Prostate Cancer Genetics: Changing the Paradigm of Care, An Issue of Urologic Clinics
- 1st Edition, Volume 48-3 - July 6, 2021
- Editors: Leonard G. Gomella, Veda Giri
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 7 9 1 6 7 - 0
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 7 9 1 6 8 - 7
In this issue of Urologic Clinics, guest editors Leonard G. Gomella and Veda Giri bring their considerable expertise to the topic of Prostate Cancer Genetics: Changing the Paradigm… Read more
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Request a sales quoteIn this issue of Urologic Clinics, guest editors Leonard G. Gomella and Veda Giri bring their considerable expertise to the topic of Prostate Cancer Genetics: Changing the Paradigm of Care.
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Forthcoming Issues
- Foreword
- Preface
- Overview of Prostate Cancer Genetic Testing
- Key points
- Prostate Cancer Predisposition
- Key points
- Introduction
- Epidemiology of prostate cancer risk
- Implication of genetic risk factors
- Linkage analysis, HOXB13
- Inherited DNA-repair gene mutations in men with aggressive prostate cancer
- African American germline predisposition to prostate cancer
- Prostate cancer as part of known cancer syndromes
- Lynch syndrome families
- Use of single gene polymorphisms in risk assessment
- Various polygenic risk score methods
- Polygenic risk score for prostate cancer risk
- Polygenic risk score for differentiating aggressiveness of prostate cancer
- Potential clinical utility of polygenic risk score
- Important considerations for implementing polygenic risk score in the clinic
- Summary
- Clinics care points
- Clinical Multigene Testing for Prostate Cancer
- Key points
- Introduction
- Genes with established or potential clinical utility in prostate cancer
- Landscape of available clinical multigene panels for prostate cancer
- Genetically characterized clinical prostate cancer cohorts
- Genetic counseling implications and challenges
- Future directions
- Summary
- Clinics care points
- Genetic Testing Guidelines and Education of Health Care Providers Involved in Prostate Cancer Care
- Key points
- Introduction
- Genetics knowledge and practice challenges for urologists
- Genetics knowledge and practice challenges for oncologists
- National Comprehensive Cancer Network guidelines for prostate cancer germline testing
- Differences in genetic testing strategies
- Implementation of germline testing for patients with prostate cancer
- Germline testing educational approaches
- Discussion
- Summary
- Clinics care points
- Genetic Counseling for Men with Prostate Cancer
- Key points
- Introduction to genetic counseling
- Cancer genetic counseling session
- Brief Review of Hereditary Cancer Syndromes with Prostate Cancer Risk with Genetic Counseling Implications
- ATM-associated cancer risks
- Genes with emerging evidence for prostate cancer risk (CHEK2, NBN, BRIP1)
- Reproductive decision making and genetic testing for inherited prostate cancer
- Psychosocial Concerns for Genetic Counseling in Men
- Clinical Implications
- New technologies
- Ethical/Legal Concerns with Genetic Counseling and Prostate Cancer
- Summary
- Clinics care points
- Basic Science and Molecular Genetics of Prostate Cancer Aggressiveness
- Key points
- Introduction
- Germline alterations associated with prostate cancer aggressiveness
- Androgen receptor pathway
- Loss of key tumor suppressors
- Tumor cell plasticity
- DNA repair pathways
- Summary
- Genetic Contribution to Metastatic Prostate Cancer
- Key points
- Introduction
- Prostate cancer has a strong heritable component
- Early sequencing discoveries in prostate metastases involve DNA repair genes
- Germline DNA repair gene mutations enriched in the population of patients with metastatic prostate cancer
- DNA repair genes: from pathways to individual genes
- Evidence for increased prostate cancer risk and lethality among male BRCA2 mutation carriers
- Association with higher grade and distinct histologic subtypes
- Association of BRCA2 mutations with more aggressive molecular signatures
- Homologous recombination DNA repair genes and emerging understanding of germline mutations in genes beyond BRCA2
- DNA mismatch repair genes (Lynch syndrome)
- HOXB13
- TP53
- Lack of diversity in datasets perpetuates health disparities
- Multigene panel testing and tumor sequencing, and their role in prostate cancer genetics
- Modifiers/polygenic risk of BRCA1/2
- Treatment implications in metastatic castration-resistant prostate cancer
- Application of knowledge to earlier disease states
- Importance of cascade testing
- Further studies and expanded applications
- Long-term follow-up registry research
- Clinics care points
- Genetically Informed Prostate Cancer Treatment for Metastatic Disease
- Key points
- Introduction
- Genetic testing strategies and implementation
- Therapeutic approach
- Summary
- Clinics care points
- Genetically Informed Prostate Cancer Screening
- Key points
- Introduction
- Controversy surrounding prostate-specific antigen testing
- Genetic predisposition to prostate cancer
- Clinical trials with genetically informed prostate cancer screening
- Current guidelines that include risk-adapted genetically informed screening
- Novel screening paradigms
- Discussion
- Summary
- Clinics care points
- Polygenic Risk Scores in Prostate Cancer Risk Assessment and Screening
- Key points
- Introduction
- Genome-wide association studies and risk variants
- Polygenic risk scores
- Polygenic risk scores for prostate cancer risk predictions
- Polygenic risk scores in non-European populations
- Polygenic risk scores and prostate cancer screening
- Polygenic risk scores and clinical outcomes
- Polygenic risk scores in combination with other prostate cancer prediction tools
- Residual risk in individuals with high- and moderate-risk pathogenic variants
- Current clinical use of prostate cancer polygenic risk scores
- Clinical trials
- Discussion
- Summary
- Clinics care points
- Germline Testing for Prostate Cancer Prognosis: Implications for Active Surveillance
- Key points
- Introduction
- Monogenic mutations and prostate cancer progression
- Monogenic mutations and their implication in active surveillance
- Polygenic risk score, prostate cancer progression, and their implications in active surveillance
- Recent progress of polygenic risk score in active surveillance: a novel hypothesis
- Summary
- Clinics care points
- Germline Predisposition to Prostate Cancer in Diverse Populations
- Key points
- Introduction
- High-penetrance germline mutations
- Low Penetrant Germline Single-Nucleotide Polymorphisms
- Other prognostic single-nucleotide polymorphisms in African American men
- Prostate cancer single-nucleotide polymorphisms among Asian and Hispanic men
- Polygenic risk score
- Future directions
- Summary
- Clinics care points
- Disclosure
- No. of pages: 240
- Language: English
- Edition: 1
- Volume: 48-3
- Published: July 6, 2021
- Imprint: Elsevier
- Hardback ISBN: 9780323791670
- eBook ISBN: 9780323791687
LG
Leonard G. Gomella
Affiliations and expertise
The Bernard W. Godwin Professor of Prostate Cancer
Chairman, Department of Urology
Senior Director Clinical Affairs, Sidney Kimmel Cancer
Center
Urology Clinical Service Line Leader
Thomas Jefferson University/Thomas Jefferson
University Hospital
1025 Walnut Street, Suite 1100
Philadelphia PA 19107VG
Veda Giri
Affiliations and expertise
Associate Professor
Director, Jefferson Clinical Cancer Genetics
Service
Thomas Jefferson University/Thomas Jefferson
University Hospital
1025 Walnut Street, Suite 1100
Philadelphia PA 19107