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Principles and Practice of Pediatric Infectious Diseases
- 6th Edition - March 10, 2022
- Editors: Sarah S. Long, Charles G. Prober, Marc Fischer, David Kimberlin
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 7 5 6 0 8 - 2
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 7 1 3 4 - 2
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 7 5 6 0 9 - 9
Comprehensive in scope, yet concise and easy to manage, Principles and Practice of Pediatric Infectious Diseases, 6th Edition, by Drs. Sarah S. Long, Charles G. Prober, Marc Fisc… Read more
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Covers the latest aspects of the COVID-19 pandemic, including manifestations, diagnosis, management, and prevention of SARS-CoV-2 infection.
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Features an easy-access format with high-yield information boxes, highlighted key points, and an abundance of detailed illustrations and at-a-glance tables.
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Allows quick look-up by clinical presentation, pathogen, or type of host.
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Highlights expanding antimicrobial resistance patterns and new therapies for viral and fungal infections and resistant bacterial infections.
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Includes coverage of the latest vaccine products, recommendations, and effectiveness.
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Reviews emerging healthcare-associated infections, their management, control, and prevention.
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Contains a new chapter on Chorioamnionitis and Neonatal Consequences.
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Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
- Cover image
- Title page
- Disclaimer
- Table of Contents
- Copyright
- Preface
- Acknowledgments
- Dedication
- Contributors
- Understanding, Controlling, and Preventing Infectious Diseases
- Section A. Epidemiology and Control of Infectious Diseases
- 1. Principles of Epidemiology and Public Health
- Descriptive Epidemiology
- Analytic Epidemiology
- Vaccine Efficacy and Effectiveness Studies
- Disease Control and Public Health Policy
- Evaluating the Medical Literature
- 2. Pediatric Healthcare: Infection Epidemiology, Prevention and Control, and Antimicrobial Stewardship
- Risk Factors for Healthcare-Associated Infections In Children
- Transmission
- Epidemiologically Important Pathogens
- Prevention Programs
- Antimicrobial Stewardship
- Isolation Precautions
- Environmental Measures
- Visitation Policies
- Occupational Health
- Infection Prevention and Control in the Nonacute Care Setting
- 3. Infections Associated With Group Childcare
- Types of Childcare Settings
- Epidemiology, Etiology, and Control of Infections
- Vaccine-Preventable Diseases
- Infections Associated With Animals
- Infectious Diseases in Adults
- Economic Impact of Group Childcare Illness
- Prevention
- 4. Infectious Diseases in Refugee and Internationally Adopted Children
- Guidelines for Evaluation
- Preventive Measures
- Section B. Prevention of Infectious Diseases
- 5. Passive Immunization
- Standard Immune Globulin (Human)
- Specific Immune Globulins for Intramuscular Administration
- Immune Globulin Intravenous (Human)
- Specific Immune Globulins for Intravenous Administration
- Monoclonal Antibodies
- Immunoglobulin Products Prepared from Animal Plasma
- Adverse Reactions to Immune Globulins Prepared from Human Plasma
- Product Shortages
- The Future
- 6. Active Immunization
- Immunization and Vaccines: Overview
- Vaccine Development, Licensure, and Approval
- Principles of Immunization Programs
- Routine Childhood and Adolescent Vaccines
- Selected Other Vaccines that can be Used in Children and Adolescents
- Sources of Information on Vaccines
- 7. Antimicrobial Chemoprophylaxis
- Chemoprophylaxis in Healthy Children
- Chemoprophylaxis for Surgical Procedures and Trauma
- Chemoprophylaxis in Special Situations and in Children With Conditions Predisposing to Infection
- 8. Protection of Travelers
- Preparation For Travel
- Malaria
- Travelers Diarrhea
- Emerging Infectious Diseases
- Immunocompromised Travelers
- Return From Travel
- Section C. Host Defenses Against Infectious Diseases
- 9. Immunologic Development and Susceptibility to Infection
- Innate Immune Response
- Adaptive Immune Response
- Interrelationships And The Future
- 10. Fever and the Inflammatory Response
- Fever
- Inflammatory Response
- Acknowledgment
- Clinical Syndromes and Cardinal Features of Infectious Diseases: Approach to Diagnosis and Initial Management
- Section A. Septicemia, Toxin-, and Inflammation-Mediated Syndromes
- 11. The Systemic Inflammatory Response Syndrome, Sepsis, and Septic Shock
- Epidemiology
- Definitions
- Etiology
- Pathophysiology
- Clinical Manifestations, Assessment and Early Initiation of Therapy
- Management
- Future Considerations
- 12. Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome
- Primary Hemophagocytic Lymphohistiocytosis
- Secondary Hemophagocytic Lymphohistiocytosis
- Pathogenesis
- Clinical, Radiologic, and Laboratory Features
- Diagnosis and Differential Diagnosis
- Treatment
- Hematopoietic Stem Cell Transplantation
- Prognosis
- Section B. Cardinal Symptom Complexes
- 13. Mucocutaneous Symptom Complexes
- Specific Distinguishing Characteristics
- Diagnosis and Empiric Therapy
- 14. Fever Without Localizing Signs
- Etiologic Agents
- Epidemiology
- Management
- 15. Prolonged, Recurrent, and Periodic Fever Syndromes
- Fever of Unknown Origin
- Deconditioning After Prolonged Perceived Illness
- Recurrent Fever and Periodic Fever Syndromes
- Other Autoinflammatory Diseases with Recurrent Fever
- 16. Lymphatic System and Generalized Lymphadenopathy
- Anatomy and Function of Lymphoid Tissue
- Developmental Changes
- Characteristics of Lymphadenopathy
- Pathogenesis of Lymphadenopathy and Lymphadenitis
- Histopathology of Lymphadenitis
- Lymphocutaneous and Oculoglandular SyndromeS
- Infectious Causes of Generalized Lymphadenopathy
- Other Causes of Generalized Lymphadenopathy
- 17. Cervical Lymphadenitis and Neck Infections
- Epidemiology
- Lymphatic Flow and Fascial Spaces of the Head and Neck
- Oculoglandular Syndrome of Parinaud
- Infectious Causes of Lymphadenitis
- Noninfectious Causes of Lymphadenopathy
- Neck Masses Not Involving Lymph Nodes
- Diagnostic Approach to Cervical Lymphadenopathy
- Management
- Complications
- 18. Mediastinal and Hilar Lymphadenopathy
- Anatomy of the Mediastinum
- Lymphatic Drainage of the Lungs and Pleura
- Epidemiology
- Characteristics of Lymphadenopathy
- Clinical Manifestations
- Diagnosis
- Infectious Causes
- Noninfectious Causes
- Diagnostic Approach
- 19. Abdominal and Retroperitoneal Lymphadenopathy
- Epidemiology and Differential Diagnosis
- Diagnostic Tests
- Management
- 20. Localized Lymphadenitis, Lymphadenopathy, and Lymphangitis
- Lymphadenopathy and Lymphadenitis
- Lymphangitis
- 21. Respiratory Tract Symptom Complexes
