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Principles and Practice of Pediatric Infectious Diseases
- 6th Edition - March 10, 2022
- Editors: Sarah S. Long, Charles G. Prober, Marc Fischer, David Kimberlin
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 7 5 6 0 8 - 2
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 7 5 6 0 9 - 9
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 7 1 3 4 - 2
Comprehensive in scope, yet concise and easy to manage, Principles and Practice of Pediatric Infectious Diseases, 6th Edition, by Drs. Sarah S. Long, Charles G. Prober, Marc Fisc… Read more
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Request a sales quoteComprehensive in scope, yet concise and easy to manage, Principles and Practice of Pediatric Infectious Diseases, 6th Edition, by Drs. Sarah S. Long, Charles G. Prober, Marc Fischer, and new editor David Kimberlin, is your go-to resource for authoritative information on infectious diseases in children and adolescents. A veritable "who's who" of global authorities provides the practical knowledge you need to understand, diagnose, and manage almost any pediatric infectious disease you may encounter.
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Covers the latest aspects of the COVID-19 pandemic, including manifestations, diagnosis, management, and prevention of SARS-CoV-2 infection.
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Features an easy-access format with high-yield information boxes, highlighted key points, and an abundance of detailed illustrations and at-a-glance tables.
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Allows quick look-up by clinical presentation, pathogen, or type of host.
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Highlights expanding antimicrobial resistance patterns and new therapies for viral and fungal infections and resistant bacterial infections.
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Includes coverage of the latest vaccine products, recommendations, and effectiveness.
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Reviews emerging healthcare-associated infections, their management, control, and prevention.
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Contains a new chapter on Chorioamnionitis and Neonatal Consequences.
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Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
- Cover image
- Title page
- Disclaimer
- Table of Contents
- Copyright
- Preface
- Acknowledgments
- Dedication
- Contributors
- Understanding, Controlling, and Preventing Infectious Diseases
- Section A. Epidemiology and Control of Infectious Diseases
- 1. Principles of Epidemiology and Public Health
- Descriptive Epidemiology
- Analytic Epidemiology
- Vaccine Efficacy and Effectiveness Studies
- Disease Control and Public Health Policy
- Evaluating the Medical Literature
- 2. Pediatric Healthcare: Infection Epidemiology, Prevention and Control, and Antimicrobial Stewardship
- Risk Factors for Healthcare-Associated Infections In Children
- Transmission
- Epidemiologically Important Pathogens
- Prevention Programs
- Antimicrobial Stewardship
- Isolation Precautions
- Environmental Measures
- Visitation Policies
- Occupational Health
- Infection Prevention and Control in the Nonacute Care Setting
- 3. Infections Associated With Group Childcare
- Types of Childcare Settings
- Epidemiology, Etiology, and Control of Infections
- Vaccine-Preventable Diseases
- Infections Associated With Animals
- Infectious Diseases in Adults
- Economic Impact of Group Childcare Illness
- Prevention
- 4. Infectious Diseases in Refugee and Internationally Adopted Children
- Guidelines for Evaluation
- Preventive Measures
- Section B. Prevention of Infectious Diseases
- 5. Passive Immunization
- Standard Immune Globulin (Human)
- Specific Immune Globulins for Intramuscular Administration
- Immune Globulin Intravenous (Human)
- Specific Immune Globulins for Intravenous Administration
- Monoclonal Antibodies
- Immunoglobulin Products Prepared from Animal Plasma
- Adverse Reactions to Immune Globulins Prepared from Human Plasma
- Product Shortages
- The Future
- 6. Active Immunization
- Immunization and Vaccines: Overview
- Vaccine Development, Licensure, and Approval
- Principles of Immunization Programs
- Routine Childhood and Adolescent Vaccines
- Selected Other Vaccines that can be Used in Children and Adolescents
- Sources of Information on Vaccines
- 7. Antimicrobial Chemoprophylaxis
- Chemoprophylaxis in Healthy Children
- Chemoprophylaxis for Surgical Procedures and Trauma
- Chemoprophylaxis in Special Situations and in Children With Conditions Predisposing to Infection
- 8. Protection of Travelers
- Preparation For Travel
- Malaria
- Travelers Diarrhea
- Emerging Infectious Diseases
- Immunocompromised Travelers
- Return From Travel
- Section C. Host Defenses Against Infectious Diseases
- 9. Immunologic Development and Susceptibility to Infection
- Innate Immune Response
- Adaptive Immune Response
- Interrelationships And The Future
- 10. Fever and the Inflammatory Response
- Fever
- Inflammatory Response
- Acknowledgment
- Clinical Syndromes and Cardinal Features of Infectious Diseases: Approach to Diagnosis and Initial Management
- Section A. Septicemia, Toxin-, and Inflammation-Mediated Syndromes
- 11. The Systemic Inflammatory Response Syndrome, Sepsis, and Septic Shock
- Epidemiology
- Definitions
- Etiology
- Pathophysiology
- Clinical Manifestations, Assessment and Early Initiation of Therapy
- Management
- Future Considerations
- 12. Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome
- Primary Hemophagocytic Lymphohistiocytosis
- Secondary Hemophagocytic Lymphohistiocytosis
- Pathogenesis
- Clinical, Radiologic, and Laboratory Features
- Diagnosis and Differential Diagnosis
- Treatment
- Hematopoietic Stem Cell Transplantation
- Prognosis
- Section B. Cardinal Symptom Complexes
- 13. Mucocutaneous Symptom Complexes
- Specific Distinguishing Characteristics
- Diagnosis and Empiric Therapy
- 14. Fever Without Localizing Signs
- Etiologic Agents
- Epidemiology
- Management
- 15. Prolonged, Recurrent, and Periodic Fever Syndromes
- Fever of Unknown Origin
- Deconditioning After Prolonged Perceived Illness
- Recurrent Fever and Periodic Fever Syndromes
- Other Autoinflammatory Diseases with Recurrent Fever
- 16. Lymphatic System and Generalized Lymphadenopathy
- Anatomy and Function of Lymphoid Tissue
- Developmental Changes
- Characteristics of Lymphadenopathy
- Pathogenesis of Lymphadenopathy and Lymphadenitis
- Histopathology of Lymphadenitis
- Lymphocutaneous and Oculoglandular SyndromeS
- Infectious Causes of Generalized Lymphadenopathy
- Other Causes of Generalized Lymphadenopathy
- 17. Cervical Lymphadenitis and Neck Infections
- Epidemiology
- Lymphatic Flow and Fascial Spaces of the Head and Neck
- Oculoglandular Syndrome of Parinaud
- Infectious Causes of Lymphadenitis
- Noninfectious Causes of Lymphadenopathy
- Neck Masses Not Involving Lymph Nodes
- Diagnostic Approach to Cervical Lymphadenopathy
- Management
- Complications
- 18. Mediastinal and Hilar Lymphadenopathy
- Anatomy of the Mediastinum
- Lymphatic Drainage of the Lungs and Pleura
- Epidemiology
- Characteristics of Lymphadenopathy
- Clinical Manifestations
- Diagnosis
- Infectious Causes
- Noninfectious Causes
- Diagnostic Approach
