Practical Dermatopathology

3rd Edition - March 5, 2021
Author: Ronald P. Rapini
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 4 1 7 8 8 - 4

Written from the perspective of both the histopathologist and clinician, Practical Dermatopathology, 3rd Edition, allows you to search by disease or pathologic feature to quickly… Read more

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Written from the perspective of both the histopathologist and clinician, Practical Dermatopathology, 3rd Edition, allows you to search by disease or pathologic feature to quickly locate key criteria and a differential diagnosis. Practical and portable, Practical Dermatopathology is your ideal high-yield microscope companion!

Cover image
Title page
Table of Contents
Copyright
Acknowledgments
Preface
Chapter 1: Clinical and Pathologic Findings with Differential Diagnostic Lists
A: Overview of clinical findings
B: Overview of pathologic findings
C: Differential diagnostic lists
Acanthosis (see Hyperplasia of epidermis, 1.61)
Erythema (see red)
Hyperpigmentation (see Brown)
Chapter 2: Eczematous and Papulosquamous Diseases
2.1: Eczema (eczematous dermatitis)
2.2: Contact dermatitis
2.3: Lichen simplex chronicus and prurigo nodularis
2.4: Pityriasis rosea (PR)
2.5: Lichen striatus
2.6: Pityriasis alba
2.7: Flegel’s disease (hyperkeratosis lenticularis perstans)
2.8: Psoriasis
2.9: Parapsoriasis
2.10: Pityriasis rubra pilaris (PRP)
2.11: Lichen planus (LP)
2.12: Lichen nitidus
2.13: Keratosis lichenoides chronica (Nekam’s disease, lichen ruber moniliformis)
2.14: Pityriasis lichenoides et varioliformis acuta (PLEVA, Mucha-Habermann disease)
2.15: Palmoplantar keratoderma (hyperkeratosis palmaris et plantaris)
Chapter 3: Reactive Erythemas
3.1: Urticaria
3.2: Erythema multiforme (EM)
3.3: Erythema annulare centrifugum (EAC)
3.4: Erythema gyratum repens (EGR)
3.5: Drug eruptions
3.6: Pruritic urticarial papules and plaques of pregnancy (PUPPP, polymorphous eruption of pregnancy, PEP)
3.7: Sweet’s syndrome (acute febrile neutrophilic dermatosis)
3.8: Wells syndrome (eosinophilic cellulitis)
3.9: Erythema ab igne
3.10: Livedo reticularis and cutis marmarata
3.11: Erythema dyschromicum perstans (ashy dermatosis, dermatitis cenicienta)
3.12: Chilblains (perniosis)
3.13: Erythromelalgia (erythermalgia)
Chapter 4: Vasculitis and Other Purpuric Diseases
4.1: Leukocytoclastic vasculitis (LCV, neutrophilic vasculitis, necrotizing vasculitis)
4.2: Granuloma faciale (GF)
4.3: Erythema elevatum diutinum (EED)
4.4: Polyarteritis nodosa (periarteritis nodosa, PAN)
4.5: Churg–Strauss syndrome (CSS; allergic granulomatous angiitis, eosinophilic granulomatosis with polyangiitis, EGPA)
4.6: Wegener’s granulomatosis (WG; granulomatosis with polyangiitis, GPA)
4.7: Lymphocytic vasculitis
4.8: Purpura pigmentosa chronica (progressive pigmentary purpura, capillaritis)
4.9: Cryoglobulinemia
4.10: Degos disease (malignant atrophic papulosis)
4.11: Behçet’s syndrome (Adamantiades–Behçet’s disease)
4.12: Pyoderma gangrenosum (PG)
4.13: Atrophie blanche (segmental hyalinizing vasculopathy, livedoid vasculopathy)
4.14: Coagulopathies
