Protein Misfolding and Human Diseases
Deciphering the Central Role of Pathological Aggregation
- 1st Edition - September 1, 2026
- Latest edition
- Editors: Pranav Kumar Prabhakar, Ajit Prakash, Mohammad Ashhar Iqbal Khan
- Language: English
Protein Misfolding and Human Diseases: Deciphering the Central Role of Pathological Aggregation investigates the misfolding of proteins and implications for a variety of debili… Read more
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- Offers insights into the molecular mechanisms underlying protein misfolding and aggregation, and their pathological consequences
- Explores potential therapeutic strategies for protein folding diseases
- Combines interdisciplinary perspectives from experts across a diverse range of fields including, structural biology, biophysics, cell biology, biochemistry, neuroscience, and clinical research
- Features case studies, key terms and learning objectives to enhance understanding
1. Protein aggregation mechanisms
Part II: Protein aggregation in neurodegenerative diseases
2. Protein aggregation in Alzheimer's disease
3. Protein aggregation in Parkinson's disease
4. Protein aggregation in Huntington's disease
5. Protein aggregation in prion diseases
6. Protein aggregation in Amyotrophic Lateral Sclerosis
Part III: Other protein aggregation diseases
7. Systemic amyloidosis
8. Protein aggregation and aging
Part IV: Structural insights and therapeutic Strategies
9. Structural insights into pathological protein aggregates: from amyloid fibrils to inclusion bodies
10. Therapeutic strategies against protein aggregation
11. Recent advances in protein aggregation research and future outlook
- Edition: 1
- Latest edition
- Published: September 1, 2026
- Language: English
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Pranav Kumar Prabhakar
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Ajit Prakash
Dr. Ajit Prakash completed his B.Sc. Biotechnology at Jamia Millia Islamia, Delhi, and M.Sc. Genomics at Madurai Kamaraj University, Tamil Nadu, India. Further, Dr. Ajit obtained his Ph.D. in Biochemistry in 2016 from Nanyang Technological University, Singapore. He carried out his first postdoctoral fellowship at the University of Cambridge, UK. Following this he worked at Lovely Professional University as an assistant professor for almost a year and then finally relocated to the USA for his second postdoc at the University of North Carolina, Chaple Hill, USA. After 5 years of postdoctoral research at UNC, he is currently working as a Research Associate at UNC, Chapel Hill, USA. In addition to 3 book chapters and a book which are under publication, Dr. Ajit has published 16 high-impact research papers/book chapters in the fields of protein biochemistry, structural biology, and molecular biology related to disease conditions like cancer, and neurological disorders.
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Mohammad Ashhar Iqbal Khan
Dr. Mohammad Ashhar Iqbal Khan is currently a Research Associate in the Department of Biochemistry and Biophysics at the University of North Carolina at Chapel Hill, USA. He completed his PhD in Biochemistry and Biophysics from the Indian Institute of Technology-Delhi in 2016. Dr. Khan's doctoral research focused on elucidating the molecular mechanisms of protein aggregation in neurodegenerative diseases like ALS and Parkinson's using biophysical techniques. As a postdoctoral researcher at UNC Chapel Hill and Lund University in Sweden, he expanded his expertise to study key cell adhesion proteins vinculin and metavinculin linked to cardiomyopathies and cancer. He has authored several peer-reviewed publications and delivered invited talks and poster presentations at scientific conferences. He is a recipient of prestigious fellowships and awards including the Erasmus Mundus Scholarship and the Carl Trygger Foundation Postdoctoral Scholarship. He serves as an editorial board member and reviewer for many reputed national and international journals.