Reconstructive Transplantation and Regenerative Surgery
The New Frontier
- 1st Edition, Volume 3 - November 3, 2025
- Editors: Vijay Gorantla, Yalcin Kulahci, Fatih Zor
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 3 0 0 8 4 - 4
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 3 0 0 8 5 - 1
Reconstructive Transplantation and Regenerative Surgery: The New Frontier, Volume Three in the Regenerative and Transplant Medicine series—explores this transformative disc… Read more
Reconstructive Transplantation and Regenerative Surgery: The New Frontier, Volume Three in the Regenerative and Transplant Medicine series—explores this transformative discipline. This integration aims to overcome the limitations of traditional vascularized organ and tissue transplantation, offering innovative solutions through cutting-edge techniques. As regenerative surgery continues to evolve, this volume serves as a comprehensive resource, highlighting the latest advancements in graft immunomodulation, neuroregeneration, gene editing, diagnostic imaging, ischemia mitigation, and graft preservation. Authored by leading experts, this volume delves into crucial topics such as cell therapies, immunobiologics, neurobiologics, and targeted therapeutic strategies like local immunosuppressive implants and immunocloaking.
It also covers cutting-edge diagnostic approaches, including non-invasive molecular imaging, nanotheranostics, and multimodal surveillance techniques. By addressing critical challenges in transplantation and regeneration, this book is an essential reference for surgeons, clinicians, trainees, scientists, and academics dedicated to advancing the field.
It also covers cutting-edge diagnostic approaches, including non-invasive molecular imaging, nanotheranostics, and multimodal surveillance techniques. By addressing critical challenges in transplantation and regeneration, this book is an essential reference for surgeons, clinicians, trainees, scientists, and academics dedicated to advancing the field.
- Focuses on vascularized organ/tissue transplantation
- Includes an overview of the field, including developments of transplantation methods and techniques
- Builds on previous works and demonstrates how regenerative and transplant medicine work together to provide an increased ability to improve health care outcomes for individuals
Physicians, Surgeons, Scientists, Academics, Biomedical Engineers, Nurses, and technical staff in Clinical Medicine, Biomedical Sciences and Biomedical Engineering
TABLE OF CONTENTS
RECONSTRUCTIVE TRANSPLANTATION
Part I – The Cutting Edge
1. The World’s Largest Single Center Experience in Face Transplantation
Viola Stögner, Alexzandra Zdrava, and Bohdan Pomahac
2. Laryngotracheal Transplantation—Evolution and Experience
Benjamin Laitman, and Eric Genden
Part II – Unique Considerations and Emerging Indications
3. Lower Limb Transplantation - Pre-Clinical Insights and Patient Considerations
Naga Anvesh Kodali, Omer Faruk Dirican, and Yalcin Kulahci
4. Penile Transplantation - Experience and Emerging Indications
Janarthanan Ramu, Bedreddin Sazoglu, and Fatih Zor
5. Whole Eye Transplantation - Knowns and Unknowns
Mariana Mayorquin, Gabriela Nava Márquez, Gustavo A. Rebolloso González
REGENERATIVE SURGERY
Part III – Targeted Technologies and Therapies
6. In-Situ, Implantable and Locally Injectable Drug Delivery - State of the Art
Mishal Khan, Amogh Gorantla, and Praveen Kumar Vemula
7. Smart Sensors for Graft Health Monitoring
Atul Sharma Vijay Gorantla, and Sameer Sonkusale
8. Opportunities in Covalent Tissue Modification for Graft-localized Drug Release
Robert Kane, Johann Karunananthan, Michael Nicosa, Yalcin Kulahci, and Anna Valujskikh
Part IV – Cellular and Regenerative Therapies
9. Cell Therapy and Immune Tolerance: State of the Art and Potential Applications in Reconstructive Transplantation
Vinay Itte and David Leonard
10. Gene Editing Strategies for Immunomodulation
Fatih Zor, Zeynep Demir, Vijay Gorantla, and Yalcin Kulahci
Part V– Graft Preservation
11. Novel Oxygen Carrier Perfusates for Transplant Applications
Vidya Surti, Amit Chandra Das, and Jelena Janjic
12. Preservation Technologies in Reconstructive Transplantation: Lessons from Solid Organ Experience
Ellie Cohen, Josh Copus, and Varun Kopparthy
Part VI – Tissue Engineering and Regenerative Biomaterials
13. Tracheal Tissue Engineering
Çağdaş Duru and Siba Haykal
14. Thymus Tissue Engineering
Gauri Kulkarni, Fatih Zor, Yalcin Kulahci, and Vijay Gorantla
15. Customized Bioresorbable Implants for Bone Fixation in Reconstructive Transplantation
Matthew Criado, John Ohodnicki, Nikhita Joy, Mayur Gaikwad, Vijay Gorantla, and Prashant Kumta
Part VII – Special Populations in Reconstructive Transplantation
Hand and Face Transplantation in Teens and Young Adults - Unique Considerations
Aarnav Gorantla and Mary Brooks Hall
RECONSTRUCTIVE TRANSPLANTATION
Part I – The Cutting Edge
1. The World’s Largest Single Center Experience in Face Transplantation
Viola Stögner, Alexzandra Zdrava, and Bohdan Pomahac
2. Laryngotracheal Transplantation—Evolution and Experience
Benjamin Laitman, and Eric Genden
Part II – Unique Considerations and Emerging Indications
3. Lower Limb Transplantation - Pre-Clinical Insights and Patient Considerations
Naga Anvesh Kodali, Omer Faruk Dirican, and Yalcin Kulahci
