Reconstructive Transplantation and Regenerative Surgery
The New Frontier
- 1st Edition, Volume 3 - December 8, 2025
- Latest edition
- Editors: Vijay Gorantla, Yalcin Kulahci, Fatih Zor
- Language: English
Reconstructive Transplantation and Regenerative Surgery: The New Frontier is the third volume in the Regenerative and Transplant Medicine Series. This volume captures a decade… Read more
Reconstructive Transplantation and Regenerative Surgery: The New Frontier is the third volume in the Regenerative and Transplant Medicine Series. This volume captures a decade of transformative progress at the intersection of reconstructive transplantation, regenerative medicine, and tissue engineering—fields that have begun to converge into a bold new frontier: regenerative surgery.
Coedited by internationally recognized leaders in the field, this authoritative work explores cutting-edge advances that are redefining the possibilities for patients with complex tissue loss and functional deficits.
Through comprehensive and original chapters written by global experts, this book charts the latest innovations in vascularized composite allotransplantation (VCA), graft immunomodulation, neurogeneration and diagnostics, ischemia mitigation and tissue preservation, and tissue engineering and biomaterials.
Comprehensive in scope and visionary in approach, Reconstructive Transplantation and Regenerative Surgery: The New Frontier is an essential resource for surgeons, researchers, biomedical engineers, and clinicians.
Coedited by internationally recognized leaders in the field, this authoritative work explores cutting-edge advances that are redefining the possibilities for patients with complex tissue loss and functional deficits.
Through comprehensive and original chapters written by global experts, this book charts the latest innovations in vascularized composite allotransplantation (VCA), graft immunomodulation, neurogeneration and diagnostics, ischemia mitigation and tissue preservation, and tissue engineering and biomaterials.
Comprehensive in scope and visionary in approach, Reconstructive Transplantation and Regenerative Surgery: The New Frontier is an essential resource for surgeons, researchers, biomedical engineers, and clinicians.
- Showcases pioneering achievements in face, limb, penile, laryngotracheal, and whole-eye transplantation
- Highlights the advances in cell therapies, gene editing, and localized immunosuppressive delivery systems for graft immunomodulation
- Presents innovations in neurobiologics, biodegradable materials, smart biosensors, and noninvasive imaging for real-time graft surveillance
- Profiles next-generation perfusates and preservation strategies adapted from solid organ transplantation
- Explores the clinical, ethical, and developmental considerations of vascularized composite allotransplantation (VCA) in adolescents and young adults
Physicians, Surgeons, Scientists, Academics, Biomedical Engineers, Nurses, and technical staff in Clinical Medicine, Biomedical Sciences and Biomedical Engineering
Section 1: RECONSTRUCTIVE TRANSPLANTATION
Part I: The Cutting Edge
1. The World’s Largest Single Center Experience in Face Transplantation
Viola A. Stögner, Alexzandra Zdrava, and Bohdan Pomahac
2. Laryngotracheal Transplantation: Evolution and Experience
Benjamin M. Laitman, Ya-Wen Chen and Eric M. Genden
Part II: Unique Considerations and Emerging Indications
3. Lower Limb Transplantation - Pre-Clinical Insights and Patient Considerations
Naga Anvesh Kodali, Omer Faruk Dirican, Fatih Zor and Yalcin Kulahci
4. Penile Transplantation: Experience and Emerging Indications
Janarthanan Ramu, Bedreddin Sazoglu, Yalcin Kulahci and Fatih Zor
5. Whole Eye Transplantation: Knowns and Unknowns
Mariana Mayorquın Ruiz, Gabriela Nava Márquez and Gustavo A. Rebolloso González
Section 2: REGENERATIVE SURGERY