- Mucopurulent Rhinorrhea
- Stridor
- Cough
- Tachypnea and Other Signs of Lower Respiratory Tract Disorders
- Differentiating Features of Pneumonia
- Hemoptysis
- 22. Abdominal Symptom Complexes
- Approach
- Acute Abdominal Pain
- Chronic or Recurrent Abdominal Pain
- 23. Neurologic Syndromes
- Headache
- Altered Mental Status
- Ataxia
- Hypotonia and Weakness
- 24. Musculoskeletal Symptom Complexes
- History
- Physical Examination
- Laboratory Evaluation and Imaging
- Limb Pain
- Back Pain
- Chest Pain
- Section C. Oral Infections and Upper and Middle Respiratory Tract Infections
- 25. Infections of the Oral Cavity
- Odontogenic Infections
- Mucosal Infections (Gingivitis, Mucositis, and Stomatitis)
- Complications of Odontogenic and Mucosal Infections
- Infections of the Salivary Gland
- Osteomyelitis
- 26. The Common Cold
- Etiology
- Epidemiology
- Pathogenesis
- Clinical Manifestations
- Differential Diagnosis
- Clinical Approach
- Management
- Complications
- Recent Advances
- 27. Pharyngitis
- Viral Pharyngitis
- Bacterial Pharyngitis
- 28. Infections Related to the Upper and Middle Airways
- Peritonsillar Abscess (Quinsy)
- Retropharyngeal AbScess
- Parapharyngeal Abscess
- Lemierre Syndrome
- Acute Epiglottitis (Supraglottitis)
- Croup (Laryngotracheitis)
- Acute Laryngitis
- Bacterial Tracheitis
- Acute Bronchitis
- 29. Otitis Media
- Acute Otitis Media
- Pathogenesis
- Microbiology
- Epidemiology
- Diagnosis
- Treatment
- Duration of Antimicrobial Therapy
- Other Forms of Otitis Media, Complications, and Sequelae
- 30. Otitis Externa and Necrotizing Otitis Externa
- Otitis Externa
- Necrotizing Otitis Externa
- 31. Mastoiditis
- Acute Mastoiditis
- Chronic Mastoiditis
- 32. Sinusitis
- Pathogenesis
- Clinical Manifestations
- Diagnostic Methods
- Microbiology
- Medical Management
- Surgical Management
- Section D. Lower Respiratory Tract Infections
- 33. Bronchiolitis
- Etiologic Agents
- Epidemiology
- Pathogenesis And Pathologic Findings
- Clinical Manifestations
- Diagnosis
- Management
- Prognosis, Complications, And Sequelae
- Prevention
- 34. Acute Pneumonia and Its Complications
- Acute Pneumonia
- Acute Complicated Pneumonia
- 35. Persistent and Recurrent Pneumonia
- Persistent or Progressive Pneumonia At A Single Site
- Persistent or Recurrent Pneumonia Not Confined To A Single Site
- 36. Pneumonia in the Immunocompromised Host
- Etiologic Agents And Epidemiology
- Secondary Immunodeficiency
- Pathogenesis And Pathologic Findings
- Clinical Manifestations And Etiologic Agents
- Management, Empiric And Definitive Therapy
- Prevention
- Section E. Cardiac and Vascular Infections
- 37. Endocarditis and Other Intravascular Infections
- Infective Endocarditis
- Other Endocarditis-Like Intravascular Infections
- 38. Myocarditis
- Etiology
- Epidemiology
- Pathophysiology
- Clinical Manifestations
- Differential Diagnosis
- Laboratory Findings and Diagnosis
- Management
- Complications
- Prevention
- 39. Pericarditis
- Etiology
- Epidemiology
- Pathogenesis
- Clinical Manifestations
- Differential Diagnosis
- Laboratory Findings and Diagnosis
- Management
- Complications
- Prognosis
- Section F. Central Nervous System Infections
- 40. Acute Bacterial Meningitis Beyond the Neonatal Period
- Etiologic Agents and Epidemiology
- Pathophysiology
- Clinical Manifestations
- Laboratory Findings And Diagnosis
- Management
- Adjunctive Therapy
- Considerations for Unusual Organisms135–138
- Prognosis and Sequelae
- Care of Contacts and Vaccine Prevention
- 41. Chronic Meningitis
- Etiology and Epidemiology
- Main Features of Agents Causing Chronic Meningitis
- Approach to Diagnosis
- Empiric Therapy
- 42. Recurrent Meningitis
- Etiologic Agents
- Epidemiology
- Pathogenesis
- Clinical Manifestations
- Diagnosis
- Treatment
- Prevention and Prophylaxis
- 43. Aseptic and Viral Meningitis
- Etiologic Agents And Epidemiology
- Pathogenesis and Pathology
- Clinical Manifestations
- Differential Diagnosis
- Laboratory Findings and Diagnosis
- Management and Empiric and Definitive Therapy
- Complications, Prognosis, and Sequelae
- Prevention
- 44. Encephalitis
- Etiologic Agents and Epidemiology
- Pathogenesis
- Clinical Manifestations and Differential Diagnosis
- Special Hosts
- Laboratory Findings
- Clinical Approach
- Management
- Complications and Prognosis
- Prevention
- 45. Parainfectious and Postinfectious Neurologic Syndromes
- Cranial Nerve Palsies
- Cerebellitis
- Transverse Myelitis
- Guillain-Barré Syndrome
- Acute Flaccid Myelitis
- Autoimmune Encephalitis
- Acute Disseminated Encephalomyelitis
- 46. Focal Suppurative Infections of the Nervous System
- Etiology
- Epidemiology
- Pathogenesis
- Clinical Manifestations
- Differential Diagnosis
- Laboratory Findings and Diagnosis
- Management
- Complications And Prognosis
- 47. Eosinophilic Meningitis
- Infectious Etiologies
- Diagnosis
- Treatment And Prevention
- Section G. Genitourinary Tract Infections
- 48. Urinary Tract Infections, Renal Abscess, and Other Complex Renal Infections
- Etiologic Agents
- Epidemiology
- Definitions
- Pathogenesis
- Risk Factors for Bacteriuria, Recurrent UTI, and Renal Damage
- Clinical Manifestations
- Laboratory Findings
- Management
- Complications and Sequelae
- Complex Urinary Tract Infections: Imaging Evaluation
- Special Considerations
- 49. Sexually Transmitted Infection Syndromes
- Prevention and Screening of Sexually Transmitted Infections
- Sexually Transmitted Infection Syndromes
- Discharge and Dysuria
- Anal Discharge and Gastrointestinal Syndromes
- Genital Ulcer and Lymphadenopathy Syndrome
- Pelvic or Scrotal Pain
- Pharyngeal Syndromes
- 50. Genitourinary Skin and Mucous Membrane Infections and Inguinal Lymphadenopathy
- Inguinal Lymphadenopathy with Genital Ulcers
- Inguinal Lymphadenopathy Without Genital Ulcers
- Genital Dermatosis
- 51. Urethritis, Vulvovaginitis, and Cervicitis
- Urethritis
- Vulvovaginitis
- Cervicitis
- 52. Pelvic Inflammatory Disease
- Epidemiology
- Etiologic Agents
- Pathophysiology
- Diagnosis
- Laboratory Findings
- Management
- Complications and Sequelae
- Prevention
- 53. Epididymitis, Orchitis, and Prostatitis
- Epididymitis
- Orchitis
- Mumps Orchitis
- Bacterial Epididymo-orchitis
- Prostatitis
- 54. Infectious Diseases Associated With Child Abuse
- Medical Evaluation
- Infectious Agents
- Section H. Gastrointestinal and Tract Infections and Intoxications
- 55. Approach to the Diagnosis and Management of Gastrointestinal Tract Infections
- Epidemiology
- Pathogenesis
- Clinical Manifestations
- Considerations of the Host and Exposures
- Diagnosis
- Management
- Prevention
- 56. Viral Gastroenteritis
- Etiologic Agents
- Epidemiology
- Pathogenesis
- Clinical Manifestations and Differential Diagnosis
- Laboratory Diagnosis
- Management
- Prevention
- 57. Inflammatory Enterocolitis
- Etiologic Agents
- Epidemiology
- Pathogenesis
- Clinical Manifestations
- Complications
- Enterocolitis in Immunocompromised Children
- Differential Diagnosis
- Diagnostic Evaluation
- Management
