Protein Homeostasis Diseases
Mechanisms and Novel Therapies
- 1st Edition - February 13, 2020
- Latest edition
- Editor: Angel L. Pey
- Language: English
Protein Homeostasis Diseases: Mechanisms and Novel Therapies offers an interdisciplinary examination of the fundamental aspects, biochemistry and molecular biology of protein h… Read more
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Description
Description
Protein Homeostasis Diseases: Mechanisms and Novel Therapies offers an interdisciplinary examination of the fundamental aspects, biochemistry and molecular biology of protein homeostasis disease, including the use of natural and pharmacological small molecules to treat common and rare protein homeostasis disorders. Contributions from international experts discuss the biochemical and genetic components of protein homeostasis disorders, the mechanisms by which genetic variants may cause loss-of-function and gain-of-toxic-function, and how natural ligands can restore protein function and homeostasis in genetic diseases. Applied chapters provide guidance on employing high throughput sequencing and screening methodologies to develop pharmacological chaperones and repurpose approved drugs to treat protein homeostasis disorders.
Key features
Key features
- Provides an interdisciplinary examination of protein homeostasis disorders, with an emphasis on treatment strategies employing small natural and pharmacological ligands
- Offers applied approaches in employing high throughput sequencing and screening to develop pharmacological chaperones to treat protein homeostasis disease
- Gathers expertise from a range of international chapter authors who work across various biological methods and disease specific disciplines of relevance
Readership
Readership
Table of contents
Table of contents
I. Introduction of protein folding and homeostasis
1. Protein folding: how, why, and beyond
2. Protein homeostasis and disease
II. Protein folding and homeostasis at the organismal and proteomic scales
3. Caenorhabditis elegans as a model organism for protein homeostasis diseases
4. Proteome-scale studies of protein stability
5. Classifying disease-associated variants using measures of protein activity and stability
III. Protein homeostasis disturbance in disease: Genetics, mechanisms, and modulation by natural ligands
6. Protein destabilization and degradation as a mechanism for hereditary disease
7. Detection of amyloid aggregation in living systems
8. Molecular mechanisms of amyloid aggregation in human proteinopathies
9. Metals and amyloid gain-of-toxic mechanisms in neurodegenerative diseases
10. Vitamin B6-dependent enzymes and disease
11. Galactosemia: opportunities for novel therapies
12. Protein homeostasis and regulation of intracellular trafficking of G protein-coupled receptors
13. Structure-guided discovery of pharmacological chaperones targeting protein conformational and misfolding diseases
14. Virtual screening in drug discovery: a precious tool for a still-demanding
challenge
15. Differential scanning fluorimetry in the screening and validation of pharmacological chaperones for soluble and membrane proteins
16. Cellular high-throughput screening
17. High-throughput screening for intrinsically disordered proteins by using biophysical methods
18. Natural and pharmacological chaperones against accelerated protein degradation: uroporphyrinogen III synthase and congenital erythropoietic porphyria
Product details
Product details
- Edition: 1
- Latest edition
- Published: February 13, 2020
- Language: English
About the editor
About the editor
AP