Precision Oncology in Liver Cancer
Genomics, Infection, and the Exposome in African and Global Contexts
- 1st Edition - November 1, 2026
- Latest edition
- Editor: Zodwa Dlamini
- Language: English
Precision Oncology in Liver Cancer: Genomics, Infection, and the Exposome in African and Global Contexts explores liver cancer through the lens of precision medicine, integr… Read more
Description
Description
Precision Oncology in Liver Cancer: Genomics, Infection, and the Exposome in African and Global Contexts explores liver cancer through the lens of precision medicine, integrating molecular profiling, environmental exposures, and targeted therapies. The book presents a multidisciplinary approach, covering infectious drivers like HBV/HCV, environmental carcinogens such as aflatoxins, and emerging tools including genomics, AI, and liquid biopsies. It emphasizes African-specific challenges and innovations, with case studies and comparative global insights. This volume equips researchers, clinicians, and policymakers with evidence-based strategies to address liver cancer disparities, offering a forward-looking framework for equitable cancer care and research in Africa and globally.
Key features
Key features
- Integrates infection, genomics, and exposome science to provide a holistic understanding of liver cancer etiology and progression
- Presents African case studies alongside global comparisons to contextualize challenges and showcase regionally relevant solutions
- Includes future-focused chapters on AI, multi-omics, and ethical frameworks to guide innovation and equitable implementation
Readership
Readership
Cancer researchers, Oncologists, Genomic scientists, Public health professionals Medical educators and students
Table of contents
Table of contents
Part I: The liver cancer landscape―Global burdens and African realities (Setting the scene: Epidemiology, disparities, and health systems readiness)
1. The global burden of liver cancer―Patterns, inequities, and precision opportunities
Zodwa Dlamini, Rodney Hull, Ravi Mehrotra
2. Liver cancer in Africa―Infection, environmental burdens, and data gaps
Benny Mosoane, Zehra Pamuklar, Maria Garcia Requesens, Anna-Karina Putineanu, Kamal S. Saini, Zodwa Dlamini
3. Health systems and precision readiness―Policy, equity, and financing gaps in Africa
Nkhensani Chauke-Malinga, Demetra Demetriou, Thabiso Victor Miya, Nonkululeko Mthembu, Paulina Czajka-Francuz, Laura Vidal, Archana Munje, Kamal S. Saini, Zodwa Dlamini
Part II: Infectious drivers of liver cancer―Viruses, coinfections, and immune disruption (Dissecting virology, immune response, and comorbid infectious contributions)
4. Hepatitis B and C-virological mechanisms, genomic alterations, and prevention gaps
Tebogo Marutha, Saidon Mbambara, Olalekan Fadebi, Idris Njanje, Pascal Bessong, Daniel Gandia, Norberto Soto, Kamal S. Saini, Zodwa Dlamini
5. HIV, liver disease, and cancer: The impact of co-infection and immunosuppression
Botle Precious Damane, Thanyani Victor Mulaudzi, Dakalo Portia Ramali, Tania Mmapule Maphoso, Shudufhadzo Singo, Mpho Mashigo-Malatsi, Pontsho Moela, Patrick McLeroth, Zehra Pamuklar, Kamal S. Saini, Yvette Hlophe, June Serem, Zodwa Dlamini
6. Parasitic and bacterial infections―The neglected infectious oncogenesis frontier
Zilungile L. Mkhize-Kwitshana, Pragalathan Naidoo, Roxanne Pillay, Zodwa Dlamini
Part III: The exposome and environmental oncology (Cumulative exposure, environmental risks, and culturally linked carcinogens)
7. Aflatoxins in African diets―Exposure, TP53 mutations, and food safety policy
Mohammed Alaouna, Ademar Dantas Da Cunha Junior, Victor Angelico, Kamal S. Saini, Zodwa Dlamini
8. Urbanization, pollution, and industrial waste―The environmental drivers of liver cancer
Nonkululeko Mthembu, Tebogo Marutha, Elisa Marie Ledet, Zodwa Dlamini