- 19. Abdominal and Retroperitoneal Lymphadenopathy
- Epidemiology and Differential Diagnosis
- Diagnostic Tests
- Management
- 20. Localized Lymphadenitis, Lymphadenopathy, and Lymphangitis
- Lymphadenopathy and Lymphadenitis
- Lymphangitis
- 21. Respiratory Tract Symptom Complexes
- Mucopurulent Rhinorrhea
- Stridor
- Cough
- Tachypnea and Other Signs of Lower Respiratory Tract Disorders
- Differentiating Features of Pneumonia
- Hemoptysis
- 22. Abdominal Symptom Complexes
- Approach
- Acute Abdominal Pain
- Chronic or Recurrent Abdominal Pain
- 23. Neurologic Syndromes
- Headache
- Altered Mental Status
- Ataxia
- Hypotonia and Weakness
- 24. Musculoskeletal Symptom Complexes
- History
- Physical Examination
- Laboratory Evaluation and Imaging
- Limb Pain
- Back Pain
- Chest Pain
- Section C. Oral Infections and Upper and Middle Respiratory Tract Infections
- 25. Infections of the Oral Cavity
- Odontogenic Infections
- Mucosal Infections (Gingivitis, Mucositis, and Stomatitis)
- Complications of Odontogenic and Mucosal Infections
- Infections of the Salivary Gland
- Osteomyelitis
- 26. The Common Cold
- Etiology
- Epidemiology
- Pathogenesis
- Clinical Manifestations
- Differential Diagnosis
- Clinical Approach
- Management
- Complications
- Recent Advances
- 27. Pharyngitis
- Viral Pharyngitis
- Bacterial Pharyngitis
- 28. Infections Related to the Upper and Middle Airways
- Peritonsillar Abscess (Quinsy)
- Retropharyngeal AbScess
- Parapharyngeal Abscess
- Lemierre Syndrome
- Acute Epiglottitis (Supraglottitis)
- Croup (Laryngotracheitis)
- Acute Laryngitis
- Bacterial Tracheitis
- Acute Bronchitis
- 29. Otitis Media
- Acute Otitis Media
- Pathogenesis
- Microbiology
- Epidemiology
- Diagnosis
- Treatment
- Duration of Antimicrobial Therapy
- Other Forms of Otitis Media, Complications, and Sequelae
- 30. Otitis Externa and Necrotizing Otitis Externa
- Otitis Externa
- Necrotizing Otitis Externa
- 31. Mastoiditis
- Acute Mastoiditis
- Chronic Mastoiditis
- 32. Sinusitis
- Pathogenesis
- Clinical Manifestations
- Diagnostic Methods
- Microbiology
- Medical Management
- Surgical Management
- Section D. Lower Respiratory Tract Infections
- 33. Bronchiolitis
- Etiologic Agents
- Epidemiology
- Pathogenesis And Pathologic Findings
- Clinical Manifestations
- Diagnosis
- Management
- Prognosis, Complications, And Sequelae
- Prevention
- 34. Acute Pneumonia and Its Complications
- Acute Pneumonia
- Acute Complicated Pneumonia
- 35. Persistent and Recurrent Pneumonia
- Persistent or Progressive Pneumonia At A Single Site
- Persistent or Recurrent Pneumonia Not Confined To A Single Site
- 36. Pneumonia in the Immunocompromised Host
- Etiologic Agents And Epidemiology
- Secondary Immunodeficiency
- Pathogenesis And Pathologic Findings
- Clinical Manifestations And Etiologic Agents
- Management, Empiric And Definitive Therapy
- Prevention
- Section E. Cardiac and Vascular Infections
- 37. Endocarditis and Other Intravascular Infections
- Infective Endocarditis
- Other Endocarditis-Like Intravascular Infections
- 38. Myocarditis
- Etiology
- Epidemiology
- Pathophysiology
- Clinical Manifestations
- Differential Diagnosis
- Laboratory Findings and Diagnosis
- Management
- Complications
- Prevention
- 39. Pericarditis
- Etiology
- Epidemiology
- Pathogenesis
- Clinical Manifestations
- Differential Diagnosis
- Laboratory Findings and Diagnosis
- Management
- Complications
- Prognosis
- Section F. Central Nervous System Infections
- 40. Acute Bacterial Meningitis Beyond the Neonatal Period
- Etiologic Agents and Epidemiology
- Pathophysiology
- Clinical Manifestations
- Laboratory Findings And Diagnosis
- Management
- Adjunctive Therapy
- Considerations for Unusual Organisms135–138
- Prognosis and Sequelae
- Care of Contacts and Vaccine Prevention
- 41. Chronic Meningitis
- Etiology and Epidemiology
- Main Features of Agents Causing Chronic Meningitis
- Approach to Diagnosis
- Empiric Therapy
- 42. Recurrent Meningitis
- Etiologic Agents
- Epidemiology
- Pathogenesis
- Clinical Manifestations
- Diagnosis
- Treatment
- Prevention and Prophylaxis
- 43. Aseptic and Viral Meningitis
- Etiologic Agents And Epidemiology
- Pathogenesis and Pathology
- Clinical Manifestations
- Differential Diagnosis
- Laboratory Findings and Diagnosis
- Management and Empiric and Definitive Therapy
- Complications, Prognosis, and Sequelae
- Prevention
- 44. Encephalitis
- Etiologic Agents and Epidemiology
- Pathogenesis
- Clinical Manifestations and Differential Diagnosis
- Special Hosts
- Laboratory Findings
- Clinical Approach
- Management
- Complications and Prognosis
- Prevention
- 45. Parainfectious and Postinfectious Neurologic Syndromes
- Cranial Nerve Palsies
- Cerebellitis
- Transverse Myelitis
- Guillain-Barré Syndrome
- Acute Flaccid Myelitis
- Autoimmune Encephalitis
- Acute Disseminated Encephalomyelitis
- 46. Focal Suppurative Infections of the Nervous System
- Etiology
- Epidemiology
- Pathogenesis
- Clinical Manifestations
- Differential Diagnosis
- Laboratory Findings and Diagnosis
- Management
- Complications And Prognosis
- 47. Eosinophilic Meningitis
- Infectious Etiologies
- Diagnosis
- Treatment And Prevention
- Section G. Genitourinary Tract Infections
- 48. Urinary Tract Infections, Renal Abscess, and Other Complex Renal Infections
- Etiologic Agents
- Epidemiology
- Definitions
- Pathogenesis
- Risk Factors for Bacteriuria, Recurrent UTI, and Renal Damage
- Clinical Manifestations
- Laboratory Findings
- Management
- Complications and Sequelae
- Complex Urinary Tract Infections: Imaging Evaluation
- Special Considerations
- 49. Sexually Transmitted Infection Syndromes
- Prevention and Screening of Sexually Transmitted Infections
- Sexually Transmitted Infection Syndromes
- Discharge and Dysuria
- Anal Discharge and Gastrointestinal Syndromes
- Genital Ulcer and Lymphadenopathy Syndrome
- Pelvic or Scrotal Pain
- Pharyngeal Syndromes
- 50. Genitourinary Skin and Mucous Membrane Infections and Inguinal Lymphadenopathy
- Inguinal Lymphadenopathy with Genital Ulcers
- Inguinal Lymphadenopathy Without Genital Ulcers
- Genital Dermatosis
- 51. Urethritis, Vulvovaginitis, and Cervicitis
- Urethritis
- Vulvovaginitis
- Cervicitis
- 52. Pelvic Inflammatory Disease
- Epidemiology
- Etiologic Agents
- Pathophysiology
- Diagnosis
- Laboratory Findings
- Management
- Complications and Sequelae
- Prevention
- 53. Epididymitis, Orchitis, and Prostatitis
- Epididymitis
- Orchitis
- Mumps Orchitis
- Bacterial Epididymo-orchitis
- Prostatitis
- 54. Infectious Diseases Associated With Child Abuse
- Medical Evaluation
- Infectious Agents
- Section H. Gastrointestinal and Tract Infections and Intoxications
- 55. Approach to the Diagnosis and Management of Gastrointestinal Tract Infections
- Epidemiology
- Pathogenesis
- Clinical Manifestations
- Considerations of the Host and Exposures
- Diagnosis
- Management
- Prevention
- 56. Viral Gastroenteritis
- Etiologic Agents
- Epidemiology
- Pathogenesis
- Clinical Manifestations and Differential Diagnosis
- Laboratory Diagnosis
- Management
- Prevention
- 57. Inflammatory Enterocolitis
- Etiologic Agents
- Epidemiology
- Pathogenesis
- Clinical Manifestations
- Complications
- Enterocolitis in Immunocompromised Children
- Differential Diagnosis
- Diagnostic Evaluation
- Management
- 58. Enteric Diseases Transmitted Through Food, Water, and Zoonotic Exposures
- Epidemiology
