Reflections on Biochemistry
In Honour of Severo Ochoa
- 1st Edition - May 18, 2014
- Imprint: Pergamon
- Editors: A. Kornberg, B. L. Horecker, L. Cornudella
- Language: English
- Paperback ISBN:9 7 8 - 0 - 0 8 - 0 2 1 0 1 0 - 0
- eBook ISBN:9 7 8 - 1 - 4 8 3 1 - 3 6 0 2 - 8
Reflections on Biochemistry: In Honour of Severo Ochoa offers reflections on a wide range of topics relating to biochemistry, including energy metabolism, lipids and saccharides,… Read more
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Request a sales quoteReflections on Biochemistry: In Honour of Severo Ochoa offers reflections on a wide range of topics relating to biochemistry, including energy metabolism, lipids and saccharides, regulation, nucleic acids and the genetic code, protein biosynthesis, and cell biology. The essays celebrate Severo Ochoa's outstanding contributions to biochemistry spanning nearly half a century. This book is comprised of 47 chapters and begins with a biography of Ochoa and his scientific work in the field of biochemistry, particularly his research on intermediary metabolism, RNA synthesis, and the genetic code. The discussion then turns to energy metabolism, photosynthesis, and fermentation, touching on topics such as the role of lactic acid in the development of biochemistry and the biosynthesis of cell components from acetate. The next section is devoted to lipids, saccharides, and cell walls and includes chapters that deal with biotin, sulfur biochemistry, and dipicolinic acid. Subsequent chapters explore hormonal regulation of adipose tissue lipolysis; the structural relationship between genes and enzymes; bacteriophages, colicins, and ribosomes; and cell biology and neurobiology. This monograph will be of interest to biochemists and students of biochemistry.
Biographical Introduction: Severo Ochoa and the Development of Biochemistry
I. Energy Metabolism, Photosynthesis, Fermentation
The Role of Lactic Acid in the Development of Biochemistry
Origins of the Concept of Oxidative Phosphorylation: Retrospectives and Perspectives
Reflections on the Evolutionary Transition from Prokaryotes to Eukaryotes
A Pathway from Psychiatry to Cancer
Bioenergetics: Past, Present and Future
Enzymes Revisited
Unraveling the Pentose Phosphate Pathway
Reducing Power and the Regulation of Photosynthesis
Studies on High-Energy Phosphate Bonds: From Biosynthetic to Mechanochemical Reactions
Glutamate Fermentation and the Discovery of B12 Coenzymes
Trailing the Propionic Acid Bacteria
Biosynthesis of Cell Components from Acetate
Lessons in Learning
The Impact of the ATP-Generating Systems
II. Lipids, Saccharides, Cell Walls
On the Evolution of a Biosynthetic Pathway
My Expeditions into Sulfur Biochemistry
The Clostridium kluyveri-Acetyl-CoA Epoch
Biotin Unmasked
The Seven Veils of Dipicolinic Acid
Enzymic Mechanisms Involved in the Synthesis of Yeast Cell Wall
III. Regulation
The Pasteur Effect in the Allosteric Era
Comparative Aspects of Hormonal Regulation of Adipose Tissue Lipolysis
Reflections on the Relevance of Biochemistry for the Understanding of Living Systems
Formation and Cleavage of C—N Bonds in Arginine Biosynthesis and Urea Formation
Molecular Ecology
IV. Nucleic Acids and the Genetic Code
For the Love of Enzymes
From Enzyme Chemistry to Genetic Manipulation
The Search for the Structural Relationship between Gene and Enzyme
Synthesis in the Study of Nucleic Acids
A Phage in New York
Bacteriophage ø29
V. Protein Biosynthesis
Protein Synthesis: Early Waves and Recent Ripples
Ten Years in Protein Synthesis
Bacteriophages, Colicins and Ribosomes: Some Reflections on my Research Career
Ribosomes: Structure, Function and Evolution
Thoughts on Polypeptide Chain Elongation
Twenty-Five Years of Research on Inhibitors of Protein Synthesis: Prospects for Future Developments in the Subject
VI. Cell Biology and Neurobiology
A Biochemist Looks at the Nervous System
Brain Damage and Perinatal Biochemistry
My Interrupted Association with Potassium
A Personal Account of My Research on Collagen and Fibrosis
VII. Science in the Time of Ochoa
Reminiscences of Severo Ochoa from Our Oxford Days
Highlights of a Friendship
Discovery Made Easy
Comments on the Productivity of Scientists
Prebiological Chemistry and the Origin of Life: A Personal Account
My Homage to Severo Ochoa
Name Index
Subject Index
- Edition: 1
- Published: May 18, 2014
- Imprint: Pergamon
- Language: English
- Paperback ISBN: 9780080210100
- eBook ISBN: 9781483136028
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