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Recent Advances in Electron Cryomicroscopy, Part A

1st Edition, Volume 81 - November 25, 2010

Editors: Vidya Venkataram, Steve Ludtke

Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 3 8 1 3 5 7 - 2
eBook ISBN:
9 7 8 - 0 - 1 2 - 3 8 1 3 5 8 - 9

Structural genomics is the systematic determination of 3-D structures of proteins representative of the range of protein structure and function found in nature. The goal is to bu… Read more

Recent Advances in Electron Cryomicroscopy, Part A

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Structural genomics is the systematic determination of 3-D structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome.

While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large-scale cloning, expression and purification. One main advantage of this approach is economy of scale.