
Rodak's Hematology
Clinical Principles and Applications
- 7th Edition - April 15, 2024
- Imprint: Elsevier
- Editors: Elaine M. Keohane, Michelle Montgomery Preston, Kamran M. Mirza, Jeanine M. Walenga
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 3 6 5 0 - 7
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 3 4 9 1 6 - 4
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 3 7 6 2 - 7
Make sure you are thoroughly prepared to work in a clinical laboratory. Rodak’s Hematology: Clinical Principles and Applications, 7th Edition uses hundreds of full-color photomicr… Read more

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Request a sales quoteMake sure you are thoroughly prepared to work in a clinical laboratory. Rodak’s Hematology: Clinical Principles and Applications, 7th Edition uses hundreds of full-color photomicrographs to help you understand the essentials of hematology and hemostasis. This new edition details the parts and functions of the cell; shows how to accurately identify cells; covers normal hematopoiesis through diseases of erythroid, myeloid, lymphoid, and megakaryocytic origins; and simplifies hemostasis and thrombosis concepts and disorders. Easy to follow and understand, this book also covers key topics, including working in the hematology and hemostasis laboratory; complementary testing areas such as flow cytometry, cytogenetics, and molecular diagnostics; and laboratory testing of blood cells and body fluid cells.
- Content throughout the text reflects the latest information on hematology and hemostasis.
- Hematology and hemostasis instruments are described, compared, and contrasted.
- More than 700 full-color illustrations and photomicrographs make it easier to visualize hematology concepts and show what you’ll encounter in the laboratory.
- Instructions for laboratory procedures include detailed figures and sources of errors.
- Case studies in each chapter provide opportunities to apply hematology concepts to real-life scenarios.
- Hematology and hemostasis reference intervals are listed on the inside front and back covers for quick reference.
- Bulleted chapter summaries make it easy for you to review important points.
- Learning objectives begin each chapter and indicate what you should achieve, with review questions appearing at the end.
- Appendices provide easy access to a list of key formulas, abbreviations, and a detailed glossary to complement learning.
- Cover image
- Title page
- Table of Contents
- Copyright
- Tribute
- Dedications
- Reviewers
- Contributors
- Preface
- Part I. Introduction to Hematology
- 1. An Overview of Clinical Laboratory Hematology
- HISTORY
- RED BLOOD CELLS
- WHITE BLOOD CELLS
