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Progress in Medicinal Chemistry

  • 1st Edition, Volume 42 - April 15, 2004
  • Author: F.D. King
  • Language: English
  • Hardback ISBN:
    9 7 8 - 0 - 4 4 4 - 5 1 1 4 3 - 0
  • eBook ISBN:
    9 7 8 - 0 - 0 8 - 0 5 1 5 1 9 - 9

This volume includes information on recent advances in five important areas: an account of inhibitors of the caspase family of proteolytic enzymes that represent a new class of an… Read more

Progress in Medicinal Chemistry

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This volume includes information on recent advances in five important areas: an account of inhibitors of the caspase family of proteolytic enzymes that represent a new class of anti-inflammatory and antiapoptotic agents of potential value in rheumatoid arthritis; and a survey of semi-synthetic and totally synthetic antibiotics and anti-HIV agents and their sites of interaction; the development of inhibitors of the intracellular enzyme acyl-CoA: cholesterol O-acyltransferase (ACAT) for the treatment of hypercholesterolemia; a description of recent progress in growth hormone secretagogues, with the focus on strategies to improve oral bioavailability and duration of action; and information on inhibition of the proteolytic enzyme, hepatitis C protease N-3(NS3), (required for vital replication) as one of the most attractive targets for HCV infections.