Rang & Dale's Pharmacology

10th Edition - April 17, 2023
Authors: James M. Ritter, Rod J. Flower, Graeme Henderson, Yoon Kong Loke, David MacEwan, Emma Robinson, James Fullerton
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 8 7 3 9 5 - 6
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 7 3 9 8 - 7

Rang and Dale’s Pharmacology is internationally acknowledged as the core textbook for students of pharmacology, and has provided accessible, up-to-date information on drugs and… Read more

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Rang and Dale’s Pharmacology is internationally acknowledged as the core textbook for students of pharmacology, and has provided accessible, up-to-date information on drugs and their mechanism of action for more than 30 years.

Now in its tenth edition, it has been updated to include important new drugs such as gene therapies, personalised medicines and the new wave of RNA drugs. However it has not lost any of the elements that have contributed to its popularity, such as color coding and illustrations, making it reader-friendly while comprehensively covering the depth of detail required.

This essential book is recommended as the first-choice undergraduate text for science and medical students and junior doctors and will also be useful for students in other professional disciplines such as pharmacy, veterinary medicine and nursing.

Instructions for online access
Cover image
Title page
Table of Contents
How to Use
Copyright
Video and Case Study Contents
Inflammation case study
Cardiovascular case study
Respiratory case study
Food and glucose regulation case study
Neurodegenerative disease case study
Epilepsy case study
Cancer case study
Videos Contents
Rang & Dale’s Pharmacology Tenth Edition Preface
Section 1. GENERAL PRINCIPLES
1. What is pharmacology?
What is a Drug?
Origins and Antecedents
Pharmacology in the 20th and 21st Centuries
2. How drugs act: general principles
Introduction
Protein Targets for Drug Binding
Desensitisation and Tolerance
Quantitative Aspects of Drug–Receptor Interactions
The Nature of Drug Effects
3. How drugs act: molecular aspects
Protein Targets for Drug Action
Receptor Proteins
Ion Channels as Drug Targets
Control of Receptor Expression
Receptors and Disease
4. How drugs act: cellular aspects – excitation, contraction and secretion
Regulation of Intracellular Calcium
Excitation
Muscle Contraction
Release of Chemical Mediators
Epithelial Ion Transport
5. How drugs act: biopharmaceuticals and gene therapy
INTRODUCTION
PROTEIN AND PEPTIDE BIOPHARMACEUTICALS
OLIGONUCLEOTIDES
GENE THERAPY
SAFETY AND SOCIETAL ISSUES
THERAPEUTIC APPLICATIONS
FUTURE DIRECTIONS
6. Cell proliferation, apoptosis, repair and regeneration
Cell Proliferation
Angiogenesis
Apoptosis and Cell Removal
Pathophysiological Implications
Therapeutic Prospects
7. Cellular mechanisms: host defence
Introduction
The Innate Immune Response
The Adaptive Immune Response
Systemic Responses in Inflammation
8. Method and measurement in pharmacology
BIOASSAY
ANIMAL MODELS OF DISEASE
PHARMACOLOGICAL STUDIES IN HUMANS
CLINICAL TRIALS
CLINICAL CONSIDERATION OF BENEFIT AND RISK
9. Absorption and distribution of drugs
Introduction
Physical Processes Underlying Drug Disposition
Drug Absorption and Routes of Administration
Distribution of Drugs in the Body
Special Drug Delivery Systems
10. Drug metabolism and elimination
INTRODUCTION
DRUG AND METABOLITE EXCRETION
11. Pharmacokinetics
Introduction: Definition and uses of Pharmacokinetics
Drug Elimination Expressed as Clearance
Single-Compartment Model
More Complicated Kinetic Models
Population Pharmacokinetics
Limitations of Pharmacokinetics
12. Individual variation, pharmacogenomics and personalised medicine
Introduction
Epidemiological Factors and Inter-Individual Variation of Drug Response
Genetic Variation in Drug Responsiveness
Therapeutic Drugs and Clinically Available Pharmacogenomic Tests
Conclusions
Section 2. CHEMICAL MEDIATORS
13. Chemical mediators and the autonomic nervous system
Historical Aspects
The Autonomic Nervous System
Some General Principles of Chemical Transmission
Basic Steps in Neurochemical Transmission: Sites of Drug Action
14. Cholinergic transmission
Muscarinic and Nicotinic Actions of Acetylcholine
Acetylcholine Receptors
Nicotinic Receptors
Physiology of Cholinergic Transmission
Effects of Drugs on Cholinergic Transmission
15. Noradrenergic transmission
Catecholamines
