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PROTAC and similar technologies
- 1st Edition, Volume 63 - November 16, 2024
- Editor: Radim Nencka
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 2 9 5 8 4 - 3
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 9 5 8 5 - 0
Annual Reports on Medicinal Chemistry: PROTAC and similar technologies Volume 63 in this series Annual Reports on Medicinal Chemistry, highlights new advances in the field, with t… Read more
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Request a sales quoteAnnual Reports on Medicinal Chemistry: PROTAC and similar technologies Volume 63 in this series Annual Reports on Medicinal Chemistry, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors.
- Provides the authority and expertise of leading contributors from an international board of authors
- Presents the latest release in Annual Reports on Medicinal Chemistry series
- Updated release includes the latest information in the field
Ideally suited for chemists engaged in multidisciplinary teams for drug discovery including medicinal chemists and others involved in chemical biology and bio-organic disciplines and computational chemistry
- PROTAC and Similar Technologies
- Cover image
- Title page
- Table of Contents
- Series Page
- Copyright
- Contributors
- Preface
- Chapter One Computational strategies for the design of proteolysis targeting chimera degraders: Artificial intelligence enabled PROTAC design
- Abstract
- Keywords
- 1 Introduction
- 2 Strategies for the construction of PROTAC degraders: Computational approaches
- 3 Computational tools for PROTAC degrader design
- 4 Target identification
- 5 Warhead selection
- 6 Molecular docking
- 7 Linker design: Linkerology
- 8 Ternary complex formation
- 9 ADME and toxicity prediction
- 10 Conclusion
- References
- Chapter Two Covalency in PROTACs: Mechanisms and applications
- Abstract
- Keywords
- 1 Introduction
- 2 Covalent PROTACs
- 2.1 Covalent to target
- 2.2 Covalent to E3
- 3 Conclusions
- 4 Software
- Acknowledgments
- References
- Chapter Three PROTACs of cyclin-dependent kinases
- Abstract
- Keywords
- 1 Introduction
- 2 Degradation capacity of PROTACs derived from CDK4/6 inhibitors
- 3 Palbociclib-based PROTACs degrade CDK4/6 or only CDK6
- 4 CDK9-targeting PROTACs are mostly derived from dual or pan-selective CDK inhibitors
- 5 Other PROTACs derived from dual or pan-selective CDK inhibitors
- 6 Conclusion
- Acknowledgment
- References
- Chapter Four BacPROTAC approach for tuberculosis drug discovery
- Abstract
- Keywords
- 1 Introduction
- 1.1 Tuberculosis
- 1.2 Current treatments and challenges
- 2 BacPROTAC as new approaches for the discovery of novel anti-Mtb agents
- 2.1 Important concepts
- 2.2 Study of the literature
- 2.3 Challenges and new horizons for the development of BacPROTAC compounds
- 3 Conclusions
- References
- No. of pages: 310
- Language: English
- Edition: 1
- Volume: 63
- Published: November 16, 2024
- Imprint: Academic Press
- Hardback ISBN: 9780443295843
- eBook ISBN: 9780443295850
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