- PLATELETS
- COMPLETE BLOOD COUNT
- BLOOD FILM EXAMINATION
- ENDOTHELIAL CELLS
- COAGULATION
- ADVANCED HEMATOLOGY PROCEDURES
- ADDITIONAL HEMATOLOGY PROCEDURES
- QUALITY ASSURANCE AND QUALITY CONTROL
- SAFETY
- 2. Patient Safety in Hematology and Hemostasis
- DEFINITION OF PATIENT SAFETY
- DEFINITION OF HEALTH CARE QUALITY
- TOTAL TESTING PROCESS IN THE CLINICAL LABORATORY
- SIX AIMS OF HEALTH CARE QUALITY
- ESSENTIAL COMPETENCIES FOR HEALTH CARE PROFESSIONALS
- APPLICATIONS IN THE HEMATOLOGY AND HEMOSTASIS LABORATORY
- SUMMARY
- 3. Quality Assurance in Hematology and Hemostasis Testing
- STATISTICAL SIGNIFICANCE AND EXPRESSIONS OF CENTRAL TENDENCY AND DISPERSION
- METHOD VALIDATION
- MULTISITE VALIDATION
- LOT-TO-LOT COMPARISONS
- REFERENCE INTERVAL AND THERAPEUTIC RANGE DEVELOPMENT
- INTERNAL QUALITY CONTROL
- EXTERNAL QUALITY ASSESSMENT
- ASSESSING DIAGNOSTIC EFFICACY
- RECEIVER OPERATING CHARACTERISTIC CURVE
- ASSAY FEASIBILITY
- LABORATORY STAFF COMPETENCE
- QUALITY ASSURANCE PLAN: PREANALYTICAL AND POSTANALYTICAL
- AGENCIES THAT ADDRESS HEMATOLOGY AND HEMOSTASIS QUALITY
- SUMMARY
- Part II. Blood Cell Production, Structure, and Function
- 4. Cell Structure and Function
- CELL ORGANIZATION
- PLASMA MEMBRANE
- NUCLEUS
- CYTOPLASM
- SELECTED CELL PROCESSES
- HEMATOPOIETIC MICROENVIRONMENT
- 5. Hematopoiesis
- HEMATOPOIETIC DEVELOPMENT
- ADULT HEMATOPOIETIC TISSUE
- HEMATOPOIETIC STEM CELLS AND CYTOKINES
- LINEAGE-SPECIFIC HEMATOPOIESIS
- THERAPEUTIC APPLICATIONS
- SUMMARY
- 6. Erythrocyte Production and Destruction
- ERYTHROPOIESIS
- DYNAMICS OF RED BLOOD CELL PRODUCTION AND DESTRUCTION
- MICROENVIRONMENT OF THE BONE MARROW
- ERYTHROCYTE DESTRUCTION
- SUMMARY
- 7. Erythrocyte Metabolism and Membrane Structure and Function
- ERYTHROCYTE METABOLISM (ENERGY PRODUCTION THROUGH ANAEROBIC GLYCOLYSIS)
- GLYCOLYSIS DIVERSION PATHWAYS (SHUNTS)
- RED BLOOD CELL MEMBRANE STRUCTURE AND FUNCTION
- SUMMARY
- 8. Hemoglobin Metabolism
- HEMOGLOBIN STRUCTURE
- HEMOGLOBIN BIOSYNTHESIS
- HEMOGLOBIN ONTOGENY
- REGULATION OF HEMOGLOBIN PRODUCTION
- HEMOGLOBIN FUNCTION
- DYSHEMOGLOBINS
- HEMOGLOBIN MEASUREMENT
- SUMMARY
- 9. Iron Kinetics and Laboratory Assessment
- IRON CHEMISTRY
- IRON KINETICS
- DIETARY IRON, BIOAVAILABILITY, AND DEMAND
- LABORATORY ASSESSMENT OF BODY IRON STATUS
- 10. Leukocyte Development, Kinetics, and Functions
- GRANULOCYTES
- MONONUCLEAR CELLS
- 11. Platelet Production, Structure, and Function
- MEGAKARYOCYTOPOIESIS
- PLATELETS
- PLATELET ULTRASTRUCTURE
- PLATELET FUNCTION
- PLATELET SIGNALING PATHWAYS
- PLATELETS AND INFLAMMATION
- PLATELET PROTEOME
- SUMMARY
- Part III. Laboratory Evaluation of Blood Cells
