Silver Nanoparticles for Drug Delivery

1st Edition - November 29, 2023
Editor: Prashant Kesharwani
Language: English
Paperback ISBN:
9 7 8 - 0 - 4 4 3 - 1 5 3 4 3 - 3
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 5 3 4 4 - 0

Silver Nanoparticles for Drug Delivery is a complete reference that provides comprehensive coverage of the principle behind the formation, characterization, application, regula… Read more

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Silver Nanoparticles for Drug Delivery is a complete reference that provides comprehensive coverage of the principle behind the formation, characterization, application, regulation, toxicity, and challenges and future perspectives of silver nanoparticles in drug delivery for the treatment of various diseases. Sections cover the synthesis and characterization of silver nanoparticles (AgNPs), historical introductions to developments, methods and characterization parameters, green and biological synthesis methods, biofate and cellular interactions of AgNPs, drug delivery for the treatment of several diseases and conditions, targeting strategies, applications in cancer diagnosis and treatment, and much more. This is a complete reference for graduate students in nanotechnology drug delivery.

Cover image
Title page
Table of Contents
Copyright
Dedication
List of contributors
About the editor
Preface
Acknowledgments
Chapter 1. History, introduction, and physicochemical properties of silver nanoparticles
Abstract
1.1 Introduction
1.2 Ancient history silver
1.3 Discovery of silver nanoparticles
1.4 Physicochemical properties of silver nanoparticles
1.5 General applications of silver nanoparticles
1.6 Silver nanoparticles with biomedical applications
1.7 Conclusion
References
Chapter 2. Synthesis methods and characterization parameters of silver nanoparticles
Abstract
2.1 Introduction
2.2 Synthesis methods of AgNPs
2.3 Characterization parameters of AgNPs
2.4 Conclusion
Conflicts of interest
References
Chapter 3. Targeting strategies and clinical implications of bio-conjugated silver nanoparticles in drug delivery
Abstract
3.1 Introduction
3.2 Experimental and applications
3.3 Conclusion
References
Chapter 4. Silver nanoparticles for pharmaceutical and biomedical applications drug delivery
Abstract
4.1 Introduction
4.2 Various methods of silver nanoparticles synthesis
4.3 Silver nanoparticles antimicrobial therapeutics
4.4 Mechanisms of action of antimicrobial agents
4.5 Antiviral ability of silver nanoparticles
4.6 The mechanisms of antiviral action of silver NPs
4.7 Anti-inflammatory activity
4.8 AgNPs treat wounds infections
4.9 Anticancer drugs
4.10 Alzheimer’s disease
4.11 Future applications
References
Chapter 5. Silver nanoparticles for cancer diagnosis and treatment of cancer
Abstract
5.1 Introduction
5.2 Mechanism of action of anticancer property
5.3 Silver nanoparticles in cancer diagnosis
5.4 Silver nanoparticles in cancer therapy
5.5 Silver nanoparticles: challenges and limitations in cancer therapy
5.6 Future perspective
5.7 Conclusion
References
Chapter 6. Silver nanoparticles to enhance photodynamic action of photosensitizers
Abstract
6.1 Introduction
6.2 Fundamentals of the photodynamic effect
6.3 AgNPs in the photodynamic action
6.4 Applications of AgNPs in photodynamic treatment
6.5 Final remarks
Acknowledgments
References
Chapter 7. Silver nanoparticles against multidrug-resistant bacteria and bacterial biofilm
Abstract
7.1 Introduction
7.2 Key concepts
7.3 Bacterial activity of AgNPs
7.4 Perspectives
Acknowledgments
References
Chapter 8. Silver nanoparticles in wound therapy and tissue regeneration
Abstract
8.1 Introduction
8.2 Different types of embedded silver nanoparticles
8.3 Properties of silver nanoparticles that fasten wound healing
8.4 The mechanism of wound healing and tissue regeneration
8.5 Case studies of silver nanoparticles in wound therapy and tissue regeneration
8.6 Toxicity associated with silver nanoparticles
8.7 Conclusion and future perspective
Acknowledgements
References
Chapter 9. Silver nanoparticles for drug delivery in inflammatory bowel disease
