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Protein Kinase Inhibitors as Sensitizing Agents for Chemotherapy

  • 1st Edition, Volume 4 - November 21, 2018
  • Latest edition
  • Editors: Benjamin Bonavida, Zhe-Sheng (Jason) Chen, Dong-Hua Yang
  • Language: English

Tyrosine Kinase Inhibitors as Sensitizing Agents for Chemotherapy, the fourth volume in the Cancer Sensitizing Agents for Chemotherapy Series, focuses on strategic combination ther… Read more

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Description

Tyrosine Kinase Inhibitors as Sensitizing Agents for Chemotherapy, the fourth volume in the Cancer Sensitizing Agents for Chemotherapy Series, focuses on strategic combination therapies that involve a variety of tyrosine kinase inhibitors working together to overcome multi-drug resistance in cancer cells. The book discusses several tyrosine kinase inhibitors that have been used as sensitizing agents, such as EGFR, BCR-ABL, ALK and BRAF. In each chapter, readers will find comprehensive knowledge on the inhibitor and its action, including its biochemical, genetic, and molecular mechanisms' emphases. This book is a valuable source for oncologists, cancer researchers and those interested in applying new sensitizing agents to their research in clinical practice and in trials.

Key features

  • Summarizes the sensitizing role of some tyrosine kinase inhibitors in existing research
  • Brings recent findings in several cancer types, both experimental and clinically, with a particular emphases on underlying biochemical, genetic, and molecular mechanisms
  • Provides an updated and comprehensive knowledge regarding the field of combinational cancer treatment

Readership

Cancer researchers; oncologists; pharmacists; graduate students on cancer studies

Table of contents

1. EGFR and HER2 inhibitors as sensitizing agents for cancer chemotherapy2. BCR-ABL inhibitors as sensitizing agents for cancer chemotherapy3. VEGFR inhibitors as sensitizing agents for cancer chemotherapy4. ALK inhibitors as sensitizing agents for cancer chemotherapy5. JAK2 inhibitors as sensitizing agents for cancer chemotherapy6. FLT3 inhibitors as sensitizing agents for cancer chemotherapy7. BRAF inhibitors as sensitizing agents for cancer chemotherapy8. Bruton kinase inhibitors as sensitizing agents for cancer chemotherapy

Product details

  • Edition: 1
  • Latest edition
  • Volume: 4
  • Published: November 29, 2018
  • Language: English

About the editors

BB

Benjamin Bonavida

Dr Bonavida has vast expertise and various reported publications in the field of tumor cell sensitization to chemotherapy (a total of greater than 500 publications) and in particular the novel role of Nitric Oxide (NO) donors in chemo-sensitization and reversal of drug resistance. In addition, he was the first scientist to co-organize an international meeting on the topic (First International Workshop on NO and Cancer, 2005).

Affiliations and expertise
Professor, Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California, USA

ZC

Zhe-Sheng (Jason) Chen

Zhe-Sheng Chen opened the St. John’s University’s first cancer pharmacology laboratory. His research interest is multidrug resistance and its reversal, novel anti-cancer drug development. Chen serves as Editor of "African Journal of Pharmacy and Pharmacology"; Editor-in-Chief of “Journal of Cancer Research Updates" and "Journal of New Developments in Chemistry". He also serves as an Editorial Board member of 25 journals, an Ad Hoc reviewer of 180 journals, and a guest editor of "Current Pharmaceutical Biotechnology", "Cancer" and "Journal of International Medical Research". Chen has over 170 papers published, 6 book chapters, and 5 patents.
Affiliations and expertise
Director, Institute for Biotechnology and Professor of Cancer Pharmacology, St. John’s University, USA

DY

Dong-Hua Yang

Dong-Hua Yang is an Assistant Professor at St. John’s University College of Pharmacy and Health Sciences. She works in the fields of Cancer Biomarkers and Cancer Pharmacology. Before joining St. John’s, she was a Research Assistant Professor at Fox Chase Cancer Center, where she took charge of the Tissue Research Service at the Biosample Repository Core Facility. She is a leading expert in the field of immunohistochemistry (IHC) and IHC quantitative analysis. She applied IHC technology to study the molecular alterations of known and novel signaling pathways that regulate embryogenesis, organ morphogenesis and tumorigenesis. Yang leads the automatic quantitative analysis (AQUA) for immunohistochemistry and immunofluorescence assays for biomarker research. Yang is the regional editor of “Current Proteomics”, guest editor of “Frontiers of Pharmacology”, “Cancers” and “Molecules”, associate editor of “ Journal of Nutritional Therapeutics”, “Journal of Cancer Research Updates” and “Journal of Analytical Oncology”, ad hoc reviewer of 0ver 50 journals. Yang has over 70 papers and 4 book chapters published.
Affiliations and expertise
Assistant Professor of Cancer biomarkers, St. John’s University College of Pharmacy and Health Sciences, USA

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