Role of Tumor Microenvironment in Breast Cancer and Targeted Therapies
- 1st Edition - August 10, 2022
- Imprint: Academic Press
- Author: Manzoor Ahmad Mir
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 8 6 9 6 - 7
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 8 6 9 7 - 4
Role of Tumor Microenvironment in Breast Cancer and Targeted Therapies discusses the current understanding of breast cancer tumor microenvironment components, their role in tumori… Read more
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Request a sales quoteRole of Tumor Microenvironment in Breast Cancer and Targeted Therapies discusses the current understanding of breast cancer tumor microenvironment components, their role in tumorigenicity and the development of therapeutic resistance, along with updates on recent advances.
- Presents up-to-date knowledge on the interplays of stromal components surrounding breast tumor cells
- Explores recent advances and trends in the molecular mechanisms of breast tumorigenesis and how to explore further molecular targets
Researchers and graduate students on cancer research
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Chapter 1: Introduction to various types of cancers
- Abstract
- 1.1: Introduction
- 1.2: Tissue homeostasis and the progression of cancer
- 1.3: Major types of cancer
- 1.4: Summary
- References
- Chapter 2: The tumor microenvironment
- Abstract
- 2.1: Introduction
- 2.2: Important players in the breast cancer immune microenvironment
- 2.3: Immunosuppressive cells
- 2.4: Tumor microenvironment-targeting therapeutics
- 2.5: Summary
- References
- Chapter 3: Role of cancer-associated fibroblasts in tumor microenvironment
- Abstract
- 3.1: Introduction
- 3.2: An overview of cancer-associated fibroblasts
- 3.3: Heterogeneity of CAFs
- 3.4: CAFs’ activation mechanism
- 3.5: Role of CAFs
- 3.6: CAF–immune microenvironment interaction in tumors
- 3.7: Challenges and directions
- 3.8: Conclusion
- References
- Chapter 4: Role of mesenchymal stem cells in tumor microenvironment
- Abstract
- 4.1: Introduction
- 4.2: MSC phenotype and origin
- 4.3: Homing to the tumor microenvironment
- 4.4: Functions in the tumor microenvironment
- 4.5: MSCs exosomes therapy in tumors
- 4.6: MSC crosstalk with immune components of the inflammatory niche in solid cancer
- 4.7: Perinatal MSC as therapeutic strategy in cancer
- 4.8: Conclusion
- References
- Chapter 5: Role of regulatory T cells in cancer
- Abstract
- 5.1: Introduction
- 5.2: Different subgroups of T regulatory cells
- 5.3: Immunosuppressive potential of T regulatory cells and cancer
- 5.4: T regulatory cell infiltration in tumor microenvironment
- 5.5: Regulatory T-cell antigen specificity in cancer
- 5.6: Role of regulatory T cells in cancer
- 5.7: Cancer vaccines and regulatory T cells
- 5.8: Targeting T regulatory cells in cancer therapy
- 5.9: Conclusion
- References
- Further reading
- Chapter 6: Role of tumor-associated macrophages in the breast tumor microenvironment
- Abstract
- 6.1: Introduction
- 6.2: Composition
- 6.3: Macrophages in the tumor microenvironment
- 6.4: Recruitment of monocytes and macrophages to breast tumors
- 6.5: Differentiation and maturation of TAMs in breast tumors
- 6.6: Relative numbers of macrophages in breast cancer progression
- 6.7: Location of macrophages in breast tumors
- 6.8: Breast cancer cell metastasis
- 6.9: Breast cancer angiogenesis
- 6.10: TAMs promote breast cancer cell stemness
- 6.11: Clinical significance of TAMs in breast tumors
- 6.12: Preclinical evidence for a role of TAMs in breast cancer treatment resistance
- 6.13: Conclusion
- References
- Further reading
- Chapter 7: Role of Tumor-associated neutrophils in the breast tumor microenvironment
- Abstract
- 7.1: Introduction
- 7.2: Immunity and cancer
- 7.3: Cells associated with breast cancer
- 7.4: Neutrophils and cancer
- 7.5: Factors affecting recruitment of TANs into the tumor
- 7.6: Mechanism behind TANs
- 7.7: Summary
- References
- Chapter 8: The extracellular matrix in breast cancer
- Abstract
- 8.1: Introduction
- 8.2: The breast tissue's ECM architecture
- 8.3: ECM changes as breast cancer progresses
- 8.4: Rigidity of the ECM and tumor development
- 8.5: In morphological breast tumor subtypes, ECM dynamics are studied
- 8.6: The dynamics of the ECM in molecular breast tumor subtypes
- 8.7: Mechanosignaling changes
- 8.8: Immune system changes
- 8.9: Vasculature changes
- 8.10: ECM and metastasis
- 8.11: Stromal remodeling is required for metastasis
- 8.12: Treatment resistance mediated by ECM
- 8.13: Limiting the entry of drugs
- 8.14: Resistance mediated through contact
- 8.15: Hypoxia and stemness levels are both on the rise
- 8.16: Dormancy induction
- 8.17: ECM remodeling as a result of treatment
- 8.18: The role of enzymes in ECM remodeling
- 8.19: The ECM of tumors can be targeted therapeutically
- 8.20: Conclusion
- References
- Chapter 9: Breast cancer stem cells and their role in tumor microenvironment
- Abstract
- 9.1: Introduction
- 9.2: Origin of BCSCs
- 9.3: Breast cancer markers and targeted pathways involved in stem cell-mediated breast cancer progression
- 9.4: BCSCs and associated cellular markers
- 9.5: BCSCs and associated signaling pathways
- 9.6: BCSCs as a predictive marker
- 9.7: BCSC metabolism and tumor microenvironment
- 9.8: BCSCs targeting in therapy resistance and drug development
- 9.9: BCSCs: Current developments and therapeutic significance
- 9.10: Summary
- References
- Further reading
- Chapter 10: Targeting tumor microenvironment for breast cancer treatment
- Abstract
- 10.1: Introduction
- 10.2: Tumor microenvironment—A suitable target for treating breast cancer
- 10.3: Chemotherapy and tumor microenvironment
- 10.4: Therapies that aim at the TME
- 10.5: Radiotherapy and tumor microenvironment
- 10.6: Nanochemotherapeutics and tumor microenvironment
- 10.7: Summary
- References
- Index
- Edition: 1
- Published: August 10, 2022
- No. of pages (Paperback): 296
- No. of pages (eBook): 296
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780443186967
- eBook ISBN: 9780443186974
MM
Manzoor Ahmad Mir
Dr. Manzoor Ahmad Mir holds a Master’s Degree in Zoology from HNBG Central University and completed his Ph.D. in Immunology at Jawaharlal Nehru University, New Delhi, and CSIR-Institute of Microbial Technology, Chandigarh. His research focuses on Cancer Biology, Combination Therapy in Breast Cancer, and Tuberculosis Immunology. Dr. Mir has published over 50 high-impact research papers and book chapters, earning multiple awards and royalties. He has authored more than 15 books with international publishers like Elsevier and Springer-Nature. Dr. Mir serves on the editorial boards of prestigious journals and has been an invited speaker at numerous scientific conferences. He is a member of several scientific organizations, including the American Association of Cancer Research and the Royal British Society. He has received the TARE Fellowship and the SRFP-2019 from Indian science academies. Dr. Mir teaches Cancer Biology and Immunology at the University of Kashmir, where he heads the Department of Bioresources.
Affiliations and expertise
Department of Bioresources, School of Biological Sciences, University of Kashmir, Srinagar, IndiaRead Role of Tumor Microenvironment in Breast Cancer and Targeted Therapies on ScienceDirect