- Clinical Manifestations, Differential Diagnosis, and Clinical Approach
- Laboratory Findings and Diagnosis
- Management
- Complications, Prognosis, and Sequalae
- Prevention
- Section I. Intra-abdominal Infections
- 59. Acute Hepatitis
- Approach To Evaluation And Diagnosis
- Infectious Causes
- Anatomic Causes
- Autoimmune Causes
- Metabolic Causes
- Toxins And Medications
- Tumors
- Idiopathic Causes
- 60. Chronic Hepatitis
- Approach to Evaluation
- Etiologic Factors
- Acknowledgement
- 61. Granulomatous Hepatitis
- Pathogenesis And Pathologic Findings
- Clinical Manifestations And Differential Diagnosis
- Diagnosis
- Management And Outcome
- 62. Acute Pancreatitis
- Pathogenesis
- Clinical Manifestations
- Diagnosis
- Differential Diagnosis
- Treatment
- Clinical Course
- 63. Cholecystitis and Cholangitis
- Pathogenesis
- Etiology
- Clinical And Laboratory Features
- Diagnosis
- Management
- Complications
- 64. Peritonitis
- Epidemiology
- Pathophysiology
- Etiology
- Clinical Manifestations
- Diagnosis
- Management
- Complications And Prognosis
- Prevention
- 65. Appendicitis
- Epidemiology
- Pathogenesis
- Etiology
- Clinical Manifestations and Differential Diagnosis
- Diagnosis
- Computed Tomography
- Magnetic Resonance Imaging
- Management
- 66. Intra-abdominal, Visceral, and Retroperitoneal Abscesses
- Intra-Abdominal Abscesses
- Visceral Organ Abscesses
- Retroperitoneal Abscesses
- Section J. Skin and Soft-Tissue Infections
- 67. Superficial Bacterial Skin Infections and Cellulitis
- Superficial Infections
- Adnexal and Follicular Infections
- Hand and Nail Infections
- Ulcerative Infections
- Soft Tissue Infections
- 68. Erythematous Macules and Papules
- Approach
- Etiologic Agents, Epidemiology, and Pathogenesis
- 69. Vesicles and Bullae
- Etiology and Clinical Manifestations
- Diagnosis
- 70. Purpura
- Types of Lesions and Pathogenesis
- Causes by Type of Lesion
- 71. Urticaria and Erythema Multiforme
- Urticaria
- Erythema Multiforme
- 72. Papules, Nodules, and Ulcers
- Molluscum Contagiosum
- Erythema Nodosum
- Gianotti-Crosti Syndrome
- Other Exanthematous Infections
- Autosensitization Reaction
- 73. Subcutaneous Tissue Infections and Abscesses
- Etiology
- Abscesses
- Necrotizing Soft Tissue Infections
- 74. Myositis, Pyomyositis, and Necrotizing Fasciitis
- Myositis
- Pyomyositis
- Necrotizing Fasciitis
- Pathogenesis
- Diagnosis
- Treatment
- Section K. Bone and Joint Infections
- 75. Osteomyelitis
- Acute Hematogenous Osteomyelitis
- Treatment
- Special Clinical Situations
- Osteomyelitis Due To Unusual Organisms
- Nonhematogenous Osteomyelitis
- Puncture Wound Osteochondritis of The Foot
- Chronic NonBacterial Osteomyelitis/Recurrent Multifocal Osteomyelitis
- Chronic Osteomyelitis
- 76. Infectious and Inflammatory Arthritis
- Infectious Arthritis
- Special Situations And Pathogens
- Reactive Arthritis
- 77. Diskitis
- Epidemiology and Etiology
- Pathogenesis and Pathologic Findings
- Clinical Manifestations
- Differential Diagnosis
- Diagnosis
- Management
- Outcome
- 78. Transient Synovitis
- Etiology And Epidemiology
- Clinical Manifestations
- Diagnosis
- Differential Diagnosis
- Treatment And Prognosis
- Section L. Eye Infections
- 79. Conjunctivitis in the Neonatal Period (Ophthalmia neonatorum)
- Pathogenesis
- Etiologic Agents
- Prophylaxis/Prevention
- 80. Conjunctivitis Beyond the Neonatal Period
- Acute Conjunctivitis
- Chronic Conjunctivitis
- 81. Infective Keratitis
- Etiology
- Interstitial And Marginal Keratitis
- Pathogenesis
- Clinical Manifestations And Diagnostic Procedures
- Management
- 82. Infective Uveitis, Retinitis, and Chorioretinitis
- Etiologic Agents of Anterior Uveitis
- Etiologic Agents of Posterior Uveitis (Retinitis)
- 83. Endophthalmitis
- Etiologic Agents
- Epidemiology and Host Factors
- Pathophysiology
- Clinical Manifestations
- Diagnostic Evaluation
- Management
- Outcome
- Prevention
- 84. Preseptal and Orbital Infections
- Differential Diagnosis
- Pathogenesis
- Preseptal Infections
- Orbital Infection
- Section M. Infections Related to Trauma, Animals, and Ticks
- 85. Infection Related To Trauma
- Epidemiology
- Pathogenesis
- Clinical Manifestations and Diagnosis
- General Principles of Management
- Infections Related To Site of Trauma
- 86. Infections Related to Burns
- Burn Wound Infection
- Other Infections
- Treatment
- Management of Outpatients
- Prevention
- 87. Infection Related To Bites
- Etiologic Agents
- Epidemiology
- Pathogenesis
- Clinical Manifestations, Differential Diagnosis, And Clinical Approach
- Laboratory Findings And Diagnosis
- Management And Presumptive Therapy
- Empiric Management When Infection Occurs
- Complications
- Prognosis And Sequelae
- Prevention
- 88. Infections Related to Pets and Exotic Animals
- Categories of Pets
- Infections (Zoonoses) Associated With Nontraditional Pets
- Infections Associated With Animals In Public Settings
- Rabies
- Injuries And Allergies
- Reportable Diseases Acquired From Nontraditional Pets And Animals In Public Settings
- Prevention Measures
- Recommendations And Guidelines
- 89. Tickborne Infections
- Epidemiology
- Pathogenesis
- Clinical Manifestations
- Diagnosis
- Treatment
- Prevention
- Section N. Infections of the Fetus and Newborn
- 90. Clinical Approach to the Neonate With Suspected Infection
- Early-Onset Sepsis in Late Preterm and Term Infants
- Early-Onset Sepsis in Preterm Infants
- Hospital-Acquired Late-Onset Sepsis
- Community-Acquired Late-Onset Sepsis
- Diagnostic Evaluation
- 91. Chorioamnionitis and Neonatal Consequences
- 92. Bacterial Infections in the Neonate
- Description of Pathogens
- Epidemiology
- Pathogenesis
- Clinical Manifestations
- Laboratory Findings and Diagnostic Tests
- Treatment
- Special Considerations
- Prevention
- 93. Viral Infections in the Fetus and Neonate
- Pathogenesis
- Epidemiology
- Clinical Manifestations
- Approach to the Neonate With Suspected Viral Infection
- 94. Healthcare-Associated Infections in the Neonate
- Definitions, Epidemiology, and Anatomic Sites Of Infection
- Pathogens Associated with Late-Onset Infections
- Clinical Manifestations
- Laboratory Diagnosis
- Treatment
- Management of Persistent Bloodstream Infections
- Prevention of Healthcare-Associated Infections
- Section O. Infections and Transplantation
- 95. Infections in Solid Organ Transplant Recipients
- Predisposition To Infection
- Timing of Infections
- Pathogen- And Organ-Specific Infections
- Management And Preventive Measures
- 96. Infections in Hematopoietic Cell Transplant Recipients
- Etiologic Agents
- Epidemiology
- Clinical Syndromes, Differential Diagnosis, And Clinical Approach
- Laboratory Findings And Diagnosis
- Management And Presumptive Therapy
- Prevention
- Section P. Infections and Cancer
- 97. Risk Factors and Infectious Agents in Children With Cancer: Fever and Granulocytopenia
- Epidemiology
- Pathogenesis and Etiologic Factors
- Etiologic Agents
- Differential Diagnosis and Clinical Approach to Diagnosis
- Management and Empiric Therapy
- Prognosis and Sequelae
- Recombinant Human Colony-Stimulating Factors
- Prevention
- 98. Clinical Syndromes of Infection in Children With Cancer
- Catheter-Associated Bacteremia and Soft-Tissue Infections
- Skin and Skin Structure Tissue Infections
- Pulmonary Infections
- Infections of the External and Middle Ear and Sinuses
- Gastrointestinal Tract Infections
- Central Nervous System Infections
- Cystitis