Classification of Adrenoceptors
Physiology of Noradrenergic Transmission
Drugs Acting on Noradrenergic Transmission
16. 5-Hydroxytryptamine and the purines
5-Hydroxytryptamine
Clinical Conditions in Which 5-HT Plays a Role
Purines
Purinergic Receptors
The Purinergic System in Health and Disease
Purines as Neurotransmitters
Summary
17. Local hormones: histamine, lipids, peptides and proteins
Introduction
What is a ‘Mediator’?
Histamine
Eicosanoids
Leukotrienes
Other Important Fatty Acid Derivatives
Platelet-Activating Factor
Sphingosine 1-Phosphate
Protein and Peptide Mediators
Biosynthesis and Regulation of Peptides
Bradykinin
Neuropeptides
Cytokines
Proteins and Peptides that Down-Regulate Inflammation
Concluding Remarks
18. Cannabinoids
Plant-Derived Cannabinoids (‘Phytocannabinoids’) And Their Pharmacological Effects
Cannabinoid Receptors
Endocannabinoids
Synthetic Cannabinoids
Clinical Applications
19. Nitric oxide and related mediators
Introduction
Biosynthesis of Nitric Oxide and its Control
Degradation and Carriage of Nitric Oxide
Effects of Nitric Oxide
Therapeutic Aspects
Clinical Conditions in Which Nitric Oxide May Play a Part
Related Mediators
Section 3. DRUGS AFFECTING MAJOR ORGAN SYSTEMS
20. The heart
Introduction
Physiology of Cardiac Function
Autonomic Control of the Heart
Cardiac Natriuretic Peptides
Ischaemic Heart Disease
Drugs that Affect Cardiac Function
21. The vascular system
Introduction
Vascular Structure and Function
Control of Vascular Smooth Muscle Tone
Vasoactive Drugs
Clinical Uses of Vasoactive Drugs
22. Atherosclerosis and lipoprotein metabolism
Introduction
Atherogenesis
Lipoprotein Transport
Prevention of Atheromatous Disease
Lipid-Lowering Drugs
Antisense Oligonucleotides
23. Haemostasis and thrombosis
Introduction
Blood Coagulation
Drugs that Act on the Coagulation Cascade
Platelet Adhesion and Activation
Fibrinolysis (Thrombolysis)
24. Haematopoietic system and treatment of anaemia
Introduction
The Haematopoietic System
Types of Anaemia
Haematinic Agents
Haematopoietic Growth Factors
Haemolytic Anaemia
25. Anti-inflammatory and immunosuppressant drugs
Introduction
Cyclo-Oxygenase Inhibitors
Antirheumatoid Drugs
BIOLOGIC DISEASE-MODIFYING ANTIRHEUMATIC DRUGS, ANTICYTOKINE DRUGS AND OTHER BIOPHARMACEUTICALS
Drugs Used in Gout
Antagonists of Histamine
Possible Future Developments in Anti-Inflammatory Therapy
26. Skin
Introduction
Structure of Skin
Common Diseases of the Skin
Drugs Acting on Skin
Principal Drugs Used in Skin Disorders
Agents Acting by Other Mechanisms
Concluding Remarks
27. The eye
Introduction
Special Pharmacokinetic Considerations in the Eye
Treatment of Inflammation and Infection in the Eye
Control of Intraocular Pressure and Treatment of Glaucoma
Ocular Vasculature and Vascular Endothelial Growth Factor Inhibitors
28. Respiratory system
The Physiology of Respiration
Pulmonary Disease and its Treatment
29. The kidney and urinary system
Introduction
Outline of Renal Function
The Structure and Function of the Nephron
Drugs Acting on the Kidney
Drugs that Alter the pH of the Urine
Drugs that Alter the Excretion of Organic Molecules
Drugs Used in Renal Failure
Drugs Used in Urinary Tract Disorders
30. The gastrointestinal tract
The Innervation and Hormones of the Gastrointestinal Tract
Gastric Secretion
Vomiting
The Motility of the GI Tract
Drugs for Chronic Bowel Disease
Drugs Affecting the Biliary System
Future Directions
31. The control of blood glucose and drug treatment of diabetes mellitus
Introduction
Control of Blood Glucose
Pancreatic Islet Hormones
Diabetes Mellitus
32. Obesity
Introduction
Obesity as a Health Problem
Homeostatic Mechanisms Controlling Energy Balance
The Pathophysiology of Human Obesity
Pharmacological Approaches to the Problem of Obesity
New Approaches to Obesity Therapy
33. The pituitary and the adrenal cortex
The Pituitary Gland
The Adrenal Cortex
New Directions in Glucocorticoid Therapy
34. The thyroid
Synthesis, Storage and Secretion of Thyroid Hormones
Regulation of Thyroid Function
Actions of the Thyroid Hormones
Transport and Metabolism of Thyroid Hormones
Abnormalities of Thyroid Function
Drugs Used in Diseases of the Thyroid
35. The reproductive system
Introduction
Endocrine Control of Reproduction
Drugs Affecting Reproductive Function
Drugs Used for Contraception
The Uterus
Erectile Dysfunction
36. Bone metabolism
Introduction
Bone Structure and Composition
Bone Remodelling
Disorders of Bone