- 58. Enteric Diseases Transmitted Through Food, Water, and Zoonotic Exposures
- Epidemiology
- Clinical Manifestations, Differential Diagnosis, and Clinical Approach
- Laboratory Findings and Diagnosis
- Management
- Complications, Prognosis, and Sequalae
- Prevention
- Section I. Intra-abdominal Infections
- 59. Acute Hepatitis
- Approach To Evaluation And Diagnosis
- Infectious Causes
- Anatomic Causes
- Autoimmune Causes
- Metabolic Causes
- Toxins And Medications
- Tumors
- Idiopathic Causes
- 60. Chronic Hepatitis
- Approach to Evaluation
- Etiologic Factors
- Acknowledgement
- 61. Granulomatous Hepatitis
- Pathogenesis And Pathologic Findings
- Clinical Manifestations And Differential Diagnosis
- Diagnosis
- Management And Outcome
- 62. Acute Pancreatitis
- Pathogenesis
- Clinical Manifestations
- Diagnosis
- Differential Diagnosis
- Treatment
- Clinical Course
- 63. Cholecystitis and Cholangitis
- Pathogenesis
- Etiology
- Clinical And Laboratory Features
- Diagnosis
- Management
- Complications
- 64. Peritonitis
- Epidemiology
- Pathophysiology
- Etiology
- Clinical Manifestations
- Diagnosis
- Management
- Complications And Prognosis
- Prevention
- 65. Appendicitis
- Epidemiology
- Pathogenesis
- Etiology
- Clinical Manifestations and Differential Diagnosis
- Diagnosis
- Computed Tomography
- Magnetic Resonance Imaging
- Management
- 66. Intra-abdominal, Visceral, and Retroperitoneal Abscesses
- Intra-Abdominal Abscesses
- Visceral Organ Abscesses
- Retroperitoneal Abscesses
- Section J. Skin and Soft-Tissue Infections
- 67. Superficial Bacterial Skin Infections and Cellulitis
- Superficial Infections
- Adnexal and Follicular Infections
- Hand and Nail Infections
- Ulcerative Infections
- Soft Tissue Infections
- 68. Erythematous Macules and Papules
- Approach
- Etiologic Agents, Epidemiology, and Pathogenesis
- 69. Vesicles and Bullae
- Etiology and Clinical Manifestations
- Diagnosis
- 70. Purpura
- Types of Lesions and Pathogenesis
- Causes by Type of Lesion
- 71. Urticaria and Erythema Multiforme
- Urticaria
- Erythema Multiforme
- 72. Papules, Nodules, and Ulcers
- Molluscum Contagiosum
- Erythema Nodosum
- Gianotti-Crosti Syndrome
- Other Exanthematous Infections
- Autosensitization Reaction
- 73. Subcutaneous Tissue Infections and Abscesses
- Etiology
- Abscesses
- Necrotizing Soft Tissue Infections
- 74. Myositis, Pyomyositis, and Necrotizing Fasciitis
- Myositis
- Pyomyositis
- Necrotizing Fasciitis
- Pathogenesis
- Diagnosis
- Treatment
- Section K. Bone and Joint Infections
- 75. Osteomyelitis
- Acute Hematogenous Osteomyelitis
- Treatment
- Special Clinical Situations
- Osteomyelitis Due To Unusual Organisms
- Nonhematogenous Osteomyelitis
- Puncture Wound Osteochondritis of The Foot
- Chronic NonBacterial Osteomyelitis/Recurrent Multifocal Osteomyelitis
- Chronic Osteomyelitis
- 76. Infectious and Inflammatory Arthritis
- Infectious Arthritis
- Special Situations And Pathogens
- Reactive Arthritis
- 77. Diskitis
- Epidemiology and Etiology
- Pathogenesis and Pathologic Findings
- Clinical Manifestations
- Differential Diagnosis
- Diagnosis
- Management
- Outcome
- 78. Transient Synovitis
- Etiology And Epidemiology
- Clinical Manifestations
- Diagnosis
- Differential Diagnosis
- Treatment And Prognosis
- Section L. Eye Infections
- 79. Conjunctivitis in the Neonatal Period (Ophthalmia neonatorum)
- Pathogenesis
- Etiologic Agents
- Prophylaxis/Prevention
- 80. Conjunctivitis Beyond the Neonatal Period
- Acute Conjunctivitis
- Chronic Conjunctivitis
- 81. Infective Keratitis
- Etiology
- Interstitial And Marginal Keratitis
- Pathogenesis
- Clinical Manifestations And Diagnostic Procedures
- Management
- 82. Infective Uveitis, Retinitis, and Chorioretinitis
- Etiologic Agents of Anterior Uveitis
- Etiologic Agents of Posterior Uveitis (Retinitis)
- 83. Endophthalmitis
- Etiologic Agents
- Epidemiology and Host Factors
- Pathophysiology
- Clinical Manifestations
- Diagnostic Evaluation
- Management
- Outcome
- Prevention
- 84. Preseptal and Orbital Infections
- Differential Diagnosis
- Pathogenesis
- Preseptal Infections
- Orbital Infection
- Section M. Infections Related to Trauma, Animals, and Ticks
- 85. Infection Related To Trauma
- Epidemiology
- Pathogenesis
- Clinical Manifestations and Diagnosis
- General Principles of Management
- Infections Related To Site of Trauma
- 86. Infections Related to Burns
- Burn Wound Infection
- Other Infections
- Treatment
- Management of Outpatients
- Prevention
- 87. Infection Related To Bites
- Etiologic Agents
- Epidemiology
- Pathogenesis
- Clinical Manifestations, Differential Diagnosis, And Clinical Approach
- Laboratory Findings And Diagnosis
- Management And Presumptive Therapy
- Empiric Management When Infection Occurs
- Complications
- Prognosis And Sequelae
- Prevention
- 88. Infections Related to Pets and Exotic Animals
- Categories of Pets
- Infections (Zoonoses) Associated With Nontraditional Pets
- Infections Associated With Animals In Public Settings
- Rabies
- Injuries And Allergies
- Reportable Diseases Acquired From Nontraditional Pets And Animals In Public Settings
- Prevention Measures
- Recommendations And Guidelines
- 89. Tickborne Infections
- Epidemiology
- Pathogenesis
- Clinical Manifestations
- Diagnosis
- Treatment
- Prevention
- Section N. Infections of the Fetus and Newborn
- 90. Clinical Approach to the Neonate With Suspected Infection
- Early-Onset Sepsis in Late Preterm and Term Infants
- Early-Onset Sepsis in Preterm Infants
- Hospital-Acquired Late-Onset Sepsis
- Community-Acquired Late-Onset Sepsis
- Diagnostic Evaluation
- 91. Chorioamnionitis and Neonatal Consequences
- 92. Bacterial Infections in the Neonate
- Description of Pathogens
- Epidemiology
- Pathogenesis
- Clinical Manifestations
- Laboratory Findings and Diagnostic Tests
- Treatment
- Special Considerations
- Prevention
- 93. Viral Infections in the Fetus and Neonate
- Pathogenesis
- Epidemiology
- Clinical Manifestations
- Approach to the Neonate With Suspected Viral Infection
- 94. Healthcare-Associated Infections in the Neonate
- Definitions, Epidemiology, and Anatomic Sites Of Infection
- Pathogens Associated with Late-Onset Infections
- Clinical Manifestations
- Laboratory Diagnosis
- Treatment
- Management of Persistent Bloodstream Infections
- Prevention of Healthcare-Associated Infections
- Section O. Infections and Transplantation
- 95. Infections in Solid Organ Transplant Recipients
- Predisposition To Infection
- Timing of Infections
- Pathogen- And Organ-Specific Infections
- Management And Preventive Measures
- 96. Infections in Hematopoietic Cell Transplant Recipients
- Etiologic Agents
- Epidemiology
- Clinical Syndromes, Differential Diagnosis, And Clinical Approach
- Laboratory Findings And Diagnosis
- Management And Presumptive Therapy
- Prevention
- Section P. Infections and Cancer
- 97. Risk Factors and Infectious Agents in Children With Cancer: Fever and Granulocytopenia
- Epidemiology
- Pathogenesis and Etiologic Factors
- Etiologic Agents
- Differential Diagnosis and Clinical Approach to Diagnosis
- Management and Empiric Therapy