- Osteoarticular Infections
- Section Q. Infections Associated With Hospitalization and Medical Devices
- 99. Healthcare-Associated Infections
- Bloodstream Infections
- Respiratory Tract Infections
- Gastrointestinal Tract Infections
- Surgical Site Infections
- 100. Clinical Syndromes of Device-Associated Infections
- Intravascular Catheter-Related Infections
- Infections of Prosthetic Valves, Patches, and Vascular Grafts
- Infections Associated With Pacemakers and Left Ventricular Assist Devices
- Infections of Central Nervous System Devices
- Infections Associated With Peritoneal Catheters
- Infections of Orthopedic Devices
- Infection of Urinary Catheters
- Section R. Infections in Patients With Deficient Defenses
- 101. Evaluation of the Child With Suspected Immunodeficiency
- Anatomic and Physiologic Abnormalities
- Underlying Conditions
- Primary Immunodeficiency Disorders
- Clinical Approach to the Child With Recurrent Infections
- Laboratory Findings and Diagnosis
- Management
- 102. Infectious Complications of Antibody Deficiency
- Approach to the Patient With A Suspected Antibody Deficiency
- Agammaglobulinemias: Severely Reduced IgG, IgA, and IgM With Absent B Lymphocytes
- Common Variable Immunodeficiency Disorders: Severely Reduced IgG, IgA, and/or IgM With Normal or Low Numbers of B Lymphocytes
- Hyper-IgM Syndromes (Hims, Class Switch Recombination Defects): Reduced IgG and IgA With Normal or Elevated IgM and Normal Numbers of B Lymphocytes
- Isotype or Light Chain Deficiencies With Normal Numbers of B Lymphocytes
- Specific Antibody Deficiency With Normal IgG Concentrations and Normal Numbers of B Lymphocytes
- Transient Hypogammaglobulinemia of Infancy
- Acquired Antibody Deficiency
- 103. Infectious Complications of Complement Deficiency and Diseases of Its Dysregulation
- Biochemistry and Biology of Complement
- Genetically Determined Deficiencies of Complement
- Secondary Deficiencies of Complement
- Diagnosis of Complement Deficiencies
- Management
- 104. Infectious Complications of Dysfunction or Deficiency of Polymorphonuclear and Mononuclear Phagocytes
- Etiologic Agents and Pathologic Findings
- Clinical Manifestations and Clinical Approach
- Management
- Complications
- Prognosis, Sequelae and Advances in Restoration of Function
- Prevention of Infection
- Specific Conditions
- 105. Infectious Complications of Cell-Mediated Immunity Other Than AIDS: Primary Immunodeficiencies
- Overview of Cell-Mediated Immunity and its Role in Control of Infections
- Severe Combined Immunodeficiency Syndrome
- Selected Non−Severe Combined Immunodeficiency Disease Disorders of T Cells and Natural Killer Cells
- 106. Infectious Complications in Special Hosts
- Sickle Hemoglobinopathy
- Asplenia And Polysplenia
- Renal Disease
- Ascites
- Iron Overload States
- Metabolic Syndrome
- Ciliary Dysfunction
- Cystic Fibrosis
- 107. Infections Related to Biologic Response Modifying Drug Therapy
- Infections Associated With use of BRMs
- Considerations For Patients Prior to Starting and During Use of BRMs
- Considerations of Infant Exposures to Maternal Brms
- 108. Infectious Complications of Corticosteroid Therapy
- Infectious Adverse Effects of Glucocorticoids
- Other Considerations
- Section S. Human Immunodeficiency Virus and the Acquired Immunodeficiency Syndrome
- 109. Epidemiology and Prevention of HIV Infection in Infants, Children, and Adolescents
- Epidemiology
- Clinical Manifestations and Progression
- Prevention
- 110. Immunopathogenesis of HIV-1 Infection
- Hiv Replication
- Immune Consequences of Untreated HIV-1 Infection
- Effects of Antiviral Therapy on Immune Function and Viral Reservoirs
- 111. Diagnosis and Clinical Manifestations of HIV Infection
- Diagnosis
- Clinical Signs, Symptoms, and Laboratory Abnormalities Associated With HIV Infection
- Organ System−Specific Manifestations of HIV Infection
- Prognosis
- 112. Infectious Complications of HIV Infection
- Pathogenesis
- Immune Reconstitution Inflammatory Syndrome
- Epidemiology and Etiologic Agents
- Approach to Suspected Infection in a Child Living With HIV
- Prevention of Infections
- Prognosis
- 113. Management of HIV Infection
- Antiretroviral Therapy
- Clinical and Laboratory Monitoring
- Infection Prevention: Immunizations and Chemoprophylaxis
- Growth and Nutrition
- Consequences of Infection and Antiretroviral Therapy by Organ Systems
- Transition of Care
- Etiologic Agents of Infectious Diseases
- A. Bacteria
- 114. Classification of Bacteria
- Identification By Phenotypic Characteristics
- Identification By Molecular Analysis
- Gram-Positive Cocci
- 115. Staphylococcus aureus
- Microbiology and Pathogenesis
- Epidemiology
- Clinical Manifestations
- Management
- Prevention
- 116. Coagulase-Negative Staphylococci and Micrococcaceae
- Coagulase-Negative Staphylococci
- Description of The Pathogen
- Pathogenesis
- Epidemiology
- Clinical Manifestations
- Treatment
- Prevention
- Coagulase-Negative Micrococcaceae
- 117. Classification of Streptococci
- 118. Streptococcus pyogenes (Group A Streptococcus)
- The Pathogen, Pathogenesis And Spectrum of Disease
- Pathogenesis And Virulence
- Acute Rheumatic Fever
- Acute Glomerulonephritis
- Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections
- Poststreptococcal Reactive Arthritis
- 119. Streptococcus agalactiae (Group B Streptococcus)
- The Pathogen and Pathogenicity
- Epidemiology
- Clinical Manifestations
- Laboratory Findings And Diagnostic Tests
- Treatment
- Special Considerations
- Prevention
- 120. Enterococcus Species
- Description of Pathogens
- Epidemiology
- Clinical Manifestations
- Treatment
- Prevention
- 121. Viridans Streptococci, Abiotrophia and Granulicatella Species, and Streptococcus bovis Group
- Description of Pathogens
- Epidemiology
- Clinical Manifestations
- Treatment
- Prevention
- 122. Groups C and G Streptococci
- Characteristics of the Pathogens
- Epidemiology
- Clinical Manifestations
- Treatment
- 123. Streptococcus pneumoniae
- Characteristics of the Pathogen
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Prognosis
- Prevention
- 124. Other Gram-Positive, Catalase-Negative Cocci: Leuconostoc and Pediococcus Species and Other Genera
- Characteristics Of Pathogens
- Epidemiology
- Clinical Manifestations
- Therapy
- Gram-Negative Cocci
- 125. Neisseria meningitidis
- Microbiology
- Virulence And Pathogenesis
- Immunity
- Epidemiology
- Clinical Manifestations
- Diagnosis
- Metabolic And Hematologic Abnormalities
- Management
- Emergency Management
- Outcome
- 126. Neisseria gonorrhoeae
- Microbiology, Virulence, Immunity, And Pathogenesis
- Epidemiology
- Antibiotic Resistance
- Clinical Manifestations
- Laboratory Findings And Diagnosis
- Treatment
- Special Considerations
- Prevention And Control
- 127. Other Neisseria Species
- Microbiology and Laboratory Diagnosis
- Epidemiology
- Clinical Manifestations of Infection
- Special Considerations and Prevention
- Gram-Positive Bacilli
- 128. Arcanobacterium haemolyticum
- Epidemiology
- Microbiology, Pathogenesis, and Virulence
- Clinical Manifestations
- Diagnosis
- 129. Bacillus Species (Including Anthrax)
- Microbiology
- Bacillus Anthracis
- Bacillus Cereus
- Bacillus Subtilis and other Bacillus Species
- 130. Corynebacterium diphtheriae
- The Pathogen
- Epidemiology
- Pathogenesis
- Clinical Manifestations
- Management of Symptomatic Patients
- Management of Others
