Protein Lipidation
- 3rd Edition, Volume 21 - January 19, 2012
- Latest edition
- Editors: Fuyuhiko Tamanoi, David S. Sigman
- Language: English
This is the first compilation of protein lipidation enzymes. This volume summarizes recent dramatic developments regarding enzymes responsible for protein lipidation, a process… Read more
This is the first compilation of protein lipidation enzymes. This volume summarizes recent dramatic developments regarding enzymes responsible for protein lipidation, a process critical for a number of physiological functions, including cell proliferation and morphology. Inhibitors of protein lipidation have recently been shown to be useful as anticancer drugs. Enzymatic mechanisms, mutational analysis, and structural studies are presented.
- The enzymatic mechanisms of protein lipidation
- Three-dimensional structures of protein farnesytransferase, protein geranylgeranytransferase II, and n-myristoryltransferase
Biochemists, molecular biologists, biotechnologists, researchers in biomedical and in pharmaceutical research, physiologists
Preface.
Mechanism of Catalysis by Protein Farnesyltransferase, R.A. Spence and P.J. Casey.
Structure of Protein Farnesyltransferase, K.L. Terry, S.B. Long, and L.S. Beese.
Mutational Analyses of Protein Farnesyltransferase, J. Urano, W. Yang, and F. Tamanoi.
Farnesyltransferase Inhibitors, J.B. Gibbs.
Protein Geranylgeranyltransferase Type I, K. Yokoyama and M.H. Geleb.
Biochemistry of Rab Geranylgeranyltransferase, M.C. Seabra.
Postisoprenylation Protein Processing: CXXX (CaaX) Endoproteases and Isoprenylcysteine Carboxyl Methyltransferase, S.G. Young, P. Ambroziak, E. Kim, and S. Clarke.
Reversible Modification of Proteins with Thioester-Linked Fatty Acids, M.E. Linder.
Biology and Enzymology of Protein N-Myristoylation, R.S. Bhatnagar, K. Ashrafi, K. Futterer, G. Waksman, and J.I. Gordon.
Chapter References.
Author Index.
Subject Index.
Mechanism of Catalysis by Protein Farnesyltransferase, R.A. Spence and P.J. Casey.
Structure of Protein Farnesyltransferase, K.L. Terry, S.B. Long, and L.S. Beese.
Mutational Analyses of Protein Farnesyltransferase, J. Urano, W. Yang, and F. Tamanoi.
Farnesyltransferase Inhibitors, J.B. Gibbs.
Protein Geranylgeranyltransferase Type I, K. Yokoyama and M.H. Geleb.
Biochemistry of Rab Geranylgeranyltransferase, M.C. Seabra.
Postisoprenylation Protein Processing: CXXX (CaaX) Endoproteases and Isoprenylcysteine Carboxyl Methyltransferase, S.G. Young, P. Ambroziak, E. Kim, and S. Clarke.
Reversible Modification of Proteins with Thioester-Linked Fatty Acids, M.E. Linder.
Biology and Enzymology of Protein N-Myristoylation, R.S. Bhatnagar, K. Ashrafi, K. Futterer, G. Waksman, and J.I. Gordon.
Chapter References.
Author Index.
Subject Index.
- Edition: 3
- Latest edition
- Volume: 21
- Published: January 19, 2012
- Language: English
FT
Fuyuhiko Tamanoi
Fuyu Tamanoi is a biochemist who has served on the UCLA School of Medicine and UCLA College faculty since he joined the Department of Microbiology, Immunology & Molecular Genetics in 1993. He became a full professor in 1997.
Affiliations and expertise
Biochemist, Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, USADS
David S. Sigman
Affiliations and expertise
University of California School of Medicine, Los Angeles, California, U.S.A.Read Protein Lipidation on ScienceDirect