Principles of Bone Biology
- 2nd Edition - January 9, 2002
- Editors: John P. Bilezikian, Lawrence G. Raisz, Gideon A. Rodan
- Language: English
Principles of Bone Biology is the essential resource for anyone involved in the study of bones. It is the most comprehensive, complete, up-to-date source of information on all as… Read more
Description
Description
Principles of Bone Biology is the essential resource for anyone involved in the study of bones. It is the most comprehensive, complete, up-to-date source of information on all aspects of bones and bone biology in one convenient source. Written and published in less than one year, it will become an indispensable resource for any scientific or medical library. This, second edition, details countless advances over the past five years, both by updating old chapters and providing additional material. It takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics.
Key features
Key features
The most current and timely source of information about the biology and pathology of bone
Provides succinct coverage of the subject
Contributors include over 200 of the most respected researchers in the field
Extensive table of contents and index for easy reference
Easy-to-read and highly informative to both the newcomer and the initiated to the field
Spans the spectrum from molecular biology to in vivo pharmacology
Complete bibliography with each entry fully referenced for additional background reading
First edition was selected by Doody Publishing as one of the 250 Best Health Science books published in 1996
Provides succinct coverage of the subject
Contributors include over 200 of the most respected researchers in the field
Extensive table of contents and index for easy reference
Easy-to-read and highly informative to both the newcomer and the initiated to the field
Spans the spectrum from molecular biology to in vivo pharmacology
Complete bibliography with each entry fully referenced for additional background reading
First edition was selected by Doody Publishing as one of the 250 Best Health Science books published in 1996
Readership
Readership
Anyone involved in bones.
Endocrinologists,
Endocrinologists,
Table of contents
Table of contents
PART I: BASIC PRINCIPLES
Cell Biology
The Structure & Development of the Skeleton
Biomechanics of Bone
Embryonic Development of Bone and the Molecular Regulation of Intramembranous and Endochondral Bone Formation
Mesenchymal Stem Cells & Osteoblast Lineage
Transcriptional Control of Osteoblast Differentiation and Function
The Osteocyte
Cells of Bone: Osteoclast Generation
Osteoclast Function
Integrin and Calcitonin Receptor Signaling in the Regulation of the Cytoskeleton and Function of Osteoclasts
Apoptosis in Bone Cells
Involvement of Nuclear Architecture in Regulating Gene Expression in Bone Cells
Biochemistry
Type I Collagen: Structure, Synthesis, and Regulation
Collagen Crosslinking & Metabolism
Bone Matrix Proteoglycans & Glycoproteins
Osteopontin
Bone Proteinases
Cell Surface Attachment Molecules
Intercellular Junctions and Cell-Cell Communication in Bone
Bone Remodeling and Mineral Homeostasis
Histomorphometric Analysis of Bone Remodeling
Phosphorus Homeostasis & Related Disorders
Magnesium Homeostasis
Metals in Bone: Aluminum, Boron, Cadmium, Chromium, Lead, Silicon, & Strontium
The Biology of the Extracellular Ca2+-Sensing Receptor (CaR)
The Hormones of Bone
Receptors for Parathyroid Hormone and Parathyroid Hormone-Related Peptide
Parathyroid Hormone - Molecular Biology
Parathyroid Hormone-Receptor Interactions
Actions of Parathyroid Hormone
Renal and Skeletal Actions of PTH and PTHrP
Physiological Actions of PTH and PTHRP: Epidermal, Mammary, Reproductive and Pancreatic Issues
Vascular, Cardiovascular and Neurological Actions of PTHrP
Nuclear Receptor Structure (VDR) and Ligand Specificities for Genomic and Rapid Biological Responses
Vitamin D Gene Regulation
Photobiology and Non-Calcemic Actions of Vitamin D
The Structure and Molecular Biology of the Calcitonin Receptor
Physiology & Pathophysiology of Calcitonin
Amylin & CGRP
Other Systemic Hormones That Influence Bone Metabolism
Estrogens & Progestins
Selective Estrogen Receptor Modulators (SERMs)
Mechanisms of Estrogen Action in Bone
Thyroid Hormone & Bone
Clinical and Basic Aspects of Glucocorticoid Action in Bone
Effects of Diabetes & Insulin on Bone Physiology
Androgens: Receptor Expression and Steroid Action in Bone
Kinins & Neuro-Osteogenic Factors
Local Regulators
The Role of Insulin-like Growth Factors & Binding Proteins in Bone Cell Biology
