Stem Cell Therapy

Practical Considerations

1st Edition - November 13, 2022
Imprint: Academic Press
Authors: Hala M. Gabr, Wael Abo El-Kheir
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 2 1 5 6 9 - 2
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 1 5 7 0 - 8

Stem cell therapy is a fast-growing field of medicine with remarkable prospects in a broad spectrum of diseases. Stem Cell Therapy: Practical Considerations addresses the biologica… Read more

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Stem cell therapy is a fast-growing field of medicine with remarkable prospects in a broad spectrum of diseases. Stem Cell Therapy: Practical Considerations addresses the biological properties of stem cells, mechanisms of action; as well as actual therapeutic decisions such as cell type, source, dose, manipulation, and route of injection.

After discussing all this data, the book will illustrate how to travel through the idea from abstract question to laboratory experiment, animal experiment and then on to design a clinical trial throughout all its phases. Written for scientists and postgraduate students in the field of stem cell research and therapy. The authors will cover practical therapeutic issues they have long experienced in the field.

Cover image
Title page
Table of Contents
Copyright
Dedication
Part I: Stem cells: basic biology
Chapter 1. Introduction
Abstract
Content
1.1 Establishing the concept of stem cells
Further reading
Chapter 2. Anatomy and Histology
Abstract
Table of Contents
2.1 Blood supply
2.2 Niche
2.3 Hemopoietic stem cell niches
2.4 Differences between osteoblastic and vascular niches
2.5 Components of the hemopoietic stem cell niche
2.6 Mesenchymal stem cell niche
2.7 Mesenchymal stem niche in adipose tissue
2.8 Niche functions
2.9 Regulation of niche function
Further reading
Chapter 3. Stem cells: definition, biological types, classifications, and properties
Abstract
Table of Contents
3.1 Definition
3.2 Classification
3.3 Properties
3.4 Differentiation
3.5 Homing and engraftment
Further reading
Part II: Stem cell induced regeneration: principles and applications
Chapter 4. Mechanisms of stem cell–related regeneration
Abstract
Content
4.1 Regulation of tissue regeneration
4.2 Overview of the mechanism of regeneration
4.3 Signaling pathways involved in stem cell transdifferentiation
4.4 Activation of endogenous repair system
4.5 Induction of angiogenesis
4.6 Secretory function
4.7 Mitochondrial transfer
4.8 Microenvironment modulation
4.9 Conclusion
Further reading
Chapter 5. Sources of stem cells for regenerative purposes
Abstract
Table of Contents
5.1 Characteristics of the ideal source of stem cells
5.2 Sources of mesenchymal stem cells
5.3 Skin mesenchymal stem cells
5.4 Periodontal ligament stem cells
5.5 Cord blood
5.6 Tissue-specific stem cells
Further reading
Chapter 6. Basic concepts in stem cell therapy: stem cell therapy strategy development
Abstract
Table of Contents
6.1 Introduction
6.2 What is the basic defect?
6.3 Which cell lineage is the best for repair? Choosing optimum cell lineage
6.4 What is the best source for a cell type? Choosing the optimum cell source
6.5 What is the optimum laboratory protocol?
6.6 Choosing the optimum route of injection
6.7 Factors affecting homing of stem cells
6.8 Optimal timing for cell therapy
6.9 Optimum number of cells for injection
6.10 Choosing the method of evaluation
Further reading
Part III: Guidelines for stem cell therapy
Chapter 7. Stem Cell Therapy: Laboratory guidelines
Abstract
Table of Contents
7.1 Introduction
7.2 Laboratory guidelines
7.3 Quality control team
Further reading
Chapter 8. Protocol guidelines for clinical decisions in stem cell therapy
Abstract
Table of Contents
8.1 Introduction
Reference
Further reading
Chapter 9. Protocol guidelines: laboratory decisions in stem cell therapy
Abstract
Table of Contents
9.1 Introduction
9.2 Choosing the cell purification level
9.3 Choice of purification strategy
9.4 Choice of stem cell differentiation status
9.5 Choice of cell dose
9.6 Choice of tracking method
Chapter 10. Phases of translational stem cell research
Abstract
Table of Contents
10.1 Introduction
10.2 Laboratory experiments
10.3 Preclinical, experimental
10.4 Clinical trials
Further reading
Chapter 11. Ethical guidelines of stem cell therapy
Abstract
Table of Contents
11.1 Introduction
Further reading
Chapter 12. Stem cell therapy: practical examples
Abstract
Table of Contents
12.1 Neuroregeneration
12.2 Experimental animal study
12.3 Results
12.4 Results of clinical translational study
12.5 Replacement of defective protein
12.6 Results
12.7 Multifactorial defects
12.8 Conclusion
Further reading
Appendix A
A.1 Standard operating procedures for stem cell therapy procedures
Index

Hala M. Gabr

Dr. Gabr is a Professor of Hematology in the Department of Clinical Pathology at Cairo University, in Egypt. She received her Doctor’s Degree in Clinical and Chemical Pathology in 1995 from Cairo University, where she also received her Bachelor, Master’s and completed her residency. Dr. Gabr’s subspecialty is tissue culture, cytogenetics and stem cell biology and she has published 27 papers in international journals. Dr. Gabr is member of the International Society for Hematology and Stem Cells "ISEH", a member of the European Society for Gene and Cell Therapy (ESGCT), a council member of the International Federation of Neurorestoratology, a scientific advisor of the "Egyptian Foundation of Molecular Biology", a scientific advisor of the "Egyptian Society for Progenitor Cell Research", a member of the Egyptian society of Laboratory medicine, a member of the Egyptian society of Hematology & Research and a reviewer for the European Journal of Gastroenterology and Hepatology.

Affiliations and expertise

Professor of Hematology, Department of Clinical Pathology, Cairo University, Egypt

Wael Abo El-Kheir

Wael Abo Elkheir completed his PhD from Cairo University, Egypt. He is the Vice President, Founder and Board Member of the Egyptian Society for Progenitor Stem Cell Research (ESPCR), a society initiated with the mission of enhancing scientific research and cooperation in the field of stem cell research and regenerative medicine. Dr. Elkheir is the Director of a number of registered clinical trials in the field of stem cell therapy, especially for neuro-regeneration and musculoskeletal disorders. He has published more than 20 papers in reputed journals. He is member of the International Society for Cellular Therapy (ISCT), a member of the National Stem Cell Committee, laboratory consultant of the Al-Azhar University Stem Cell Therapy for Spinal Cord Injury Project, laboratory consultant of the National Institute for Cardiology Project for Stem Cell Therapy and scientific advisor of the "Egyptian Foundation of Molecular Biology".

Affiliations and expertise

Vice President, Founder and Board Member, Egyptian Society for Progenitor Stem Cell Research, Cairo, Egypt

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health