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Principles of Regenerative Medicine

  • 1st Edition - November 19, 2007
  • Editors: Anthony Atala, Robert Lanza, Robert Nerem, James A. Thomson
  • Language: English

Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the… Read more

Description

Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure.

Key features

* Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology
* The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine
* New discoveries from leading researchers on restoration of diseased tissues and organs

Readership

Advanced researchers in bioengineering, stem cell biology, and developmental biology.

Table of contents

Introduction to Regenerative Medicine


1
Current and Future Perspectives of Regenerative Medicine
Anthony Atala
Mark E. Furth


2
Fundamentals of Cell-Based Therapies
Ross Tubo


3
Stem Cell Research in Regenerative Medicine
Robert M. Nerem
AM Doyle
T Ahsan

Biologic and Molecular Basis of Regenerative Medicine


4
Molecular Organization of Cells
Carol A. Erickson
Jon D. Ahlstrom


5
Cell-ECM Interactions in Repair and Regeneration
Manuela Martins-Green
M. Petreaca


6
Developmental Mechanisms of Regeneration and Strategies of Regenerative Medicien
David L. Stocum


7
Molecular Basis of Pluripotency
Ali H. Brivanlou
Ariel J. Levine


8
How Cells Change Their Phenotype
Peter Andrews
Paul J. Gokhale


9
Somatic Cloning and Epigenetic Reprogramming in Mammals
Heiner Niemann
Christine Wrenzycki
Wilfried A. Kues
Andrea Lucas-Hahn
Joseph W. Warnwath


10
Transgenic Cloned Goats and Cows for the Production of Therapeutic Proteins
Harry Meade
William Gavin
LiHow Chen
David L. Melican
Carol A. Ziomek
Yann Echelard

Cells and Tissue Development


11
Genetic Approaches in Human Embryonic Stem Cells and Their Derivatives: Prospect for Regenerative Medicine
Mickie Bhatia
Junfeng Ji
Bonan Zhong


12
Embryonic Stem Cells: Derivation and Properties
James Thomson
Junying Yu


13
Stem Cells Derived from Amniotic Fluid and Placenta
Paolo De Coppi
Georg Van Dyke
M. Minhaj Siddiqui
Anthony Atala


14
Stem Cells Derived from Cord Blood
Julie Allickson


15
Multipotent Adult Progenitor Cells: Isolation and Induction
Catherine Verfaillie


16
Bone Marrow Stem Cells: Properties and Pluripotency
Ren Ke Li
Munira Xaymardan
Massimo Cimini
Richard D. Weisel


17
Hematopoietic Stem Cells: Properties , Markers and Therapeutics
M.A Goodell
S.M. Chambers
K.K. Lin


18
Neural Stem Cells: Multipotency Beyond Self-renewal and Phenotypic Differentiation
Evan Snyder
Yang D. Teng
Peter M. Black
F.N. Santos
Deniz Konya
Kook In Park
Richard L. Sidman


19
Mesenchymal Stem Cells
Daniel Gazit
Zumila Gazit
Hadi Aslan
Yossi Gafni
Nadav Kimelman
Gadi Pelled


20
Stem Cells and Maturational Lineage Biology: Implications for Clinical, Research and Commercial Programs
Lola Reid
Hsin-lei Yao
N. Cheng


21
Skeletal Muscle Stem Cells
Helen Blau
Jason H. Pomerantz


22
Islet Cell Therapy and Pancreatic Stem Cells
Camillo Ricordi
Juan Dominguez-Bendala
Antonello Pileggi


23
Regenerative Medicine for Diseases of the Retina
Thomas A. Reh
Deepak Lamba


24
Peripheral Blood Stem Cells
Shay Soker
Gunter Schuch
J. Koudy Williams


25
Prospects of Somatic cell Nuclear Transfer Derived Embryonic Stem Cells in Regenerative Medicine
Jose Cibelli
Z. Beyhan


26
Somatic Cells: Growth and Expansion Potential of T Lymphocytes
Rita B. Effros


27
Mechanical and Chemical Determinants of Tissue Development
David Kaplan
Jonathan A. Kluge
Gary G. Leisk


28
Morphogenesis, Bone morphogenetic Proteins and Regenerative Medicine
A. Hari Reddi


29
Physical Stress as a Factor in Tissue Growth and Remodeling
Robert Guldberg
Christopher S. Gemmiti
Yash Kolambkar
Blaise Porter