Drugs Used in Bone Disorders
Section 4. NERVOUS SYSTEM
37. Chemical transmission and drug action in the central nervous system
Introduction
Chemical Signalling in the Nervous System
Targets for Drug Action
Drug Action in the Central Nervous System
The Classification of Psychotropic Drugs
38. Amino acid transmitters
Excitatory Amino Acids
Glutamate
γ-AMINOBUTYRIC ACID
Glycine
Concluding Remarks
39. Other transmitters and modulators
Introduction
Noradrenaline
Dopamine
5-Hydroxytryptamine
Acetylcholine
Purines
Histamine
Other CNS Mediators
A Final Message
40. Neurodegenerative diseases
Protein Misfolding and Aggregation in Chronic Neurodegenerative Diseases
Mechanisms of Neuronal Death
Ischaemic Brain Damage
Dementia
Parkinson’s Disease
Essential Tremor
Huntington’s Disease
Amyotrophic Lateral Sclerosis
Spinal Muscular Atrophy
Multiple Sclerosis
41. General anaesthetic agents
Overview
Introduction
Mechanism of Action of Anaesthetic Drugs
Intravenous Anaesthetic Agents
Inhalation Anaesthetics
Individual Inhalation Anaesthetics
Sedation and Balanced Anaesthesia
42. Headache
Headache
Types of Headaches
Drug Therapy for Headache
Summary
43. Analgesic drugs
Introduction
Neural Mechanisms of Pain
Analgesic Drugs
Chronic Pain
44. Local anaesthetics and other drugs affecting sodium channels
Local Anaesthetics
Other Drugs That Affect Sodium Channels
45. Anxiolytic and hypnotic drugs
The Nature Of Anxiety And Its Treatment
Measurement Of Anxiolytic Activity
Drugs Used To Treat Anxiety
Delayed Anxiolytic Effect Of Drugs Acting Via Serotonergic Mechanisms
Drugs Used To Treat Insomnia (Hypnotic Drugs)
46. Antiepileptic drugs
Overview
Introduction
The Nature of Epilepsy
Antiepileptic Drugs
Muscle Spasm and Muscle Relaxants
47. Antipsychotic drugs
Introduction
The Nature of Schizophrenia
Antipsychotic Drugs
Future Developments
48. Antidepressant drugs
The Nature of Depression
Theories of Depression
Antidepressant Drugs
Clinical Effectiveness of Antidepressant Treatments
Future Antidepressant Drugs
Brain Stimulation Therapies
Drug Treatment of Bipolar Disorder
49. Psychoactive drugs
Introduction
Psychomotor Stimulants
Cognition-Enhancing Drugs
Psychedelic Drugs
Dissociative Drugs
Depressants
Synthetic Cannabinoid Receptor Agonists
50. Drug use and addiction
Drug Use
Harm Reduction
Section 5. DRUGS USED FOR THE TREATMENT OF INFECTIONS AND CANCER
51. Basic principles of antimicrobial chemotherapy
Background
The Molecular Basis of Chemotherapy
Resistance to Antibacterial Drugs
Current Status of Antibiotic Resistance in Bacteria
52. Antibacterial drugs
INTRODUCTION
ANTIBACTERIAL AGENTS THAT INTERFERE WITH FOLATE SYNTHESIS OR ACTION
β-LACTAM ANTIBIOTICS AND OTHER AGENTS THAT INTERFERE WITH BACTERIAL WALL OR MEMBRANE SYNTHESIS
ANTIMICROBIAL AGENTS AFFECTING BACTERIAL PROTEIN SYNTHESIS
ANTIMICROBIAL AGENTS AFFECTING TOPOISOMERASE
MISCELLANEOUS ANTIBACTERIAL AGENTS
ANTIMYCOBACTERIAL AGENTS
PROSPECTS FOR NEW ANTIBACTERIAL DRUGS
53. Antiviral drugs
Background Information About Viruses
The Host–Virus Interaction
HIV and AIDS
COVID-19
Antiviral Drugs
Combination Therapy For HIV
COVID-19 Pharmacotherapy
Prospects for New Antiviral Drugs
54. Antifungal drugs
Fungi and Fungal Infections
Drugs Used to Treat Fungal Infections
Future Developments
55. Antiprotozoal drugs
Background
Host–Parasite Interactions
Malaria and Antimalarial Drugs
Amoebiasis and Amoebicidal Drugs
Trypanosomiasis and Trypanocidal Drugs
Other Protozoal Infections and Drugs Used to Treat Them
Future Developments
56. Antihelminthic drugs
Helminth Infections
Antihelminthic Drugs
Resistance to Antihelminthic Drugs
Vaccines and Other Novel Approaches
57. Anticancer drugs
Introduction
The Pathogenesis of Cancer
General Principles of Cytotoxic Anticancer Drugs
Anticancer Drugs
Future Developments
Section 6. SPECIAL TOPICS
58. Harmful effects of drugs
Introduction
Classification of Adverse Drug Reactions
Drug Toxicity
Immunological Reactions to Drugs
59. Lifestyle and drugs in sport
What are Lifestyle Drugs?
Classification of Lifestyle Drugs
Cognitive Enhancers
Drugs and Sex
Drugs in Sport
Regulatory, Societal and Ethical Issues
Conclusion
60. Drug discovery and development
Drug Discovery: Background
The Stages of a Project
Biopharmaceuticals
Commercial Aspects
Future Prospects
A Final Word
Index

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James M. Ritter

Rod J. Flower

Graeme Henderson

Yoon Kong Loke

David MacEwan

Emma Robinson

James Fullerton