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Practical Pulmonary Pathology
A Diagnostic Approach
- 4th Edition - November 22, 2022
- Editors: Maxwell L. Smith, Kevin O. Leslie, Mark R. Wick
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 7 9 5 4 7 - 0
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 8 4 4 0 - 3
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 7 9 5 4 8 - 7
Part of the in-depth and practical Pattern Recognition series, Practical Pulmonary Pathology, 4th Edition, helps you arrive at an accurate diagnosis by using a pattern-based… Read more
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Request a sales quotePart of the in-depth and practical Pattern Recognition series, Practical Pulmonary Pathology, 4th Edition, helps you arrive at an accurate diagnosis by using a pattern-based approach. Leading diagnosticians in pulmonary pathology offer practical assistance in identifying all major neoplastic and non-neoplastic diseases of the lungs, guiding you from a pathological pattern through the appropriate work-up, around the pitfalls, and to the best diagnosis. More than 1,000 high-quality illustrations capture key morphologic patterns for a full range of common and rare conditions and assist in the interpretation of complex diagnostic puzzles. A unique “visual index” at the beginning of the book directs you to the exact chapter and specific page you need for in-depth diagnostic guidance.
Helps you quickly recognize the vast variety of appearances of the lung that result from infections, tumors, and tumor-like lesions, both malignant and benign.
Discusses advances in molecular diagnostic testing, its capabilities and its limitations, including targeted/personalized medicine.
Incorporates clinicopathologic background and relevant data from ancillary techniques (immunohistochemistry, cytogenetics, and molecular genetics), giving you the tools you need to master the latest breakthroughs in diagnostic technology.
Covers the latest TNM staging and WHO classification systems, as well as new diagnostic biomarkers and their utility in differential diagnosis, newly described variants, and new histologic entities.
Color-codes patterns to specific entities, and summarizes key points in tables, charts, and graphs so you can quickly and easily find what you are looking for.
Shares the knowledge and expertise of new co-editor, Dr. Maxwell L. Smith.
Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
- Cover image
- Title page
- Table of Contents
- Copyright
- List of Contributors
- Series Preface
- Preface
- Pattern Based Approach to Diagnosis
- List of Tables
- List of Illustrations
- 1. Lung anatomy
- Development and gross anatomy
- Microscopic anatomy
- Pulmonary arteries
- Pulmonary veins
- Bronchial arteries
- Pulmonary lymphatics
- Other pulmonary lymphoid tissue
- Composite microscopic anatomy and relationship to distribution of lung diseases
- References
- 2. Pulmonary function testing for pathologists
- Lung volumes
- Tools to measure volumes
- Interpretation of lung volumes
- Flows
- Airway resistance
- Summary
- References
- 3. Optimal processing of diagnostic lung specimens
- Specimens obtained through the flexible bronchoscope
- Specimens obtained by transthoracic needle biopsy and aspiration
- Specimens obtained by thoracoscopy
- Conclusion
- References
- 4. Computed tomography of diffuse lung diseases and solitary pulmonary nodules
- Foundations
- Diffuse lung diseases
- Septal pattern
- Fibrotic pattern
- Nodular pattern
- Alveolar pattern
- Cystic pattern
- Dark lung pattern
- Imaging of the solitary pulmonary nodule
- References
- 5. Developmental and pediatric lung disease
- Processing of pediatric lung biopsy specimens
- Processing of pediatric cystic lung lesion specimens
- Cysts and masses
- Pulmonary hyperlucency
- Disorders of lung development
- Vascular disorders
- Complications of prematurity
- Pediatric interstitial lung disease
- References
- 6. Acute lung injury
- Practical approach to the differential diagnosis of acute lung injury for pathologists
- History and nomenclature of acute lung injury, acute respiratory distress syndrome, diffuse alveolar damage, and acute interstitial pneumonia
- Diffuse alveolar damage: The morphologic prototype of acute lung injury
- Specific causes of acute lung injury
- Clinicopathologic correlation
- References
- 7. Lung infections
- Histologic patterns of lung infection
- Useful tools and strategies
- Agents of infection
- Mycobacterial infections
- Fungal pneumonias
- Viral pneumonia
- Parasitic infections
- References
- 8. Chronic diffuse lung diseases
- Patterns encountered in this chapter
- Idiopathic interstitial pneumonias
- Chronic manifestations of systemic collagen vascular disease
- Diffuse eosinophilic lung disease (pulmonary eosinophilia)
- Drug-associated diffuse lung disease
