Protein Kinases in Development and Disease

Chapter One: WNK Kinases in Development and Disease

• Abstract
• 1 Introduction
• 2 The WNK-SPAK/OSR1 Kinase Cascade: Roles in Physiology and Disease
• 3 Emerging Functions of the WNK Signaling Axis in Development
• 4 Functions of WNKs in Cancer
• 5 Conclusions
• Acknowledgments

Chapter Two: SGK1: The Dark Side of PI3K Signaling

• Abstract
• 1 Introduction: The Glucocorticoid-Regulated Kinase Family
• 2 SGK1: Expression and Stability Control
• 3 SGK1 Is Activated in a PI3K-Dependent Manner
• 4 AKT and SGK1: Target Overlap and Selectivity
• 5 Roadblocks to Defining Specific SGK1 Functions
• 6 SGK1 in Development and Differentiation
• 7 SGK1 and Cancer
• 8 Concluding Remarks
• Acknowledgments

Chapter Three: Homeodomain-Interacting Protein Kinases: Diverse and Complex Roles in Development and Disease

• Abstract
• 1 Introduction
• 2 Requirements for Hipk Proteins During Development
• 3 Hipk Roles in Regulation of Diverse Signaling Pathways
• 4 Regulation of Hipk Activity
• 5 Hipks in Disease
• 6 Conclusions
• Acknowledgments

Chapter Four: ROR-Family Receptor Tyrosine Kinases

• Abstract
• 1 Domain Architecture and Expression Patterns
• 2 ROR Function as a WNT Receptor and Its Role in WNT Signal Transduction
• 3 Human Inheritable Syndromes Caused by ROR2 Mutation
• 4 The Role of ROR-Family RTKs in Embryonic Development

Chapter Five: Regulation of Drosophila Development by the Golgi Kinase Four-Jointed

• Abstract
• 1 Introduction
• 2 Genetic and Molecular Identification of Drosophila Four-Jointed
• 3 The Fat/Dachsous/Four-Jointed Pathway
• 4 Biochemical Characterization of Fj
• 5 Modulation of Fat-Ds Binding by Fj
• 6 Fj Polarizes Fat Activity
• 7 Vertebrate Four-Jointed, Fat, Dachsous, and Other Kinases in the Secretory Pathway
• 8 Conclusion
• Acknowledgments

Chapter Six: The Hippo Pathway: A Master Regulatory Network Important in Development and Dysregulated in Disease

• Abstract
• 1 Introduction
• 2 The Highly Conserved Core Kinase Cassette
• 3 The Hippo Pathway Restricts Mass Accumulation and Proliferation
• 4 The Hippo Pathway Regulates Apoptosis
• 5 The Hippo Pathway Restricts Organ Size and Maintains Organ Homeostasis
• 6 Molecular Mechanisms and Additional Roles of the Hippo Pathway: Posttranslational Targets and Transcriptional Outputs
• 7 Upstream Signals and Regulators and Mechanisms of Pathway Homeostasis
• 8 Dysregulation of the Hippo Pathway in Disease
• 9 Conclusions and Open Questions
• Acknowledgments

Chapter Seven: Regulation of Embryonic and Postnatal Development by the CSF-1 Receptor

• Abstract
• 1 Introduction
• 2 The CSF-1R in Mononuclear Phagocyte Development
• 3 CSF-1-Regulated Macrophages in Tissue Morphogenesis and Organismal Growth
• 4 Regulation of Osteoclasts and Bone Development by CSF-1
• 5 Direct Regulation of Nonhematopoietic Cells by the CSF-1R
• 6 Conclusions
• Acknowledgments

Chapter Eight: Glycogen Synthase Kinase 3: A Kinase for All Pathways?

• Abstract
• 1 The Early Years
• 2 GSK-3 Isoforms, Orthologues, and Expression
• 3 GSK-3 Structure
• 4 Regulation
• 5 Signaling Infidelity
• 6 So How Is Specificity Achieved?
• 7 Lessons From GSK-3 KO Mice
• 8 Therapeutic Perspectives
• 9 Conclusions and Perspectives
• Acknowledgments

Chapter Nine: CK1 in Developmental Signaling: Hedgehog and Wnt

• Abstract
• 1 Introduction
• 2 CK1 in the Regulation of Hh Pathway
• 3 CK1 in Wnt Signaling
• 4 Regulation of CK1 in Hh and Wnt Signaling
• 5 Conclusion
• Acknowledgments

Chapter Ten: Ligand Receptor-Mediated Regulation of Growth in Plants

• Abstract
• 1 Introduction
• 2 Novel and Unique Plant Signaling Pathways
• 3 Plasma Membrane as the Site of Peptide Ligand Sensing by Receptors
• 4 FERONIA and Its Gene Family in Plant Growth and Development
• 5 Organ Size and Growth Are Determined by Stimulation and Inhibition by Signaling Pathways in Plants and Animals
• 6 RALF Family and Function in Plant Growth and Development
• 7 RALF-Like Peptides Are Not Only Produced by Plants But Also by Pathogenic Microbes
• 8 Other Endogenous Hormone-Like Peptides and Their Receptor Pairs for Plant Growth, Development, and Physiology
• 9 Conclusion and Future Perspectives

Chapter Eleven: Regulation of Cell Polarity by PAR-1/MARK Kinase

• Abstract
• 1 Introduction
• 2 Structure and Regulation of PAR-1/MARK Kinases
• 3 Regulation of Cell Polarity by the PAR Proteins
• 4 Asymmetric Division of the C. elegans Zygote
• 5 Establishment of the Anterior/Posterior Axis During Drosophila Oogenesis
• 6 MARK Kinases and Neurogenesis
• 7 PAR-1 and Disease
• 8 Concluding Remarks

Chapter Twelve: Receptor Tyrosine Kinases and Phosphatases in Neuronal Wiring: Insights From Drosophila

• Abstract
• 1 Introduction
• 2 Model Circuits Used to Study the Genetic Control of Neuronal Wiring in Drosophila
• 3 Receptor Tyrosine Kinase
• 4 Receptor Protein Tyrosine Phosphatases
• 5 Future Directions
• 6 Conclusions
• Acknowledgments

Chapter Thirteen: VEGF Receptor Tyrosine Kinases: Key Regulators of Vascular Function

• Abstract
• 1 Introduction
• 2 Structure and Function of VEGFRs
• 3 An Evolutionary Perspective on VEGFR Function
• 4 Neuropilins: Coreceptors Modulating VEGFR Signaling
• 5 VEGFR Ligands
• 6 Perspective
• Acknowledgments