- Prognosis and Sequelae
- Recombinant Human Colony-Stimulating Factors
- Prevention
- 98. Clinical Syndromes of Infection in Children With Cancer
- Catheter-Associated Bacteremia and Soft-Tissue Infections
- Skin and Skin Structure Tissue Infections
- Pulmonary Infections
- Infections of the External and Middle Ear and Sinuses
- Gastrointestinal Tract Infections
- Central Nervous System Infections
- Cystitis
- Osteoarticular Infections
- Section Q. Infections Associated With Hospitalization and Medical Devices
- 99. Healthcare-Associated Infections
- Bloodstream Infections
- Respiratory Tract Infections
- Gastrointestinal Tract Infections
- Surgical Site Infections
- 100. Clinical Syndromes of Device-Associated Infections
- Intravascular Catheter-Related Infections
- Infections of Prosthetic Valves, Patches, and Vascular Grafts
- Infections Associated With Pacemakers and Left Ventricular Assist Devices
- Infections of Central Nervous System Devices
- Infections Associated With Peritoneal Catheters
- Infections of Orthopedic Devices
- Infection of Urinary Catheters
- Section R. Infections in Patients With Deficient Defenses
- 101. Evaluation of the Child With Suspected Immunodeficiency
- Anatomic and Physiologic Abnormalities
- Underlying Conditions
- Primary Immunodeficiency Disorders
- Clinical Approach to the Child With Recurrent Infections
- Laboratory Findings and Diagnosis
- Management
- 102. Infectious Complications of Antibody Deficiency
- Approach to the Patient With A Suspected Antibody Deficiency
- Agammaglobulinemias: Severely Reduced IgG, IgA, and IgM With Absent B Lymphocytes
- Common Variable Immunodeficiency Disorders: Severely Reduced IgG, IgA, and/or IgM With Normal or Low Numbers of B Lymphocytes
- Hyper-IgM Syndromes (Hims, Class Switch Recombination Defects): Reduced IgG and IgA With Normal or Elevated IgM and Normal Numbers of B Lymphocytes
- Isotype or Light Chain Deficiencies With Normal Numbers of B Lymphocytes
- Specific Antibody Deficiency With Normal IgG Concentrations and Normal Numbers of B Lymphocytes
- Transient Hypogammaglobulinemia of Infancy
- Acquired Antibody Deficiency
- 103. Infectious Complications of Complement Deficiency and Diseases of Its Dysregulation
- Biochemistry and Biology of Complement
- Genetically Determined Deficiencies of Complement
- Secondary Deficiencies of Complement
- Diagnosis of Complement Deficiencies
- Management
- 104. Infectious Complications of Dysfunction or Deficiency of Polymorphonuclear and Mononuclear Phagocytes
- Etiologic Agents and Pathologic Findings
- Clinical Manifestations and Clinical Approach
- Management
- Complications
- Prognosis, Sequelae and Advances in Restoration of Function
- Prevention of Infection
- Specific Conditions
- 105. Infectious Complications of Cell-Mediated Immunity Other Than AIDS: Primary Immunodeficiencies
- Overview of Cell-Mediated Immunity and its Role in Control of Infections
- Severe Combined Immunodeficiency Syndrome
- Selected Non−Severe Combined Immunodeficiency Disease Disorders of T Cells and Natural Killer Cells
- 106. Infectious Complications in Special Hosts
- Sickle Hemoglobinopathy
- Asplenia And Polysplenia
- Renal Disease
- Ascites
- Iron Overload States
- Metabolic Syndrome
- Ciliary Dysfunction
- Cystic Fibrosis
- 107. Infections Related to Biologic Response Modifying Drug Therapy
- Infections Associated With use of BRMs
- Considerations For Patients Prior to Starting and During Use of BRMs
- Considerations of Infant Exposures to Maternal Brms
- 108. Infectious Complications of Corticosteroid Therapy
- Infectious Adverse Effects of Glucocorticoids
- Other Considerations
- Section S. Human Immunodeficiency Virus and the Acquired Immunodeficiency Syndrome
- 109. Epidemiology and Prevention of HIV Infection in Infants, Children, and Adolescents
- Epidemiology
- Clinical Manifestations and Progression
- Prevention
- 110. Immunopathogenesis of HIV-1 Infection
- Hiv Replication
- Immune Consequences of Untreated HIV-1 Infection
- Effects of Antiviral Therapy on Immune Function and Viral Reservoirs
- 111. Diagnosis and Clinical Manifestations of HIV Infection
- Diagnosis
- Clinical Signs, Symptoms, and Laboratory Abnormalities Associated With HIV Infection
- Organ System−Specific Manifestations of HIV Infection
- Prognosis
- 112. Infectious Complications of HIV Infection
- Pathogenesis
- Immune Reconstitution Inflammatory Syndrome
- Epidemiology and Etiologic Agents
- Approach to Suspected Infection in a Child Living With HIV
- Prevention of Infections
- Prognosis
- 113. Management of HIV Infection
- Antiretroviral Therapy
- Clinical and Laboratory Monitoring
- Infection Prevention: Immunizations and Chemoprophylaxis
- Growth and Nutrition
- Consequences of Infection and Antiretroviral Therapy by Organ Systems
- Transition of Care
- Etiologic Agents of Infectious Diseases
- A. Bacteria
- 114. Classification of Bacteria
- Identification By Phenotypic Characteristics
- Identification By Molecular Analysis
- Gram-Positive Cocci
- 115. Staphylococcus aureus
- Microbiology and Pathogenesis
- Epidemiology
- Clinical Manifestations
- Management
- Prevention
- 116. Coagulase-Negative Staphylococci and Micrococcaceae
- Coagulase-Negative Staphylococci
- Description of The Pathogen
- Pathogenesis
- Epidemiology
- Clinical Manifestations
- Treatment
- Prevention
- Coagulase-Negative Micrococcaceae
- 117. Classification of Streptococci
- 118. Streptococcus pyogenes (Group A Streptococcus)
- The Pathogen, Pathogenesis And Spectrum of Disease
- Pathogenesis And Virulence
- Acute Rheumatic Fever
- Acute Glomerulonephritis
- Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections
- Poststreptococcal Reactive Arthritis
- 119. Streptococcus agalactiae (Group B Streptococcus)
- The Pathogen and Pathogenicity
- Epidemiology
- Clinical Manifestations
- Laboratory Findings And Diagnostic Tests
- Treatment
- Special Considerations
- Prevention
- 120. Enterococcus Species
- Description of Pathogens
- Epidemiology
- Clinical Manifestations
- Treatment
- Prevention
- 121. Viridans Streptococci, Abiotrophia and Granulicatella Species, and Streptococcus bovis Group
- Description of Pathogens
- Epidemiology
- Clinical Manifestations
- Treatment
- Prevention
- 122. Groups C and G Streptococci
- Characteristics of the Pathogens
- Epidemiology
- Clinical Manifestations
- Treatment
- 123. Streptococcus pneumoniae
- Characteristics of the Pathogen
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Prognosis
- Prevention
- 124. Other Gram-Positive, Catalase-Negative Cocci: Leuconostoc and Pediococcus Species and Other Genera
- Characteristics Of Pathogens
- Epidemiology
- Clinical Manifestations
- Therapy
- Gram-Negative Cocci
- 125. Neisseria meningitidis
- Microbiology
- Virulence And Pathogenesis
- Immunity
- Epidemiology
- Clinical Manifestations
- Diagnosis
- Metabolic And Hematologic Abnormalities
- Management
- Emergency Management
- Outcome
- 126. Neisseria gonorrhoeae
- Microbiology, Virulence, Immunity, And Pathogenesis
- Epidemiology
- Antibiotic Resistance
- Clinical Manifestations