- 12. Manual, Semiautomated, and Point-of-Care Testing in Hematology
- SPECIMEN COLLECTION
- MANUAL CELL COUNTS
- HEMOGLOBIN DETERMINATION
- MICROHEMATOCRIT
- RULE OF THREE
- RED BLOOD CELL INDICES
- RETICULOCYTE COUNT
- ERYTHROCYTE SEDIMENTATION RATE
- ADDITIONAL TESTS FOR RED BLOOD CELLS
- POINT-OF-CARE TESTING
- SUMMARY
- 13. Automated Blood Cell Analysis
- GENERAL PRINCIPLES OF AUTOMATED BLOOD CELL ANALYSIS
- PRINCIPAL ANALYZERS
- VALIDATION AND CALIBRATION OF AUTOMATED ANALYZERS
- LIMITATIONS AND INTERFERENCES
- CLINICAL UTILITY OF AUTOMATED BLOOD CELL ANALYSIS
- ANALYZER SELECTION
- 14. Examination of the Peripheral Blood Film and Correlation With the Complete Blood Count
- PERIPHERAL BLOOD FILMS
- SUMMARIZING COMPLETE BLOOD COUNT RESULTS
- SUMMARY
- 15. Bone Marrow Examination
- BONE MARROW ANATOMY AND ARCHITECTURE
- INDICATIONS FOR BONE MARROW EXAMINATION
- BONE MARROW SPECIMEN COLLECTION SITES
- BONE MARROW ASPIRATION AND BIOPSY
- PREPARATION OF THE BONE MARROW SPECIMEN
- EXAMINING BONE MARROW ASPIRATE OR IMPRINT
- EXAMINING THE BONE MARROW CORE BIOPSY SPECIMEN
- DEFINITIVE BONE MARROW STUDIES
- BONE MARROW EXAMINATION REPORTS
- SUMMARY
- Part IV. Erythrocyte Disorders
- 16. Anemias: Red Blood Cell Morphology and Approach to Diagnosis
- DEFINITION OF ANEMIA
- IMPORTANCE OF PATIENT HISTORY AND CLINICAL FINDINGS
- PHYSIOLOGIC ADAPTATIONS IN PATIENTS WITH ANEMIA
- MECHANISMS OF ANEMIA
- LABORATORY DIAGNOSIS OF ANEMIA
- APPROACH TO EVALUATING ANEMIAS
- 17. Disorders of Iron Kinetics and Heme Metabolism
- GENERAL CONCEPTS IN IRON-RELATED DISORDERS
- IRON-RESTRICTED ANEMIAS
- PORPHYRIAS
- SIDEROBLASTIC ANEMIAS
- IRON OVERLOAD
- DIFFERENTIAL DIAGNOSIS
- 18. Anemias Caused by Defects of DNA Metabolism
- ETIOLOGY
- SYSTEMIC MANIFESTATIONS OF FOLATE AND VITAMIN B12 DEFICIENCY
- CAUSES OF VITAMIN DEFICIENCIES
- LABORATORY DIAGNOSIS
- MACROCYTIC NONMEGALOBLASTIC ANEMIAS
- TREATMENT
- SUMMARY
- 19. Bone Marrow Failure
- PATHOPHYSIOLOGY OF BONE MARROW FAILURE
- APLASTIC ANEMIA
- OTHER FORMS OF BONE MARROW FAILURE
- 20. Introduction to Increased Destruction of Erythrocytes
- CLASSIFICATION OF HEMOLYTIC DISORDERS
- PHYSIOLOGIC HEMOLYSIS
- PATHOLOGIC HEMOLYSIS
- CLINICAL FEATURES
- LABORATORY FINDINGS
- DIFFERENTIAL DIAGNOSIS
- SUMMARY
- 21. Intrinsic Defects Leading to Increased Erythrocyte Destruction
- RED BLOOD CELL MEMBRANE ABNORMALITIES
- RED BLOOD CELL ENZYMOPATHIES
- 22. Extrinsic Defects Leading to Increased Erythrocyte Destruction—Nonimmune Causes
- MICROANGIOPATHIC HEMOLYTIC ANEMIA
- MACROANGIOPATHIC HEMOLYTIC ANEMIA
- HEMOLYTIC ANEMIA CAUSED BY INFECTIOUS AGENTS
- HEMOLYTIC ANEMIA CAUSED BY OTHER RED BLOOD CELL INJURY
- 23. Extrinsic Defects Leading to Increased Erythrocyte Destruction—Immune Causes
