Quantum Pharmacology
- 2nd Edition - March 2, 1983
- Imprint: Butterworth-Heinemann
- Author: W. G. Richards
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 0 8 - 7 0 9 5 0 - 7
- Paperback ISBN:9 7 8 - 1 - 4 8 3 1 - 3 1 2 5 - 2
- eBook ISBN:9 7 8 - 1 - 4 8 3 1 - 6 3 6 7 - 3
Quantum Pharmacology, Second Edition discusses molecular pharmacology, molecular quantum mechanics, and the applications of theory to experiment. The book reviews molecular and… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quoteQuantum Pharmacology, Second Edition discusses molecular pharmacology, molecular quantum mechanics, and the applications of theory to experiment. The book reviews molecular and quantitative pharmacology, as well as acetylcholines, catecholamines, and histamines. The text also discusses the central nervous system in relation to monoamines, acetylcholines, amino acids, and peptides. The book explains wave functions and orbitals, secular equations, matrix elements, and self-consistent molecular orbitals. One way to improve wave functions as a result of a self-consistent field or as an approximate calculation, is to permit different configurations to interact. Linear mixing will lead to improved wave functions. The investigator can compute wave functions and energies of molecules for any set of nuclear coordinates. Quantum chemical calculations treat conformation as similar with geometry; calculations are performed for a series of positions in one part of a molecule relative to another. The investigator can then compare the energies found in each position. The book points out that calculations of conformational internal energy surfaces for flexible pharmacological molecules treating the molecule or ion as isolated in space fit in with observed results of crystallographic experiments. The text is suitable for pharmacologists, and scientists involved in molecular pharmacology, medicinal chemistry, and quantum chemistry.
Preface to Second EditionPreface to First EditionIntroductionPart I—Molecular Pharmacology 1 Small Molecules in Biology 2 Quantitative Pharmacology 3 Acetylcholine 4 Catecholamines 5 Histamine 6 Central Nervous System I. Monoamines and Acetylcholine 7 Central Nervous System II. Amino Acids and Peptides 8 Anaesthetics 9 Chemotherapy 10 Other AreasPart II—Molecular Quantum Mechanics 11 Wave Functions and Orbitals 12 Approximate Wave Functions 13 Calculated Molecular Properties 14 Running a CalculationPart III—Applications of Theory to Experiment 15 Conformations 16 Electronic Charge Distribution and Potential 17 Solvation 18 Entropy Effects 19 Activity Correlations 20 Enzymes as Receptors 21 ConclusionsPart IV—BibliographyIndex
- Edition: 2
- Published: March 2, 1983
- No. of pages (eBook): 288
- Imprint: Butterworth-Heinemann
- Language: English
- Hardback ISBN: 9780408709507
- Paperback ISBN: 9781483131252
- eBook ISBN: 9781483163673
Read Quantum Pharmacology on ScienceDirect