Regenerative Hepatology and Liver Transplantation
- 1st Edition, Volume 2 - July 25, 2025
- Imprint: Academic Press
- Editors: Paulo Martins, Pedro Baptista
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 2 3 5 2 4 - 9
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 3 6 4 9 - 9
Regenerative Hepatology and Liver Transplantation is the second volume in the Regenerative and Transplant Medicine series. This volume is essential as no field in the biomedical sc… Read more
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Regenerative Hepatology and Liver Transplantation is the second volume in the Regenerative and Transplant Medicine series. This volume is essential as no field in the biomedical sciences has more interest than organ transplantation regarding regenerative medicine, primarily because of the urgent need to improve transplant outcomes and increase transplantation rates is critical to treat the many patients suffering from liver disease.
The goal of this book is to bridge regenerative hepatology and transplant medicine, by illustrating the state of the art of clinical liver transplantation, as well as of the progress of regenerative medicine (RM) investigations aiming at the bioengineering, regeneration, and repair of the liver.
This volume is necessary and would be placed well in the current global trend toward increasing organ donation utilizing such cutting-edge technologies. Written by the world’s experts in the field of liver diseases, it is a perfect reference for transplant operators, researchers, regenerative medicine operators, tissue engineering operators, biotech operators, and those in academia, industry, and regulatory agencies working to advance the field.
The goal of this book is to bridge regenerative hepatology and transplant medicine, by illustrating the state of the art of clinical liver transplantation, as well as of the progress of regenerative medicine (RM) investigations aiming at the bioengineering, regeneration, and repair of the liver.
This volume is necessary and would be placed well in the current global trend toward increasing organ donation utilizing such cutting-edge technologies. Written by the world’s experts in the field of liver diseases, it is a perfect reference for transplant operators, researchers, regenerative medicine operators, tissue engineering operators, biotech operators, and those in academia, industry, and regulatory agencies working to advance the field.
- Second volume in the Regenerative and Transplant Medicine series, focusing on the liver
- Covers the liver and diseases, transplantation, cell transplantation, liver preservation and machine perfusion, and liver bioengineering
- Builds on previous works and demonstrates how regenerative and transplant medicine work together to provide an increased ability to improve health care outcomes for individuals
Transplant operators, researchers, regenerative medicine operators, tissue engineering operators, biotech operators, Academia, Industry and Regulatory agencies and operators. General surgery, transplant fellows in regenerative medicine
Section I: The liver and liver diseases
1. Prevalence of liver disease around the world
Helena Cortez-Pinto, Ana Craciun, Ricardo Crespo and Sofia Carvalhana
2. Viral hepatitis
Jean-Charles Duclos-Vallee
3. Non-alcoholic steatohepatitis
Miguel Pinheiro, Marta B. Afonso and Cecılia M.P. Rodrigues
4. Alcoholic liver disease
Zachary DeVore, Philip McNamara, Dimitri Belkin, Naveen Ganjoo and Deepika Devuni
5. Liver fibrosis and cirrhosis
Philipp Schwabl, Margarita Papatheodoridi and Massimo Pinzani
6. Biomarkers in liver disease and transplantation: Outlook for precision medicine
Ruslan A. Mammadov, Vincent T. Janmaat, Cornelia J. Verhoeven, Jan N.M. IJzermans,
Maikel P. Peppelenbosch, Luc J.W. van der Laan and Henk P. Roest
Section II: Liver transplantation
7. Living donor liver transplantation
Han Li, Paulo Martins, Babak Mavahedi and Adel Bozorgzadeh
8. Small-for-size syndrome in liver transplantation
Martin Montenovo
9. Clinical trials design and endpoints in liver transplantation
Richard W. Laing, Amanda P.C.S. Boteon and Yuri L. Boteon
10. Oncologic liver transplantation: Transplant oncology
Taizo Hibi
11. Management of hepatocellular carcinoma
Alejandro Serrablo, Alejandra Utrillas-Fornals, Pablo Parra, Luis Tejedor and Leyre Serrablo
Section III: Cell transplantation
12. Human hepatocyte transplantation
Jessica Nulty, Hanish Anand and Anil Dhawan
13. Mesenchymal stem cell transplantation
M. Najimi, G. de Bodt, G. Jannone and E.M. Sokal
14. Biliary tree stem cell transplantation
Savino Paradiso, Federica Cremisini, Matteo Franchitto, Guido Carpino and Vincenzo Cardinale
Section IV: Liver preservation and machine perfusion
15. General principles of organ preservation in liver transplantation
S.H. Abbas, F. Dengu and P.J. Friend
16. Ischemia-reperfusion injury
Joan Rosello Catafau and Arnau Panisello Rosello
Section V: Regenerative medicine in liver disease and transplantation
17. Liver regeneration
Udayan Apte
18. Whole-liver bioengineering: The future of transplantation medicine