- Prevention
- 131. Other Corynebacteria
- Corynebacterium Jeikeium
- Other Corynebacterium Species
- 132. Listeria monocytogenes
- Description of the Pathogen
- Epidemiology
- Pathogenesis
- Immunity
- Clinical Syndromes
- Diagnosis
- Treatment
- Prevention
- 133. Other Gram-Positive Bacilli
- Erysipelothrix Rhusiopathiae
- Rothia Dentocariosa
- Rhodococcus (Corynebacterium) Equi
- Gardnerella Vaginalis
- Lactobacillus Species
- Tsukamurella Species
- Cellulosimicrobium (Formerly Oerskovia) Species
- Kurthia Species
- 134. Mycobacterium tuberculosis
- Immunology and Pathogenesis
- Epidemiology
- Clinical Manifestations
- Diagnosis
- Therapy
- Bacillus Calmette–Guérin Vaccines
- 135. Mycobacterium Nontuberculosis Species
- Epidemiology
- Pathogenesis
- Laboratory Diagnosis
- Clinical Manifestations
- Treatment
- Prevention
- 136. Nocardia Species
- Microbiology
- Epidemiology
- Pathogenesis
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Enterobacteriaceae: Gram-Negative Bacilli
- 137. Escherichia coli
- Pathogenesis
- Epidemiology
- Clinical Manifestations
- Post-Diarrheal Manifestations
- Laboratory Findings And Diagnosis
- Treatment
- Prevention
- 138. Klebsiella and Raoultella Species
- Microbiology And Epidemiology
- Clinical Manifestations
- Treatment
- Prevention
- 139. Klebsiella granulomatis: Granuloma Inguinale (Donovanosis)
- Clinical Manifestations
- Laboratory Diagnosis
- Management
- Prevention And Control
- 140. Enterobacter, Cronobacter, and Pantoea Species
- Microbiology And Epidemiology
- Clinical Manifestations
- Treatment
- 141. Citrobacter Species
- Microbiology And Epidemiology
- Clinical Manifestations
- Treatment
- 142. Less Commonly Encountered Enterobacterales
- Microbiology, Epidemiology, Clinical Manifestations, and Treatment
- 143. Plesiomonas shigelloides
- Description of Pathogen
- Clinical Manifestations and Diagnosis
- Treatment
- 144. Proteus, Providencia, and Morganella Species
- Microbiology and Epidemiology
- Clinical Manifestations
- Treatment
- 145. Serratia Species
- Microbiology
- Epidemiology
- Clinical Manifestations
- Management
- Acknowledgments
- 146. Salmonella Species
- Description of The Pathogen
- Epidemiology
- Clinical Manifestations
- Laboratory Findings And Diagnostic Tests
- Treatment
- Special Considerations
- Prevention
- 147. Shigella Species
- The Pathogen, Virulence Factors, and Pathogenesis
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Prevention
- 148. Yersinia Species
- Pathogens and Pathogenesis
- Yersinia enterocolitica
- Yersinia pseudotuberculosis
- Yersinia pestis
- Nonenterobacteriaceae: Gram-Negative Bacilli
- 149. Acinetobacter Species
- Microbiology
- Epidemiology
- Clinical Manifestations
- Treatment
- 150. Aeromonas Species
- Description of the Pathogen
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnostic Tests
- Treatment
- Special Considerations
- Prevention
- 151. Less Commonly Encountered NonentericGram-Negative Bacilli
- Microbiology and Epidemiology
- Clinical Manifestations, Diagnosis, and Treatment
- 152. Eikenella, Pasteurella, and Chromobacterium Species
- Microbiology
- Pathophysiology And Epidemiology
- Clinical Manifestations
- Treatment And Prevention
- 153. Moraxella Species
- Microbiology
- Epidemiology
- Clinical Manifestations
- Treatment
- Prevention
- 154. Pseudomonas Species and Related Organisms
- 155. Pseudomonas aeruginosa
- Microbiology
- Virulence Factors and Pathogenesis
- Epidemiology and Clinical Manifestations
- Treatment
- Prevention
- 156. Burkholderia cepacia Complex and Other Burkholderia Species
- Burkholderia Cepacia Complex
- Burkholderia Gladioli
- Burkholderia Pseudomallei Group
- 157. Stenotrophomonas maltophilia
- Virulence Factors
- Epidemiology
- Clinical Manifestations and Treatment
- 158. Vibrio cholerae (Cholera)
- The Pathogen And Microbiology
- Virulence And Pathogenesis
- Immune Response And Susceptibility
- Epidemiology
- Clinical Manifestations
- Laboratory Findings And Diagnosis
- Treatment
- Prevention
- 159. Other Vibrio Species
- Description of the Pathogens
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnostic Tests
- Treatment
- Prevention
- Gram-Negative Coccobacilli
- 160. Bartonella Species (Cat-Scratch Disease)
- The Pathogen And Epidemiology
- Clinical Manifestations
- Laboratory Findings And Diagnosis
- Treatment
- Complications, Sequelae, And Prognosis
- Prevention
- 161. Brucella Species (Brucellosis)
- Pathogen and Pathogenesis
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment and Outcome
- Prevention
- 162. Bordetella pertussis (Pertussis) and Other Bordetella Species
- Etiology And Bordetella Species
- Epidemiology
- Pathogen, Pathophysiology, Transmission, And Immunity
- Clinical Manifestations
- Differential Diagnosis
- Laboratory Findings
- Diagnosis
- Complications And Outcome
- Management
- Control Measures
- Prevention
- 163. Campylobacter jejuni and Campylobacter coli
- Description of the Pathogen
- Epidemiology
- Pathogenesis and Immunity
- Clinical Manifestations
- Diagnosis
- Treatment
- Prevention
- 164. Other Campylobacter Species
- Campylobacter Fetus
- Campylobacter Upsaliensis
- Campylobacter Lari
- Other Campylobacter Species
- 165. Capnocytophaga Species
- Human Capnocytophaga
- Zoonotic Capnocytophaga
- 166. Chlamydophila (Chlamydia) pneumoniae
- The Pathogen
- Epidemiology
- Clinical Manifestations
- Laboratory Diagnosis
- Treatment
- Complications
- 167. Chlamydia trachomatis
- The Pathogen and Pathogenesis
- Epidemiology
- Clinical Manifestations
- Laboratory Diagnosis
- Treatment
- Complications and Sequelae
- Prevention
- 168. Chlamydia (Chlamydophila) psittaci (Psittacosis)
- The Pathogen
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnostic Tests
- Treatment
- 169. Coxiella burnetii (Q Fever)
- The Pathogen
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Special Considerations
- Prevention
- 170. Family Anaplasmataceae (Anaplasmosis, Ehrlichiosis, Neorickettsiosis, and Neoehrlichiosis)
- Description of the Pathogens
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnostic Tests
- Treatment
- Prevention
- 171. Francisella tularensis (Tularemia)
- Description of Pathogen and Epidemiology
- Pathogenesis and Immunity
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Prevention
- 172. Haemophilus influenzae
- The Pathogen
- Epidemiology
- Pathogenesis
- Immunity
- Clinical Manifestations of Haemophilus Influenzae Type B Infection
- Clinical Manifestations of Nontypable Haemophilus Influenzae Infection
- Diagnosis
- Treatment
- Prevention
- 173. Other Haemophilus Species and Aggregatibacter Species
- Haemophilus Influenzae Biogroup Aegyptius
- Haemophilus Ducreyi
- Oral and Pharyngeal Haemophilus and Aggregatibacter Species
- 174. Helicobacter pylori
- The Pathogen
- Epidemiology
- Pathogenesis
- Clinical Manifestations
- Diagnosis
- Treatment
- Prevention
- 175. Other Gastric and Enterohepatic Helicobacter Species
- The Pathogens
- Epidemiology
- Clinical Manifestations
- Diagnosis
- Treatment
- 176. Kingella Species
- Microbiology
- Virulence And Pathogenesis
- Immunity
- Epidemiology
- Clinical Manifestations
- Diagnosis
- Treatment
- 177. Legionella Species
- Pathogenesis And Epidemiology
- Clinical Manifestations
- Laboratory Diagnosis
- Treatment
- Prevention
- 178. Rickettsia rickettsii (Rocky Mountain Spotted Fever)
- Description of The Pathogen
- Epidemiology
- Clinical Manifestations