Part III: Targeted Technologies and Therapies
6. In-Situ, Implantable and Locally Injectable Drug Delivery: State of the Art
Mishal Khan, Amogh Gorantla, and Praveen Kumar Vemula
7. Smart Sensors for Graft Health Monitoring
Atul Sharma, Vijay s. Gorantla and Sameer Sonkusale
8. Opportunities in Covalent Tissue Modification for Graft-localized Drug Release
Robert R. Kane, Johann W. Karunananthan, Michael Nicosa, Yalcin Kulahci and Anna Valujskikh
Part IV: Cellular and Regenerative Therapies
9. Cell Therapy and Immune Tolerance: State of the Art and Potential Applications in Reconstructive Transplantation
Vinay Itte and David A. Leonard
10. Gene Editing Strategies for Immunomodulation
Zeynep Demir, Vijay S. Gorantla, Yalcin Kulahci and Fatih Zor
Part V: Graft Preservation
11. Novel Oxygen Carrier Perfusates for Transplant Applications
Vidya Surti, Amit Chandra Das and Jelena M. Janjic
12. Preservation Technologies in Reconstructive Transplantation: Lessons from Solid Organ Experience
Ellie Cohen, Josh Copus and Varun Kopparthy
Part VI: Tissue Engineering and Regenerative Biomaterials
13. Tracheal Tissue Engineering
Çağdaş Duru and Siba Haykal
14. Thymus Tissue Engineering
Gauri Kulkarni, Fatih Zor, Yalcin Kulahci and Vijay S. Gorantla
15. Customized Bioresorbable Implants for Bone Fixation in Reconstructive Transplantation
Matthew Criado, John Ohodnicki, Nikhita Joy, Mayur Gaikwad, Vijay S. Gorantla and Prashant N. Kumta
Part VII: Special Populations in Reconstructive Transplantation
16. Hand and Face Transplantation in Teens and Young Adults: Unique Considerations
Aarnav Gorantla and Mary Brooks Hall
Part I: The Cutting Edge
1. The World’s Largest Single Center Experience in Face Transplantation
Viola A. Stögner, Alexzandra Zdrava, and Bohdan Pomahac
2. Laryngotracheal Transplantation: Evolution and Experience
Benjamin M. Laitman, Ya-Wen Chen and Eric M. Genden
Part II: Unique Considerations and Emerging Indications
3. Lower Limb Transplantation - Pre-Clinical Insights and Patient Considerations
Naga Anvesh Kodali, Omer Faruk Dirican, Fatih Zor and Yalcin Kulahci
4. Penile Transplantation: Experience and Emerging Indications
Janarthanan Ramu, Bedreddin Sazoglu, Yalcin Kulahci and Fatih Zor
5. Whole Eye Transplantation: Knowns and Unknowns
Mariana Mayorquın Ruiz, Gabriela Nava Márquez and Gustavo A. Rebolloso González
Section 2: REGENERATIVE SURGERY
Part III: Targeted Technologies and Therapies
6. In-Situ, Implantable and Locally Injectable Drug Delivery: State of the Art
Mishal Khan, Amogh Gorantla, and Praveen Kumar Vemula
7. Smart Sensors for Graft Health Monitoring
Atul Sharma, Vijay s. Gorantla and Sameer Sonkusale
8. Opportunities in Covalent Tissue Modification for Graft-localized Drug Release
Robert R. Kane, Johann W. Karunananthan, Michael Nicosa, Yalcin Kulahci and Anna Valujskikh
Part IV: Cellular and Regenerative Therapies
9. Cell Therapy and Immune Tolerance: State of the Art and Potential Applications in Reconstructive Transplantation
Vinay Itte and David A. Leonard
10. Gene Editing Strategies for Immunomodulation
Zeynep Demir, Vijay S. Gorantla, Yalcin Kulahci and Fatih Zor
Part V: Graft Preservation
11. Novel Oxygen Carrier Perfusates for Transplant Applications
Vidya Surti, Amit Chandra Das and Jelena M. Janjic
12. Preservation Technologies in Reconstructive Transplantation: Lessons from Solid Organ Experience
Ellie Cohen, Josh Copus and Varun Kopparthy
Part VI: Tissue Engineering and Regenerative Biomaterials
13. Tracheal Tissue Engineering
Çağdaş Duru and Siba Haykal
14. Thymus Tissue Engineering
Gauri Kulkarni, Fatih Zor, Yalcin Kulahci and Vijay S. Gorantla
15. Customized Bioresorbable Implants for Bone Fixation in Reconstructive Transplantation
Matthew Criado, John Ohodnicki, Nikhita Joy, Mayur Gaikwad, Vijay S. Gorantla and Prashant N. Kumta
Part VII: Special Populations in Reconstructive Transplantation