9. Alcohol, herbal remedies, and cultural practices―Unpacking the double-edged sword
Thabiso Victor Miya, Kamal S. Saini, Zodwa Dlamini
Part IV: Precision oncology tools―Genomics, microbiome, and digital disruption (Multiomics, technology, and patient empowerment in liver cancer)
10. The genomic landscape of liver cancer―Somatic mutations, pathways, and subtypes
Rodney Hull, Jyotsna Batra, Zodwa Dlamini
11. African genomes and the precision gap―Inclusion, diversity, and innovation
Rahaba Marima, Thabiso Victor Miya, Babatunde Alabi, Palesa C. Koatale, Yulianna Tymovska, Liliana Baila, Rachel Misner, Kamal S. Saini, Richard Khanyile, Zodwa Dlamini
12. The liver―gut microbiome axis- dysbiosis, inflammation, and oncogenesis
Thifhelimbilu Emmanuel Luvhengo, Thabiso Victor Miya, Paulo Nunes, Carmen Besliu, Heidi Ko, Kamal S. Saini, Zodwa Dlamini
13. Liquid biopsy and predictive biomarkers―noninvasive tools for early detection
Meshack Bida, Lesedi Nevondo, Cawekazi Catherine Cingo, Amanda Nogueira, Konstantine Haradinov, Maria Berraondo, Kamal S. Saini, Zodwa Dlamini
14. Artificial intelligence in liver cancer―From radiomics to smart surveillance
Sikhumbuzo Mbatha, Tebogo Marutha, Maria Garcia Requesens, Arun Mankan, Ashokkumar Deenabandu, Kamal S. Saini, Zodwa Dlamini
15. Patient centric technologies: Empowering individuals in liver cancer care
Talent Chipiti, Tendai Makwikwi, Kopang C. Mokhetho, Sandra McGuigan, Krane Huang, Jennifer Brondon, Kamal S. Saini, Zodwa Dlamini
PART V: Ethics, Decolonization, and Future Directions (Towards sustainable, equitable, and African-led liver cancer solutions)
16. Integrating multi-omics and systems thinking―the future of liver cancer research
Afra Basera, Samuel Mpala, Olalekan Fadebi, Tebogo Marutha, Rahaba Marima, Georgios Lolas, Zodwa Dlamini
17. Decolonizing liver cancer research―Ethics, capacity and local ownership
Langanani Mbodi, Vusumuzi David Maringa, Mary Augusta Adam, Bernard David Uzabakiriho, Rachel Misner, Anumeha Prasad, Rohan Paranjpe, Sharadchandra K. Prasad, Zodwa Dlamini
18. Vision for the future: Innovation, collaboration, and a liver cancer-free Africa
Zodwa Dlamini, Tebogo Marutha, Nonkululeko Mthembu, Georgios Lolas
1. The global burden of liver cancer―Patterns, inequities, and precision opportunities
Zodwa Dlamini, Rodney Hull, Ravi Mehrotra
2. Liver cancer in Africa―Infection, environmental burdens, and data gaps
Benny Mosoane, Zehra Pamuklar, Maria Garcia Requesens, Anna-Karina Putineanu, Kamal S. Saini, Zodwa Dlamini
3. Health systems and precision readiness―Policy, equity, and financing gaps in Africa
Nkhensani Chauke-Malinga, Demetra Demetriou, Thabiso Victor Miya, Nonkululeko Mthembu, Paulina Czajka-Francuz, Laura Vidal, Archana Munje, Kamal S. Saini, Zodwa Dlamini
Part II: Infectious drivers of liver cancer―Viruses, coinfections, and immune disruption (Dissecting virology, immune response, and comorbid infectious contributions)
4. Hepatitis B and C-virological mechanisms, genomic alterations, and prevention gaps
Tebogo Marutha, Saidon Mbambara, Olalekan Fadebi, Idris Njanje, Pascal Bessong, Daniel Gandia, Norberto Soto, Kamal S. Saini, Zodwa Dlamini
5. HIV, liver disease, and cancer: The impact of co-infection and immunosuppression
Botle Precious Damane, Thanyani Victor Mulaudzi, Dakalo Portia Ramali, Tania Mmapule Maphoso, Shudufhadzo Singo, Mpho Mashigo-Malatsi, Pontsho Moela, Patrick McLeroth, Zehra Pamuklar, Kamal S. Saini, Yvette Hlophe, June Serem, Zodwa Dlamini
6. Parasitic and bacterial infections―The neglected infectious oncogenesis frontier
Zilungile L. Mkhize-Kwitshana, Pragalathan Naidoo, Roxanne Pillay, Zodwa Dlamini
Part III: The exposome and environmental oncology (Cumulative exposure, environmental risks, and culturally linked carcinogens)