Platelet-Derived Growth Factor & the Skeleton
Fibroblast Growth Factor and Fibroblast Growth Factor Receptor Families in Bone
Vascular Endothelial Growth Factors
Transforming Growth Factor (beta
Bone Morphogenetic Proteins
Bone Morphogenetic Protein Receptors & Actions
Colony-Stimulating Factors
Local Regulators of Bone: IL-1, TNF, Lymphotoxin, Interferon-?, IL-8, IL-10, IL-4, the LIF/IL-6 Family, and Additional Cytokines
Prostaglandins & Bone Metabolism
Nitric Oxide and other Vasoactive Agents
PART II: MOLECULAR MECHANISMS OF METABOLIC BONE DISEASES
Molecular Basis of PTH Overexpression
Familial Benign Hypocalciuric Hypercalcemia and Neonatal Primary Hyperparathyroidism
Multiple Endocrine Neoplasia Type I
The Role of the RET Proto-oncogene in Multiple Endocrine Neoplasia Type 2
Systemic Factors in Skeletal Manifestations of Malignancy
Local Factors in Skeletal Malignancy
Molecular Basis of PTH Underexpression
Jansen's Metaphyseal Chondrodysplasia & Blomstrand's Lethal Chondrodysplasia: Two Genetic Disorders Caused by PTH/PTHrP Receptor Mutations
Signal Transduction via G Proteins; Pseudohypoparathyroidism
Other Skeletal Diseases Resulting from G Protein Defects - Fibrous Dysplasia & McCune-Albright Syndrome
Osteogenesis Imperfecta
Hereditary Deficiencies in Vitamin D Action
Oncogenic Osteomalacia
Osteopetrosis
Hypophosphatasia: Nature's Window on Alkaline Phosphatase Function in Man
Paget's Disease of Bone
Genetic Determinants of Bone Mass
Pathophysiology of Osteoporosis
Evaluation of Risk for Osteoporosis Fractures
PART III: PHARMACOLOGIC MECHANISMS OF THERAPEUTICS
Pharmacologic Mechanisms of Therapeutics: Parathyroid Hormone
Calcium
Calcium Receptors as Novel Drug Targets
Bisphosphonates: Mechanisms of Action
Fluoride in Osteoporosis
The Pharmacology of Estrogens in Osteoporosis
Pharmacologic Mechanisms of Therapeutics: Vitamin D & Analogs
Molecular and Clinical Pharmacology of Calcitonin
Growth Hormone and Insulin-like Growth Factor-I Treatment for Metabolic Bone Diseases
Anabolic Steroid Effects on Bone in Women
Estrogen Effects on Bone in the Male Skeleton
Mechanisms of Exercise Effects on Bone
PART IV: METHODS IN BONE RESEARCH
Application of Transgenic Mice to Problems of Skeletal Bone
Use of Cultured Osteoblastic Cells to Identify and Characterize Transcriptional Regulatory Complexes
Current Methodologic Issues in Cell & Tissue Culture
Biochemical Markers of Bone Metabolism
Methods and Clinical Issues in Bone Densitometry and Quantitative Ultrasonometry
Controversies in Bone Mass Measurement
Macro and Micro Imaging of Bone Architecture
Transilial Bone Biopsy
Animal Models in Osteoporosis Research
Defining the Genetics of Osteoporosis - Using the Mouse to Understand Man
Cell Biology
The Structure & Development of the Skeleton
Biomechanics of Bone
Embryonic Development of Bone and the Molecular Regulation of Intramembranous and Endochondral Bone Formation
Mesenchymal Stem Cells & Osteoblast Lineage
Transcriptional Control of Osteoblast Differentiation and Function
The Osteocyte
Cells of Bone: Osteoclast Generation
Osteoclast Function
Integrin and Calcitonin Receptor Signaling in the Regulation of the Cytoskeleton and Function of Osteoclasts
Apoptosis in Bone Cells
Involvement of Nuclear Architecture in Regulating Gene Expression in Bone Cells
Biochemistry
Type I Collagen: Structure, Synthesis, and Regulation
Collagen Crosslinking & Metabolism
Bone Matrix Proteoglycans & Glycoproteins
Osteopontin
Bone Proteinases
Cell Surface Attachment Molecules
Intercellular Junctions and Cell-Cell Communication in Bone
Bone Remodeling and Mineral Homeostasis
Histomorphometric Analysis of Bone Remodeling
Phosphorus Homeostasis & Related Disorders
Magnesium Homeostasis
Metals in Bone: Aluminum, Boron, Cadmium, Chromium, Lead, Silicon, & Strontium
The Biology of the Extracellular Ca2+-Sensing Receptor (CaR)
The Hormones of Bone
Receptors for Parathyroid Hormone and Parathyroid Hormone-Related Peptide
Parathyroid Hormone - Molecular Biology
Parathyroid Hormone-Receptor Interactions
Actions of Parathyroid Hormone
Renal and Skeletal Actions of PTH and PTHrP
Physiological Actions of PTH and PTHRP: Epidermal, Mammary, Reproductive and Pancreatic Issues
Vascular, Cardiovascular and Neurological Actions of PTHrP
Nuclear Receptor Structure (VDR) and Ligand Specificities for Genomic and Rapid Biological Responses
Vitamin D Gene Regulation
Photobiology and Non-Calcemic Actions of Vitamin D
The Structure and Molecular Biology of the Calcitonin Receptor
Physiology & Pathophysiology of Calcitonin
Amylin & CGRP
