Principles of Biomaterials Encapsulation: Volume One

1st Edition - October 13, 2022
Editors: Farshid Sefat, Gholamali Farzi, Masoud Mozafari
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 9 4 7 - 9
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 9 4 3 - 1

Principles of Biomaterials Encapsulation: Volume One, provides an expansive and in-depth resource covering the key principles, biomaterials, strategies and techniques for e… Read more

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Principles of Biomaterials Encapsulation: Volume One, provides an expansive and in-depth resource covering the key principles, biomaterials, strategies and techniques for encapsulation.

Volume One begins with an introduction to encapsulation, with subsequent chapters dedicated to a broad range of encapsulation principles and techniques, including spray chilling and cooling, microemulsion, polymerization, extrusion, cell microencapsulation and much more. This book methodically details each technique, assessing the advantages and disadvantages of each, allowing the reader to make an informed decision when using encapsulation in their research.

Principles of Biomaterials Encapsulation: Volume One enables readers to learn about the various strategies and techniques available for encapsulation of a wide selection of biomedical substrates, such as drugs, cells, hormones, growth factors and so on. 　

Written and edited by well-versed materials scientists with extensive clinical, biomedical and regenerative medicine experience, this book offers a deeply interdisciplinary look at encapsulation in translational medicine. As such, this book will provide a useful resource to a broad readership, including those working in the fields of materials science, biomedical engineering, regenerative and translational medicine, pharmacology, chemical engineering and nutritional science.

Cover image
Title page
Table of Contents
Copyright
Contributors
Preface
Section 1: Introduction
Chapter 1: An introduction to biomaterials encapsulation
Abstract
1.1: Introduction
1.2: Conclusion
References
Chapter 2: Encapsulation techniques overview
Abstract
2.1: Introduction
2.2: Different encapsulation techniques
2.3: Future of encapsulation in regenerative medicine
References
Section 2: Encapsulation principles and techniques
Chapter 3: Encapsulation of bioactive compunds: Role of nanotechnology
Abstract
3.1: Introduction
3.2: Nanomaterials
3.3: Scaffolds
3.4: Applications of nanomaterials in tissue regeneration
3.5: Conclusion
References
Chapter 4: Morphology control in encapsulation
Abstract
4.1: Introduction
4.2: Microencapsulation definition and its applications
4.3: Coating and encapsulation
4.4: Microcapsules versus microspheres and microparticles
4.5: Micro- and nanocapsules
4.6: Core-shell particle morphology
4.7: Equilibrium morphology considerations
4.8: Conclusion
References
Chapter 5: Encapsulation: Advances in cell encapsulation
Abstract
5.1: Introduction
5.2: Cell encapsulation biomaterials
5.3: Cell encapsulation techniques
5.4: Common applications to diseases/disorders
5.5: Conclusion
References
Chapter 6: Encapsulation: Spray chilling and cooling
Abstract
6.1: Introduction
6.2: Spray chilling technology
6.3: Spray chilling, spray cooling, and spray congealing are three different technologies
6.4: Spray chilling vs spray drying: What's the difference?
6.5: Variables in the process
6.6: Material characteristics
6.7: Advantages and disadvantages of the spray chilling process
6.8: Applications
6.9: Characterization
6.10: Release studies
6.11: Future trends
6.12: Conclusions
References
Chapter 7: Encapsulation: Spinning disk technology
Abstract
7.1: Introduction
7.2: Principles of spinning disk encapsulation
7.3: Droplet generation parameters
7.4: Summary
References
Chapter 8: Encapsulation: Fluidized bed coating technology
Abstract
8.1: Introduction
8.2: What is fluidized bed coating technology?
8.3: Effective variables in fluidized bed coating
8.4: Novel designed fluidizing method
8.5: Pharmaceutical application of the fluidized bed coating
8.6: Conclusion
References
Chapter 9: Encapsulation: Microemulsion
Abstract
9.1: Introduction
9.2: Formulation development
9.3: Preparation of microemulsions
9.4: Characterization of microemulsions
9.5: Current trend and applications of microemulsions/encapsulation
9.6: Commercial products available in the microemulsion market
9.7: Conclusion
References
Chapter 10: Encapsulation: Electrospray
Abstract
10.1: Introduction
10.2: Basic principles of electrospray process
10.3: Morphology of electrosprayed particles
10.4: Influence of parameters
10.5: Current limitations
10.6: Summary
References
Chapter 11: Encapsulation: Melt dispersion
Abstract
11.1: Introduction
11.2: Melt dispersion: Basic principle
11.3: Melt emulsification and homogenization
11.4: Melt spraying
11.5: Materials for encapsulation
11.6: Encapsulates characteristics
11.7: Applications
11.8: Melt-dispersion technology disadvantages
11.9: Future perspectives and conclusion
References
Chapter 12: Encapsulation: Pan-coating
Abstract
12.1: Introduction
12.2: Basic principle
12.3: Conventional pan-coating method: Design and executive operation
12.4: Vented pan-coating method: Design and executive operation
12.5: Pan-coating characteristics
12.6: Applications
12.7: Troubleshooting
12.8: Conclusion
References
Chapter 13: Encapsulation via electrospinning technology
Abstract
13.1: Introduction
13.2: Electrospinning process in biomedical application
13.3: Influence of parameters
13.4: Recent advances in bioactive compound encapsulation by electrospinning method
13.5: Summary
References
Chapter 14: Microencapsulation: Spray drying
Abstract
14.1: Spray drying technique
14.2: Spray drying design and stages
14.3: Process parameters
14.4: Product characteristics
14.5: Advantages and disadvantages of spray drying
14.6: Novel devices and methods
14.7: Spray drying application in pharmaceutics
14.8: Different administration routes of spray-dried drug particles
14.9: Conclusion
References
Chapter 15: Microencapsulation: Air suspension technique
Abstract
15.1: Introduction
15.2: Conclusion
References
Chapter 16: Microencapsulation: Polymerization
Abstract
16.1: Introduction
16.2: Emulsion polymerization
16.3: In situ polymerization
16.4: Suspension polymerization
16.5: Dispersion polymerization
16.6: Interfacial polymerization
16.7: Conclusion
References
Chapter 17: Microencapsulation: Coacervation phase separation
Abstract
17.1: Introduction
17.2: Phase separation by coacervation
17.3: Conventional and novel biopolymers used in coacervation
17.4: Characterization and optimization of coacervates/complex coacervates
17.5: Recent investigation on microencapsulation of pharmaceuticals through coacervation
17.6: Conclusion
References
Chapter 18: Microencapsulation: Solvent evaporation
Abstract
18.1: Introduction
18.2: Materials selection in solvent evaporation technique
18.3: Solvent evaporation mechanisms
18.4: Kinetics of solvent evaporation
18.5: Thermodynamics of phase separation
18.6: Microcapsules morphologies
18.7: Summary
References
Chapter 19: Microencapsulation: Extrusion
Abstract
19.1: Introduction
19.2: Extrusion-based microencapsulation
19.3: Summary
References
Chapter 20: Microencapsulation: Dripping and jet break-up
Abstract
20.1: Introduction
20.2: Dripping and jet break-up; principle and theory
20.3: Particles shape: Collecting distance effect
20.4: Application
20.5: Advantages and disadvantages
20.6: Conclusion
References
Chapter 21: Microencapsulation: Annular jet process
Abstract
21.1: Introduction
21.2: Process technologies
21.3: Summary
References
Chapter 22: Microencapsulation: Phase inversion precipitation
Abstract
22.1: Introduction
22.2: Binodal and demixing procedure
22.3: Different types of phase inversion
22.4: Summary
References
Chapter 23: Cell microencapsulation
Abstract
23.1: Introduction
23.2: The requirements for cell microencapsulation technology
23.3: Applied biomaterials for cell microencapsulation
23.4: Application of cell microencapsulation in clinical and in vivo studies
23.5: Current challenges, concluding remarks, and prospects
23.6: Summary
References
Index