Diogo Marques, Natalia Sanchez Romero, Sandra Meliton Barbancho, Alvaro Blanes Rodriguez, Pilar Sainz de la Masa Arnal, Helen Almeida, Pablo Royo Dachary and Pedro M. Baptista
19. Nanotechnology application in liver transplantation
Christine G. Yao
20. Acute liver failure and bioreactors/liver assist devices
Manon Guillet, Claire de Lartigue, Ulysse Pereira, Marwa Hussein, Mattia Pasqua and Cecile Legallais
21. Hepatobiliary organoids and large-scale expansion for regenerative therapies
Kerstin Schneeberger, Sara Morini and Bart Spee
22. Liver aging
Eric Felli and Jordi Gracia-Sancho
1. Prevalence of liver disease around the world
Helena Cortez-Pinto, Ana Craciun, Ricardo Crespo and Sofia Carvalhana
2. Viral hepatitis
Jean-Charles Duclos-Vallee
3. Non-alcoholic steatohepatitis
Miguel Pinheiro, Marta B. Afonso and Cecılia M.P. Rodrigues
4. Alcoholic liver disease
Zachary DeVore, Philip McNamara, Dimitri Belkin, Naveen Ganjoo and Deepika Devuni
5. Liver fibrosis and cirrhosis
Philipp Schwabl, Margarita Papatheodoridi and Massimo Pinzani
6. Biomarkers in liver disease and transplantation: Outlook for precision medicine
Ruslan A. Mammadov, Vincent T. Janmaat, Cornelia J. Verhoeven, Jan N.M. IJzermans,
Maikel P. Peppelenbosch, Luc J.W. van der Laan and Henk P. Roest
Section II: Liver transplantation
7. Living donor liver transplantation
Han Li, Paulo Martins, Babak Mavahedi and Adel Bozorgzadeh
8. Small-for-size syndrome in liver transplantation
Martin Montenovo
9. Clinical trials design and endpoints in liver transplantation
Richard W. Laing, Amanda P.C.S. Boteon and Yuri L. Boteon
10. Oncologic liver transplantation: Transplant oncology
Taizo Hibi
11. Management of hepatocellular carcinoma
Alejandro Serrablo, Alejandra Utrillas-Fornals, Pablo Parra, Luis Tejedor and Leyre Serrablo
Section III: Cell transplantation
12. Human hepatocyte transplantation
Jessica Nulty, Hanish Anand and Anil Dhawan
13. Mesenchymal stem cell transplantation
M. Najimi, G. de Bodt, G. Jannone and E.M. Sokal
14. Biliary tree stem cell transplantation
Savino Paradiso, Federica Cremisini, Matteo Franchitto, Guido Carpino and Vincenzo Cardinale
Section IV: Liver preservation and machine perfusion
15. General principles of organ preservation in liver transplantation
S.H. Abbas, F. Dengu and P.J. Friend
16. Ischemia-reperfusion injury
Joan Rosello Catafau and Arnau Panisello Rosello
Section V: Regenerative medicine in liver disease and transplantation
17. Liver regeneration
Udayan Apte
18. Whole-liver bioengineering: The future of transplantation medicine
Diogo Marques, Natalia Sanchez Romero, Sandra Meliton Barbancho, Alvaro Blanes Rodriguez, Pilar Sainz de la Masa Arnal, Helen Almeida, Pablo Royo Dachary and Pedro M. Baptista
19. Nanotechnology application in liver transplantation
Christine G. Yao
20. Acute liver failure and bioreactors/liver assist devices
Manon Guillet, Claire de Lartigue, Ulysse Pereira, Marwa Hussein, Mattia Pasqua and Cecile Legallais
21. Hepatobiliary organoids and large-scale expansion for regenerative therapies
Kerstin Schneeberger, Sara Morini and Bart Spee
22. Liver aging
Eric Felli and Jordi Gracia-Sancho
- Edition: 1
- Volume: 2
- Published: July 25, 2025
- Imprint: Academic Press
- Language: English
PM
Paulo Martins
Paulo Martins MD, PhD, FAST, FEBS, FACS is a Transplant Surgeon and the lead of the Transplantation Lab. He is an associate Professor of Surgery and Adjunct Prof of Pathology at the University of Oklahoma. He graduated from the Federal University of Bahia in Brazil, completed a PhD in transplant immunology at the University of Berlin, and a transplant surgery fellowship at Harvard University (MGH). He is a member of the Sigma Xi Scientific Research Honor Society, Alpha Omega Alpha honor society. He was the previous chair of the International Liver Transplant Society Basic and Translational Science committee and current chair of the American Society of Transplantation Organ Preservation and Recovery committee. He is in the top 2% World Scientist list from Elsevier/Stanford University.
Affiliations and expertise
Associate Professor of Surgery, University of Massachusetts, UMass Memorial Medical Center, Worcester, MA, United StatesPB
Pedro Baptista
Pedro Baptista, PharmD, PhD, Marie Curie Alumni, is a Senior ARAID Researcher at IIS Aragon, Zaragoza, Spain, where he directs the Laboratory of Organ Bioengineering and Regenerative Medicine. He serves as a Visiting Professor of Biomedical Engineering at Universidad Carlos III de Madrid. Dr. Baptista earned his Pharmacy Degree from the University of Lisbon and completed his PhD training at the Wake Forest Institute for Regenerative Medicine in Winston-Salem, NC, USA. He is Secretary General of the European Society of Artificial Organs (ESAO) and Chair of the European Association for the Study of the Liver (EASL) Regenerative Hepatology Consortium. Dr. Baptista has published extensively in high-impact journals on organ bioengineering, organoids, and regenerative hepatology, holds four patents, and has successfully spun off several related technologies into companies.
Affiliations and expertise
Group Leader and Visiting Professor, Health Research Institute of Aragon, Zaragoza, Spain, and Carlos III University, Madrid, Spain