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Reflections on Biochemistry

In Honour of Severo Ochoa

1st Edition - January 1, 1976

Editors: A. Kornberg, B. L. Horecker, L. Cornudella

eBook ISBN:

9 7 8 - 1 - 4 8 3 1 - 3 6 0 2 - 8

Reflections on Biochemistry: In Honour of Severo Ochoa offers reflections on a wide range of topics relating to biochemistry, including energy metabolism, lipids and saccharides,… Read more

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Reflections on Biochemistry: In Honour of Severo Ochoa offers reflections on a wide range of topics relating to biochemistry, including energy metabolism, lipids and saccharides, regulation, nucleic acids and the genetic code, protein biosynthesis, and cell biology. The essays celebrate Severo Ochoa's outstanding contributions to biochemistry spanning nearly half a century. This book is comprised of 47 chapters and begins with a biography of Ochoa and his scientific work in the field of biochemistry, particularly his research on intermediary metabolism, RNA synthesis, and the genetic code. The discussion then turns to energy metabolism, photosynthesis, and fermentation, touching on topics such as the role of lactic acid in the development of biochemistry and the biosynthesis of cell components from acetate. The next section is devoted to lipids, saccharides, and cell walls and includes chapters that deal with biotin, sulfur biochemistry, and dipicolinic acid. Subsequent chapters explore hormonal regulation of adipose tissue lipolysis; the structural relationship between genes and enzymes; bacteriophages, colicins, and ribosomes; and cell biology and neurobiology. This monograph will be of interest to biochemists and students of biochemistry.

Biographical Introduction: Severo Ochoa and the Development of Biochemistry

I. Energy Metabolism, Photosynthesis, Fermentation

The Role of Lactic Acid in the Development of Biochemistry

Origins of the Concept of Oxidative Phosphorylation: Retrospectives and Perspectives

Reflections on the Evolutionary Transition from Prokaryotes to Eukaryotes

A Pathway from Psychiatry to Cancer

Bioenergetics: Past, Present and Future

Enzymes Revisited

Unraveling the Pentose Phosphate Pathway

Reducing Power and the Regulation of Photosynthesis

Studies on High-Energy Phosphate Bonds: From Biosynthetic to Mechanochemical Reactions

Glutamate Fermentation and the Discovery of B12 Coenzymes

Trailing the Propionic Acid Bacteria

Biosynthesis of Cell Components from Acetate

Lessons in Learning

The Impact of the ATP-Generating Systems

II. Lipids, Saccharides, Cell Walls

On the Evolution of a Biosynthetic Pathway

My Expeditions into Sulfur Biochemistry

The Clostridium kluyveri-Acetyl-CoA Epoch

Biotin Unmasked

The Seven Veils of Dipicolinic Acid

Enzymic Mechanisms Involved in the Synthesis of Yeast Cell Wall

III. Regulation

The Pasteur Effect in the Allosteric Era

Comparative Aspects of Hormonal Regulation of Adipose Tissue Lipolysis

Reflections on the Relevance of Biochemistry for the Understanding of Living Systems

Formation and Cleavage of C—N Bonds in Arginine Biosynthesis and Urea Formation

Molecular Ecology

IV. Nucleic Acids and the Genetic Code

For the Love of Enzymes

From Enzyme Chemistry to Genetic Manipulation

The Search for the Structural Relationship between Gene and Enzyme

Synthesis in the Study of Nucleic Acids

A Phage in New York

Bacteriophage ø29

V. Protein Biosynthesis

Protein Synthesis: Early Waves and Recent Ripples

Ten Years in Protein Synthesis

Bacteriophages, Colicins and Ribosomes: Some Reflections on my Research Career

Ribosomes: Structure, Function and Evolution

Thoughts on Polypeptide Chain Elongation

Twenty-Five Years of Research on Inhibitors of Protein Synthesis: Prospects for Future Developments in the Subject

VI. Cell Biology and Neurobiology

A Biochemist Looks at the Nervous System

Brain Damage and Perinatal Biochemistry

My Interrupted Association with Potassium

A Personal Account of My Research on Collagen and Fibrosis

VII. Science in the Time of Ochoa

Reminiscences of Severo Ochoa from Our Oxford Days

Highlights of a Friendship

Discovery Made Easy

Comments on the Productivity of Scientists

Prebiological Chemistry and the Origin of Life: A Personal Account

My Homage to Severo Ochoa

Name Index

Subject Index