Role of Nutrigenomics in Modern-day Healthcare and Drug Discovery
- 1st Edition - October 15, 2022
- Imprint: Elsevier
- Editors: Genevieve Dable-Tupas, Chukwuebuka Egbuna
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 4 4 1 2 - 8
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 5 9 6 2 - 2
Role of Nutrigenomics in Modern-day Healthcare and Drug Discovery presents novel insights into how these tools can be applied in the study of nutrient-gene interaction for the m… Read more
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Request a sales quoteRole of Nutrigenomics in Modern-day Healthcare and Drug Discovery presents novel insights into how these tools can be applied in the study of nutrient-gene interaction for the management of certain disease conditions without using synthetic drugs or other treatments that come with side effects. Divided into three parts, Part I presents chapters that give background information of the subject while laying a framework for other chapters to follow. Part II presents chapters that discuss the role of nutrigenomics in healthcare, while Part III presents chapters that discuss the role of nutrigenomics in modern day drug discovery.
Written by a global team of experts from key institutions around the world, this book is useful for drug developers, medicinal chemists, public health scientists, molecular biologists, biochemists, toxicologists and food scientists.
- Provides readers with background information on the role of nutrigenomics in healthcare, with a focus on emerging topics in nutrigenetics and nutrigenomics
- Presents chapters that discusses the role of nutrigenomics in the modern day drug discovery for the treatment and management of diseases
- Includes a wide array of definitions, methods, summaries, figures and tables to aid readers with understanding and application
Researchers in organic and medicinal chemistry including drug developers, medicinal chemists, toxicologists, nutritionists
- Cover
- Title page
- Table of Contents
- Copyright
- Contributors
- Section A: Foundational information
- 1: General principles in nutrigenomics and nutrigenetics
- Abstract
- Modern nutrition science and research
- Comparison of nutrigenomics and nutrigenetics
- Application of nutrigenetics
- Applications of nutrigenomics
- Tools in nutrigenomics and nutrigenetics studies
- Future of nutrigenomics and nutrigenetics
- Conclusion
- References
- 2: Nutrigenomics and nutrigenetics: Importance in health and diseases
- Abstract
- Introduction
- Nutrigenomics in health and diseases
- Nutrigenetics in health and diseases
- Personalized nutrition: A key to better health outcomes
- Challenges
- Conclusion
- References
- 3: Nutrigenomics research: Methods and applications
- Abstract
- Introduction
- Omics technologies
- Application of omics technologies in nutrition
- Research methods commonly utilized in nutrigenomics studies
- Challenges
- Conclusion
- References
- Section B: Role of nutrigenomics in healthcare
- 4: Nutrigenomics of type 2 diabetes: Gene–diet interactions
- Abstract
- Introduction
- Basic concepts
- Nutrigenomics
- Genetics of type 2 diabetes mellitus (T2DM)
- Complications of type 2 diabetes mellitus
- Nutrient-gene interactions in diabetes mellitus pathogenesis
- Gene–diet interactions, phenotype, and epigenetic modifications caused by nutrients
- Dietary interventions for prevention and management of T2DM
- Conclusion
- References
- 5: Role of nutrigenomics in diabetes care and prevention
- Abstract
- Introduction
- Classification of diabetes mellitus
- Nutrigenomics and diabetes
- Management of diabetes
- Prevention
- Future challenges
- Conclusion
- References
- 6: Role of nutrigenomics in obesity, hypertension, and cardiovascular diseases
- Abstract
- Introduction
- Genomics and obesity
- Genomics and hypertension
- Genomics and cardiovascular diseases
- Future challenges
- Conclusion
- References
- 7: Nutrigenomics in the management and prevention of malnutrition, stunting, and other nutritional disorders
- Abstract
- Introduction
- Classification of nutritional disorders
- Genomics and nutrition
- Nutrigenomics and stunting
- Treatment and management
- Conclusion
- References
- 8: Nutrigenomics in the management and prevention of cancer
- Abstract
- Introduction
- Overview of cancer pathogenesis
- Nutrient gene-cancer interaction
- Diet and cancer prevention and management
- Conclusions and future perspectives
- References
- 9: Nutrigenomics in the management and prevention of metabolic disorders
- Abstract
- Introduction
- Metabolic disorders
- Factors associated with metabolic disorders
- Genomic and metabolism
- Future challenges
- Conclusion
- References
- Section C: Nutrigenomics and drug discovery
- 10: Roles of nutrigenomics in drug discovery and development
- Abstract
- Introduction
- Epigenetics