30
Engineering Cellular Microenvironments
Christopher S. Chen
Wendy F. Liu
Elliot E. Hui
Sangeeta N. Bhatia


31
Applications of Nanotechnology for Regenerative Medicine
Ben Harrison


32
Gene Chips in Regenerative Medicine
Jason Hipp
Anthony Atala

Biomaterials for Regenerative Medicine


33
Design Principles in Biomaterials and Scaffolds
Tae Gwan Park
Hyukjin Lee


34
Natural Polymers
Stephen Badylak


35
Synthetic Polymers
A.G. Mikos
M.C. Hacker


36
Hybrid, Composite, and Complex Biomaterials for Scaffolds
Hae Bang Lee
Gilson Khang
Hee Kim
Moon Suk Kim


37
Surface Modification of Biomaterials
Andres Garcia


38
Cell-Substrate Interactions in Regenerative Medicine
Kam W. Leong
Aparna Nori
Evelyn K.F. Yim
Sulin Chen


39
Histogenesis in Three Dimensional Scaffolds
Jennifer West
Nicole M. Bergman


40
Biocompatibility and Bioresponse to Biomaterials
James Anderson


41
Healing
William J. Lindblad


42
Precision Control of Proteins at Interfaces for Tissue Engineering and Regenerative Medicine
Buddy Ratner

Therapeutic Applications: Cell Therapy


43
Biomineralization and Bone Regeneration
Peter X. Ma
Jiang Hu
Xiaohua Liu



44
Blood Substitutes: Reverse Evolution from Oxygen Carrying to Non-Oxygen Carrying Plasma Expanders
Mark Van Dyke
Amy Tsai
Marcos Intaglietta


45
Articular Cartilage
Myron Spector
Francois Ng kee Kwong


46
Implantation of myogenic Cells in Skeletal Muscles
Jacques Tremblay
Daniel Skuk


47
Clinical Islet Transplantation
A.M. James Shapiro
Juliet A. Emamaulle


48
Cell-Based Repair for Regeneration and Neovascularization: What, Why, How and Where are We Going in the Next 5 - 10 Years?
Andrey G. Zenovich


49
Retinal pigment epithelium derived from embryonic stem cells
Irina Klimanskaya


50
Cell Therapies for Bone Regeneration
Scott P. Bruder
Rehan N. Khanzada
Chantal E. Holy
F. Jerry Volenec


51
Cell-Based Therapies for Musculoskeletal Repair
Rocky Tuan
Wan -Ju Li
David P. Patterson
George T.J. Huang
Kiran Gollapudi


52
Hepatocyte Transplantation
Steven C. Strom
Ewa C.S. Ellis


53
Bioartificial Livers
Lola Reid
Randall E. McClelland


54
Neuronal Transplantation for Stroke
Douglas Kondziolka
Lawrence Wechsler


55
Cell-Based Drug Delivery
Grace Lim

Therapeutic Applications: Tissue Therapy


56
Fetal Tissues
Chester Koh
Seyung Chung


57
Engineering of Large Diameter Vessels
George Christ
Saami K. Yazdani


58
Engineering of Small Diameter Vessels
Robert Tranquillo
Chrysanthi Williams


59
Vascular Assembly in Engineered and Natural Tissues
Larry V. McIntire
Eric M Brey


60
Cardiac Tissue
Michael V. Sefton
Milica Radisic


61
Regenerative Medicine in the Cornea
May Griffith
Heather Sheardown


62
Alimentary Tract
Mike Chen


63
Liver Cell-based Therapy in Regnerative Medicine - Bioreactors as Enabling Technology
Jorg Gerlach
Mariah Hout
Keneth Gage
Katrin Zeilinger


64
Kidney-Intracorporeal
James Yoo


65
Kidney
H. David Humes
William H. Fissell


66
Genitourinary System
Anthony Atala


67
Tissue Engineering of the Reproductive System
Roger De Filippo


68
Therapeutic Opportunities for Bone Grafting
Jeffrey O. Hollinger
John P. Schmitz
Thomas A. Einhorn
Gary E. Friedlaender
Chris R. Brown
Scott D. Bowden
Samuel Lynch


69
Cartilage Tissue Engineering
Jennifer Elisseeff
Paulesh Shah
Alexander Hillel
Ronald Silverman


70
Phalanges and Small Joints
Makoto Komura
James Yoo


71
Functional Tissue Engineering of Ligament and Tendon Injuries
Savio L.-Y. Woo
Alejandro J. Almarza


72
Tissue Therapy: Implications of Regenerative Medicine for Skeletal Muscle
Johnny Huard
Shen Wei


73
Central Nervous System
Molly Shoichet
Jordan H. Wosnick
M. Douglas Baumann


74
Peripheral Nerve Regeneration
Ravi Bellamkonda
Mahesh C. Dodla


75
Dental Tissue Engineering
Pamela Yelick
Yan Lin


76
Innovative Regenerative Medicine Approaches to Skin Cell-Based Therapy for Patiens with Burn Injuries
Jorg Gerlach
Steven E. Wolf
Christa Johnen
Bernd Hartman


