Sickle Cell Syndromes, An Issue of Hematology/Oncology Clinics of North America

1st Edition, Volume 36-6 - November 18, 2022
Editors: Sophie Lanzkron, Jane Little
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 9 8 6 6 3 - 2
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 8 6 6 4 - 9

In this issue of Hematology/Oncology Clinics, guest editors Drs. Sophie Lanzkron and Jane Little bring their considerable expertise to the topic of Sickle Cell Syndromes. Top… Read more

Sickle Cell Syndromes, An Issue of Hematology/Oncology Clinics of North America

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In this issue of Hematology/Oncology Clinics, guest editors Drs. Sophie Lanzkron and Jane Little bring their considerable expertise to the topic of Sickle Cell Syndromes. Top experts in the field cover key topics such as structural racism and impact on sickle cell disease (SCD); pathophysiology and biomarkers of SCD; genetic modifiers of SCD; allogeneic transplant and gene therapy: reproductive health; chronic pain; and more.

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Preface
Structural Racism and Impact on Sickle Cell Disease: Sickle Cell Lives Matter
Key points
Background
Evidence: a cacophony of disparities and dysfunction
Discussion
Summary
Clinics care points
Sickle Cell Disease Pathophysiology and Related Molecular and Biophysical Biomarkers
Key points
Introduction
Biomarkers of acute clinical complications
Biomarkers of sickle cell disease chronic complications
Biomarkers in clinical trials and precision medicine
Red cell function assays in development and clinical validation
Summary
Clinics care points
Genetic Modifiers of Sickle Cell Disease
Key points
Introduction
Approaches to find genetic variants that affect human diseases
Known sickle cell disease genetic modifiers
Future genetic modifiers discovery and utilization in sickle cell disease
Potential usefulness of genetic information for clinical risk stratification and guiding current therapy and clinical trials of new therapeutic approaches
Summary
Clinics care points
Supplementary data
Economics of Sickle Cell Disease and Evidence to Support Comprehensive Care
Key points
Introduction
Summary
Quality of Life in Sickle Cell Disease: What Matters
Key points
Introduction
Risk and resilience factors in sickle cell disease
Screening and interventions
What matters–positive sickle cell disease self-management
Discussion
Summary
Clinics care points
Chronic Pain: Prevalence and Management
Key points
Introduction
Summary
Clinics care points
The Development of Neuroimaging Biomarkers for Cognitive Decline in Sickle Cell Disease
Key points
Cognitive dysfunction in the absence of stroke
Imaging Biomarkers for the Neurologic Complications of Sickle Cell Disease
Conclusion
Disclosure
Potential conflicts of interest
Clinical Vignettes Part I
Clinical Vignettes, Part II: Eyes, Teeth, and Bone
The Cardiopulmonary Complications of Sickle Cell Disease
Key points
Introduction
Acute chest syndrome
Asthma and airways disease in individuals with sickle cell disease
Lung function in sickle cell disease
Sleep-disordered breathing and nocturnal hypoxemia
Pulmonary vascular disease
Sickle cell disease cardiomyopathy
Clinics care points
Sickle Cell Disease and the Kidney: Filters Gone Awry
Key points
Introduction/history/definitions/background
Discussion
Clinics care points
Go the Distance: Reproductive Health Care for People with Sickle Cell Disease
Key points
Overview
Clinics care points
Genotyping and the Future of Transfusion in Sickle Cell Disease
Key points
An unfortunate case
Introduction
Conclusions and future directions
Clinics care points: the goal
The Evolving Landscape of Drug Therapies for Sickle Cell Disease
Key points
Introduction
Pathophysiology
Approaches to the management of sickle cell disease
Drug trials for sickle cell disease
Challenge of clinical endpoints
Our approach to use of approved drugs
Summary
Author contributions
Funding
Disclosures
Allogeneic Transplant and Gene Therapy: Evolving Toward a Cure
Key points
Introduction
Summary
Clinics care points

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Physical sciences & Engineering

Social sciences & Humanities

Health

Sickle Cell Syndromes, An Issue of Hematology/Oncology Clinics of North America

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Sophie Lanzkron

Jane Little