Limited Offer
Scheuer's Liver Biopsy Interpretation
- 10th Edition - June 5, 2020
- Author: Jay H. Lefkowitch
- Language: English
- Hardback ISBN:9 7 8 - 0 - 7 0 2 0 - 7 5 8 4 - 1
Trusted for more than 50 years by pathologists in practice and in training, Scheuer’s Liver Biopsy Interpretation is a well-organized, superbly illustrated guide designed to help s… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quoteTrusted for more than 50 years by pathologists in practice and in training, Scheuer’s Liver Biopsy Interpretation is a well-organized, superbly illustrated guide designed to help solve diagnostic problems at the microscope. Authored by renowned expert Dr. Jay Lefkowitch and reflecting the extensive experience of the late Dr. Peter Scheuer, this practical text contains technical tips, diagnostic clues, and pearls on all aspects of liver pathology diagnosis, including acute and chronic hepatitis, biliary tract diseases, childhood disorders, and hepatic neoplasms – as well as ancillary topics such as biopsy assessment, laboratory techniques, normal liver histology, and transplantation. Throughout the text, histopathologic features are correlated with clinical features, molecular genetics, and immunohistochemistry to provide a practical account of how pathology impacts the diagnosis and management of liver disease.
- Covers key topics such as genomic alterations in liver tumours, diagnosis of acute liver allograft rejection, scoring systems for non-alcoholic fatty liver disease, and discussions of immunohistochemical features wherever relevant.
- Presents the latest information on next generation sequencing and drug-induced liver injury, including adverse reactions to new biologics and alternative medicines to help both the clinician and pathologist avoid diagnostic errors.
- Features many new illustrations, including over 300 large, full-color and fully annotated photomicrographs that illustrate a wide range of pathologic appearances and help identify each diagnostic entity under discussion.
- Offers coverage of cytopathology in the assessment of liver tumors to provide further clinical clues to diagnosis.
- Provides basic overview of major histopathologic diagnostic problems in paediatric liver biopsy, including biliary atresia and several types of progressive familial intrahepatic cholestasis
- Provides new and updated algorithms, tables and images highlighting key features of each diagnostic entity – ideal as a concise review during sign out or for studying and board preparation.
- Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
- Cover image
- Title page
- Table of Contents
- Dedication
- Copyright
- Preface
- Acknowledgements
- Chapter 1. General Principles of Biopsy Assessment
- Introduction
- Type and adequacy of liver biopsy specimen
- The specimen at the bedside and in the laboratory
- Chapter 2. Laboratory Techniques
- Processing of the specimen
- Choice of stains
- Chapter 3. The Normal Liver
- Structures and components
- Normal appearances in childhood
- Ageing
- Biopsy of the normal liver
- Chapter 4. Assessment and Differential Diagnosis of Pathological Features
- Initial examination and reporting
- Basic patterns of injury
- Differential diagnosis of individual findings
- Chapter 5. Biliary Disease
- Introduction
- Cholestasis
- Large bile-duct obstruction
- Cholangitis: infection of the biliary tree
- Primary sclerosing cholangitis
- Primary biliary cholangitis (formerly primary biliary cirrhosis)
- Other disorders with intrahepatic bile-duct loss
- Chapter 6. Acute Viral Hepatitis
- Introduction
- Pathological features
- Individual causes of viral hepatitis
- Differential diagnosis of acute viral hepatitis
- Fate and morphological sequelae of acute viral hepatitis
- Chapter 7. Steatosis, Steatohepatitis and Related Conditions
- Steatosis
- Alcoholic and non-alcoholic fatty liver disease
- Steatohepatitis, alcoholic and non-alcoholic
- Other alcohol-related liver lesions
- Chapter 8. Drugs and Toxins
- Introduction
- Classification and mechanisms
- Commonly implicated and newer agents
- Morphological categories
- Chapter 9. Chronic Hepatitis
- Definition and causes
- Classification and nomenclature
- Use of liver biopsy in chronic hepatitis
- Histological features of chronic hepatitis
- Individual causes of chronic hepatitis
- Differential diagnosis of chronic hepatitis
- Semi-quantitative scoring: grading and staging
- Chapter 10. Cirrhosis
- Introduction
- Diagnosis of cirrhosis by liver biopsy
- Assessment of cause
- Stage of development
- Histological activity
- Complications
- Chapter 11. Neoplasms and Nodules
- Introduction
- Neoplasms and nodules in adults
- Extrahepatic malignancy and the liver
- Neoplasms and nodules in children
- Cytopathological diagnosis
- Chapter 12. Vascular Disorders
- The hepatic arteries
- The portal veins
- The hepatic sinusoids
- Venous congestion and outflow obstruction
- Chapter 13. Childhood Liver Disease and Metabolic Disorders
- Introduction
- Diagnostic approach to neonatal liver biopsy
- Neonatal hepatitis
- Extrahepatic biliary atresia
- Choledochal cyst
- Paucity of intrahepatic bile ducts in childhood
- Fibropolycystic diseases
- Inherited metabolic disorders
- Parenteral nutritions
- Hyperbilirubinaemias
- Inherited cholestatic syndromes
- Cirrhosis in childhood
- Chapter 14. Disturbances of Copper and Iron Metabolism
- Wilson’s disease (hepatolenticular degeneration)
- Iron overload
- Primary iron overload disorders
- Secondary iron overload disorders
- Chapter 15. The Liver in Systemic Disease and Pregnancy
- Introduction
- Granulomas
- Viral diseases
- Rickettsial, bacterial and fungal infections
- Parasitic diseases
- Gastrointestinal disorders and the liver
- Haematological disorders and the liver
- The liver in rheumatoid, immune-complex and collagen diseases
- Amyloidosis and light-chain deposition
- The liver in the porphyrias
- Non-specific reactive changes
- The liver in pregnancy
- Chapter 16. The Liver in Organ Transplantation
- Introduction
- Liver transplantation
- Renal transplantation
- Bone marrow transplantation
- Chapter 17. Electron Microscopy and Other Techniques
- Introduction
- Electron microscopy of liver biopsies
- The normal liver and examples of ultrastructural changes in disease
- Immunoelectron microscopy
- Scanning electron microscopy
- Immunohistochemistry
- Gene array, gene sequencing and molecular analysis
- Glossary
- Index
- Information about COVID-19 and the liver
- No. of pages: 464
- Language: English
- Edition: 10
- Published: June 5, 2020
- Imprint: Elsevier
- Hardback ISBN: 9780702075841
JL