16. Hand and Face Transplantation in Teens and Young Adults: Unique Considerations
Aarnav Gorantla and Mary Brooks Hall
- Edition: 1
- Latest edition
- Volume: 3
- Published: December 8, 2025
- Language: English
VG
Vijay Gorantla
Dr. Gorantla is a tenured professor of surgery at Wake Forest University School of Medicine and the Wake Forest Institute for Regenerative Medicine. He is the director of the Vascularized Composite Allotransplantation (VCA) Program at Atrium Health Wake Forest Baptist. His research interests include biosensors and biosensing techniques, cellular therapies, nanomedicine, organ transplantations, reconstructive surgeries, regenerative medicine and its applications in transplantation and regenerative, pharmacology. Additionally, he studies the relationship between the immune system and the regenerative, oncogenic and autoimmune processes. Dr. Gorantla was a key member of the team that performed the nation’s first hand transplant at the University of Louisville in 1999. He co-founded the first national society for VCA, the American Society for Reconstructive Transplantation (ASRT). Dr. Gorantla has authored more than 100 scientific papers and 15 book chapters in the field of VCA and is currently co-editing a comprehensive book on the subject of regenerative surgery.
Affiliations and expertise
Department of Surgery, Advocate Health, Wake Forest University School of Medicine, Winston- Salem, NC, United StatesYK
Yalcin Kulahci
Dr. Yalcin Kulahci is a Plastic and Reconstructive Surgeon with specific expertise in Reconstructive Surgery and Microsurgery. He is dual board-certified in Oral and Maxillofacial Surgery and Hand Surgery and was recruited as faculty in 2008 to the Gulhane Military Medical Academy (GMMA) in Istanbul, affiliated with NATO and USUHS. In 2011, Dr. Kulahci was appointed as an Associate Professor at the same institution. In 2012, he became a founding academic staff member for the Department of Hand and Upper Extremity Surgery in Ankara, Turkiye. In 2019, he was recruited to the Wake Forest Institute for Regenerative Medicine following 22 years of honorable service with the Military Health System in Turkey. Dr. Kulahci is currently a faculty member at the Wake Forest School of Medicine and has a comprehensive publication record in clinical reconstructive surgery and microsurgery, with decades of translational research experience in VCA.
Affiliations and expertise
Department of Surgery, Advocate Health, Wake Forest University School of Medicine, Winston- Salem, NC, United StatesFZ
Fatih Zor
Dr. Zor is a Plastic and Reconstructive Surgeon with specific expertise in Reconstructive Surgery and Microsurgery. He served as assistant professor of Plastic Surgery and chief combat surgeon in Turkish Armed Forces for over 15 years. Dr. Zor established the first military VCA programs in Turkey and obtained approval for both hand and face transplantation in 2011. Given his field experience in battlefield medicine and expertise in complex reconstruction, tissue regeneration, and hand/face transplantation, he was recruited to Wake Forest Institute for Regenerative Medicine as a faculty in 2017. He participated on several collaborative multi-institutional RTRP and PRMRP awards in the area of reconstructive transplantation and tissue generation. Currently, he's working as Burn Surgery Fellow in Indiana University School of Medicine.
My research focus is on immunomodulation, non-invasive VCA monitoring, peripheral and optic nerve regeneration, nanomedicine applications involving transplant and tissue regeneration indications and multimodality imaging strategies for VCA.
Affiliations and expertise
Department of Plastic Surgery, Indiana University, Indianapolis, IN, United StatesRead Reconstructive Transplantation and Regenerative Surgery on ScienceDirect