- OVERVIEW OF IMMUNE HEMOLYTIC ANEMIAS
- AUTOIMMUNE HEMOLYTIC ANEMIA
- ALLOIMMUNE HEMOLYTIC ANEMIAS
- DRUG-INDUCED IMMUNE HEMOLYTIC ANEMIA
- 24. Hemoglobinopathies (Structural Defects in Hemoglobin)
- STRUCTURE OF GLOBIN GENES
- HEMOGLOBIN DEVELOPMENT
- GENETIC MUTATIONS
- ZYGOSITY
- PATHOPHYSIOLOGY
- NOMENCLATURE
- HEMOGLOBIN S
- HEMOGLOBIN C
- HEMOGLOBIN C-HARLEM (HEMOGLOBIN C-GEORGETOWN)
- HEMOGLOBIN E
- HEMOGLOBIN O-ARAB
- HEMOGLOBIN D AND HEMOGLOBIN G
- COMPOUND HETEROZYGOSITY WITH HEMOGLOBIN S AND ANOTHER β-GLOBIN GENE MUTATION
- CONCOMITANT CIS MUTATIONS WITH HEMOGLOBIN S
- HEMOGLOBIN M
- UNSTABLE HEMOGLOBIN VARIANTS
- HEMOGLOBINS WITH INCREASED AND DECREASED OXYGEN AFFINITY
- GLOBAL BURDEN OF HEMOGLOBINOPATHIES
- SUMMARY
- 25. Thalassemias
- DEFINITIONS AND HISTORY
- EPIDEMIOLOGY
- GENETICS OF GLOBIN SYNTHESIS
- CATEGORIES OF THALASSEMIA
- GENETIC DEFECTS CAUSING THALASSEMIA
- PATHOPHYSIOLOGY
- β-GLOBIN GENE CLUSTER THALASSEMIA
- α-THALASSEMIA
- THALASSEMIA ASSOCIATED WITH STRUCTURAL HEMOGLOBIN VARIANTS
- DIAGNOSIS OF THALASSEMIA
- Part V. Leukocyte Disorders
- 26. Nonmalignant Leukocyte Disorders
- PRIMARY IMMUNODEFICIENCY DISORDERS/INBORN ERRORS OF IMMUNITY
- LYSOSOMAL STORAGE DISORDERS
- MORPHOLOGIC ABNORMALITIES OF LEUKOCYTES WITHOUT ASSOCIATED IMMUNE DEFICIENCY
- QUANTITATIVE ABNORMALITIES OF LEUKOCYTES
- SECONDARY MORPHOLOGIC CHANGES IN LEUKOCYTES
- INFECTIOUS MONONUCLEOSIS
- 27. Introduction to Hematologic Neoplasms
- GENERAL CHARACTERISTICS OF HEMATOLOGIC NEOPLASMS
- INCIDENCE, PREVALENCE, AND ETIOLOGY
- CLASSIFICATION SCHEMES
- MOLECULAR PATHOGENESIS
- THERAPY
- 28. Flow Cytometric Analysis in Hematologic Disorders
- SPECIMEN PROCESSING
- FLOW CYTOMETRY: PRINCIPLE AND INSTRUMENTATION
- ANALYSIS OF FLOW CYTOMETRIC DATA
- CELL POPULATIONS IDENTIFIED BY FLOW CYTOMETRY
- FLOW CYTOMETRIC ANALYSIS OF MYELOID NEOPLASMS (ACUTE MYELOID LEUKEMIAS AND CHRONIC MYELOID NEOPLASMS)
- FLOW CYTOMETRIC ANALYSIS OF LYMPHOID NEOPLASMS (LYMPHOBLASTIC LEUKEMIA/LYMPHOMA AND MATURE LYMPHOID NEOPLASMS)
- OTHER APPLICATIONS OF FLOW CYTOMETRY BEYOND IMMUNOPHENOTYPING OF HEMATOLOGIC MALIGNANCIES
- 29. Molecular Diagnostics in Hematopathology
- STRUCTURE AND FUNCTION OF DNA
- MOLECULAR DIAGNOSTIC TESTING OVERVIEW
- NUCLEIC ACID ISOLATION
- AMPLIFICATION OF NUCLEIC ACIDS BY POLYMERASE CHAIN REACTION
- DETECTION OF AMPLIFIED DNA
- REAL-TIME POLYMERASE CHAIN REACTION
- NUCLEIC ACID SEQUENCING
- CHROMOSOMAL MICROARRAYS
- PATHOGEN DETECTION AND INFECTIOUS DISEASE LOAD
- CURRENT DEVELOPMENTS
- 30. Cytogenetics
- REASONS FOR CHROMOSOME ANALYSIS
- CHROMOSOME STRUCTURE
- CHROMOSOME IDENTIFICATION
- TECHNIQUES FOR CHROMOSOME PREPARATION AND ANALYSIS
