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Procedures in Cosmetic Dermatology: Botulinum Toxin
- 5th Edition - October 29, 2022
- Authors: Alastair Carruthers, Jean Carruthers, Jeffrey S. Dover, Murad Alam, Omer Ibrahim
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 8 3 1 1 6 - 1
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 3 1 1 7 - 8
Offering a step-by-step, practical approach to this commonly performed cosmetic procedure, Procedures in Cosmetic Dermatology: Botulinum Toxin, 5th Edition, enables you to master… Read more
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Request a sales quoteProvides complete, clear descriptions and rationales for injection placement for facial and neck rejuvenation and hyperhidrosis, including difficult areas like eyebrow shaping and treatment of masseter hypertrophy.
Covers new developments in the field including new treatment sites, new methods of using the toxins, an upcoming topical toxin, and new longer-acting and shorter-onset, shorter-lasting toxins.
Features high-quality images and 25 new videos demonstrating exactly how to perform injection techniques.
Addresses the differences in doses and particular characteristics among different botulinum toxin preparations in every chapter.
Includes procedural how-to's, step-by-step advice on proper techniques, case studies, contraindications and managing complications, and pearls and pitfalls.
- An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.
- If you encounter issues with your eBook please contact Elsevier eBook+ support via [email protected].
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Dermatologists, dermatologic surgeons, derm surgery fellows
- Cover image
- Title page
- Table of Contents
- Series Editors
- Copyright
- Video contents
- Series Preface
- Series Preface First Edition
- Preface
- List of Contributors
- Dedication
- List of Tables
- List of Illustrations
- Part I. Basic Science and Clinical Use of Neuromodulators
- 1. Update on noncosmetic uses of botulinum neurotoxins
- Introduction
- Strabismus
- Blepharospasm
- Sialorrhea
- Summary
- Acknowledgements
- Further reading
- 2. History of cosmetic botulinum toxin
- Introduction
- Serendipitous discovery
- Patient zero and the first clinical trials
- FDA approval
- Longevity of response
- The global face of BoNT-A
- Further reading
- 3. Pharmacology of BOTOX® cosmetic
- Introduction
- Serotypes and structure
- Manufacturing and formulation
- Mechanism of action
- Clinical pharmacology of onabotulinumtoxinA in aesthetics
- Approvals
- Exploration of potential new uses in dermatology
- Summary and conclusions
- Disclosures
- Acknowledgments
- Further reading
- 4. Abobotulinum toxin A: Science and clinical usage
- Clinical studies performed for abobotulinumtoxinA
- New clinical uses and research
- Further reading
- 5. Basic science: Xeomin
- Introduction
- Properties of incobotulinumtoxinA
- Clinical performance of incobotulinumtoxinA
- Clinical experience with incobotulinumtoxinA
- Conclusions
- Further reading
- 6. Prabotulinum toxin A
- Introduction
- Manufacturing
- Clinical
- Real-world experience
- Conclusions
- Further reading
- 7. Basic science: Myobloc®
- Pharmacology of botulinum toxin B
- Immunogenicity of Myobloc
- Liquid formulation of Myobloc
- Myobloc in the aesthetics practice
- Treatment considerations for Myobloc
- Adverse events
- Conclusions
- Further reading
- 8. Basic science of botulinum toxin E
- Introduction
- Properties and structure
- Mechanism of action
- Exploration of potential new uses in dermatology
- Summary and conclusions
- Further reading
- 9. Neuronox®, Innotox®, and Coretox®
- Introduction
- Manufacturing process of Neuronox®, Innotox®, and Coretox®
- Composition and formulation of Neuronox®, Innotox®, and Coretox®
- Pharmacodynamics of Neuronox®, Innotox®, and Coretox®
- Clinical experience with Neuronox®, Innotox®, and Coretox®
- Use of Neuronox®, Innotox®, and Coretox® in Asians
- Conclusion
- Further reading
- 10. DaxibotulinumtoxinA for injection (DAXI)
- DAXI clinical program: Treatment of glabellar lines
- DAXI clinical data in therapeutic studies: Treatment of cervical dystonia and adult upper limb spasticity
- Conclusion
- Further reading
- 11. Comparison of botulinum toxins
- Introduction
- Background
- Types of botulinum toxin A
- Mechanism
- Composition
- Dosing
- Efficacy
- Duration
- Diffusion
- Safety
- Limited treatment response
- Storage
- Conclusions
- Further reading
- 12. Topical botulinum toxin type A
- Introduction
- Barriers to transdermal permeation
- Cell-penetrating peptides
- Nano-emulsion delivery systems
- Cell penetrating protein delivery of topical botulinum toxin type A
- Allergan botulinum toxin type A topical nanoparticle delivery system
- Conclusions
- Further reading
- 13. Reconstitution and dilution
- Introduction
- Reconstitution diluents
- Foaming, shaking, and stirring
- Concentration of toxin: Does it matter?
