Progress in Medicinal Chemistry
- 1st Edition, Volume 39 - April 24, 2002
- Editors: F.D. King, A.W. Oxford
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 4 - 5 4 7 8 4 - 2
- Hardback ISBN:9 7 8 - 0 - 4 4 4 - 5 0 9 5 9 - 8
- eBook ISBN:9 7 8 - 0 - 0 8 - 0 5 1 5 1 1 - 3
This volume covers contemporary advances in five important areas of pharmacology and medicinal chemistry including: a comprehensive account of inhibitors of the caspase family of… Read more
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Request a sales quoteThis volume covers contemporary advances in five important areas of pharmacology and medicinal chemistry including: a comprehensive account of inhibitors of the caspase family of proteolytic enzymes that represent a new class of anti-inflammatory and antiapoptotic agents of potential value in rheumatoid arthritis, and other peripheral and central indications; adoc umented survey of semi-synthetic and totally synthetic antibiotics and anti HIV agents and their sites of interaction; inhibitors of the intracellular enzyme acyl-CoA: cholesterol O-acyltransferase (ACAT) developed for the treatment of hypercholesterolemia; and recent progress in growth hormone secretagogues, with the focus on strategies to improve oral bioavailability and duration of action. Inhibition of the proteolytic enzyme, hepatitis C protease N-3(NS3), required for viral replication, is one of the most attractive targets for HCV infections. Progress and prospects in the design of peptide and non-peptide inhibitors are described here. design and clinical potential of new drug molecules; valuable summaries of structure-activity relationships in topical areas of medicinal chemistry; and extensive references to the biology, medicinal chemistry and clinical aspects of each topic.
- No. of pages: 273
- Language: English
- Edition: 1
- Volume: 39
- Published: April 24, 2002
- Imprint: Elsevier Science
- Paperback ISBN: 9780444547842
- Hardback ISBN: 9780444509598
- eBook ISBN: 9780080515113
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F.D. King
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