Other Systemic Hormones That Influence Bone Metabolism
Estrogens & Progestins
Selective Estrogen Receptor Modulators (SERMs)
Mechanisms of Estrogen Action in Bone
Thyroid Hormone & Bone
Clinical and Basic Aspects of Glucocorticoid Action in Bone
Effects of Diabetes & Insulin on Bone Physiology
Androgens: Receptor Expression and Steroid Action in Bone
Kinins & Neuro-Osteogenic Factors
Local Regulators
The Role of Insulin-like Growth Factors & Binding Proteins in Bone Cell Biology
Platelet-Derived Growth Factor & the Skeleton
Fibroblast Growth Factor and Fibroblast Growth Factor Receptor Families in Bone
Vascular Endothelial Growth Factors
Transforming Growth Factor (beta
Bone Morphogenetic Proteins
Bone Morphogenetic Protein Receptors & Actions
Colony-Stimulating Factors
Local Regulators of Bone: IL-1, TNF, Lymphotoxin, Interferon-?, IL-8, IL-10, IL-4, the LIF/IL-6 Family, and Additional Cytokines
Prostaglandins & Bone Metabolism
Nitric Oxide and other Vasoactive Agents
PART II: MOLECULAR MECHANISMS OF METABOLIC BONE DISEASES
Molecular Basis of PTH Overexpression
Familial Benign Hypocalciuric Hypercalcemia and Neonatal Primary Hyperparathyroidism
Multiple Endocrine Neoplasia Type I
The Role of the RET Proto-oncogene in Multiple Endocrine Neoplasia Type 2
Systemic Factors in Skeletal Manifestations of Malignancy
Local Factors in Skeletal Malignancy
Molecular Basis of PTH Underexpression
Jansen's Metaphyseal Chondrodysplasia & Blomstrand's Lethal Chondrodysplasia: Two Genetic Disorders Caused by PTH/PTHrP Receptor Mutations
Signal Transduction via G Proteins; Pseudohypoparathyroidism
Other Skeletal Diseases Resulting from G Protein Defects - Fibrous Dysplasia & McCune-Albright Syndrome
Osteogenesis Imperfecta
Hereditary Deficiencies in Vitamin D Action
Oncogenic Osteomalacia
Osteopetrosis
Hypophosphatasia: Nature's Window on Alkaline Phosphatase Function in Man
Paget's Disease of Bone
Genetic Determinants of Bone Mass
Pathophysiology of Osteoporosis
Evaluation of Risk for Osteoporosis Fractures
PART III: PHARMACOLOGIC MECHANISMS OF THERAPEUTICS
Pharmacologic Mechanisms of Therapeutics: Parathyroid Hormone
Calcium
Calcium Receptors as Novel Drug Targets
Bisphosphonates: Mechanisms of Action
Fluoride in Osteoporosis
The Pharmacology of Estrogens in Osteoporosis
Pharmacologic Mechanisms of Therapeutics: Vitamin D & Analogs
Molecular and Clinical Pharmacology of Calcitonin
Growth Hormone and Insulin-like Growth Factor-I Treatment for Metabolic Bone Diseases
Anabolic Steroid Effects on Bone in Women
Estrogen Effects on Bone in the Male Skeleton
Mechanisms of Exercise Effects on Bone
PART IV: METHODS IN BONE RESEARCH
Application of Transgenic Mice to Problems of Skeletal Bone
Use of Cultured Osteoblastic Cells to Identify and Characterize Transcriptional Regulatory Complexes
Current Methodologic Issues in Cell & Tissue Culture
Biochemical Markers of Bone Metabolism
Methods and Clinical Issues in Bone Densitometry and Quantitative Ultrasonometry
Controversies in Bone Mass Measurement
Macro and Micro Imaging of Bone Architecture
Transilial Bone Biopsy
Animal Models in Osteoporosis Research
Defining the Genetics of Osteoporosis - Using the Mouse to Understand Man
Product details
Product details
- Edition: 2
- Published: January 9, 2002
- Language: English
About the editors
About the editors
JB
John P. Bilezikian
John P. Bilezikian, MD, the Dorothy L. and Daniel H. Silberberg Professor of Medicine and Professor of Pharmacology at the College of Physicians & Surgeons, Columbia University is Chief of the Division of Endocrinology and Director of the Metabolic Bone Diseases Program at Columbia University Medical Center. Dr. Bilezikian received his undergraduate training at Harvard College and his medical training at the College of Physicians & Surgeons. He completed four years of house staff training (internship, residency and Chief Residency) on the Medical Service at Columbia Presbyterian Medical Center. Dr. Bilezikian received his training in Metabolic Bone Diseases and in Endocrinology at the NIH in the Mineral Metabolism Branch under the tutelage of Dr. Gerald Aurbach. Dr. Bilezikian belongs to a number of professional societies including the American Society for Bone and Mineral Research, of which he served as President, 1995-1996 and the International Society of Clinical Densitometry, of which he served as President, 1999-2001. He serves on the Board of Governors of the International Osteoporosis Foundation (1998-present) and on its Committee of Scientific Advisors (2001-present). He is Chair of the Endocrine Fellows Foundation. He