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Progress in Medicinal Chemistry
- 1st Edition, Volume 39 - April 24, 2002
- Editors: F.D. King, A.W. Oxford
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 4 - 5 4 7 8 4 - 2
- Hardback ISBN:9 7 8 - 0 - 4 4 4 - 5 0 9 5 9 - 8
- eBook ISBN:9 7 8 - 0 - 0 8 - 0 5 1 5 1 1 - 3
This volume covers contemporary advances in five important areas of pharmacology and medicinal chemistry including: a comprehensive account of inhibitors of the caspase family of… Read more
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Request a sales quoteThis volume covers contemporary advances in five important areas of pharmacology and medicinal chemistry including: a comprehensive account of inhibitors of the caspase family of proteolytic enzymes that represent a new class of anti-inflammatory and antiapoptotic agents of potential value in rheumatoid arthritis, and other peripheral and central indications; adoc umented survey of semi-synthetic and totally synthetic antibiotics and anti HIV agents and their sites of interaction; inhibitors of the intracellular enzyme acyl-CoA: cholesterol O-acyltransferase (ACAT) developed for the treatment of hypercholesterolemia; and recent progress in growth hormone secretagogues, with the focus on strategies to improve oral bioavailability and duration of action. Inhibition of the proteolytic enzyme, hepatitis C protease N-3(NS3), required for viral replication, is one of the most attractive targets for HCV infections. Progress and prospects in the design of peptide and non-peptide inhibitors are described here. design and clinical potential of new drug molecules; valuable summaries of structure-activity relationships in topical areas of medicinal chemistry; and extensive references to the biology, medicinal chemistry and clinical aspects of each topic.
- No. of pages: 273
- Language: English
- Edition: 1
- Volume: 39
- Published: April 24, 2002
- Imprint: Elsevier Science
- Paperback ISBN: 9780444547842
- Hardback ISBN: 9780444509598
- eBook ISBN: 9780080515113
FK
F.D. King
Affiliations and expertise
SmithKIine Beecham Pharmaceuticals
New Frontiers Science Park (North)
Third AvenueAO
A.W. Oxford
Affiliations and expertise
Consultant in Medicinal ChemistryRead Progress in Medicinal Chemistry on ScienceDirect