7. Aflatoxins in African diets―Exposure, TP53 mutations, and food safety policy
Mohammed Alaouna, Ademar Dantas Da Cunha Junior, Victor Angelico, Kamal S. Saini, Zodwa Dlamini
8. Urbanization, pollution, and industrial waste―The environmental drivers of liver cancer
Nonkululeko Mthembu, Tebogo Marutha, Elisa Marie Ledet, Zodwa Dlamini
9. Alcohol, herbal remedies, and cultural practices―Unpacking the double-edged sword
Thabiso Victor Miya, Kamal S. Saini, Zodwa Dlamini
Part IV: Precision oncology tools―Genomics, microbiome, and digital disruption (Multiomics, technology, and patient empowerment in liver cancer)
10. The genomic landscape of liver cancer―Somatic mutations, pathways, and subtypes
Rodney Hull, Jyotsna Batra, Zodwa Dlamini
11. African genomes and the precision gap―Inclusion, diversity, and innovation
Rahaba Marima, Thabiso Victor Miya, Babatunde Alabi, Palesa C. Koatale, Yulianna Tymovska, Liliana Baila, Rachel Misner, Kamal S. Saini, Richard Khanyile, Zodwa Dlamini
12. The liver―gut microbiome axis- dysbiosis, inflammation, and oncogenesis
Thifhelimbilu Emmanuel Luvhengo, Thabiso Victor Miya, Paulo Nunes, Carmen Besliu, Heidi Ko, Kamal S. Saini, Zodwa Dlamini
13. Liquid biopsy and predictive biomarkers―noninvasive tools for early detection
Meshack Bida, Lesedi Nevondo, Cawekazi Catherine Cingo, Amanda Nogueira, Konstantine Haradinov, Maria Berraondo, Kamal S. Saini, Zodwa Dlamini
14. Artificial intelligence in liver cancer―From radiomics to smart surveillance
Sikhumbuzo Mbatha, Tebogo Marutha, Maria Garcia Requesens, Arun Mankan, Ashokkumar Deenabandu, Kamal S. Saini, Zodwa Dlamini
15. Patient centric technologies: Empowering individuals in liver cancer care
Talent Chipiti, Tendai Makwikwi, Kopang C. Mokhetho, Sandra McGuigan, Krane Huang, Jennifer Brondon, Kamal S. Saini, Zodwa Dlamini
PART V: Ethics, Decolonization, and Future Directions (Towards sustainable, equitable, and African-led liver cancer solutions)
16. Integrating multi-omics and systems thinking―the future of liver cancer research
Afra Basera, Samuel Mpala, Olalekan Fadebi, Tebogo Marutha, Rahaba Marima, Georgios Lolas, Zodwa Dlamini
17. Decolonizing liver cancer research―Ethics, capacity and local ownership
Langanani Mbodi, Vusumuzi David Maringa, Mary Augusta Adam, Bernard David Uzabakiriho, Rachel Misner, Anumeha Prasad, Rohan Paranjpe, Sharadchandra K. Prasad, Zodwa Dlamini
18. Vision for the future: Innovation, collaboration, and a liver cancer-free Africa
Zodwa Dlamini, Tebogo Marutha, Nonkululeko Mthembu, Georgios Lolas
Product details
Product details
- Edition: 1
- Latest edition
- Published: November 1, 2026
- Language: English
About the editor
About the editor
Zodwa Dlamini
Editor
Zodwa Dlamini is a Professor of Molecular Oncology and the founding Director and the Executive Head of the Pan African Cancer Research Institute (PACRI) in South Africa. She is the Director of South African Medical Research Council (SAMRC) Precision Oncology Research Unit (PORU). She is the DSI/NRF SARChI Chair in Precision Oncology and Cancer Prevention (POCP). She is a member of the American Association for Cancer Research (AACR) Advisory Group on Sub-Saharan Africa. She is a member of the AACR Pathology Resources in Africa Advisory Group. Professor Dlamini is a member of the African Organisation for Research and Training in Cancer (AORTIC) Research Committee Scientific Advisory Board. She is an elected member of the Academy of Science of South Africa. Professor Dlamini is an overseas Fellow of the Royal Society of Medicine (London). She is the Associate Editor for Frontiers in Oncology: Cancer Genetics Section
Affiliations and expertise
University of Pretoria, South AfricaView book on ScienceDirect
View book on ScienceDirect
Read Precision Oncology in Liver Cancer on ScienceDirect