- CYTOGENETIC NOMENCLATURE
- CHROMOSOME ABNORMALITIES
- CANCER CYTOGENETICS
- CHROMOSOMAL MICROARRAY ANALYSIS
- 31. Acute Leukemias
- CLASSIFICATION SCHEMES FOR ACUTE LEUKEMIAS
- ACUTE LYMPHOBLASTIC LEUKEMIA
- ACUTE MYELOID LEUKEMIA
- ACUTE LEUKEMIAS OF AMBIGUOUS LINEAGE
- CYTOCHEMICAL STAINS AND INTERPRETATIONS
- 32. Myeloproliferative Neoplasms
- BCR::ABL1-POSITIVE MYELOPROLIFERATIVE NEOPLASMS
- BCR::ABL1-NEGATIVE MYELOPROLIFERATIVE NEOPLASMS
- OTHER MYELOPROLIFERATIVE NEOPLASMS
- MYELOID/LYMPHOID NEOPLASMS
- MASTOCYTOSIS
- 33. Myelodysplastic Neoplasms
- ETIOLOGY
- MORPHOLOGIC ABNORMALITIES IN PERIPHERAL BLOOD AND BONE MARROW
- DIFFERENTIAL DIAGNOSIS
- ABNORMAL CELLULAR FUNCTION
- CLASSIFICATION OF MYELODYSPLASTIC NEOPLASMS
- MYELODYSPLASTIC NEOPLASMS WITH DEFINING GENETIC ABNORMALITIES
- MYELODYSPLASTIC NEOPLASMS, MORPHOLOGICALLY DEFINED
- CHILDHOOD MYELODYSPLASTIC NEOPLASMS
- MYELODYSPLASTIC/MYELOPROLIFERATIVE NEOPLASMS
- CYTOGENETICS, MOLECULAR ALTERATIONS, AND EPIGENETICS
- PROGNOSIS
- TREATMENT
- 34. Mature Lymphoid Neoplasms
- GENETIC ABNORMALITIES
- CLASSIFICATION SCHEMAS BASED ON CELL DIFFERENTIATION
- APPROACH TO DIAGNOSIS: INTERFACE BETWEEN CLINICAL AND LABORATORY MEDICINE
- DIAGNOSTIC PROCEDURES
- DIAGNOSTIC EVALUATION
- LEUKEMIAS
- NON-HODGKIN LYMPHOMA
- HODGKIN LYMPHOMA
- PLASMA CELL NEOPLASMS
- Part VI. Hemostasis and Thrombosis
- 35. Normal Hemostasis
- OVERVIEW OF HEMOSTASIS
- VASCULAR INTIMA IN HEMOSTASIS
- PLATELETS
- COAGULATION SYSTEM
- COAGULATION REGULATORY MECHANISMS
- FIBRINOLYSIS
- 36. Hemorrhagic Disorders and Laboratory Assessment
- BLEEDING SYMPTOMS
- ACQUIRED COAGULOPATHIES
- CONGENITAL COAGULOPATHIES
- 37. Qualitative Disorders of Platelets and Vasculature
- QUALITATIVE PLATELET DISORDERS: INHERITED DEFECTS
- QUALITATIVE PLATELET DISORDERS: ACQUIRED DEFECTS
- VASCULAR DISORDERS
- 38. Quantitative Disorders of Platelets: Thrombocytopenia and Thrombocytosis
- THROMBOCYTOPENIA: DECREASE IN CIRCULATING PLATELETS
- THROMBOCYTOSIS: INCREASE IN CIRCULATING PLATELETS
- 39. Thrombotic Disorders and Laboratory Assessment
- THROMBOSIS RISK TESTING DEVELOPMENTS
- THROMBOSIS ETIOLOGY AND PREVALENCE
- THROMBOSIS RISK FACTORS
- LABORATORY EVALUATION OF THROMBOPHILIA
- ARTERIAL THROMBOSIS PREDICTORS
- VENOUS THROMBOEMBOLIC DISEASE DIAGNOSIS
- DISSEMINATED INTRAVASCULAR COAGULATION
- HEPARIN-INDUCED THROMBOCYTOPENIA
- THROMBOINFLAMMATION
- THROMBOSIS RISK TESTING FUTURE
- SUMMARY
- 40. Antithrombotic Therapies and Laboratory Assessment
- Thrombosis and Antithrombotic Therapy
- Warfarin
- Unfractionated Heparin
- Low-Molecular-weight Heparin
- Fondaparinux
- Direct Anti-Xa Oral Anticoagulants
- Direct Thrombin Inhibitors