- Laboratory Findings And Diagnosis
- Treatment
- Special Considerations
- Prevention And Control
- 127. Other Neisseria Species
- Microbiology and Laboratory Diagnosis
- Epidemiology
- Clinical Manifestations of Infection
- Special Considerations and Prevention
- Gram-Positive Bacilli
- 128. Arcanobacterium haemolyticum
- Epidemiology
- Microbiology, Pathogenesis, and Virulence
- Clinical Manifestations
- Diagnosis
- 129. Bacillus Species (Including Anthrax)
- Microbiology
- Bacillus Anthracis
- Bacillus Cereus
- Bacillus Subtilis and other Bacillus Species
- 130. Corynebacterium diphtheriae
- The Pathogen
- Epidemiology
- Pathogenesis
- Clinical Manifestations
- Management of Symptomatic Patients
- Management of Others
- Prevention
- 131. Other Corynebacteria
- Corynebacterium Jeikeium
- Other Corynebacterium Species
- 132. Listeria monocytogenes
- Description of the Pathogen
- Epidemiology
- Pathogenesis
- Immunity
- Clinical Syndromes
- Diagnosis
- Treatment
- Prevention
- 133. Other Gram-Positive Bacilli
- Erysipelothrix Rhusiopathiae
- Rothia Dentocariosa
- Rhodococcus (Corynebacterium) Equi
- Gardnerella Vaginalis
- Lactobacillus Species
- Tsukamurella Species
- Cellulosimicrobium (Formerly Oerskovia) Species
- Kurthia Species
- 134. Mycobacterium tuberculosis
- Immunology and Pathogenesis
- Epidemiology
- Clinical Manifestations
- Diagnosis
- Therapy
- Bacillus Calmette–Guérin Vaccines
- 135. Mycobacterium Nontuberculosis Species
- Epidemiology
- Pathogenesis
- Laboratory Diagnosis
- Clinical Manifestations
- Treatment
- Prevention
- 136. Nocardia Species
- Microbiology
- Epidemiology
- Pathogenesis
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Enterobacteriaceae: Gram-Negative Bacilli
- 137. Escherichia coli
- Pathogenesis
- Epidemiology
- Clinical Manifestations
- Post-Diarrheal Manifestations
- Laboratory Findings And Diagnosis
- Treatment
- Prevention
- 138. Klebsiella and Raoultella Species
- Microbiology And Epidemiology
- Clinical Manifestations
- Treatment
- Prevention
- 139. Klebsiella granulomatis: Granuloma Inguinale (Donovanosis)
- Clinical Manifestations
- Laboratory Diagnosis
- Management
- Prevention And Control
- 140. Enterobacter, Cronobacter, and Pantoea Species
- Microbiology And Epidemiology
- Clinical Manifestations
- Treatment
- 141. Citrobacter Species
- Microbiology And Epidemiology
- Clinical Manifestations
- Treatment
- 142. Less Commonly Encountered Enterobacterales
- Microbiology, Epidemiology, Clinical Manifestations, and Treatment
- 143. Plesiomonas shigelloides
- Description of Pathogen
- Clinical Manifestations and Diagnosis
- Treatment
- 144. Proteus, Providencia, and Morganella Species
- Microbiology and Epidemiology
- Clinical Manifestations
- Treatment
- 145. Serratia Species
- Microbiology
- Epidemiology
- Clinical Manifestations
- Management
- Acknowledgments
- 146. Salmonella Species
- Description of The Pathogen
- Epidemiology
- Clinical Manifestations
- Laboratory Findings And Diagnostic Tests
- Treatment
- Special Considerations
- Prevention
- 147. Shigella Species
- The Pathogen, Virulence Factors, and Pathogenesis
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Prevention
- 148. Yersinia Species
- Pathogens and Pathogenesis
- Yersinia enterocolitica
- Yersinia pseudotuberculosis
- Yersinia pestis
- Nonenterobacteriaceae: Gram-Negative Bacilli
- 149. Acinetobacter Species
- Microbiology
- Epidemiology
- Clinical Manifestations
- Treatment
- 150. Aeromonas Species
- Description of the Pathogen
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnostic Tests
- Treatment
- Special Considerations
- Prevention
- 151. Less Commonly Encountered NonentericGram-Negative Bacilli
- Microbiology and Epidemiology
- Clinical Manifestations, Diagnosis, and Treatment
- 152. Eikenella, Pasteurella, and Chromobacterium Species
- Microbiology
- Pathophysiology And Epidemiology
- Clinical Manifestations
- Treatment And Prevention
- 153. Moraxella Species
- Microbiology
- Epidemiology
- Clinical Manifestations
- Treatment
- Prevention
- 154. Pseudomonas Species and Related Organisms
- 155. Pseudomonas aeruginosa
- Microbiology
- Virulence Factors and Pathogenesis
- Epidemiology and Clinical Manifestations
- Treatment
- Prevention
- 156. Burkholderia cepacia Complex and Other Burkholderia Species
- Burkholderia Cepacia Complex
- Burkholderia Gladioli
- Burkholderia Pseudomallei Group
- 157. Stenotrophomonas maltophilia
- Virulence Factors
- Epidemiology
- Clinical Manifestations and Treatment
- 158. Vibrio cholerae (Cholera)
- The Pathogen And Microbiology
- Virulence And Pathogenesis
- Immune Response And Susceptibility
- Epidemiology
- Clinical Manifestations
- Laboratory Findings And Diagnosis
- Treatment
- Prevention
- 159. Other Vibrio Species
- Description of the Pathogens
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnostic Tests
- Treatment
- Prevention
- Gram-Negative Coccobacilli
- 160. Bartonella Species (Cat-Scratch Disease)
- The Pathogen And Epidemiology
- Clinical Manifestations
- Laboratory Findings And Diagnosis
- Treatment
- Complications, Sequelae, And Prognosis
- Prevention
- 161. Brucella Species (Brucellosis)
- Pathogen and Pathogenesis
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment and Outcome
- Prevention
- 162. Bordetella pertussis (Pertussis) and Other Bordetella Species
- Etiology And Bordetella Species
- Epidemiology
- Pathogen, Pathophysiology, Transmission, And Immunity
- Clinical Manifestations
- Differential Diagnosis
- Laboratory Findings
- Diagnosis
- Complications And Outcome
- Management
- Control Measures
- Prevention
- 163. Campylobacter jejuni and Campylobacter coli
- Description of the Pathogen
- Epidemiology
- Pathogenesis and Immunity
- Clinical Manifestations
- Diagnosis
- Treatment
- Prevention
- 164. Other Campylobacter Species
- Campylobacter Fetus
- Campylobacter Upsaliensis
- Campylobacter Lari
- Other Campylobacter Species
- 165. Capnocytophaga Species
- Human Capnocytophaga
- Zoonotic Capnocytophaga
- 166. Chlamydophila (Chlamydia) pneumoniae
- The Pathogen
- Epidemiology
- Clinical Manifestations
- Laboratory Diagnosis
- Treatment
- Complications
- 167. Chlamydia trachomatis
- The Pathogen and Pathogenesis
- Epidemiology
- Clinical Manifestations
- Laboratory Diagnosis
- Treatment
- Complications and Sequelae
- Prevention
- 168. Chlamydia (Chlamydophila) psittaci (Psittacosis)
- The Pathogen
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnostic Tests
- Treatment
- 169. Coxiella burnetii (Q Fever)
- The Pathogen
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Special Considerations
- Prevention
- 170. Family Anaplasmataceae (Anaplasmosis, Ehrlichiosis, Neorickettsiosis, and Neoehrlichiosis)
- Description of the Pathogens
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnostic Tests
- Treatment
- Prevention
- 171. Francisella tularensis (Tularemia)
- Description of Pathogen and Epidemiology
- Pathogenesis and Immunity
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Prevention
- 172. Haemophilus influenzae
- The Pathogen
- Epidemiology