Farshid Sefat

Dr. Farshid Sefat is Associate Professor and Programme Leader in the Biomedical and Electronic Engineering Department at the University of Bradford (UK). He was head of Biomedical Engineering Department at King Faisal University (Saudi Arabia) and Visiting Professor at Stevens Institute of Technology (New Jersey, USA). He completed his post doctorate research assistant at University of Sheffield (UK) in cornea tissue engineering. Dr. Sefat received his Ph.D. and BEng. degrees from University of Bradford in Biomedical Engineering. His research is based on developing biomaterials to control cellular behavior with particular emphasis in developing engineered materials for various tissue engineering applications. He’s an author of >150 peer-reviewed journal articles, editorials, and review papers and >80 book chapters/edited books. He’s on the editorial boards and reviewer of >30 numerous journals including Materials Today, Acta Biomaterialia, IEEE, Bone, MDPI, Journal of Orthopaedics & Rheumatology, Materials Science and Engineering C and Journal of Biomechanics.

Affiliations and expertise

Associate Professor, Biomedical and Electronic Engineering Department, University of Bradford, UK

Gholamali Farzi

Dr. Gholamali Farzi is a Professor of Polymer Engineering at Faculty of Engineering in Hakim Sabzevari University, Sabzevar, Iran, where he is teaching polymer engineering and polymer composite materials for students in Ph.D. and MSc level. Dr. Farzi obtained his Ph.D. from the University of Lyon (France) in 2007, then he completed his post-doctoral fellowship in University of Lyon 1. Dr Farzi doing extensive research in the field of polymer encapsulation and he has very close collaboration with French universities.

Affiliations and expertise

Professor, Polymer Engineering, Faculty of Engineering, Hakim Sabzevari University, Sabzevar, Iran

Masoud Mozafari

Dr. Masoud Mozafari is a Fellow at Lunenfeld Tanenbaum Research Institute, Mount Sinai Health Hospital, University of Toronto. He was previously Assistant Professor and Director of the Bioengineering Lab, at the Nanotechnology and Advanced Materials Department, Materials and Energy Research Center, Cellular and Molecular Research Center, and Department of Tissue Engineering and Regenerative Medicine of the Iran University of Medical Sciences (IUMS), Tehran, Iran. Dr. Mozafari’s research interests range across biomaterials, nanotechnology, and tissue engineering, and he is known for the development of strategies for the treatment of damaged tissues and organs, and controlling biological substances for targeted delivery into the human body. Dr. Mozafari has received several awards, including the Khwarizmi Award and the Julia Polak European Doctorate Award for outstanding translational research contributions to the field of biomaterials. He has also received the WIPO Medal for Inventors from The World Intellectual Property Organization (WIPO), in recognition of his contributions to economic and technological development. Dr. Mozafari is currently working on the editorial board of several journals.

Affiliations and expertise

Research Fellow, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Canada

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Principles of Biomaterials Encapsulation: Volume One

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Farshid Sefat

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Masoud Mozafari