- Switching Anticoagulants and Periprocedural Management
- Antiplatelet Therapy
- Fibrinolytic Therapy
- Future of Antithrombotic Therapy
- Summary
- 41. Laboratory Evaluation of Hemostasis
- HEMOSTASIS LABORATORY TESTING
- HEMOSTASIS SPECIMEN COLLECTION
- HEMOSTASIS SPECIMEN MANAGEMENT
- PLATELET FUNCTION TESTS
- PLATELET ACTIVATION MARKERS
- CLOT-BASED SCREENING TESTS FOR COAGULATION DISORDERS
- COAGULATION FACTOR ASSAYS
- FIBRINOLYSIS ASSAYS
- VISCOELASTOMETRY AND GLOBAL COAGULATION ASSAYS
- GENETIC TESTING FOR HEMOSTATIC DISORDERS
- 42. Hemostasis and Coagulation Instrumentation
- THE CLINICAL COAGULATION LABORATORY
- ASSAY ENDPOINT DETECTION PRINCIPLES
- ADVANTAGES AND DISADVANTAGES OF DETECTION METHODS
- COAGULATION INSTRUMENTATION AND TECHNOLOGY ADVANCEMENTS
- SELECTION OF COAGULATION INSTRUMENTATION
- CURRENTLY AVAILABLE COAGULATION INSTRUMENTS
- POINT-OF-CARE COAGULATION TESTING
- GLOBAL HEMOSTASIS ASSESSMENT
- PLATELET FUNCTION TESTING
- MOLECULAR GENETIC TESTING IN COAGULATION
- Part VII. Hematology and Hemostasis in Selected Populations
- 43. Hematology and Hemostasis in the Pediatric, Pregnant, Geriatric, and Transgender Populations
- PEDIATRIC HEMATOLOGY AND HEMOSTASIS
- GESTATIONAL HEMATOLOGY AND HEMOSTASIS
- GERIATRIC HEMATOLOGY AND HEMOSTASIS
- TRANSGENDER POPULATIONS
- ECHAPTERS (EVOLVE)
- E1. Safety in the Hematology Laboratory
- STANDARD PRECAUTIONS
- OCCUPATIONAL HAZARDS
- E2. Blood Specimen Collection
- SAFETY
- RESPONSIBILITY OF THE PHLEBOTOMIST IN INFECTION CONTROL
- PHYSIOLOGIC FACTORS AFFECTING TEST RESULTS
- VENIPUNCTURE
- SKIN PUNCTURE
- QUALITY ASSURANCE IN BLOOD SPECIMEN COLLECTION
- SPECIMEN HANDLING
- LEGAL ISSUES IN PHLEBOTOMY
- SUMMARY
- E3. Care and Use of the Microscope
- PRINCIPLES OF MICROSCOPY
- COMPONENT PARTS AND THEIR FUNCTIONS
- OPERATING PROCEDURE WITH KOEHLER ILLUMINATION
- IMMERSION OIL AND TYPES
- CARE OF THE MICROSCOPE
- BASIC TROUBLESHOOTING
- OTHER MICROSCOPES USED IN THE CLINICAL LABORATORY
- SUMMARY
- E4. Body Fluid Analysis in the Hematology Laboratory
- PERFORMING CELL COUNTS ON BODY FLUIDS
- PERFORMING DIFFERENTIAL COUNTS ON BODY FLUIDS
- CEREBROSPINAL FLUID
- SEROUS FLUID
- SYNOVIAL FLUID
- BRONCHOALVEOLAR LAVAGE SPECIMENS
- SUMMARY
- APPENDICES (EVOLVE)
- Appendix A. Abbreviations
- Appendix B. List of Formulas
- Appendix C. Answers
- Appendix D. Glossary
- INDEX
- Hematology/Body Fluids/Hemostasis Reference Intervals
- Edition: 7
- Published: April 15, 2024
- Imprint: Elsevier
- No. of pages: 928
- Language: English
- Paperback ISBN: 9780323936507
- eBook ISBN: 9780443349164
- eBook ISBN: 9780323937627
EK
Elaine M. Keohane
MM
Michelle Montgomery Preston
KM
Kamran M. Mirza
JW