- Diffuse lung diseases with granulomas
- Miscellaneous diffuse lung diseases
- Practical approach to the differential diagnosis of diffuse lung diseases
- References
- 9. Nonneoplastic pathology of the large and small airways
- Large airways: Trachea and bronchi
- Small airways
- Clinicopathologic entities with prominent airway manifestations
- Occupational airway diseases
- References
- 10. Pneumoconioses
- Overview and general considerations
- Types of pneumoconiosis
- References
- 11. Pulmonary vasculitis and pulmonary hemorrhage
- Pulmonary vasculitis
- Pulmonary hemorrhage
- References
- 12. Pulmonary hypertension
- Introduction
- Morphologic features of the pulmonary vasculature
- Definition of pulmonary hypertension
- Classification and genetics of pulmonary hypertension
- Pathologic features of pulmonary hypertension
- Thrombotic and embolic hypertension
- Pulmonary venous hypertension
- Pulmonary hypertension secondary to intrinsic lung disease or hypoxia
- Morphologic mimics of pulmonary hypertension
- Pathogenesis and treatment of pulmonary hypertension
- References
- 13. Pathology of lung transplantation
- Introduction
- Pulmonary allograft rejection
- Chronic lung allograft dysfunction
- Infection
- Posttransplantation lymphoproliferative disorders
- Transplantation procedure-related complications
- Recurrence of the primary disease
- Aspiration
- Donor-related pathology
- References
- 14. Neuroendocrine neoplasms of the lung
- Introduction and general considerations
- Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia
- Carcinoid tumor
- Atypical carcinoid
- Large cell neuroendocrine carcinoma
- Small cell carcinoma
- Primitive neuroectodermal tumor
- Other rare neuroendocrine tumors
- References
- 15. Sarcomas and sarcomatoid neoplasms of the lungs and pleural surfaces
- Introduction
- General concepts
- Pleomorphic spindle cell neoplasms
- Monomorphic spindle cell neoplasms
- Epithelioid and rhabdoid malignancies
- Small round cell sarcomas
- References
- 16. Hematolymphoid disorders
- Special studies
- Reactive lymphoid proliferations
- Neoplastic and malignant lymphoid proliferations
- Myeloid proliferations
- References
- 17. Non-neuroendocrine carcinomas (excluding sarcomatoid carcinoma) and salivary gland-type tumors of the lung
- Lung carcinoma: General considerations
- Specific subtypes of lung carcinoma (excluding neuroendocrine and sarcomatoid carcinomas)
- Practical approach to the diagnosis of lung carcinoma in small biopsy specimens, including cytology specimens
- Approach to the diagnosis of lung carcinoma in resection specimens
- References
- 18. Metastatic tumors in the lung: A practical approach to diagnosis
- Pathophysiologic methods of malignant spread
- Pleural metastases
- Endobronchial metastases
- Modalities for the diagnosis of pleuropulmonary metastases
- Practical approach to differential diagnosis
- References
- 19. Pseudoneoplastic lesions of the lungs and pleural surfaces
- Mesenchymal lesions
- Fibroinflammatory lesions
- Lymphoid lesions
- Epithelioid lesions
- Reactive/atypical II pneumocytes
- Other
- Pseudoneoplastic lesions of the pleural surfaces
- References
- 20. Benign and borderline tumors of the lungs and pleura
- Benign pleuropulmonary neoplasms
- Benign tumors that are principally tracheal and endobronchial
- Benign lesions affecting either the airways or the lung parenchyma
- Benign tumors of the pleura
- Biologically borderline tumors of the lung and pleura
- Other lesions
- References
- 21. Malignant and borderline mesothelial tumors of the pleura
- Mesothelioma
- Etiologic considerations in pleural mesothelioma
- Molecular genetics of mesothelioma
- Gross features of pleural mesothelioma
- Histopathologic features of pleural mesothelioma
- Cytopathologic features of pleural mesothelioma
- Histochemical features of pleural mesothelioma
- Electron microscopic features of pleural mesothelioma
- Immunohistochemical findings in pleural mesothelioma
- Differential diagnosis of benign versus malignant mesothelial proliferations
- Differential diagnosis of epithelioid pleural mesothelioma
- Benign and borderline (low-grade malignant) mesothelial tumors
- Staging and grading of malignant mesothelioma
- References
- Appendix: Miscellaneous distinctive histopathologic findings
- Index
- No. of pages: 880
- Language: English
- Edition: 4
- Published: November 22, 2022
- Imprint: Elsevier
- Hardback ISBN: 9780323795470
- eBook ISBN: 9780443284403
- eBook ISBN: 9780323795487
MS
Maxwell L. Smith
Affiliations and expertise
Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Scottsdale, ArizonaKL
Kevin O. Leslie
Affiliations and expertise
Professor of Pathology, Mayo Clinic Arizona, Scottsdale, Arizona, USAMW
Mark R. Wick
Affiliations and expertise
Professor of Pathology, University of Virginia Health System, Charlottesville, Virginia, USA