Steroid Hormone Receptors in Health and Disease

1st Edition - November 29, 2023
Imprint: Academic Press
Authors: Raj Kumar, Iain J. McEwan
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 1 1 4 1 - 2
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 9 8 4 6 - 8

Steroid Hormone Receptors in Endocrine Physiology and Diseases covers the role of steroid hormones in human physiology and receptor activity in the pathophysiology of diseas… Read more

Steroid Hormone Receptors in Health and Disease

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Steroid Hormone Receptors in Endocrine Physiology and Diseases covers the role of steroid hormones in human physiology and receptor activity in the pathophysiology of disease. The book discusses how these receptors can be used as therapeutic targets for the treatment of conditions from cancer to aging, offering immediate applications of biochemical principles into clinical applications such as diagnosis and treatment. This book is a valuable reference for graduate and postdoctoral scientists but is also ideal for medical students interested in the functional role of various steroid hormone receptors in a wide variety of endocrine related diseases.Steroid hormone receptors (SHRs) are known to play vital roles in normal physiology through the control of development, differentiation, metabolic homeostasis and reproduction. Due to their involvement in various pathological and disease conditions, SHRs are also important therapeutic targets in several disorders including inflammation, autoimmune diseases, hormone-dependent cancers, osteoporosis and cardiovascular diseases.

Cover image
Title page
Table of Contents
Copyright
Preface
Chapter 1. A brief history of steroid hormones and steroid receptor biology
Abstract
Introduction
Steroid hormones
Discovery, purification, and synthetic synthesis of steroid hormones
Receptor proteins and mechanism of hormone action
Conclusions and future perspectives
References
Chapter 2. Hormone-dependent cancers
Abstract
Introduction
Breast cancer
Prostate cancer
Ovarian cancer
Endometrial cancer
Conclusions
References
Chapter 3. Steroids and cardiovascular and metabolic disorders
Abstract
Introduction
Metabolic syndrome
Meabolic disorders and steroid hormone receptors
Role of GR in obesity
Role of MR in hypertension
Role of ER in cardiovascular diseases
Role of PR in metabolic disorders
Conclusions and future perspectives
References
Chapter 4. Steroid hormone receptors in aging and neurodegenerative diseases
Abstract
Introduction
Aging
Neurodegenerative diseases
Steroid hormone receptors and aging
Steroid hormone receptors and neurodegenerative diseases
Conclusions and future perspectives
References
Chapter 5. Steroid hormones and infection and immunity
Abstract
Introduction
Role of hypothalamic–pituitary–adrenal and hypothalamic–pituitary–gonadal axis in immunity
Steroid hormone receptors regulation of immune responses in cancer
Steroidogenesis and its role in immune regulation
Influence of sex hormones on vaccine-induced immunity
Glucocorticoids, inflammation, and autoimmune diseases
Steroid hormones and COVID-19
Conclusions and future perspectives
References
Chapter 6. Endocrine disruptors: the enemy without
Abstract
Introduction
Chemical nature of EDCs
Mechanism of action
Impact of EDC on human health—results from animal studies and human cohorts
Conclusions and future perspectives
References
Chapter 7. The gut microbiota—as an endocrine organ
Abstract
Introduction
Steroid biosynthesis and metabolism
The gut microbiota and sex differences
The gut microbiota and sex hormones
Gut microbiota associated with life events, age and sex differences
Conclusion and future perspectives
References
Chapter 8. Summary and future perspectives
Steroid receptor structure and tissue-specific gene regulation
Steroid receptors and metabolism
Steroid hormones and receptors in healthy aging
Environmental impacts on steroid receptor function
The gut microbiota and steroid hormone levels and signaling
Concluding remarks
Index

Raj Kumar

Raj Kumar, Ph.D., is a Professor and Chair of the Department of Pharmaceutical and Biomedical Sciences at the Touro College of Pharmacy, Touro University, New York, NY, . For more than 20-years, Dr. Kumar has been actively pursuing structure-based drug designing for endocrine related diseases. Dr. Kumar has co-authored about 100 publications, including research articles, invited reviews/book chapters, books and a patent. Current research projects in Dr Kumar’s group are multidisciplinary and focus on the structural and functional aspects of the steroid hormone receptors. Dr. Kumar’s publications are highly cited, and has received several research grant funding including National Institutes of Health (NIH) RO1 grants. Dr. Kumar has spoken at several events as invited speaker, served as an editorial board member for scientific journals, served on various grant review panels, including NIH and the National Science Foundation (NSF)..

Affiliations and expertise

Professor of Biochemistry, University of Houston College of Medicine, USA

Iain J. McEwan

Iain McEwan, Ph.D., is a Professor of Molecular and Cellular Endocrinology and has over 25 years research experience in steroid receptor signaling and managing a productive research group, with over 77 peer reviewed publications. Current research projects in Dr McEwan’s group are multidisciplinary and focus on fundamental and translational aspects of androgen receptor expression, structure, and function. Research funding sources include the Medical Research Council (UK), Prostate Cancer Research (UK) and local charities. Dr. McEwan sits on a several grant awarding committees for Prostate Cancer UK and is co-chair of the Translational Clinical Sciences panel, Chief Scientist Office (Scottish Government). . He has edited or co-edited several books on the nuclear receptor superfamily and co-authored a book of ‘Testosterone: From Basic Research to Clinical Applications’.

Affiliations and expertise

Professor in Molecular and Cellular Endocrinology, Institute of Medical Sciences, University of Aberdeen, UK

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

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