- Shifting the paradigm from treatment to prevention in nutrition and pharmacology
- Nutrigenomics and personalized nutrition
- Ethical, legal, and social implications of nutrigenomics and pharmacogenomics
- Conclusion
- References
- 11: Bioactive compounds of nutrigenomic importance
- Abstract
- Introduction
- Dietary phytochemicals
- Bioactive compounds
- Physiologic effects of bioactive compounds
- Role of bioactive compounds in chronic diseases
- Ethical considerations
- Future prospects
- Challenges
- Conclusion
- References
- 12: Bioactive compounds in the management of nutritional disorders
- Abstract
- Introduction
- Nutrition-mediated disorders, pathologies, symptoms, and causative effects
- Bioactive compounds, their dietary sources, chemistry, biological functions and nutritional significance
- Nutraceuticals as epigenetic modulators
- Challenges
- Conclusion
- References
- Further reading
- 13: Dietary compounds as inhibitors of DNA methyltransferases
- Abstract
- Introduction
- Dietary components and their sources
- Inhibitory effect of dietary components on DNA methyltransferases
- Dietary polyphenols as inhibitors of DNA methyltransferase
- Flavonoids as a modulator to inhibit DNA methyltransferase in different diseases
- Future projection and conclusion
- References
- 14: Bioactive compounds in diabetes care and prevention
- Abstract
- Introduction
- Pathophysiologic dysfunction in diabetes
- Conventional drugs for diabetes
- Bioactive compounds from natural products with antidiabetic activities
- Role of bioactive compounds in the gut microbiota to prevent and manage diabetes mellitus
- Metformin effects on the gut microbiome
- Future challenges
- Conclusion
- References
- 15: Bioactive compounds in cancer care and prevention
- Abstract
- Introduction
- Overview of currently used drugs for cancer treatment
- Anticancer drugs from plants
- Medicinal plants with evidence of anticancer activity
- Challenges and future perspectives
- Conclusion
- References
- 16: Role of medicinal plants and their bioactive compounds in obesity, hypertension, and cardiovascular diseases
- Abstract
- Introduction
- Medicinal plants with antihypertensive activities
- Medicinal plants with bioactivities against cardiovascular diseases
- Medicinal plants with antiobesity activities
- Challenges
- Future prospects
- Conclusion
- References
- 17: Bioactive compounds for metabolic diseases
- Abstract
- Introduction
- Bioactive compounds
- Metabolic disorders
- Conventional management
- Future prospects and challenges
- Conclusion
- References
- Further reading
- 18: Applications of nanotechnology in nutrigenomics
- Abstract
- Introduction
- Types of nanocarriers for bioactives
- Concepts of nutrigenomics
- Applications of nanotechnology in nutrigenomics
- Conclusion
- References
- 19: Regulations and ethical considerations in nutrigenomics research
- Abstract
- Introduction
- Ethical, legal, and social aspects of nutrigenomics
- The future with nutrigenomics
- Conclusion
- References
- Further reading
- Index
- Edition: 1
- Published: October 15, 2022
- No. of pages (Paperback): 596
- No. of pages (eBook): 596
- Imprint: Elsevier
- Language: English
- Paperback ISBN: 9780128244128
- eBook ISBN: 9780323859622
GD
Genevieve Dable-Tupas
Genevieve Dable Tupas, MD, MMCE, FPPS, FPSECP is an Associate Professor at the Research Center, College of Medicine, Davao Medical School Foundation, Inc, Davao City, Philippines. Her research interests include natural products research, clinical epidemiology, and their translation to benefit the community.
Affiliations and expertise
Associate Professor, Research Center, College of Medicine, Davao Medical School Foundation, Inc, Davao City, PhilippinesCE
Chukwuebuka Egbuna
Chukwuebuka Egbuna (PhD) is a chartered chemist and academic researcher. He is a member of the Institute of Chartered Chemists of Nigeria (ICCON), the Nigerian Society of Biochemistry and Molecular Biology (NSBMB), and the Royal Society of Chemistry (RSC) (United Kingdom). Dr. Egbuna is the founder and editor of the Elsevier book series on Drug Discovery Update. The series includes books, monographs, and edited collections from all areas of drug discovery including emerging therapeutic claims for the treatment of diseases. He has published research articles in many international journals of repute and is ranked among the top 500 Nigerian scientists in SciVal/SCOPUS. He has edited more than 25 books with Elsevier, Springer, Wiley, and Taylor & Francis. His most recent book is the three volume Coronavirus Drug Discovery, published by Elsevier. Dr. Egbuna is the founder and the publishing director of IPS Intelligentsia Publishing Services.
Affiliations and expertise
Africa Centre of Excellence in Public Health and Toxicological Research, University of Port Harcourt, NigeriaRead Role of Nutrigenomics in Modern-day Healthcare and Drug Discovery on ScienceDirect