Role of TRPV4 Channels in Different Organ Systems
- 1st Edition, Volume 89 - September 23, 2022
- Imprint: Academic Press
- Editor: Swapnil K. Sonkusare
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 9 9 7 8 2 - 9
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 9 7 8 3 - 6
Role of TRPV4 Channels in Different Organ Systems, Volume 89, the latest release in the Current Topics in Membranes series, provides an in-depth description of the role of TRPV4 io… Read more
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Request a sales quoteRole of TRPV4 Channels in Different Organ Systems, Volume 89, the latest release in the Current Topics in Membranes series, provides an in-depth description of the role of TRPV4 ion channels in different organ systems under healthy and disease conditions. Research over the last two decades shows crucial physiological and pathological roles for TRPV4 channels. In this volume, we present chapters focusing on TRPV4 channels in the vasculature, lungs, heart, kidney, bladder, skin, musculoskeletal system, eye, and immune cells. Understanding the behavior of TRPV4 channels in various organ systems will provide a big picture on their physiological roles and therapeutic targeting.
- Provides a review of the role of TRPV4 channels in different organ systems
- Presents a review of recent literature on TRPV4 channels
- Includes easy to understand graphics, perspectives and future directions
Physiologists, ion channel researchers, electrophysiologists, neuroscientists, clinician researchers studying TRP channels, TRP channel researchers
- Cover image
- Title Page
- Table of Contents
- Copyright
- Contributors
- Preface
- Acknowledgments
- Chapter One: TRPV4-dependent signaling mechanisms in systemic and pulmonary vasculature
- Abstract
- 1: Introduction
- 2: TRPV4 channel structure
- 3: Ca2 + influx signals through TRPV4 channels and channel regulation by Ca2 +
- 4: TRPV4 channels in vascular disease conditions
- 5: Conclusion
- References
- Chapter Two: Endothelial TRPV4 channels in lung edema and injury
- Abstract
- 1: Introduction
- 2: Structure and properties
- 3: TRPV4 channels in the lung
- 4: TRPV4 channels in the pulmonary endothelium
- 5: TRPV4 channels in lung edema and injury
- 6: Potential role of TRPV4 channels in lung edema and injury in COVID-19 patients
- 7: Conclusions and future directions
- References
- Chapter Three: Cardiac TRPV4 channels
- Abstract
- 1: Introduction
- 2: Cardiac myocyte excitation-contraction coupling
- 3: TRPV4 expression in cardiac myocytes
- 4: TRPV4 localization in cardiac myocytes
- 5: Role of TRPV4 in cardiac myocyte Ca2 + handling
- 6: Role of TRPV4 in cardiac myocyte electrophysiology and arrhythmia
- 7: Conclusions
- References
- Chapter Four: Evolving concepts of TRPV4 in controlling flow-sensitivity of the renal nephron
- Abstract
- 1: Overview of TRPV4 structure, gating, and mechanosensitivity
- 2: TRPV4 expression in different segments of the renal nephron
- 3: TRPV4 functions as a pressure sensor in the proximal tubule
- 4: Flow-sensitive TRPV4 [Ca2 +]i signaling and O2− production in the ascending loop of Henle
- 5: Kaliuretic actions of TRPV4 in the distal nephron
- 6: Impaired TRPV4 activity in the setting of polycystic kidney disease
- 7: Final remarks and conclusions
- Funding
- References
- Chapter Five: Transient receptor potential vanilloid type 4 (TRPV4) in urinary bladder structure and function
- Abstract
- 1: Introduction
- 2: LUT tissues
- 3: Neural control of micturition
- 4: Neurochemistry of LUT afferent neurons
- 5: Urothelial signaling
- 6: Interstitial cystitis/bladder pain syndrome (IC/BPS)
- 7: Pathophysiology
- 8: IC/BPS animal models
- 9: Mechanotransduction
- 10: Transient receptor potential (TRP) channels
- 11: TRPV4 channels and the urinary bladder
- 12: TRPV4 and bladder function
- 13: TRPV channels and pain
