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Progress in Medicinal Chemistry
1st Edition - July 3, 1998
Editors: G. P. Ellis, D.K. Luscombe, A.W. Oxford
Hardback ISBN:9780444829092
9 7 8 - 0 - 4 4 4 - 8 2 9 0 9 - 2
eBook ISBN:9780080862835
9 7 8 - 0 - 0 8 - 0 8 6 2 8 3 - 5
Eminent scientists at the cutting edge of pharmacology and medicinal chemistry research provide us with yet another excellent addition to this famous series. The focus on… Read more
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Eminent scientists at the cutting edge of pharmacology and medicinal chemistry research provide us with yet another excellent addition to this famous series. The focus on bacterial resistance mechanisms serves to highlight an important area of unmet medical need requiring the attention of medicinal chemists. Five topical subjects are reviewed: the biosynthesis, metabolism and function of Vitamin D3 and the potential application of its analogues in bone disorders and immune-related diseases; the therapeutic potential of neurokinin antagonists; opioid receptor antagonists; the mechanisms of bacterial resistance; and a survey of recent advances in cannabinoid research. This volume will deservedly take its place in clinical and industrial pharmaceutical libraries, and will prove invaluable to medicinal chemists.
Preface
1: Modern View of Vitamin D3 and its Medicinal Uses
INTRODUCTION
METABOLISM OF VITAMIN D3
REGULATION OF VITAMIN D3 METABOLISM
MOLECULAR MECHANISM OF 1,25-DIHYDROXYVITAMIN D3 ACTION
TREATMENT OF CALCIUM AND PHOSPHORUS DISORDERS WITH VITAMIN D3 METABOLITES AND ANALOGUES
VITAMIN D3 ANALOGUES OF CLINICAL IMPORTANCE FOR OTHER TYPES OF DISEASES
CONCLUDING REMARKS
ACKNOWLEDGMENTS
2: Neurokinin Receptor Antagonists
INTRODUCTION
BIOLOGICAL ACTIONS OF NEUROKININS AND NEUROKININ ANTAGONISTS
NK1 RECEPTOR-SELECTIVE NON-PEPTIDE ANTAGONISTS
DUAL NK1/NK2 RECEPTOR ANTAGONISTS
NK2 RECEPTOR-SELECTIVE NON-PEPTIDE ANTAGONISTS
NK3 RECEPTOR-SELECTIVE NON-PEPTIDE ANTAGONISTS
CLINICAL STUDIES
CONCLUSIONS
3: Opioid Receptor Antagonists
INTRODUCTION
DETERMINATION OF RECEPTOR SELECTIVITY AND ANTAGONISM
UNIVERSAL OPIOID RECEPTOR ANTAGONISTS
μ OPIOID RECEPTOR SELECTIVE ANTAGONISTS
κ OPIOID RECEPTOR SELECTIVE ANTAGONISTS
δ OPIOID RECEPTOR SELECTIVE ANTAGONISTS
CONCLUSION
4: Mechanisms of Bacterial Resistance to Antibiotics and Biocides
INTRODUCTION
MECHANISMS OF INTRINSIC RESISTANCE (INTRINSIC INSUSCEPTIBILITY)
MECHANISMS OF ACQUIRED RESISTANCE
PATHOGENIC RESISTANT GRAM-POSITIVE BACTERIA
MECHANISMS OF MULTIDRUG RESISTANCE IN GRAM-NEGATIVE BACTERIA
LINKED ANTIBIOTIC-BIOCIDE RESISTANCE
OVERCOMING BACTERIAL RESISTANCE
CONCLUDING REMARKS
5: Towards cannabinoid drugs – revisited
INTRODUCTION
CANNABINOID RECEPTORS AND ENDOGENOUS LIGANDS
STRUCTURE-ACTIVITY RELATIONSHIPS (SAR)
MEDICINAL PROPERTIES OF CANNABINOIDS
CONCLUSIONS
Subject Index
Cumulative Index of Authors for Volumes 1–35
Cumulative Index of Subjects for Volumes 1–35
No. of pages: 258
Language: English
Published: July 3, 1998
Imprint: Elsevier Science
Hardback ISBN: 9780444829092
eBook ISBN: 9780080862835
GE
G. P. Ellis
Affiliations and expertise
Department of Chemistry, University
of Wales Institute of Science and Technology.
King Edward VII Avenue, Cardiff