- Laboratory Findings And Diagnosis
- Treatment
- Special Considerations
- Prevention And Control
- 179. Other Rickettsia Species
- Rickettsia Prowazekii (Classic Louse-Borne Epidemic Typhus: Brill-Zinsser Disease Or Recrudescent Typhus; Sylvatic Or Flying Squirrel-Associated Typhus)
- Rickettsia Typhi (Murine Typhus; Endemic Or Flea-Borne Typhus)
- Rickettsia Felis (Cat Flea Rickettsiosis) And Related Agents
- Rickettsia Akari (Rickettsialpox)
- Rickettsia Parkeri Rickettsiosis
- Rickettsia Philipii (Pacific Coast Tick Fever)
- Other Rickettsia Agents And Orientia (African Tick Bite Fever And Other Travel-Associated Rickettsioses, Including Scrub Typhus)
- 180. Streptobacillus moniliformis (Rat-Bite Fever)
- Epidemiology
- Clinical Findings
- Diagnosis
- Treatment
- Prevention
- 181. Other Gram-Negative Coccobacilli
- Aggregati Bacter Species
- Bartonella Species
- Cardiobacterium Hominis
- Treponemataceae (Spiral Organisms)
- 182. Treponema pallidum (Syphilis)
- Microbiology and Pathogenesis
- Epidemiology
- Clinical Manifestations
- Diagnosis
- Treatment and Follow-up
- Prevention
- 183. Other Treponema Species
- Yaws
- Endemic Syphilis (Bejel)
- Pinta
- Treatment
- 184. Leptospira Species (Leptospirosis)
- Pathogens and Pathogenesis
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnostic Tests
- Treatment
- Maternal and Congenital Leptospirosis
- Prevention
- 185. Borrelia burgdorferi (Lyme Disease)
- Pathogenesis and Immunity
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment and Outcomes
- Special Consideration: Congenital Lyme Disease
- Prevention
- 186. Other Borrelia Species and Spirillum minus
- Borrelia Species (Relapsing Fever)
- Borrelia Mayonii
- Spirillum Minus (Rat-Bite Fever)
- Anaerobic Bacteria
- 187. Anaerobic Bacteria: Clinical Concepts and the Microbiome in Health and Disease
- Classification
- Indigenous Flora
- Microbiome In Health And Disease
- Pathogenesis of Anaerobic Infections
- Clinical Clues And Approach To Diagnosis
- 188. Clostridium tetani (Tetanus)
- Microbiology And Pathogenesis
- Clinical Manifestations
- Diagnosis And Differential Diagnosis
- Treatment And Outcome
- Prevention
- 189. Clostridium botulinum (Botulism)
- Etiology And Pathogenesis
- Epidemiology
- Clinical Manifestations
- Differential Diagnosis
- Diagnosis
- Hospital Course
- Management
- Outcome And Prevention
- Foodborne Botulism
- Wound Botulism
- Vaccine
- 190. Clostridioides difficile
- The Pathogen
- Epidemiology
- Clinical Manifestations
- Diagnosis
- Treatment
- Prevention
- 191. Other Clostridium Species
- Clinical Manifestations
- Diagnosis
- Treatment
- Prevention
- 192. Bacteroides and Prevotella Species and Other Anaerobic Gram-Negative Bacilli
- Pathophysiology
- Clinical Manifestation And Prediction Of Pathogens
- Treatment
- Prevention
- 193. Fusobacterium Species
- Description Of The Pathogen
- Epidemiology
- Clinical Manifestations
- Laboratory Findings And Diagnosis
- Treatment
- Special Considerations
- Prevention
- 194. Anaerobic Cocci
- Pathophysiology And Predisposing Conditions
- Clinical Manifestations
- Treatment
- 195. Anaerobic Gram-Positive Nonsporulating Bacilli (Including Actinomycosis)
- Cutibacterium Species
- Actinomyces Species
- Other Gram-Positive Bacilli
- Mycoplasma
- 196. Mycoplasma pneumoniae
- Description of the Pathogen
- Pathogenesis
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- 197. Other Mycoplasma Species
- Mycoplasma Hominis
- Mycoplasma Genitalium
- Other Mycoplasma Species
- 198. Ureaplasma urealyticum
- Microbiology
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Diseases of Possible Infectious or Unknown Etiology
- 199. Kawasaki Disease
- Etiology and Epidemiology
- Pathology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Special Considerations
- 200. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
- Case Definition
- Epidemiology
- Pathogenesis
- Clinical Manifestations and Evaluation
- Management
- Outcomes
- Section B. Viruses
- 201. Classification of Human Viruses
- DNA Viruses: Poxviridae
- 202. Poxviridae
- Variola And Vaccinia
- Zoonotic Poxviruses
- Molluscum Contagiosum
- DNA Viruses: Herpesviridae
- 203. Introduction to Herpesviridae
- 204. Herpes Simplex Virus
- Pathophysiology
- Immunity
- Epidemiology
- Clinical Syndromes
- Laboratory Findings And Diagnostic Techniques
- Treatment
- Prevention
- 205. Varicella-Zoster Virus
- Pathogenesis
- Epidemiology
- Varicella
- Herpes Zoster
- Laboratory Findings and Diagnosis
- Treatment
- Prevention
- 206. Cytomegalovirus
- The Virus
- Pathogenesis
- Immunity
- Epidemiology
- Clinical Manifestations
- Laboratory Diagnosis
- Management And Antiviral Therapy
- Prevention
- 207. Human Herpesviruses 6 and 7 (Roseola, Exanthem Subitum)
- Human Herpesvirus 6
- Human Herpesvirus 7
- 208. Epstein-Barr Virus (Mononucleosis and Lymphoproliferative Disorders)
- Description Of The Pathogen
- Epidemiology
- Pathogenesis Of Infectious Mononucleosis In Previously Healthy Children
- Clinical Aspects Of Infectious Mononucleosis
- Pathogenesis And Disease In Immunosuppressed Persons
- 209. Human Herpesvirus 8 (Kaposi Sarcoma–Associated Herpesvirus)
- DNA Viruses: Adenoviridae
- 210. Adenoviruses
- Epidemiology
- Clinical Disease
- Diagnosis
- Prevention and Treatment
- DNA Viruses: Papovaviridae
- 211. Human Papillomavirus
- The Virus And Pathogenesis
- Immunity
- Epidemiology And Clinical Features
- Laboratory Screening And Diagnosis
- Management
- Prevention
- 212. BK, JC, and Other Human Polyomaviruses
- Epidemiology
- Bk Virus
- Hematopoietic Stem Cell Transplant Recipients
- Jc Virus
- Merkel Cell Virus
- Trichodysplasia Spinulosa-Associate Polyomavirus
- DNA Viruses: Hepadnaviridae
- 213. Hepatitis B and Hepatitis D Viruses
- Hepatitis B Virus
- Hepatitis Delta Virus
- DNA Viruses: Parvoviridae
- 214. Human Parvoviruses (Parvovirus B19 and Bocavirus)
- Parvovirus B19
- RNA Viruses: Reoviridae
- 215. Coltivirus (Colorado Tick Fever)
- Tick Vector and Vertebrate Hosts
- Other Related Tick-borne Coltiviruses
- 216. Rotaviruses
- Description of the Pathogens
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnostic Tests
- Treatment
- Prevention
- RNA Viruses: Togaviridae, Flaviviridae, and Bunyaviridae
- 217. Togaviridae: Alphaviruses
- Epidemiology and Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Prevention
- 218. Flaviviruses
- Specific Agents
- Diagnosis
- Prevention
- 219. Bunyaviruses
- Description of Pathogen
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Prevention
- 220. Hepatitis C Virus
- Pathogen
- Pathogenesis and Immunity
- Epidemiology
- Clinical Manifestations and Natural History
- Diagnostic Testing and Screening
- Management
- Counseling Parents and Children Regarding Transmission and Prevention
- Treatment
- Prevention
- 221. Rubella Virus
- Pathogen, Pathogenesis, and Immune Response
- Epidemiology
- Clinical Manifestations
- Laboratory Findings And Diagnosis
- Treatment
- Complications Of Acquired Rubella
- Prevention
- RNA Viruses: Coronaviridae
- 222. Human Coronaviruses
- Overview of the Viruses
- Endemic HCOV (HCoV-229E, HCoV-OC43, HCoV-NL63, and HCoV-HKU1)
- Sars-CoV-1
- Mers-CoV
- Sars-CoV-2
- RNA Viruses: Paramyxoviridae
- 223. Parainfluenza Viruses
- Description of the Pathogen
- Epidemiology
- Transmission
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Special Considerations
- Prevention
- 224. Mumps Virus
