Primary Biliary Cholangitis , An Issue of Clinics in Liver Disease

1st Edition, Volume 26-4 - October 21, 2022
Editor: Binu V. John
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 9 7 2 9 4 - 9
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 7 2 9 5 - 6

In this issue of Clinics in Liver Disease, guest editor Dr. John V. Binu brings his considerable expertise to the topic of Primary Biliary Cholangitis. PBC leads to inflammation… Read more

Primary Biliary Cholangitis , An Issue of Clinics in Liver Disease

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In this issue of Clinics in Liver Disease, guest editor Dr. John V. Binu brings his considerable expertise to the topic of Primary Biliary Cholangitis. PBC leads to inflammation and scarring of the small bile ducts, and, if untreated, can lead to cirrhosis and liver failure. In this issue, top experts provide a state-of-the-art review of diagnosis and treatment for this chronic, progressive liver disorder.

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Preface
Contemporary Epidemiology of Primary Biliary Cholangitis
Key points
Introduction
Natural history and treatment benefit
Risk factors
Precision medicine in primary biliary cholangitis
Summary and future prospective
Financial support
Clinics care points
Genetics of Primary Biliary Cholangitis
Key points
Introduction
Discussion
Summary
Immunologic Responses and the Pathophysiology of Primary Biliary Cholangitis
Key points
Introduction
Autoantibody
Biliary epithelial cell
Aberrant immunoregulation
Genetic susceptibility
Environmental trigger
Summary
Funding
Autoantibodies in Primary Biliary Cholangitis
Key points
Introduction
Summary
Clinics care points
Prognostic Scoring Systems in Primary Biliary Cholangitis: An Update
Key points
Need for prognostic scoring systems in primary biliary cholangitis
Historical prognostic scoring systems
The biochemical response to treatment
Bringing forward risk-stratification at disease onset
Possibilities from integrating multiomics data through artificial intelligence for phenotype definition and disease trajectories
Summary
Clinics care points
Primary Biliary Cholangitis in Males: Pathogenesis, Clinical Presentation, and Prognosis
Introduction
Pathogenesis
Diagnosis
Epidemiology
Clinical, biochemical, and histopathological differences in male versus female primary biliary cholangitis
Management of primary biliary cholangitis in males
Summary
Clinics care points
Disclaimer
Conflicts of interests
The Inconvenient Truth of Primary Biliary Cholangitis/Autoimmune Hepatitis Overlap Syndrome
Key points
Introduction
Inconvenient truths about diagnostic criteria for overlap
Evidence behind existing treatment paradigms
Practical advice and future directions
Clinics care points
Grant support and funding
Noninvasive Evaluation of Fibrosis and Portal Hypertension in Primary Biliary Cholangitis
Key points
Introduction
From histologic stage to noninvasive diagnosis of compensated advanced primary biliary cholangitis
Noninvasive evaluation of fibrosis in primary biliary cholangitis
Noninvasive evaluation of portal hypertension in primary biliary cholangitis
Summary
Hepatocellular Carcinoma in Primary Biliary Cholangitis
Key points
Introduction
Summary
Clinics care points
Disclaimer
Conflicts of interests
Treatment of Primary Biliary Cholangitis: First-Line and Second-Line Therapies
Key points
Introduction
First-line therapies
Second-line therapies
Obeticholic acid and fibrate combination
Immunosuppressant agents
Treatment of associated conditions
Summary
Clinics care points
Evaluation and Management of Pruritus in Primary Biliary Cholangitis
Key points
Introduction
Clinical picture of pruritus in primary biliary cholangitis
Epidemiology of pruritus in primary biliary cholangitis
Pathogenesis of pruritus in primary biliary cholangitis
Evaluation of pruritus in primary biliary cholangitis
Management of pruritus in primary biliary cholangitis
Summary
Clinics care points
Novel Therapies in Primary Biliary Cholangitis: What Is in the Pipeline?
Key points
Introduction
Summary
Clinics Care Points
Liver Transplantation for Primary Biliary Cholangitis
Key points
Introduction
Natural course
Treatment
Risk assessment
Liver transplantation
Trends in liver transplant for primary biliary cholangitis
Summary
Clinics care points

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Primary Biliary Cholangitis , An Issue of Clinics in Liver Disease

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Binu V. John