4. Penile Transplantation - Experience and Emerging Indications
Janarthanan Ramu, Bedreddin Sazoglu, and Fatih Zor
5. Whole Eye Transplantation - Knowns and Unknowns
Mariana Mayorquin, Gabriela Nava Márquez, Gustavo A. Rebolloso González
REGENERATIVE SURGERY
Part III – Targeted Technologies and Therapies
6. In-Situ, Implantable and Locally Injectable Drug Delivery - State of the Art
Mishal Khan, Amogh Gorantla, and Praveen Kumar Vemula
7. Smart Sensors for Graft Health Monitoring
Atul Sharma Vijay Gorantla, and Sameer Sonkusale
8. Opportunities in Covalent Tissue Modification for Graft-localized Drug Release
Robert Kane, Johann Karunananthan, Michael Nicosa, Yalcin Kulahci, and Anna Valujskikh
Part IV – Cellular and Regenerative Therapies
9. Cell Therapy and Immune Tolerance: State of the Art and Potential Applications in Reconstructive Transplantation
Vinay Itte and David Leonard
10. Gene Editing Strategies for Immunomodulation
Fatih Zor, Zeynep Demir, Vijay Gorantla, and Yalcin Kulahci
Part V– Graft Preservation
11. Novel Oxygen Carrier Perfusates for Transplant Applications
Vidya Surti, Amit Chandra Das, and Jelena Janjic
12. Preservation Technologies in Reconstructive Transplantation: Lessons from Solid Organ Experience
Ellie Cohen, Josh Copus, and Varun Kopparthy
Part VI – Tissue Engineering and Regenerative Biomaterials
13. Tracheal Tissue Engineering
Çağdaş Duru and Siba Haykal
14. Thymus Tissue Engineering
Gauri Kulkarni, Fatih Zor, Yalcin Kulahci, and Vijay Gorantla
15. Customized Bioresorbable Implants for Bone Fixation in Reconstructive Transplantation
Matthew Criado, John Ohodnicki, Nikhita Joy, Mayur Gaikwad, Vijay Gorantla, and Prashant Kumta
Part VII – Special Populations in Reconstructive Transplantation
Hand and Face Transplantation in Teens and Young Adults - Unique Considerations
Aarnav Gorantla and Mary Brooks Hall
- Edition: 1
- Volume: 3
- Published: November 3, 2025
- Language: English
VG
Vijay Gorantla
Dr. Gorantla is a tenured professor of surgery at Wake Forest University School of Medicine and the Wake Forest Institute for Regenerative Medicine. He is the director of the Vascularized Composite Allotransplantation (VCA) Program at Atrium Health Wake Forest Baptist. His research interests include biosensors and biosensing techniques, cellular therapies, nanomedicine, organ transplantations, reconstructive surgeries, regenerative medicine and its applications in transplantation and regenerative, pharmacology. Additionally, he studies the relationship between the immune system and the regenerative, oncogenic and autoimmune processes. Dr. Gorantla was a key member of the team that performed the nation’s first hand transplant at the University of Louisville in 1999. He co-founded the first national society for VCA, the American Society for Reconstructive Transplantation (ASRT). Dr. Gorantla has authored more than 100 scientific papers and 15 book chapters in the field of VCA and is currently co-editing a comprehensive book on the subject of regenerative surgery.
Affiliations and expertise
Wake Forest Institute for Regenerative Medicine, USAYK
Yalcin Kulahci
Dr. Yalcin Kulahci is a Plastic and Reconstructive Surgeon with specific expertise in Reconstructive Surgery and Microsurgery. He is dual board-certified in Oral and Maxillofacial Surgery and Hand Surgery and was recruited as faculty in 2008 to the Gulhane Military Medical Academy (GMMA) in Istanbul, affiliated with NATO and USUHS. In 2011, Dr. Kulahci was appointed as an Associate Professor at the same institution. In 2012, he became a founding academic staff member for the Department of Hand and Upper Extremity Surgery in Ankara, Turkiye. In 2019, he was recruited to the Wake Forest Institute for Regenerative Medicine following 22 years of honorable service with the Military Health System in Turkey. Dr. Kulahci is currently a faculty member at the Wake Forest School of Medicine and has a comprehensive publication record in clinical reconstructive surgery and microsurgery, with decades of translational research experience in VCA.
Affiliations and expertise
Instructor, Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC, USAFZ
Fatih Zor
Dr. Zor is a Plastic and Reconstructive Surgeon with specific expertise in Reconstructive Surgery and Microsurgery. He served as assistant professor of Plastic Surgery and chief combat surgeon in Turkish Armed Forces for over 15 years. Dr. Zor established the first military VCA programs in Turkey and obtained approval for both hand and face transplantation in 2011. Given his field experience in battlefield medicine and expertise in complex reconstruction, tissue regeneration, and hand/face transplantation, he was recruited to Wake Forest Institute for Regenerative Medicine as a faculty in 2017. He participated on several collaborative multi-institutional RTRP and PRMRP awards in the area of reconstructive transplantation and tissue generation. Currently, he's working as Burn Surgery Fellow in Indiana University School of Medicine.
My research focus is on immunomodulation, non-invasive VCA monitoring, peripheral and optic nerve regeneration, nanomedicine applications involving transplant and tissue regeneration indications and multimodality imaging strategies for VCA.
Affiliations and expertise
Burn Surgery Fellow, Indiana University School of Medicine, Indianapolis, IN, USA