4.15: Solar purpura
4.16: Thrombotic and embolic diseases
4.17: Scurvy
4.18: Coumarin-induced necrosis
4.19: Buerger’s disease (thromboangiitis obliterans)
Chapter 5: Intraepidermal Vesicular and Pustular Diseases
5.1: Acropustulosis of infancy
5.2: Transient neonatal pustular melanosis
5.3: Erythema toxicum neonatorum
5.4: Pemphigus
5.5: Hailey–Hailey disease (benign familial pemphigus)
5.6: Grover’s disease (transient acantholytic dermatosis, TAD)
5.7: Friction blister
Chapter 6: Subepidermal Vesicular Diseases
6.1: Bullous pemphigoid (BP)
6.2: Mucous membrane pemphigoid (cicatricial pemphigoid)
6.3: Pemphigoid gestationis (herpes gestationis, HG)
6.4: Linear IgA bullous dermatosis
6.5: Dermatitis herpetiformis (DH)
6.6: Epidermolysis bullosa (EB)
6.7: Burns
6.8: Ischemic bullae
6.9: Bullosis diabeticorum
Chapter 7: Noninfectious Granulomas
7.1: Granuloma annulare (GA)
7.2: Necrobiosis lipoidica
7.3: Rheumatoid nodule
7.4: Actinic granuloma of O’Brien (annular elastolytic granuloma)
7.5: Sarcoidosis
7.6: Foreign body granuloma
7.7: Cheilitis granulomatosa
7.8: Multicentric reticulohistiocytosis (MRH)
7.9: Xanthoma
7.10: Juvenile xanthogranuloma (JXG)
7.11: Necrobiotic xanthogranuloma (NXG)
7.12: Verruciform xanthoma (VX)
7.13: Other rare histiocytoses
Chapter 8: Deposition and Metabolic Diseases
8.1: Porphyria
8.2: Colloid milium
8.3: Lipoid proteinosis (hyalinosis cutis et mucosae, Urbach–Wiethe disease)
8.4: Amyloidosis
8.5: Gout
8.6: Generalized myxedema
8.7: Pretibial myxedema
8.8: Papular mucinosis (lichen myxedematosus)
8.9: Digital mucous cyst (digital myxoid pseudocyst, digital synovial cyst)
8.10: Mucocele (mucous cyst of the mouth)
8.11: Focal mucinosis of the skin
8.12: Scleredema of Buschke
8.13: Reticular erythematous mucinosis syndrome (REM syndrome)
8.14: Mucopolysaccharidoses
8.15: Calcinosis cutis
8.16: Ochronosis
8.17: Hemochromatosis
8.18: Argyria
8.19: Nephrogenic systemic fibrosis (nephrogenic fibrosing dermopathy, scleromyxedema-like fibromucinosis of renal disease)
8.20: Miscellaneous deposition diseases
Chapter 9: Alterations of Connective Tissue
9.1: Solar elastosis
9.2: Radiodermatitis
9.3: Scleroderma
9.4: Atrophoderma of Pasini and Pierini
9.5: Lichen sclerosus (lichen sclerosus et atrophicus, LS&A)
9.6: Progeria
9.7: Pachydermoperiostosis
9.8: Pseudoxanthoma elasticum (PXE, Gronblad–Strandberg syndrome)
9.9: Ehlers–Danlos syndrome (EDS)
9.10: Cutis laxa
9.11: Anetoderma (macular atrophy)
9.12: Kyrle’s disease (hyperkeratosis follicularis et parafollicularis in cutem penetrans)
9.13: Elastosis perforans serpiginosa (EPS)
9.14: Reactive perforating collagenosis (RPC)
9.15: Mid-dermal elastolysis
Chapter 10: Adnexal Inflammatory Diseases
10.1: Acne
10.2: Folliculitis
10.3: Perforating folliculitis
10.4: Trichostasis spinulosa
10.5: Keratosis pilaris (KP) and lichen spinulosus
10.6: Miliaria
10.7: Fox–Fordyce disease (apocrine miliaria)
10.8: Follicular mucinosis (MF, alopecia mucinosa)
10.9: Alopecia areata (AA)
10.10: Pseudopelade of Brocq
10.11: Follicular trauma
10.12: Androgenetic alopecia (AGA)
10.13: Lipedematous alopecia
10.14: Telogen effluvium (TE)