- Conclusions
- Further reading
- 14. Benzyl alcohol
- Introduction
- Saline with benzyl alcohol: Early evidence of anesthetic efficacy and historical concerns
- Saline with benzyl alcohol: Randomized controlled trials with botulinum toxin
- Saline with benzyl alcohol: Use in combination with lidocaine infiltration
- Saline with benzyl alcohol: Use in comparison with lidocaine infiltration
- Safety of saline with benzyl alcohol
- Summary of key concepts
- Further reading
- Part II. Neuromodulator Injection Sites
- 15. Treatment of glabellar lines with neuromodulators
- Introduction
- Anatomy
- Injection technique (see Videos 15.1A–C “Botulinum Toxin Glabella”)
- Dosing
- Novel botulinum neurotoxins
- Special considerations
- Potential adverse events
- Conclusion
- Further reading
- 16. Treatment of frontalis and horizontal forehead lines with neuromodulators
- Introduction
- Anatomy
- Special considerations
- Conclusion
- Further reading
- Frontalis injection techniques
- More
- 17. Shaping the eyebrow and upper face (palpebral aperture) with neuromodulators
- The periorbital region
- The palpebral aperture
- Further reading
- 18. Treatment of crow’s feet
- Introduction
- Anatomy of crow’s feet lateral orbital rhytides
- The youthful eye
- The aging eye
- Pretreatment assessment
- Treatment
- Adjunctive treatments
- Complications
- Conclusions
- Further reading
- 19. Treatment of infraorbital/upper and lower eyelids with neuromodulators
- Introduction
- Anatomy of the eye
- Periorbital aging
- Patient assessment and selection
- Contraindications
- Indications and techniques
- Hypertrophic orbicularis, infraorbital rhytides, and widening of the eye
- Lid ptosis, malposition, and asymmetry
- Periorbital / orbicularis muscle and fissure asymmetry, synkinesis and miscellaneous spastic disorders
- Other periorbital effects
- Adjunctive treatments for the lid
- Adverse events
- Conclusions
- Further reading
- 20. Treatment of the midface with botulinum toxin
- Introduction
- “Bunny” lines
- Gummy smile
- Zygomaticus complex
- Nasal tip
- Rosacea
- Conclusion
- Further reading
- 21. Treatment of orbicularis oris, mentalis, depressor anguli oris with neuromodulators
- Introduction
- Patient assessment
- Orbicularis oris
- Mentalis
- Depressor anguli oris
- Conclusion
- Further reading
- 22. Platysma, nefertiti lift, and beyond
- Introduction
- Anatomy
- Treatment techniques
- Technical variations for lower face and platysma neuromodulator treatment
- Frequency of treatment
- Side effects
- Combination treatments for neck and lower face rejuvenation
- Conclusions
- Further reading
- 23. The masseters: Hypertrophy, bruxism, and facial shaping with botulinum toxin
- Introduction
- Anatomic considerations
- Dose and injection paradigm
- Aesthetic benefit
- Bruxism
- Side effects and complications
- Conclusions
- Further reading
- 24. Treatment of darker skin types with neuromodulators
- Introduction
- Racial and ethnic differences in photoaging
- Safety and efficacy of botulinum toxins in darker skin types
- Approach to botulinum toxin in ethnic skin
- Ethnic specific applications of botulinum toxin
- Conclusions
- Further reading
- 25. Combination noninvasive facial aesthetic treatments with botulinum toxin type A
- Anatomy related to multiple therapeutic modalities
- Combination therapy in the upper face
- Combination therapy in the lower face
- Injectables
- Skin tightening
- Vascular lesions and pigmentation
- Topical agents
- Sequence and timing of a multimodal approach
- Summary
- Further reading
- 26. Treatment of focal axillary hyperhidrosis with neuromodulators (and non-axillary regions)
- Introduction
- Epidemiology
- Quality of life
- Clinical assessment of hyperhidrosis
- Botulinum toxin therapy
- Axillary hyperhidrosis
- Use of botulinum toxin type B for hyperhidrosis
- Techniques for non-axillary hyperhidrosis
- Future directions
- Further reading
- 27. Botulinum toxin for the treatment of palmoplantar hyperhidrosis
- Introduction: Epidemiology and pathophysiology
- Patient evaluation
- Botulinum toxin as a treatment for hyperhidrosis
- Patient preparation and pain control
- Reconstitution and injection techniques
- Results and complications
- Conclusions
- Further reading
- Part III. Future Directions for Aesthetic Neuromodulators
- 28. The future of neuromodulators in aesthetic medicine
- Introduction
- Conclusions
- Further reading
- 29. Neuromodulator immunogenicity
- Introduction
- Pathogenesis of immunogenicity
- Genetic predisposition to the immunogenicity
- Antibody assay methods
- Challenges and solution
- Real-world evidence
- Conclusions
- Further reading
- Index
- No. of pages: 296
- Language: English
- Edition: 5
- Published: October 29, 2022
- Imprint: Elsevier
- Hardback ISBN: 9780323831161
- eBook ISBN: 9780323831178
AC
Alastair Carruthers
JC
Jean Carruthers
JD
Jeffrey S. Dover
MA