Regulation of Macromolecular Synthesis By Low Molecular Weight Mediators
- 1st Edition - January 1, 1979
- Imprint: Academic Press
- Editor: Gebhard Koch
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 4 1 7 5 8 0 - 8
- Paperback ISBN:9 7 8 - 0 - 1 2 - 4 3 1 4 5 3 - 5
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 1 5 2 5 5 - 6
Regulation of Macromolecular Synthesis by Low Molecular Weight Mediators contains the proceedings of the Workshop on Regulation of Macromolecular Synthesis by Low Molecular Weight… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quoteRegulation of Macromolecular Synthesis by Low Molecular Weight Mediators contains the proceedings of the Workshop on Regulation of Macromolecular Synthesis by Low Molecular Weight Mediators held at Hamburg on May 29-31, 1979. The book discusses the functions and metabolism of guanosine 3',5'-bis(diphosphate); the purine nucleotides and sporulation; and the highly phosphorylated nucleotide in eukaryotes. The text also describes the alteration of translational mechanisms, as well as 2,5-oligoadenylic acid and interferon.
Contributors
Foreword
Preface
Opening Remarks:
Oligonucleotides and Growth Regulation
I. Functions and Metabolism of Guanosine 3',5'-Bis(Diphosphate) [ppGpp]
1. Stringent Control In Bacterial Systems
Stringent Control of Translational Accuracy
Guanosine 3,5'-Bispyrophosphate is a Dispensable Metabolite
Studies on the Coordination of tRNA-Charging and Polypeptide Synthesis Activity in Escherichia Coli
Deletion of relA and relX in Escherichia Coli has no Effect on Basal or Carbon-Downshift ppGpp Synthesis
2. Effect of ppGpp on RNA Polymerase and Transcription in E. Coli
Molecular Interactions in the Initiation of rRNA Synthesis in Prokaryotes
The Regulation of RNA Polymerase by Guanosine 5'-Disphosphate 3'-Diphosphate
3. Metabolism of ppGpp In Cell-Free Bacterial Systems
Synthesis and Degradation of the Pleiotropic Effector Guanosine 3',-5'Bis(Disphosphate) in Bacteria
Biosynthesis of Guanosine Tetraphosphate in Bacillus Brevis
4. Failure to Detect ppGpp In Eukaryotes
A Radioimmunoassay for ppGpp
Guanosine 3',5'-Bis (Diphosphate) Search in Eukaryotes
II. Purine Nucleotides and Sporulation
Initiation of Bacterial and Yeast Sporulation by Partial Deprivation of Guanine Nucleotides
Regulation of Sporulation by Highly Phosphorylated Nucleotides in Bacillus Subtilis
III. Highly Phosphorylated Nucleotides in Eukaryotes
1. Isolation and Characterization of Novel Dinucleotides
Studies on the Biosynthesis and Function of Dinucleoside Polyphosphates in Artemia Embryos
Historical Background on Adenosine 5,5'-P1,P4-Tetraphosphate (Ap4A) and Current Developments
The Accumulation of Highly Phosphorylated Compounds in Drosophila Melanogaster Cells after Heat Shock
HS3—A Bizzare Dinucleoside Polyphosphate as Possible Pleiotypic Regulator of Eukaryotes
2. Effects of Dinucleotide and Adenosine Nucleotide Pools in Replication of DNA and Protein Synthesis
Diadenosine Tetraphosphate (Ap4A)—A Ligand of DNA Polymerase α and Trigger of Replication
Elevated Nuclear ATP Pools and ATP/ADP Ratios Mediate Adenosine Toxicity in Fibroblasts
Relation of Protein Synthesis to the Content of Adenosine Polyphosphates
IV. Alteration of Translational Mechanisms
Nucleosidetriphosphate Mediated Discrimination of Gene Expression in T1-Infected E. Coli
Compartmentalization of Phosphate Donor Pool for Ribosomal Protein S6 before and after Stimulation of Quiescent Mouse Fibroblast Cells with Serum, and Nondependence of the Phosphorylation of cAMP Pools
Membrane Mediated Amplification of Translational Control in Eukaryotes: A Pleiotropic Effect
Mode of Action of Hemin-Controlled Translational Inhibitor
V. 2',5'- Oligo a and Interferon
Induction, Purification, and Properties of 2',5'-Oligoadenylate Synthetase
Mechanism of Action of 2-5A in Intact Cells
2',5'-0ligo(A): A Mediator of Viral RNA Cleavage in Interferon-Treated Cells?
Studies on Interferon Action: Synthesis, Degradation, and Biological Activity of (2',5')-0ligoisoadenylate
Concluding Remarks
Low Molecular Weight Mediators of Macromolecular Synthesis—An Overview
Index
- Edition: 1
- Published: January 1, 1979
- No. of pages (eBook): 390
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780124175808
- Paperback ISBN: 9780124314535
- eBook ISBN: 9780323152556
Read Regulation of Macromolecular Synthesis By Low Molecular Weight Mediators on ScienceDirect