10.15: Neutrophilic eccrine hidradenitis
Chapter 11: Some Genodermatoses
11.1: Ichthyosis
11.2: Ectodermal dysplasia
11.3: Darier’s disease (Darier–White disease, keratosis follicularis)
11.4: Dyskeratosis congenita (DKC)
11.5: Rothmund–Thomson syndrome (poikiloderma congenitale)
11.6: Incontinentia pigmenti (IP, Bloch–Sulzberger syndrome)
11.7: Hypomelanosis of Ito (incontinentia pigmenti achromians)
11.8: Goltz syndrome (focal dermal hypoplasia)
11.9: Albinism (oculocutaneous albinism)
11.10: Bloom syndrome (congenital telangiectatic erythema)
11.11: Xeroderma pigmentosum (XP)
11.12: Ataxia–telangiectasia (Louis–Bar syndrome)
11.13: Other genetic conditions
Chapter 12: Bacterial Diseases
12.1: Impetigo
12.2: Toxin-induced bacterial diseases
12.3: Infectious cellulitis
12.4: Anthrax
12.5: Corynebacterial infections
12.6: Tularemia
12.7: Chancroid
12.8: Granuloma inguinale (donovanosis)
12.9: Rhinoscleroma
12.10: Tuberculosis
12.11: Atypical mycobacterial infections
12.12: Hansen’s disease (leprosy)
12.13: Syphilis
12.14: Borreliosis
12.15: Bartonella infections
12.16: Actinomycosis
12.17: Nocardiosis
12.18: Gonococcemia
12.19: Meningococcemia
12.20: Ecthyma gangrenosum
12.21: Malakoplakia
12.22: Brucellosis
12.23: Yersiniosis
Chapter 13: Fungal Diseases
13.1: Dermatophytosis (tinea)
13.2: Tinea versicolor (TV, pityriasis versicolor)
13.3: Tinea nigra
13.4: Candidiasis (moniliasis, candidosis)
13.5: Cryptococcosis
13.6: Coccidioidomycosis
13.7: South American blastomycosis (paracoccidioidomycosis)
13.8: North American blastomycosis
13.9: Histoplasmosis
13.10: Chromomycosis (chromoblastomycosis)
13.11: Sporotrichosis
13.12: Zygomycosis (phycomycosis, mucormycosis)
13.13: Aspergillosis
13.14: Mycetoma (madura foot, maduromycosis)
13.15: Rhinosporidiosis
13.16: Lobomycosis (Lobo’s disease, lacaziosis, keloidal blastomycosis)
13.17: Pheohyphomycosis
13.18: Hyalohyphomycosis
13.19: Talaromycosis (formerly Penicilliosis)
Chapter 14: Viral, Rickettsial, and Chlamydial Diseases
14.1: Human papillomavirus infection (HPV, viral wart, verruca)
14.2: Herpes simplex (HSV, herpes type 1 and 2) and varicella zoster (VZV, herpes type 3)
14.3: Smallpox and vaccinia
14.4: Molluscum contagiosum
14.5: Orf and milker’s nodule (collectively called farmyard pox)
14.6: Coxsackie virus infection
14.7: Viral exanthems
14.8: Epstein–Barr virus infection (EBV, herpes type 4)
14.9: Cytomegalovirus infection (CMV, herpes type 5)
14.10: Kawasaki’s disease
14.11: Gianotti–Crosti syndrome (papular acrodermatitis of childhood)
14.12: Human immunodeficiency virus (HIV) infection
14.13: Rickettsial diseases
14.14: Lymphogranuloma venereum (LGV)
14.15: Psittacosis
14.16: Trichodysplasia spinulosa
Chapter 15: Parasitic Diseases
15.1: Leishmaniasis
15.2: Protothecosis
15.3: Cysticercosis
15.4: Dirofilariasis
15.5: Onchocerciasis
15.6: Cutaneous larval migrans
15.7: Arthropod bites and stings (arthropod assaults)
15.8: Demodicosis
15.9: Scabies
15.10: Myiasis
15.11: Tungiasis
15.12: Pneumocystosis
15.13: Amebiasis
15.14: Trypanosomiasis
15.15: Toxoplasmosis
15.16: Schistosomiasis
Chapter 16: Panniculitis
