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Steroid Hormone Receptors in Health and Disease
- 1st Edition - November 29, 2023
- Authors: Raj Kumar, Iain J. McEwan
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 1 1 4 1 - 2
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 9 8 4 6 - 8
Steroid Hormone Receptors in Endocrine Physiology and Diseases covers the role of steroid hormones in human physiology and receptor activity in the pathophysiology of diseas… Read more
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Request a sales quoteSteroid Hormone Receptors in Endocrine Physiology and Diseases covers the role of steroid hormones in human physiology and receptor activity in the pathophysiology of disease. The book discusses how these receptors can be used as therapeutic targets for the treatment of conditions from cancer to aging, offering immediate applications of biochemical principles into clinical applications such as diagnosis and treatment. This book is a valuable reference for graduate and postdoctoral scientists but is also ideal for medical students interested in the functional role of various steroid hormone receptors in a wide variety of endocrine related diseases.Steroid hormone receptors (SHRs) are known to play vital roles in normal physiology through the control of development, differentiation, metabolic homeostasis and reproduction. Due to their involvement in various pathological and disease conditions, SHRs are also important therapeutic targets in several disorders including inflammation, autoimmune diseases, hormone-dependent cancers, osteoporosis and cardiovascular diseases.
- Discusses the importance of steroid hormone receptors in the physiology and pathophysiology of various endocrine related diseases
- Provides state-of-the-art information based on key research findings in the field, along with hypotheses and perspectives for future directions for basic and translational research and clinical applications
- Offers a comprehensive description of the challenges associated with steroid hormone receptors-based therapies
Graduate students, advanced undergraduate students, researchers and clinicians working in the field of endocrinology, Pharmaceutical and biopharma companies
- Cover image
- Title page
- Table of Contents
- Copyright
- Preface
- Chapter 1. A brief history of steroid hormones and steroid receptor biology
- Abstract
- Introduction
- Steroid hormones
- Discovery, purification, and synthetic synthesis of steroid hormones
- Receptor proteins and mechanism of hormone action
- Conclusions and future perspectives
- References
- Chapter 2. Hormone-dependent cancers
- Abstract
- Introduction
- Breast cancer
- Prostate cancer
- Ovarian cancer
- Endometrial cancer
- Conclusions
- References
- Chapter 3. Steroids and cardiovascular and metabolic disorders
- Abstract
- Introduction
- Metabolic syndrome
- Meabolic disorders and steroid hormone receptors
- Role of GR in obesity
- Role of MR in hypertension
- Role of ER in cardiovascular diseases
- Role of PR in metabolic disorders
- Conclusions and future perspectives
- References
- Chapter 4. Steroid hormone receptors in aging and neurodegenerative diseases
- Abstract
- Introduction
- Aging
- Neurodegenerative diseases
- Steroid hormone receptors and aging
- Steroid hormone receptors and neurodegenerative diseases
- Conclusions and future perspectives
- References
- Chapter 5. Steroid hormones and infection and immunity
- Abstract
- Introduction
- Role of hypothalamic–pituitary–adrenal and hypothalamic–pituitary–gonadal axis in immunity
- Steroid hormone receptors regulation of immune responses in cancer
- Steroidogenesis and its role in immune regulation
- Influence of sex hormones on vaccine-induced immunity
- Glucocorticoids, inflammation, and autoimmune diseases
- Steroid hormones and COVID-19
- Conclusions and future perspectives
- References
- Chapter 6. Endocrine disruptors: the enemy without
- Abstract
- Introduction
- Chemical nature of EDCs
- Mechanism of action
- Impact of EDC on human health—results from animal studies and human cohorts
- Conclusions and future perspectives
- References
- Chapter 7. The gut microbiota—as an endocrine organ
- Abstract
- Introduction
- Steroid biosynthesis and metabolism
- The gut microbiota and sex differences
- The gut microbiota and sex hormones
- Gut microbiota associated with life events, age and sex differences
- Conclusion and future perspectives
- References
- Chapter 8. Summary and future perspectives
- Steroid receptor structure and tissue-specific gene regulation
- Steroid receptors and metabolism
- Steroid hormones and receptors in healthy aging
- Environmental impacts on steroid receptor function
- The gut microbiota and steroid hormone levels and signaling
- Concluding remarks
- Index
- No. of pages: 172
- Language: English
- Edition: 1
- Published: November 29, 2023
- Imprint: Academic Press
- Paperback ISBN: 9780323911412
- eBook ISBN: 9780323998468
RK
Raj Kumar
Raj Kumar, Ph.D., is a Professor and Chair of the Department of Pharmaceutical and Biomedical Sciences at the Touro College of Pharmacy, Touro University, New York, NY, . For more than 20-years, Dr. Kumar has been actively pursuing structure-based drug designing for endocrine related diseases. Dr. Kumar has co-authored about 100 publications, including research articles, invited reviews/book chapters, books and a patent. Current research projects in Dr Kumar’s group are multidisciplinary and focus on the structural and functional aspects of the steroid hormone receptors. Dr. Kumar’s publications are highly cited, and has received several research grant funding including National Institutes of Health (NIH) RO1 grants. Dr. Kumar has spoken at several events as invited speaker, served as an editorial board member for scientific journals, served on various grant review panels, including NIH and the National Science Foundation (NSF)..
Affiliations and expertise
Professor of Biochemistry, University of Houston College of Medicine, USAIM
Iain J. McEwan
Iain McEwan, Ph.D., is a Professor of Molecular and Cellular Endocrinology and has over 25 years research experience in steroid receptor signaling and managing a productive research group, with over 77 peer reviewed publications. Current research projects in Dr McEwan’s group are multidisciplinary and focus on fundamental and translational aspects of androgen receptor expression, structure, and function. Research funding sources include the Medical Research Council (UK), Prostate Cancer Research (UK) and local charities. Dr. McEwan sits on a several grant awarding committees for Prostate Cancer UK and is co-chair of the Translational Clinical Sciences panel, Chief Scientist Office (Scottish Government). . He has edited or co-edited several books on the nuclear receptor superfamily and co-authored a book of ‘Testosterone: From Basic Research to Clinical Applications’.
Affiliations and expertise
Professor in Molecular and Cellular Endocrinology, Institute of Medical Sciences, University of Aberdeen, UKRead Steroid Hormone Receptors in Health and Disease on ScienceDirect