- Pathogenesis
- Immunity
- Clinical Manifestations of Haemophilus Influenzae Type B Infection
- Clinical Manifestations of Nontypable Haemophilus Influenzae Infection
- Diagnosis
- Treatment
- Prevention
- 173. Other Haemophilus Species and Aggregatibacter Species
- Haemophilus Influenzae Biogroup Aegyptius
- Haemophilus Ducreyi
- Oral and Pharyngeal Haemophilus and Aggregatibacter Species
- 174. Helicobacter pylori
- The Pathogen
- Epidemiology
- Pathogenesis
- Clinical Manifestations
- Diagnosis
- Treatment
- Prevention
- 175. Other Gastric and Enterohepatic Helicobacter Species
- The Pathogens
- Epidemiology
- Clinical Manifestations
- Diagnosis
- Treatment
- 176. Kingella Species
- Microbiology
- Virulence And Pathogenesis
- Immunity
- Epidemiology
- Clinical Manifestations
- Diagnosis
- Treatment
- 177. Legionella Species
- Pathogenesis And Epidemiology
- Clinical Manifestations
- Laboratory Diagnosis
- Treatment
- Prevention
- 178. Rickettsia rickettsii (Rocky Mountain Spotted Fever)
- Description of The Pathogen
- Epidemiology
- Clinical Manifestations
- Laboratory Findings And Diagnosis
- Treatment
- Special Considerations
- Prevention And Control
- 179. Other Rickettsia Species
- Rickettsia Prowazekii (Classic Louse-Borne Epidemic Typhus: Brill-Zinsser Disease Or Recrudescent Typhus; Sylvatic Or Flying Squirrel-Associated Typhus)
- Rickettsia Typhi (Murine Typhus; Endemic Or Flea-Borne Typhus)
- Rickettsia Felis (Cat Flea Rickettsiosis) And Related Agents
- Rickettsia Akari (Rickettsialpox)
- Rickettsia Parkeri Rickettsiosis
- Rickettsia Philipii (Pacific Coast Tick Fever)
- Other Rickettsia Agents And Orientia (African Tick Bite Fever And Other Travel-Associated Rickettsioses, Including Scrub Typhus)
- 180. Streptobacillus moniliformis (Rat-Bite Fever)
- Epidemiology
- Clinical Findings
- Diagnosis
- Treatment
- Prevention
- 181. Other Gram-Negative Coccobacilli
- Aggregati Bacter Species
- Bartonella Species
- Cardiobacterium Hominis
- Treponemataceae (Spiral Organisms)
- 182. Treponema pallidum (Syphilis)
- Microbiology and Pathogenesis
- Epidemiology
- Clinical Manifestations
- Diagnosis
- Treatment and Follow-up
- Prevention
- 183. Other Treponema Species
- Yaws
- Endemic Syphilis (Bejel)
- Pinta
- Treatment
- 184. Leptospira Species (Leptospirosis)
- Pathogens and Pathogenesis
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnostic Tests
- Treatment
- Maternal and Congenital Leptospirosis
- Prevention
- 185. Borrelia burgdorferi (Lyme Disease)
- Pathogenesis and Immunity
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment and Outcomes
- Special Consideration: Congenital Lyme Disease
- Prevention
- 186. Other Borrelia Species and Spirillum minus
- Borrelia Species (Relapsing Fever)
- Borrelia Mayonii
- Spirillum Minus (Rat-Bite Fever)
- Anaerobic Bacteria
- 187. Anaerobic Bacteria: Clinical Concepts and the Microbiome in Health and Disease
- Classification
- Indigenous Flora
- Microbiome In Health And Disease
- Pathogenesis of Anaerobic Infections
- Clinical Clues And Approach To Diagnosis
- 188. Clostridium tetani (Tetanus)
- Microbiology And Pathogenesis
- Clinical Manifestations
- Diagnosis And Differential Diagnosis
- Treatment And Outcome
- Prevention
- 189. Clostridium botulinum (Botulism)
- Etiology And Pathogenesis
- Epidemiology
- Clinical Manifestations
- Differential Diagnosis
- Diagnosis
- Hospital Course
- Management
- Outcome And Prevention
- Foodborne Botulism
- Wound Botulism
- Vaccine
- 190. Clostridioides difficile
- The Pathogen
- Epidemiology
- Clinical Manifestations
- Diagnosis
- Treatment
- Prevention
- 191. Other Clostridium Species
- Clinical Manifestations
- Diagnosis
- Treatment
- Prevention
- 192. Bacteroides and Prevotella Species and Other Anaerobic Gram-Negative Bacilli
- Pathophysiology
- Clinical Manifestation And Prediction Of Pathogens
- Treatment
- Prevention
- 193. Fusobacterium Species
- Description Of The Pathogen
- Epidemiology
- Clinical Manifestations
- Laboratory Findings And Diagnosis
- Treatment
- Special Considerations
- Prevention
- 194. Anaerobic Cocci
- Pathophysiology And Predisposing Conditions
- Clinical Manifestations
- Treatment
- 195. Anaerobic Gram-Positive Nonsporulating Bacilli (Including Actinomycosis)
- Cutibacterium Species
- Actinomyces Species
- Other Gram-Positive Bacilli
- Mycoplasma
- 196. Mycoplasma pneumoniae
- Description of the Pathogen
- Pathogenesis
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- 197. Other Mycoplasma Species
- Mycoplasma Hominis
- Mycoplasma Genitalium
- Other Mycoplasma Species
- 198. Ureaplasma urealyticum
- Microbiology
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Diseases of Possible Infectious or Unknown Etiology
- 199. Kawasaki Disease
- Etiology and Epidemiology
- Pathology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Special Considerations
- 200. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
- Case Definition
- Epidemiology
- Pathogenesis
- Clinical Manifestations and Evaluation
- Management
- Outcomes
- Section B. Viruses
- 201. Classification of Human Viruses
- DNA Viruses: Poxviridae
- 202. Poxviridae
- Variola And Vaccinia
- Zoonotic Poxviruses
- Molluscum Contagiosum
- DNA Viruses: Herpesviridae
- 203. Introduction to Herpesviridae
- 204. Herpes Simplex Virus
- Pathophysiology
- Immunity
- Epidemiology
- Clinical Syndromes
- Laboratory Findings And Diagnostic Techniques
- Treatment
- Prevention
- 205. Varicella-Zoster Virus
- Pathogenesis
- Epidemiology
- Varicella
- Herpes Zoster
- Laboratory Findings and Diagnosis
- Treatment
- Prevention
- 206. Cytomegalovirus
- The Virus
- Pathogenesis
- Immunity
- Epidemiology
- Clinical Manifestations
- Laboratory Diagnosis
- Management And Antiviral Therapy
- Prevention
- 207. Human Herpesviruses 6 and 7 (Roseola, Exanthem Subitum)
- Human Herpesvirus 6
- Human Herpesvirus 7
- 208. Epstein-Barr Virus (Mononucleosis and Lymphoproliferative Disorders)
- Description Of The Pathogen
- Epidemiology
- Pathogenesis Of Infectious Mononucleosis In Previously Healthy Children
- Clinical Aspects Of Infectious Mononucleosis
- Pathogenesis And Disease In Immunosuppressed Persons
- 209. Human Herpesvirus 8 (Kaposi Sarcoma–Associated Herpesvirus)
- DNA Viruses: Adenoviridae
- 210. Adenoviruses
- Epidemiology
- Clinical Disease
- Diagnosis
- Prevention and Treatment
- DNA Viruses: Papovaviridae
- 211. Human Papillomavirus
- The Virus And Pathogenesis
- Immunity
- Epidemiology And Clinical Features
- Laboratory Screening And Diagnosis
- Management
- Prevention
- 212. BK, JC, and Other Human Polyomaviruses
- Epidemiology
- Bk Virus
- Hematopoietic Stem Cell Transplant Recipients
- Jc Virus
- Merkel Cell Virus
- Trichodysplasia Spinulosa-Associate Polyomavirus
- DNA Viruses: Hepadnaviridae
- 213. Hepatitis B and Hepatitis D Viruses
- Hepatitis B Virus
- Hepatitis Delta Virus
- DNA Viruses: Parvoviridae
- 214. Human Parvoviruses (Parvovirus B19 and Bocavirus)
- Parvovirus B19
- RNA Viruses: Reoviridae
- 215. Coltivirus (Colorado Tick Fever)
- Tick Vector and Vertebrate Hosts