77
Military Needs and Solutions in Regenerative Medicine
Alan Russell
Sara Wargo

Regulations and Ethics


78
Ethical Considerations
Louis M. Guenin


79
Religious Considerations
Laurie Zoloth


80
U.S. Stem Cell Research Policy: An Introduction
Josephine Johnston


81
Overview of FDA Regulatory Process
Celia Witten
Ashok Batra
Charles N. Durfor
Stephen H. Hilbert
Davis S. Kaplan
Donald Fink
Deborah Vavoie
Ellen Maher
Richard McFarland


82
Current Issues in U.S. Patent Law
Patrea Pabst

Product details

About the editors

AA

Anthony Atala

Anthony Atala, M.D., is the Director of the Wake Forest Institute for Regenerative Medicine, and the W.H. Boyce Professor and Chair of the Department of Urology at Wake Forest University. Dr. Atala is a practicing surgeon and a researcher in the area of regenerative medicine. His current work focuses on growing new human cells, tissues and organs.

Dr. Atala works with several journals and serves in various roles, including Editor-in-Chief of Current Stem Cell Research and Therapy, and Therapeutic Advances in Urology; as Associate Editor of the Journal of Tissue Engineering and Regenerative Medicine, The Journal of Rejuvenation Research, Nanotechnology in Engineering and Medicine, Gene Therapy and Regulation, and Current Reviews in Urology; as Executive Board Member or Section Editor of the journal Tissue Engineering and International Journal of Artificial Organs, and as Editorial Board member of the International Journal of Stem Cells, Stem Cell Review Letters, Expert Opinion on Biological Therapy, Biomedical Materials, Recent Patents on Regenerative Medicine, the Journal of the American College of Surgeons, the Journal of Urology, BMC Urology, Urology, and Current Opinion in Urology.

Dr. Atala is a recipient of the US Congress funded Christopher Columbus Foundation Award, bestowed on a living American who is currently working on a discovery that will significantly affect society, and the Gold Cystoscope Award for advances in his field. Dr. Atala was named by Scientific American as a Medical Treatments Leader of the Year for his contributions to the fields of cell, tissue and organ regeneration. In 2006, he was named by Fast Company magazine as one of 50 people who “will change how we work and live over the next 10 years. Dr. Atala’s work was listed as Discover Magazine`s Number 1 Top Science Story of the Year in the field of medicine, and as Time Magazine’s top 10 medical breakthroughs of the year in 2007. A Time Magazine poll ranked Dr. Atala as the 56th most influential person of the year in 2007. Esquire Magazine in 2008 named Dr. Atala one of the 75 most influential persons of the 21st century. Fast Company Magazine named Dr. Atala one of 100 Most Creative People in Business in 2009. Dr. Atala was featured in U.S. News & World Report as one of “14 Medical Pioneers Who Aren’t Holding Back.”

Dr. Atala has led or served several national professional and government committees, including the National Institutes of Health working group on Cells and Developmental Biology, and the National Institutes of Health Bioengineering Consortium. He is currently an NIH “Quantum Grant” awardee. Dr. Atala heads a team of over 250 physicians and researchers. Ten applications of technologies developed in Dr. Atala's laboratory have been used clinically. He is the editor of nine books, including Minimally Invasive Urology, Methods of Tissue Engineering, Principles of Regenerative Medicine, and Foundations of Regenerative Medicine, and has published more than 300 journal articles and has applied for or received over 200 national and international patents.

Affiliations and expertise
Director, Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA

RL

Robert Lanza

Robert Lanza is an American scientist and author whose research spans the range of natural science, from biology to theoretical physics. TIME magazine recognized him as one of the “100 Most Influential People in the World,” and Prospect magazine named him one of the Top 50 “World Thinkers.” He has hundreds of scientific publications and over 30 books, including definitive references in the fields of stem cells, tissue engineering, and regenerative medicine. He’s a former Fulbright Scholar and studied with polio-pioneer Jonas Salk and Nobel laureates Gerald Edelman (known for his work on the biological basis of consciousness) and Rodney Porter. He also worked closely (and co-authored papers in Science on self-awareness and symbolic communication) with noted Harvard psychologist BF Skinner. Dr. Lanza was part of the team that cloned the world’s first human embryo, the first endangered species, and published the first-ever reports of pluripotent stem cell use in humans.
Affiliations and expertise
Astellas Institute for Regenerative Medicine, Westborough, MA, USA

JT

James A. Thomson

Affiliations and expertise
Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, USA

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