16.1: Erythema nodosum (EN)
16.2: Weber–Christian disease (relapsing febrile nodular non-suppurative panniculitis)
16.3: Cold panniculitis
16.4: Sclerema neonatorum
16.5: Subcutaneous fat necrosis of the newborn
16.6: Erythema induratum (nodular vasculitis)
16.7: Superficial thrombophlebitis
16.8: Pancreatic panniculitis
16.9: Lipodermatosclerosis (hypodermitis sclerodermiformis, sclerosing panniculitis)
16.10: Alpha-1 antitrypsin deficiency panniculitis
16.11: Lipodystrophy
Chapter 17: Other Non-neoplastic Diseases
17.1: Acrodermatitis enteropathica
17.2: Vitiligo
17.3: Graft-versus-host disease (GVH, GVHD)
17.4: Aplasia cutis congenita
17.5: Polymorphous light eruption (PMLE)
17.6: Lupus erythematosus (LE)
17.7: Dermatomyositis
17.8: Relapsing polychondritis
17.9: Chondrodermatitis nodularis chronica helicis (CNCH, CNH)
17.10: Other pigmentary anomalies
17.11: Other mouth lesions
Chapter 18: Epithelial Neoplasms
18.1: Epidermal nevus (linear epidermal nevus)
18.2: Seborrheic keratosis (SK)
18.3: Acrokeratosis verruciformis (AKV)
18.4: Porokeratosis
18.5: Acanthosis nigricans
18.6: Clear cell acanthoma (pale cell acanthoma)
18.7: Warty dyskeratoma
18.8: Actinic keratosis (AK, solar keratosis)
18.9: Arsenical keratosis
18.10: Bowen’s disease (squamous cell carcinoma in situ, SCCis, intraepidermal SCC)
18.11: Squamous cell carcinoma (SCC)
18.12: Keratoacanthoma (KA)
18.13: Paget’s disease
18.14: Basal cell carcinoma (BCC)
18.15: Onychomatricoma
Chapter 19: Cysts
19.1: Follicular infundibular cyst (epidermal inclusion cyst, epidermoid cyst)
19.2: Pilar cyst (trichilemmal cyst, isthmus-catagen cyst, wen)
19.3: Dermoid cyst
19.4: Vellus hair cyst
19.5: Steatocystoma
19.6: Cervical thymic cyst
19.7: Cutaneous ciliated cyst
19.8: Thyroglossal duct cyst
19.9: Branchial cleft cyst
19.10: Bronchogenic cyst
19.11: Hidrocystoma (cystadenoma)
19.12: Median raphe cyst of the penis
19.13: Auricular pseudocyst
Chapter 20: Melanocytic Neoplasms
20.1: Freckle (ephelis, plural is ephelides)
20.2: Café-au-lait spot (café-au-lait macule, CALM)
20.3: Lentigo simplex
20.4: Solar lentigo
20.5: Melanocytic nevus (poor synonyms: common mole, nevocellular nevus)
20.6: Spitz nevus (antiquated synonyms: spindle and epithelioid cell nevus, S&E nevus, benign juvenile melanoma)
20.7: Dysplastic nevus (DN, nevus with architectural disorder, NAD, NWAD, Clark nevus, atypical nevus)
20.8: Blue nevus
20.9: Nevus of Ota (nevus fuscocaeruleus ophthalmomaxillaris), nevus of Ito (nevus fuscocaeruleus acromiodeltoideus)
20.10: Mongolian spot
20.11: Melanoma
Chapter 21: Sebaceous Neoplasms
21.1: Sebaceous hyperplasia
21.2: Nevus sebaceus (organoid nevus)
21.3: Sebaceous adenoma
21.4: Basal cell carcinoma with sebaceous differentiation
21.5: Sebaceous carcinoma
Chapter 22: Follicular Neoplasms
22.1: Trichofolliculoma
22.2: Trichoepithelioma (TE)
22.3: Pilomatrixoma (pilomatricoma, calcifying epithelioma of Malherbe)
22.4: Proliferating pilar cyst (proliferating trichilemmal cyst, pilar tumor, proliferating follicular cystic neoplasm, giant hair matrix tumor)
22.5: Trichilemmoma (tricholemmoma)
22.6: Fibrofolliculoma and trichodiscoma