- Description of the Pathogen
- Epidemiology
- Pathogenesis and Immune Response
- Clinical Manifestations
- Complications
- Diagnosis
- Treatment and Prevention
- 225. Respiratory Syncytial Virus
- The Pathogen
- Epidemiology
- Pathogenesis and the Immune Response
- Clinical Manifestations
- Laboratory Diagnosis
- Management
- Prevention
- Future Directions
- 226. Human Metapneumovirus
- Description of Pathogen
- Epidemiology
- Clinical Manifestations
- Laboratory and Imaging Findings and Diagnosis
- Treatment
- Special Considerations
- Prevention
- 227. Rubeola Virus: Measles and Subacute Sclerosing Panencephalitis
- The Pathogen and Pathogenesis
- Immune Response
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Complications and Special Considerations
- Measles in Immunocompromised Hosts
- Prevention
- RNA Viruses: Rhabdoviridae
- 228. Rabies Virus
- The Virus
- Pathogenesis
- Virulence and Immunity
- Epidemiology
- Clinical Manifestations
- Laboratory Diagnosis
- Management
- Prevention
- RNA Viruses: Orthomyxoviridae
- 229. Influenza Viruses
- Microbiology
- Pathogenesis
- Immunity
- Epidemiology
- Clinical Manifestations
- Complications
- Laboratory and Radiographic Findings
- Diagnosis
- Treatment
- Prevention
- Chemoprophylaxis
- Special Considerations
- Zoonotic Influenza
- RNA Viruses: Arenaviridae and Filoviridae
- 230. Filoviruses and Arenaviruses
- Description of the Pathogens
- Epidemiology
- Pathogenesis
- Clinical Manifestations
- Laboratory Testing
- Treatment
- Prevention
- RNA Viruses: Retroviridae
- 231. Introduction to Retroviridae
- 232. Human T-Cell Lymphotropic Viruses
- Epidemiology
- Clinical Manifestations
- 233. Human Immunodeficiency Virus
- Human Immunodeficiency Virus Type 1
- Human Immunodeficiency Virus Type 2
- Acknowledgment
- RNA Viruses: Picornaviridae
- 234. Introduction to Picornaviridae
- Biology
- 235. Polioviruses
- Pathogen and Pathophysiology
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnostic Tests
- Treatment
- Special Considerations
- Prevention
- Author Note
- 236. Enteroviruses and Parechoviruses
- Pathogenesis
- Immunity
- Epidemiology
- Transmission
- Clinical Manifestations
- Infection in Special Hosts
- Parechovirus Infections
- Laboratory Diagnosis
- Treatment
- Prevention
- 237. Hepatitis A Virus
- The Pathogen
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Prevention
- Post-Exposure Prophylaxis
- 238. Rhinoviruses
- Description of Pathogens and Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Special Considerations
- Prevention
- RNA Viruses: Caliciviridae
- 239. Caliciviruses
- Pathogens and Pathogenesis
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnostic Tests
- Management
- Prevention
- 240. Astroviruses
- Description of Pathogen
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment and Prevention
- 241. Hepatitis E Virus
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Prevention
- Newly Identified Viruses
- Section C. Fungi
- 242. Classification of Fungi
- The Agents
- Laboratory Findings and Diagnosis
- Clinical Manifestations
- 243. Candida Species
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Prevention
- 244. Aspergillus Species
- Microbiology
- Clinical Manifestations
- Epidemiology and Risk Factors
- Diagnosis
- Treatment
- Prognosis
- 245. Agents of Hyalohyphomycosis and Phaeohyphomycosis
- Agents of Hyalohyphomycosis (Fusarium, Scedosporium, Paecilomyces, and Penicillium Species)
- Agents of Phaeohyphomycosis (Bipolaris/Curvularia, Alternaria, Exophiala, Exserohilum, Cladophialophora Species, and Lomentospora Prolificans)
- 246. Agents of Mucormycosis
- Epidemiology
- Clinical Manifestations
- Diagnosis
- Treatment
- Prevention
- 247. Malassezia Species
- Microbiology
- Epidemiology
- Clinical Manifestations
- Diagnosis
- Treatment
- 248. Sporothrix schenckii Complex (Sporotrichosis)
- Microbiology
- Epidemiology
- Clinical Manifestations
- Diagnosis
- Treatment
- Prevention
- 249. Cryptococcus Species
- Epidemiology
- Clinical Manifestations
- Diagnosis
- Treatment
- Special Management Considerations
- Prevention
- 250. Histoplasma capsulatum (Histoplasmosis)
- The Pathogen
- Pathogenesis
- Immunity
- Epidemiology
- Clinical Manifestations
- Laboratory Findings, Imaging, and Diagnosis
- Treatment
- Special Considerations
- Prevention
- 251. Pneumocystis jirovecii
- Description of Pathogen
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Special Considerations
- Treatment
- Prevention
- 252. Blastomyces Species (Blastomycosis)
- Microbiology
- Pathogenesis And Immunity
- Epidemiology and Acquisition
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Special Considerations
- Outcomes and Prevention
- 253. Coccidioides immitis and Coccidioides posadasii (Coccidioidomycosis)
- The Pathogen
- Epidemiology
- Clinical Manifestations
- Diagnosis
- Treatment
- Special Considerations
- Prevention
- 254. Superficial Fungal Infections
- Tinea Capitis
- Onychomycosis
- Tinea Corporis, Tinea Cruris, and Tinea Faciei
- Tinea Pedis
- Candidiasis
- Malassezia Infections
- 255. Agents of Eumycotic Mycetoma: Pseudallescheria boydii and Scedosporium apiospermum
- Microbiology
- Virulence and Immunity
- Pathogenesis
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment and Special Considerations
- Prevention
- Pseudallescheria Boydii (Scedosporium Boydii)
- Section D. Human Parasites and Vectors
- 256. Classification of Parasites
- Parasitic Protozoa
- Parasitic Animalia
- 257. Ectoparasites (Lice and Scabies)
- Pediculosis
- Scabies
- Protozoa
- 258. Babesia Species (Babesiosis)
- Description of The Pathogen
- Epidemiology
- Clinical Manifestations
- Laboratory Findings And Diagnosis
- Treatment
- Special Considerations
- Prevention
- 259. Balantioides coli (Formerly Balantidium coli)
- Life Cycle And Description
- Epidemiology
- Clinical Manifestations
- Diagnosis
- Treatment And Prevention
- 260. Blastocystis Species
- Organism
- Epidemiology
- Clinical Manifestations
- Diagnosis
- Treatment and Prevention
- 261. Cryptosporidium Species
- The Pathogen
- Epidemiology
- Clinical Manifestations
- Laboratory Diagnosis
- Treatment
- Special Considerations
- Prevention
- 262. Endolimax nana
- Description of Endolimax Nana
- Epidemiology and Clinical Manifestations
- Diagnosis and Treatment
- 263. Entamoeba histolytica (Amebiasis)
- Description of the Pathogen
- Pathogenesis
- Immunity
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Prevention
- 264. Other Entamoeba, Amebae, and Intestinal Flagellates
- Entamoeba Histolytica/Entamoeba Dispar Group
- Other Entamoeba Species
- Other Intestinal Amebae and Flagellates
- 265. Giardia intestinalis (Giardiasis)
- Pathogen and Pathogenesis
- Epidemiology
- Clinical Manifestations
- Diagnosis
- Treatment
- Prevention
- 266. Cystoisospora (Isospora) and Cyclospora Species
- Pathogens
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Prevention
- 267. Leishmania Species (Leishmaniasis)
- Description of the Pathogen
- Pathogenesis and Immunity
- Epidemiology
- Clinical Manifestations
- Diagnosis
- Treatment
- Prevention and Control
- 268. Microsporidia
- Pathogen
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Prevention
- 269. Naegleria fowleri
- Description of the Pathogen
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Prevention
- 270. Acanthamoeba Species
- Description of Pathogen
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Prevention