- Other Related Tick-borne Coltiviruses
- 216. Rotaviruses
- Description of the Pathogens
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnostic Tests
- Treatment
- Prevention
- RNA Viruses: Togaviridae, Flaviviridae, and Bunyaviridae
- 217. Togaviridae: Alphaviruses
- Epidemiology and Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Prevention
- 218. Flaviviruses
- Specific Agents
- Diagnosis
- Prevention
- 219. Bunyaviruses
- Description of Pathogen
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Prevention
- 220. Hepatitis C Virus
- Pathogen
- Pathogenesis and Immunity
- Epidemiology
- Clinical Manifestations and Natural History
- Diagnostic Testing and Screening
- Management
- Counseling Parents and Children Regarding Transmission and Prevention
- Treatment
- Prevention
- 221. Rubella Virus
- Pathogen, Pathogenesis, and Immune Response
- Epidemiology
- Clinical Manifestations
- Laboratory Findings And Diagnosis
- Treatment
- Complications Of Acquired Rubella
- Prevention
- RNA Viruses: Coronaviridae
- 222. Human Coronaviruses
- Overview of the Viruses
- Endemic HCOV (HCoV-229E, HCoV-OC43, HCoV-NL63, and HCoV-HKU1)
- Sars-CoV-1
- Mers-CoV
- Sars-CoV-2
- RNA Viruses: Paramyxoviridae
- 223. Parainfluenza Viruses
- Description of the Pathogen
- Epidemiology
- Transmission
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Special Considerations
- Prevention
- 224. Mumps Virus
- Description of the Pathogen
- Epidemiology
- Pathogenesis and Immune Response
- Clinical Manifestations
- Complications
- Diagnosis
- Treatment and Prevention
- 225. Respiratory Syncytial Virus
- The Pathogen
- Epidemiology
- Pathogenesis and the Immune Response
- Clinical Manifestations
- Laboratory Diagnosis
- Management
- Prevention
- Future Directions
- 226. Human Metapneumovirus
- Description of Pathogen
- Epidemiology
- Clinical Manifestations
- Laboratory and Imaging Findings and Diagnosis
- Treatment
- Special Considerations
- Prevention
- 227. Rubeola Virus: Measles and Subacute Sclerosing Panencephalitis
- The Pathogen and Pathogenesis
- Immune Response
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Complications and Special Considerations
- Measles in Immunocompromised Hosts
- Prevention
- RNA Viruses: Rhabdoviridae
- 228. Rabies Virus
- The Virus
- Pathogenesis
- Virulence and Immunity
- Epidemiology
- Clinical Manifestations
- Laboratory Diagnosis
- Management
- Prevention
- RNA Viruses: Orthomyxoviridae
- 229. Influenza Viruses
- Microbiology
- Pathogenesis
- Immunity
- Epidemiology
- Clinical Manifestations
- Complications
- Laboratory and Radiographic Findings
- Diagnosis
- Treatment
- Prevention
- Chemoprophylaxis
- Special Considerations
- Zoonotic Influenza
- RNA Viruses: Arenaviridae and Filoviridae
- 230. Filoviruses and Arenaviruses
- Description of the Pathogens
- Epidemiology
- Pathogenesis
- Clinical Manifestations
- Laboratory Testing
- Treatment
- Prevention
- RNA Viruses: Retroviridae
- 231. Introduction to Retroviridae
- 232. Human T-Cell Lymphotropic Viruses
- Epidemiology
- Clinical Manifestations
- 233. Human Immunodeficiency Virus
- Human Immunodeficiency Virus Type 1
- Human Immunodeficiency Virus Type 2
- Acknowledgment
- RNA Viruses: Picornaviridae
- 234. Introduction to Picornaviridae
- Biology
- 235. Polioviruses
- Pathogen and Pathophysiology
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnostic Tests
- Treatment
- Special Considerations
- Prevention
- Author Note
- 236. Enteroviruses and Parechoviruses
- Pathogenesis
- Immunity
- Epidemiology
- Transmission
- Clinical Manifestations
- Infection in Special Hosts
- Parechovirus Infections
- Laboratory Diagnosis
- Treatment
- Prevention
- 237. Hepatitis A Virus
- The Pathogen
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Prevention
- Post-Exposure Prophylaxis
- 238. Rhinoviruses
- Description of Pathogens and Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Special Considerations
- Prevention
- RNA Viruses: Caliciviridae
- 239. Caliciviruses
- Pathogens and Pathogenesis
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnostic Tests
- Management
- Prevention
- 240. Astroviruses
- Description of Pathogen
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment and Prevention
- 241. Hepatitis E Virus
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Prevention
- Newly Identified Viruses
- Section C. Fungi
- 242. Classification of Fungi
- The Agents
- Laboratory Findings and Diagnosis
- Clinical Manifestations
- 243. Candida Species
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Prevention
- 244. Aspergillus Species
- Microbiology
- Clinical Manifestations
- Epidemiology and Risk Factors
- Diagnosis
- Treatment
- Prognosis
- 245. Agents of Hyalohyphomycosis and Phaeohyphomycosis
- Agents of Hyalohyphomycosis (Fusarium, Scedosporium, Paecilomyces, and Penicillium Species)
- Agents of Phaeohyphomycosis (Bipolaris/Curvularia, Alternaria, Exophiala, Exserohilum, Cladophialophora Species, and Lomentospora Prolificans)
- 246. Agents of Mucormycosis
- Epidemiology
- Clinical Manifestations
- Diagnosis
- Treatment
- Prevention
- 247. Malassezia Species
- Microbiology
- Epidemiology
- Clinical Manifestations
- Diagnosis
- Treatment
- 248. Sporothrix schenckii Complex (Sporotrichosis)
- Microbiology
- Epidemiology
- Clinical Manifestations
- Diagnosis
- Treatment
- Prevention
- 249. Cryptococcus Species
- Epidemiology
- Clinical Manifestations
- Diagnosis
- Treatment
- Special Management Considerations
- Prevention
- 250. Histoplasma capsulatum (Histoplasmosis)
- The Pathogen
- Pathogenesis
- Immunity
- Epidemiology
- Clinical Manifestations
- Laboratory Findings, Imaging, and Diagnosis
- Treatment
- Special Considerations
- Prevention
- 251. Pneumocystis jirovecii
- Description of Pathogen
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Special Considerations
- Treatment
- Prevention
- 252. Blastomyces Species (Blastomycosis)
- Microbiology
- Pathogenesis And Immunity
- Epidemiology and Acquisition
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Special Considerations
- Outcomes and Prevention
- 253. Coccidioides immitis and Coccidioides posadasii (Coccidioidomycosis)
- The Pathogen
- Epidemiology
- Clinical Manifestations
- Diagnosis
- Treatment
- Special Considerations
- Prevention
- 254. Superficial Fungal Infections
- Tinea Capitis
- Onychomycosis
- Tinea Corporis, Tinea Cruris, and Tinea Faciei
- Tinea Pedis
- Candidiasis
- Malassezia Infections
- 255. Agents of Eumycotic Mycetoma: Pseudallescheria boydii and Scedosporium apiospermum
- Microbiology
- Virulence and Immunity
- Pathogenesis
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment and Special Considerations
- Prevention
- Pseudallescheria Boydii (Scedosporium Boydii)
- Section D. Human Parasites and Vectors
- 256. Classification of Parasites
- Parasitic Protozoa
- Parasitic Animalia
- 257. Ectoparasites (Lice and Scabies)
- Pediculosis
- Scabies
- Protozoa
- 258. Babesia Species (Babesiosis)
- Description of The Pathogen
- Epidemiology
- Clinical Manifestations
- Laboratory Findings And Diagnosis
- Treatment