- 14: TRPV4 function in NGF-OE mice that exhibit increased voiding frequency and somatic sensitivity
- 15: TRPV4 has a functional role in ATP release via vesicular exocytosis
- 16: ATP and TRPV4 activate cells in the laminar propria network, leading to the appearance of organized, propagating wavefronts
- Disclaimers
- References
- Chapter Six: The role of TRPV4 channels in cutaneous epithelia
- Abstract
- 1: Introduction
- 2: TRPV4 in skin barrier function
- 3: TRPV4 in hair growth
- 4: TRPV4 in sensory perception
- 5: TRPV4 in cutaneous immune regulation
- 6: TRPV4 in nociception
- 7: TRPV4 in itch
- 8: TRPV4 in skin cancer
- 9: Conclusions
- Acknowledgments
- References
- Chapter Seven: Function and regulation of thermosensitive ion channel TRPV4 in the immune system
- Abstract
- 1: Introduction
- 2: Ion channels in immune cells
- 3: TRPV4 gene, variants and mutations
- 4: TRPV4 as a functional tetrameric protein
- 5: Temperature effect and presence of TRPV4 in immune cells: Physiological and pathophysiological contexts
- 6: TRPV4 expression and function in T cell
- 7: TRPV4 expression and function in mast cell
- 8: TRPV4 in dendritic cells
- 9: TRPV4 in macrophage and relevant functions
- 10: Microglia
- 11: Astrocytes
- 12: Roles of TRPV4 in neuroimmune interactions
- 13: TRPV4 in auto-immune disorders
- 14: Steroids in TRPV4-mediated immunomodulation
- 15: Temperature, immunity, and importance of TRPV4 in the evolution of the immune system
- 16: Conclusion
- Acknowledgments
- References
- Chapter Eight: TRPV4: Cell type-specific activation, regulation and function in the vertebrate eye
- Abstract
- 1: Introduction
- 2: Cornea
- 3: Sclera
- 4: Ciliary body
- 5: Trabecular meshwork
- 6: Ciliary muscle
- 7: Schlemm's canal
- 8: Lens
- 9: Retina
- 10: One protein to confound them all
- 11: Summary
- Acknowledgments
- References
- Chapter Nine: Role of TRPV4 in skeletal function and its mutant-mediated skeletal disorders
- Abstract
- 1: TRP channels: A brief overview
- 2: About TRPV4
- 3: TRPV4 expression in tissues with mesodermal lineage and other tissues
- 4: Clinical characteristics of TRPV4 mutation-mediated disorders
- 5: Molecular and cellular characteristics of TRPV4 mutants
- 6: Lessons learned from genetic animal models and gene diversity in human population
- 7: Conclusion and future outlook
- Acknowledgments
- References
- Edition: 1
- Volume: 89
- Published: September 23, 2022
- No. of pages (Hardback): 264
- No. of pages (eBook): 264
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780323997829
- eBook ISBN: 9780323997836
SS
Swapnil K. Sonkusare
Swapnil Sonkusare is an Associate Professor in Molecular Physiology and Biological Physics and a Resident Faculty in the Robert M. Berne Cardiovascular Research Center at the University of Virginia, Charlottesville. His research focuses on the regulation of blood flow and blood pressure by calcium signaling mechanisms in the vascular wall. He has investigated vascular calcium channels in health and disease throughout his scientific career. His main goals are to define the abnormalities in vascular calcium signaling mechanisms in cardiovascular disorders and to identify novel therapeutic targets. His laboratory routinely uses high-end calcium imaging, superresolution imaging, patch-clamp electrophysiology, vascular assays, mouse models of vascular disorders, and transgenic mice. Current NIH- and AHA-funded studies in my laboratory use this unique combination of techniques to address 1) new calcium signaling mechanisms that control vascular contractility and blood pressure in systemic and pulmonary vasculature; 2) contribution of impaired vascular calcium signaling and vascular inflammation to obesity-induced hypertension.
Affiliations and expertise
University of Virginia, Charlottesville, VA, USARead Role of TRPV4 Channels in Different Organ Systems on ScienceDirect