- 271. Plasmodium Species (Malaria)
- Description of The Pathogen
- Epidemiology
- Clinical Manifestations
- Laboratory Findings And Diagnosis
- Treatment
- Prevention
- 272. Sarcocystis Species
- Pathogen
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnostic Tests
- Treatment and Prevention
- 273. Toxoplasma gondii (Toxoplasmosis)
- Pathogen and Life Cycle
- Epidemiology
- Pathogenesis and Immune Response
- Clinical Manifestations
- Diagnosis
- Treatment
- Prevention
- 274. Trichomonas vaginalis
- Description of The Pathogen
- Epidemiology
- Clinical Manifestations
- Laboratory Findings And Diagnostic Tests
- Treatment
- Special Considerations
- Prevention
- 275. Trypanosoma Species (Trypanosomiasis)
- Human African Trypanosomiasis
- American Trypanosomiasis
- Nematodes
- 276. Intestinal Nematodes
- Ascaris Lumbricoides (Roundworm)
- Hookworm (Ancylostoma Duodenale, Ancylostoma Caninum, Ancylostoma Ceylanicum, and Necator Americanus)
- Trichuris Trichiura
- Enterobius Vermicularis
- Strongyloides Stercoralis and Strongyloides Fuelleborni
- 277. Tissue Nematodes
- Toxocara Canis, Toxocara Cati, and Baylisascaris Procyonis
- Angiostrongylus Species
- Gnathostoma Spinigerum
- Ancylostoma Braziliense
- Ascarids of Marine Mammals
- Trichinella Spiralis (Trichinellosis)
- 278. Blood and Tissue Nematodes: Filarial Worms
- Lymphatic Filariasis
- Onchocerciasis
- Loiasis
- Other Causes of Filariasis
- Dirofilariasis
- Cestodes
- 279. Diphyllobothriidae, Dipylidium and Hymenolepis Species
- Diphyllobothriidae
- Dipylidium Caninum
- Hymenolepis Nana And Hymenolepis Diminuta
- 280. Taenia solium, Taenia asiatica, and Taenia saginata: Taeniasis and Cysticercosis
- Taeniasis
- Cysticercosis
- 281. Echinococcus Species: Agents of Echinococcosis
- Echinococcus Granulosus
- Echinococcus Mulitlocularis
- Echinococcus Vogeli
- 282. Taenia (Multiceps) multiceps and Taenia serialis: Coenurosis
- Epidemiology and Life Cycle
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Prevention
- Trematodes
- 283. Intestinal Trematodes
- Fasciolopsiasis
- Heterophyiasis And Metagonimiasis
- Echinostome Infections
- Clinical Manifestations
- 284. Clonorchis, Opisthorchis, Fasciola, and Paragonimus Species
- Clonorchiasis and Opisthorchiasis
- Fascioliasis
- Paragonimiasis
- 285. Blood Trematodes: Schistosomiasis
- Biology
- Epidemiology
- Pathogenesis
- Clinical Features
- Diagnosis
- Management
- Special Considerations
- Prevention
- Laboratory Diagnosis and Therapy for Infectious Diseases
- Section A. The Clinician and the Laboratory
- 286. Laboratory Diagnosis of Infection Due to Bacteria, Fungi, Parasites, and Rickettsiae
- Bacteria
- Fungi
- Parasites
- Rickettsiae
- Immunoserology
- Newer Technologies
- 287. Laboratory Diagnosis of Infection Due to Viruses,Chlamydia, and Mycoplasma
- Viruses
- Chlamydiaceae
- Mycoplasma
- 288. Use of Common Clinical Laboratory Tests to Assess Infectious and Inflammatory Diseases
- Acute Phase Response
- Erythrocyte Sedimentation Rate
- C-Reactive Protein
- Procalcitonin
- Iron Metabolism, Ferritin, and Hepcidin
- Other Acute Phase Proteins and Cytokines
- Hemoglobin
- Leukocytes
- Platelets
- Metabolic Abnormalities
- Nonspecific Antibodies
- Section B. Anti-Infective Therapy
- 289. Principles of Anti-Infective Therapy
- Selecting Optimal Antimicrobial Therapy
- Antimicrobial Susceptibility Testing and Interpretation
- Site Of Infection
- Antimicrobial Combinations
- Dosing, Route, and Duration of Therapy
- Outpatient Parenteral Antimicrobial Therapy
- 290. Mechanisms and Detection of Antimicrobial Resistance
- Genetics of Antimicrobial Resistance
- Mechanisms of Resistance
- Detection of Antimicrobial Resistance
- Special Considerations
- 291. Pharmacokinetic and Pharmacodynamic Basis of Optimal Antimicrobial Therapy
- Basic Concepts in Clinical Pharmacokinetics
- Drug Disposition in Specific Patient Populations
- Basis for Drug-Drug Interactions
- Pharmacodynamic Interactions
- Integration of Pharmacokinetic and Pharmacodynamic Principles for Optimal Antibiotic Dosing Regimens
- Pharmacokinetic and Pharmacodynamic Relationships of Other Antimicrobial Agents
- Future Considerations
- 292. Antibacterial Agents
- Cell Envelope-Active Agents
- Cell Wall-Active Agents
- Cell Membrane-Active Agents
- Salivaricins
- Ribosome-Active Antibiotics
- Nucleic Acid-Active Antibiotics
- 293. Antifungal Agents
- Antifungal Agents for Treatment of Superficial Infections
- Antifungal Agents for Treatment of Invasive Infections
- 294. Topical Antimicrobial Agents
- Agents for Ophthalmic Infections
- Agents for Otic Infections
- Agents for Skin Infections
- Agents USED IN Burn Management
- 295. Antiviral Agents
- Anti-Herpesvirus Drugs
- Anti-Influenza Drugs
- Anti-Hepatitis Virus Drugs
- Anti-Coronavirus Drugs
- 296. Antiparasitic Agents
- Treatment of Luminal Protozoa
- Treatment of Kinetoplastidea Infections
- Antimalarial Therapy
- Antibacterial Agents with Antiprotozoan Activity
- Treatment of Helminthic Infections
- Intestinal Nematodes
- Systemic Nematodes
- Trematodes and Cestodes
- Index
- No. of pages: 1720
- Language: English
- Edition: 6
- Published: March 10, 2022
- Imprint: Elsevier
- Hardback ISBN: 9780323756082
- eBook ISBN: 9780323756099
- eBook ISBN: 9780443271342
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Sarah S. Long
Sarah S. Long is Professor of pediatrics at Drexel University College of Medicine. Dr. Long is an associate editor of The Journal of Pediatrics, as well as the Red Book Report of the Committee on Infectious Diseases of the American Academy of Pediatrics. She has chaired the program committee for annual meetings of the American Academy of Pediatrics, the Infectious Diseases Society of America and the Pediatric Infectious Diseases Society. She sits on research advisory committees for the National Institutes of Health and the Centers for Disease Control and Prevention.
Affiliations and expertise
Associate editor of The Journal of Pediatrics, as well as the Red Book Report of the Committee on Infectious Diseases of the American Academy of PediatricsCP
Charles G. Prober
Affiliations and expertise
Senior Associate Vice Provost for Health Education and Professor of Pediatrics (infectious diseases) and of Microbiology and Immunology at Stanford University School of MedicineMF
Marc Fischer
Dr. Marc Fischer is a pediatric infectious disease specialist in Fort Collins, Colorado. He received his medical degree from Duke University School of Medicine and has been in practice for more than 20 years.
DK
David Kimberlin
David Kimberlin, MD is Professor/Co-Director, Division of Pediatric Infectious Diseases/Sergio B. Stagno, MD Endowed Chair in Pedaitric Infectious Diseases/Vice Chair for Clinical and Translational Research at Children’s Alabama, Birmingham. Dr. Kimberlin is a world renowned pediatric infectious diseases specialist at the University of Alabama, is at the fulcrum of NIH- sponsored multicentered clinical trials especially related to antiviral therapy, is the chief editor of the Red Book Report of the Committee on Infectious Diseases of the American Academy of Pediatrics, and a national leader in academic and subspecilty societies. He has been a contributor of critical chapters in PPPID since its inception.
Affiliations and expertise
University of Alabama Heersink School of MedicineRead Principles and Practice of Pediatric Infectious Diseases on ScienceDirect