Radiation Biology
Molecular Foundations and Clinical Applications
- 1st Edition - October 20, 2026
- Latest edition
- Authors: Barry S. Rosenstein, Jerome M. Karp
- Language: English
Radiation Biology: Molecular Foundations and Clinical Applications is a comprehensive exploration of the effects of radiation on living organisms, delving into the molecular… Read more
Description
Description
Radiation Biology: Molecular Foundations and Clinical Applications is a comprehensive exploration of the effects of radiation on living organisms, delving into the molecular mechanisms underlying cellular responses. This book examines critical topics such as radiation-induced DNA damage, repair processes, and molecular signaling pathways. It provides a detailed look at how cells respond to radiation, addressing cell cycle control, apoptosis, and the effects of radiation on immune system functionality. As a resource for researchers, it bridges the gap between molecular biology and clinical oncology, offering insights into radiation's role in both therapeutic contexts and its broader impact on human biology.
In addition to its focus on molecular responses, the book covers topics like tumor microenvironment and metabolism, the role of epigenetics in radiation biology, and the hallmarks of cancer relevant to radiation therapy. It also provides discussions on chemotherapeutic agents, radiation carcinogenesis, and the complex interplay between radiation and cancer biology. The later sections extend the scope to tissue, organ, and systemic effects of radiation, making it an invaluable reference for professionals in molecular biology, oncology, and related fields striving to push the boundaries of radiation research.
Key features
Key features
- Focuses on radiation biology at the molecular, cellular, tissue/organ, and individual level
- Addresses each topic from fundamentals through to clinical applications
- Considers the latest advances in the field of radiation biology and radiation oncology
- Includes a chapter summary and multiple-choice questions at the end of each chapter to review the material and assist in preparing for board examinations
Readership
Readership
Table of contents
Table of contents
1. Radiation Physics and Chemistry
Part II: Effects of Radiation at the Molecular Level
2. Deoxyribonucleic Acid Damage
3. DNA Repair
Part III: Effects of Radiation at the Cellular Level
4. Proliferative Cell Signaling
5. The Cell Cycle
6. Cell Death
7. Mathematical Models of Cell Survival
8. Modifiers of the Radiation Dose-Response Curve
9. The Oxygen Effect
Part IV: Effects of Radiation at the Tissue and Organ Level
10. Principles of Tissue Radiobiology
11. Fractionation and Dose Rate
12. Normal Tissue Toxicity
Part V: Effects of Radiation on the Human Body
13. Human Radiation Exposure
14. Whole-body Radiation
15. Mutagenic Effects of Radiation
Part VI: Cancer Biology
16. Carcinogenesis
17. Tumor Growth
18. Biomarkers in Cancer
19. Chemotherapy and Targeted Agents
20. The Immune System and Cancer
Product details
Product details
- Edition: 1
- Latest edition
- Published: October 20, 2026
- Language: English
About the authors
About the authors
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Barry S. Rosenstein
Dr. Rosenstein is a Professor of Radiation Oncology and a Professor of Genetics & Genomic Sciences at the Icahn School of Medicine at Mount Sinai. He is a renowned educator who has received numerous teaching awards. More than 600 trainees from multiple radiation oncology and medical physics residency programs have taken Dr. Rosenstein’s 60-hour course in radiation and cancer biology. He also provides lectures in radiation biology and radiation safety for radiology residents. Dr. Rosenstein has served as a member of the Radiation Oncology Radiation/Cancer Biology Committee and the Radiology Physics Committee of the American Board of Radiology. He created and was the editor-in-chief of the widely used American Society for Radiation Oncology (ASTRO) Radiation and Cancer Biology Practice Examination and Study Guide. The focus of Dr. Rosenstein’s research program has been the identification of genetic/genomic markers associated with the development of adverse effects resulting from radiotherapy.
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Jerome M. Karp
Dr. Karp is a radiation oncologist at Sheba Medical Center, and a research instructor at NYU Grossman School of Medicine, specializing in the treatment of patients with central nervous system malignancies. His research interests include bioinformatic analysis of brain tumors and liquid biopsies, effects of radiation on cells of the nervous system, and radiation-induced malignancies. Dr. Karp lectures radiation oncology and physics residents internationally on radiobiology, clinical oncology, and radiosurgery, and has served as a member of the American Society for Radiation Oncology (ASTRO) Education Committee.