- Special Considerations
- Prevention
- 259. Balantioides coli (Formerly Balantidium coli)
- Life Cycle And Description
- Epidemiology
- Clinical Manifestations
- Diagnosis
- Treatment And Prevention
- 260. Blastocystis Species
- Organism
- Epidemiology
- Clinical Manifestations
- Diagnosis
- Treatment and Prevention
- 261. Cryptosporidium Species
- The Pathogen
- Epidemiology
- Clinical Manifestations
- Laboratory Diagnosis
- Treatment
- Special Considerations
- Prevention
- 262. Endolimax nana
- Description of Endolimax Nana
- Epidemiology and Clinical Manifestations
- Diagnosis and Treatment
- 263. Entamoeba histolytica (Amebiasis)
- Description of the Pathogen
- Pathogenesis
- Immunity
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Prevention
- 264. Other Entamoeba, Amebae, and Intestinal Flagellates
- Entamoeba Histolytica/Entamoeba Dispar Group
- Other Entamoeba Species
- Other Intestinal Amebae and Flagellates
- 265. Giardia intestinalis (Giardiasis)
- Pathogen and Pathogenesis
- Epidemiology
- Clinical Manifestations
- Diagnosis
- Treatment
- Prevention
- 266. Cystoisospora (Isospora) and Cyclospora Species
- Pathogens
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Prevention
- 267. Leishmania Species (Leishmaniasis)
- Description of the Pathogen
- Pathogenesis and Immunity
- Epidemiology
- Clinical Manifestations
- Diagnosis
- Treatment
- Prevention and Control
- 268. Microsporidia
- Pathogen
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Prevention
- 269. Naegleria fowleri
- Description of the Pathogen
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Prevention
- 270. Acanthamoeba Species
- Description of Pathogen
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Prevention
- 271. Plasmodium Species (Malaria)
- Description of The Pathogen
- Epidemiology
- Clinical Manifestations
- Laboratory Findings And Diagnosis
- Treatment
- Prevention
- 272. Sarcocystis Species
- Pathogen
- Epidemiology
- Clinical Manifestations
- Laboratory Findings and Diagnostic Tests
- Treatment and Prevention
- 273. Toxoplasma gondii (Toxoplasmosis)
- Pathogen and Life Cycle
- Epidemiology
- Pathogenesis and Immune Response
- Clinical Manifestations
- Diagnosis
- Treatment
- Prevention
- 274. Trichomonas vaginalis
- Description of The Pathogen
- Epidemiology
- Clinical Manifestations
- Laboratory Findings And Diagnostic Tests
- Treatment
- Special Considerations
- Prevention
- 275. Trypanosoma Species (Trypanosomiasis)
- Human African Trypanosomiasis
- American Trypanosomiasis
- Nematodes
- 276. Intestinal Nematodes
- Ascaris Lumbricoides (Roundworm)
- Hookworm (Ancylostoma Duodenale, Ancylostoma Caninum, Ancylostoma Ceylanicum, and Necator Americanus)
- Trichuris Trichiura
- Enterobius Vermicularis
- Strongyloides Stercoralis and Strongyloides Fuelleborni
- 277. Tissue Nematodes
- Toxocara Canis, Toxocara Cati, and Baylisascaris Procyonis
- Angiostrongylus Species
- Gnathostoma Spinigerum
- Ancylostoma Braziliense
- Ascarids of Marine Mammals
- Trichinella Spiralis (Trichinellosis)
- 278. Blood and Tissue Nematodes: Filarial Worms
- Lymphatic Filariasis
- Onchocerciasis
- Loiasis
- Other Causes of Filariasis
- Dirofilariasis
- Cestodes
- 279. Diphyllobothriidae, Dipylidium and Hymenolepis Species
- Diphyllobothriidae
- Dipylidium Caninum
- Hymenolepis Nana And Hymenolepis Diminuta
- 280. Taenia solium, Taenia asiatica, and Taenia saginata: Taeniasis and Cysticercosis
- Taeniasis
- Cysticercosis
- 281. Echinococcus Species: Agents of Echinococcosis
- Echinococcus Granulosus
- Echinococcus Mulitlocularis
- Echinococcus Vogeli
- 282. Taenia (Multiceps) multiceps and Taenia serialis: Coenurosis
- Epidemiology and Life Cycle
- Clinical Manifestations
- Laboratory Findings and Diagnosis
- Treatment
- Prevention
- Trematodes
- 283. Intestinal Trematodes
- Fasciolopsiasis
- Heterophyiasis And Metagonimiasis
- Echinostome Infections
- Clinical Manifestations
- 284. Clonorchis, Opisthorchis, Fasciola, and Paragonimus Species
- Clonorchiasis and Opisthorchiasis
- Fascioliasis
- Paragonimiasis
- 285. Blood Trematodes: Schistosomiasis
- Biology
- Epidemiology
- Pathogenesis
- Clinical Features
- Diagnosis
- Management
- Special Considerations
- Prevention
- Laboratory Diagnosis and Therapy for Infectious Diseases
- Section A. The Clinician and the Laboratory
- 286. Laboratory Diagnosis of Infection Due to Bacteria, Fungi, Parasites, and Rickettsiae
- Bacteria
- Fungi
- Parasites
- Rickettsiae
- Immunoserology
- Newer Technologies
- 287. Laboratory Diagnosis of Infection Due to Viruses,Chlamydia, and Mycoplasma
- Viruses
- Chlamydiaceae
- Mycoplasma
- 288. Use of Common Clinical Laboratory Tests to Assess Infectious and Inflammatory Diseases
- Acute Phase Response
- Erythrocyte Sedimentation Rate
- C-Reactive Protein
- Procalcitonin
- Iron Metabolism, Ferritin, and Hepcidin
- Other Acute Phase Proteins and Cytokines
- Hemoglobin
- Leukocytes
- Platelets
- Metabolic Abnormalities
- Nonspecific Antibodies
- Section B. Anti-Infective Therapy
- 289. Principles of Anti-Infective Therapy
- Selecting Optimal Antimicrobial Therapy
- Antimicrobial Susceptibility Testing and Interpretation
- Site Of Infection
- Antimicrobial Combinations
- Dosing, Route, and Duration of Therapy
- Outpatient Parenteral Antimicrobial Therapy
- 290. Mechanisms and Detection of Antimicrobial Resistance
- Genetics of Antimicrobial Resistance
- Mechanisms of Resistance
- Detection of Antimicrobial Resistance
- Special Considerations
- 291. Pharmacokinetic and Pharmacodynamic Basis of Optimal Antimicrobial Therapy
- Basic Concepts in Clinical Pharmacokinetics
- Drug Disposition in Specific Patient Populations
- Basis for Drug-Drug Interactions
- Pharmacodynamic Interactions
- Integration of Pharmacokinetic and Pharmacodynamic Principles for Optimal Antibiotic Dosing Regimens
- Pharmacokinetic and Pharmacodynamic Relationships of Other Antimicrobial Agents
- Future Considerations
- 292. Antibacterial Agents
- Cell Envelope-Active Agents
- Cell Wall-Active Agents
- Cell Membrane-Active Agents
- Salivaricins
- Ribosome-Active Antibiotics
- Nucleic Acid-Active Antibiotics
- 293. Antifungal Agents
- Antifungal Agents for Treatment of Superficial Infections
- Antifungal Agents for Treatment of Invasive Infections
- 294. Topical Antimicrobial Agents
- Agents for Ophthalmic Infections
- Agents for Otic Infections
- Agents for Skin Infections
- Agents USED IN Burn Management
- 295. Antiviral Agents
- Anti-Herpesvirus Drugs
- Anti-Influenza Drugs
- Anti-Hepatitis Virus Drugs
- Anti-Coronavirus Drugs
- 296. Antiparasitic Agents
- Treatment of Luminal Protozoa
- Treatment of Kinetoplastidea Infections
- Antimalarial Therapy
- Antibacterial Agents with Antiprotozoan Activity
- Treatment of Helminthic Infections
- Intestinal Nematodes
- Systemic Nematodes
- Trematodes and Cestodes
- Index
- No. of pages: 1720
- Language: English
- Edition: 6
- Published: March 10, 2022
- Imprint: Elsevier
- Hardback ISBN: 9780323756082
- eBook ISBN: 9780443271342
- eBook ISBN: 9780323756099
SL
Sarah S. Long
CP
Charles G. Prober
MF
Marc Fischer
DK