights new advances in the field, with this new volume presenting interesting chapters on a… Read more
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Request a sales quoteStromal Signaling in Cancer, Volume 154 in the Advances in Cancer Research series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics surrounding cancer research. Each chapter is written by an international board of authors.
- Provides the authority and expertise of leading contributors from an international board of authors
- Presents the latest release in the Advances in Cancer Research series
- Updated release includes the latest information on Stromal Signaling in Cancer
Researchers and students in the basic and clinical sciences of cancer biology and oncology, plus related areas in genetics, immunology, pharmacology, cell biology, and molecular biology
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Chapter One: The pathologic diagnosis of carcinoma in various tissues
- Abstract
- 1: Introduction
- 2: Breast carcinoma
- 3: Colorectal carcinoma
- 4: Lung carcinoma
- 5: Pancreatic carcinoma
- 6: Hepatocellular carcinoma
- 7: Prostate carcinoma
- 8: Central nervous system malignancy
- References
- Chapter Two: Predictive value of collagen in cancer
- Abstract
- 1: Introduction
- 2: Breast cancer
- 3: Lung cancer
- 4: Hepatocellular carcinoma (liver cancer)
- 5: Colon cancer
- 6: Pancreatic cancer
- 7: Perspectives and conclusions
- Acknowledgments
- Author contributions
- References
- Chapter Three: Molecular sensors for detection of tumor-stroma crosstalk
- Abstract
- 1: Introduction
- 2: Force biosensors
- 3: Imaging reporters for single-cell kinase signaling
- 4: Biosensors for detection of cellular metabolic activity
- 5: Detecting cell-cell interactions
- 6: Conclusion and future perspectives
- Acknowledgments
- References
- Chapter Four: Diverse roles of tumor-stromal PDGFB-to-PDGFRβ signaling in breast cancer growth and metastasis
- Abstract
- 1: Introduction
- 2: PDGF ligand isoforms and their receptors
- 3: Autocrine pro-tumorigenic mechanisms of PDGFB-to-PDGFRβ signaling
- 4: Paracrine PDGFB-to-PDGFRβ mediated tumor-stromal cross-talk
- 5: PDGFB-to-PDGFRβ signaling in the promotion of breast cancer metastasis
- 6: Therapeutic strategies targeting PDGFB-to-PDGFRβ signaling
- 7: Conclusion and perspectives
- Acknowledgments
- conflicts of interest
- References
- Chapter Five: Meaningful connections: Interrogating the role of physical fibroblast cell–cell communication in cancer
- Abstract
- 1: Introduction
- 2: Fibroblast-fibroblast homotypic interactions
- 3: Fibroblast-cancer heterotypic interactions
- 4: Fibroblast–immune heterotypic interactions
- 5: Fibroblast–ECM interactions
- 6: Discussion
- Acknowledgments
- References
- Chapter Six: Origin, activation and heterogeneity of fibroblasts associated with pancreas and breast cancers
- Abstract
- 1: Introduction
- 2: Tissue origins of CAFs
- 3: CAFs generation and activation
- 4: Conclusions and future directions
- References
- Chapter Seven: PTEN in cancer associated fibroblasts
- Abstract
- 1: Introduction
- 2: PTEN and its downstream effectors
- 3: PTEN and the ECM
- 4: CAF PTEN maintains epithelial homeostasis
- 5: Mechanisms of PTEN inactivation in CAFs
- 6: Translational and clinical impact
- 7: Conclusions and perspectives
- References
- Chapter Eight: High-dimensionality reduction clustering of complex carbohydrates to study lung cancer metabolic heterogeneity
- Abstract
- 1: Introduction
- 2: Results
- 3: Discussion
- 4: Limitations and future directions
- 5: Methods
- Acknowledgments
- References
- No. of pages: 266
- Language: English
- Edition: 1
- Volume: 154
- Published: April 20, 2022
- Imprint: Academic Press
- Hardback ISBN: 9780323854238
- eBook ISBN: 9780323854245
PA
Peggi Angel
Peggi Angel works at the Medical University of South Carolina, South Carolina, USA
Affiliations and expertise
Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, SC, USAMO
Michael Ostrowski
Dr. Michael Ostrowski works at the Medical University of South Carolina in SC, USA.
Affiliations and expertise
Medical University of South Carolina, SC, USA.Read Stromal Signaling in Cancer on ScienceDirect