Abstract
Abbreviations
9.1 Introduction
9.2 Silver nanoparticles: characterization and synthesis
9.3 Biological properties of silver nanoparticles
9.4 Silver nanoparticle toxicity testing
9.5 Silver nanoparticles as potential drugs in IBD
9.6 IBD and colon-target drug delivery system
9.7 Conclusions
Acknowledgements
Authors’ contributions
Author disclosures
References
Chapter 10. Silver nanoparticles for the management of neurological diseases
Abstract
Abbreviations
10.1 Introduction
10.2 Biomedical applications of AgNPs in CNS diseases
10.3 Knowledge gaps and challenges for the CNS clinical translation of AgNPs
10.4 Conclusions and future perspectives
Acknowledgments
References
Chapter 11. Nutritional plants, phytochemicals, microorganisms-derived silver nanoparticles and their diabetic managements
Abstract
11.1 Introduction
11.2 Synthesis of silver nanoparticles
11.3 Chemical synthesis of silver nanoparticles
11.4 Physical synthesis of silver nanoparticles
11.5 Biological synthesis of silver nanoparticles
11.6 Bacteria-derived synthesis of silver nanoparticles
11.7 Fungi-derived synthesis of silver nanoparticles
11.8 Plant-derived synthesis of silver nanoparticles
11.9 Phytochemicals-derived synthesis of silver nanoparticles
11.10 Silver nanoparticles and their antidiabetic agents
11.11 SNP mechanism of action in diabetic management
11.12 Silver nanoparticles and their diabetic wound healing
11.13 Conclusions
Acknowledgment
Conflict of interest
References
Chapter 12. Silver nanoparticles in dentistry
Abstract
12.1 Introduction
12.2 Antimicrobial properties of silver nanoparticles
12.3 Silver nanoparticles in dentistry
12.4 Conclusion and future prospects
References
Chapter 13. Silver nanoparticles and their role in the treatment of endodontic infections
Abstract
13.1 Introduction
13.2 Silver nanoparticles in dentistry
Acknowledgment
References
Chapter 14. Silver nanoparticles for treatment of COVID-19 and other viral diseases
Abstract
14.1 Introduction
14.2 Silver nanoparticles for diagnosis of COVID-19 and other viral diseases
14.3 Nanoparticles for vaccine development against COVID-19 and other viral diseases
14.4 Mechanisms of antiviral activities of silver nanoparticles
14.5 Silver nanoparticles for treatment of COVID-19
14.6 Silver nanoparticles for treatment of other viral diseases
14.7 Silver nanoparticles in clinical trials for COVID-19 and other viral/microbial diseases
14.8 Limitations of silver nanoparticles for treatment of COVID-19 and other viral diseases
14.9 Conclusions
Acknowledgment
References
Chapter 15. Biological toxicity, safety issues, and environmental hazards associated with silver nanoparticles
Abstract
15.1 Introduction
15.2 AgNPs and biological toxicity
15.3 Environmental and safety issues of AgNPs
15.4 Conclusion
References
Chapter 16. Silver nanoparticle–induced ecotoxicity
Abstract
16.1 Introduction
16.2 Silver nanoparticles’ (AgNPs) discharge into environments and estimated concentrations
16.3 Intrinsic properties and transformations influencing AgNP ecotoxicity
16.4 Main AgNP ecotoxicological effects on biota
16.5 Concluding remarks and gaps of knowledge
Acknowledgments
Author contributions
Declaration of competing interest
References
Chapter 17. Clinical translation of silver nanoparticles into the market
Abstract
17.1 Introduction
17.2 Overview on the market status and clinical profile of AgNPs
17.3 Challenges hampering the clinical translation of AgNPs
17.4 Approaches enabling the clinical translation of AgNPs
17.5 Competing technologies to AgNPs
17.6 Concluding remarks and future perspectives
References
Chapter 18. Conclusion and future prospective of silver nanoparticles
Abstract
18.1 Introduction
18.2 Synthesis of silver nanoparticles and its biological effects
18.3 Physicochemical properties of silver nanoparticles
18.4 Different applications of silver nanoparticles
18.5 Toxicity and environmental risk of silver nanoparticles
18.6 Summary and outlook
Acknowledgements
References
Index

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Prashant Kesharwani