served as Editor-in-Chief of the Journal of Clinical Endocrinology and Metabolism (2000-2004) and as Senior Associate Editor of the Journal of Bone and Mineral Research (2008-2012). He is Executive Advisory Editor of Bone Research (2013-present). His books include Editor-in-Chief of The Parathyroids [1994, 2001, 2014], and co-editor of The Aging Skeleton (1999), Dynamics of Bone and Cartilage Metabolism (1999, 2006), Principles of Bone Biology (1996, 2002, 2008) and Osteoporosis in Men (2010). He served as co-chair of the last three NIH Workshops on Primary Hyperparathyroidism (2002, 2008, 2013). He is the recipient of the Distinguished Physician Award of the Endocrine Society, the Frederic C. Bartter Award of the American Society for Bone and Mineral Research (ASBMR) for Excellence in Clinical Research and the First Annual Global Leadership Award of the International Society of Clinical Densitometry. In 2009, he received the Gideon A. Rodan Excellence in Mentorship Award from the ASBMR. He received the Laureate Distinguished Educator Award of The Endocrine Society in 2014. In 2014, he was made honorary member of the Brazilian Society of Endocrinology and Metabolism. His publications number over 700.
Affiliations and expertise
Columbia University, New York, New York, U.S.A.LR
Lawrence G. Raisz
Dr. Raisz is Professor of Medicine and Program Director of the General Clinical Research Center at the University of Connecticut Health Center. He has been carrying out laboratory and clinical studies in the field of osteoporosis and bone metabolism for over 40 years. He has mentored a large number of investigators in these areas both here at the University of Connecticut and previously at the University of Rochester School of Medicine. His current studies include an analysis of the effects of estrogen and androgen on the expression of cytokines and growth factors in bone, which is being carried out in both humans and animal models, studies of the role of prostaglandins in bone metabolism using transgenic mice, studies on the effects of progestins on bone turnover in postmenopausal women and tissue culture and animal studies on new antiresorptive and anabolic agents carried out in collaboration with the pharmaceutical industry.
Affiliations and expertise
Professor of Medicine and Program Director of the General Clinical Research Center at the University of Connecticut Health CenterGR
Gideon A. Rodan
Dr. Rodan graduated from the Hebrew University Medical School (Jerusalem) in 1965, had two years residency in oncology and obtained a Ph.D. in chemistry in 1970 from the Weizmann Institute of Science, Israel. In 1970, he joined the University of Connecticut, where he became chairman of the Department of Oral Biology in 1978. In 1985, he was recruited by Merck to head the Department of Bone Biology and Osteoporosis Research and, since 1986, holds a joint appointment at the University of Pennsylvania as Adjunct Professor of Pathology.
The scientific contributions of Dr. Rodan and his colleagues include: establishment and characterization of osteoblastic cell lines in culture, which helped define the osteoblastic phenotype, the sequential expression of phenotypic genes, the interaction between osteoblasts and osteoclasts, and the development of a sensitive parathyroid hormone bioassay, which eventually led to the purification of parathyroid hormone-related peptide; other contributions include bone cell responses to mechanical stimuli and the role of prostaglandin E in that process. At Merck, Dr. Rodan initiated the effort which led to the development of the osteoporosis drug Fosamax and contributed to the understanding of the mode of action of bisphosphonates.
Dr. Rodan has served on NIH study sections, council and other advisory panels; he has been an Associate Editor of the Journal of Bone and Mineral Research, is currently Associate Editor of Bone, and member of several editorial boards. Dr. Rodan has been council member, program chairman and president of ASBMR; member of the Board of Directors of the National Osteoporosis Foundation and is currently president elect of the International Bone and Mineral Society. Dr. Rodan is the recipient of the Kennedy prize from the Weizmann Institute of science, the Neuman prize from the ASBMR, the Pioneer Award of the National Osteoporosis Foundation and the Goldhaber award of Harvard School of Dental Medicine.
Affiliations and expertise
Merck Research Labs, West Point, Pennsylvania, U.S.A.View book on ScienceDirect
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