22.7: Trichoblastoma (TBL)
Chapter 23: Sweat Gland Neoplasms
23.1: Eccrine nevus and apocrine nevus
23.2: Hidradenoma papilliferum
23.3: Syringocystadenoma papilliferum (SCAP)
23.4: Cylindroma of skin
23.5: Nipple adenoma (erosive adenomatosis of the nipple, papillary adenoma of the nipple)
23.6: Tubular apocrine adenoma
23.7: Syringoma
23.8: Papillary eccrine adenoma
23.9: Nodular hidradenoma (eccrine acrospiroma)
23.10: Eccrine poroma
23.11: Eccrine spiradenoma
23.12: Chondroid syringoma (mixed tumor of skin)
23.13: Sweat gland carcinoma
Chapter 24: Myeloproliferative Disorders
24.1: Mycosis fungoides (MF)
24.2: Sezary syndrome
24.3: Adult T-cell leukemia–lymphoma (ATLL)
24.4: Subcutaneous T-cell lymphoma
24.5: CD30 + lymphoproliferative disorders
24.6: Natural killer (NK) cell and cytotoxic lymphomas
24.7: Other T-cell lymphomas
24.8: Primary cutaneous follicular center lymphoma (PCFCL)
24.9: Primary cutaneous marginal zone lymphoma (PCMZL)
24.10: Primary cutaneous diffuse large B-cell lymphoma, leg type (DLBCLLT)
24.11: Other B-cell lymphomas
24.12: Multiple myeloma (plasma cell myeloma)
24.13: Intravascular lymphoma
24.14: Pseudolymphoma (cutaneous lymphoid hyperplasia, lymphocytoma cutis, lymphadenosis benigna cutis, Spiegler–Fendt sarcoid, Bäfverstedt syndrome)
24.15: Hodgkin lymphoma
24.16: Leukemia cutis
24.17: Mastocytosis
24.18: Langerhans cell histiocytosis (LCH, histiocytosis X, Langerhans cell granulomatosis)
24.19: Cutaneous extramedullary hematopoiesis
Chapter 25: Vascular Proliferations and Neoplasms
25.1: Hemangioma and vascular malformation
25.2: Angiokeratoma
25.3: Pyogenic granuloma (PG, lobular capillary hemangioma)
25.4: Angiolymphoid hyperplasia with eosinophilia (ALHE, antiquated name: histiocytoid hemangioma)
25.5: Glomus tumor
25.6: Hemangiopericytoma
25.7: Angiosarcoma
25.8: Intravascular papillary endothelial hyperplasia (IPEH, Massońs pseudoangiosarcoma)
25.9: Kaposi sarcoma (KS)
25.10: Lymphangioma
Chapter 26: Neural Neoplasms
26.1: Neurofibroma (NF)
26.2: Schwannoma (neurilemmoma)
26.3: Neuroma
26.4: Granular cell tumor
26.5: Heterotopic neuroglial tissue
26.6: Heterotopic meningeal tissue
26.7: Myxoid neurothekeoma (nerve sheath myxoma)
26.8: Merkel cell carcinoma (MCC, neuroendocrine carcinoma of the skin, trabecular carcinoma)
26.9: Malignant peripheral nerve sheath tumor (MPNST, malignant schwannoma, antiquated name neurofibrosarcoma)
Chapter 27: Fibrohistiocytic Proliferations and Neoplasms
27.1: Dermatofibroma (DF, benign fibrous histiocytoma, subepidermal nodular fibrosis)
27.2: Scar (cicatrix)
27.3: Angiofibroma (fibrous papule)
27.4: Acrochordon (skin tag, soft fibroma, fibroepithelial polyp, FEP)
27.5: Acquired digital fibrokeratoma
27.6: Connective tissue nevus
27.7: Infantile digital fibromatosis (inclusion body fibromatosis)
27.8: Nodular fasciitis (pseudosarcomatous fasciitis)
27.9: Giant cell tumor of tendon sheath (giant cell tumor of soft tissue)
27.10: Dermatofibrosarcoma protuberans (DFSP)
27.11: Pleomorphic sarcoma (malignant fibrous histiocytoma, MFH)
27.12: Atypical fibroxanthoma (AFX, superficial malignant fibrous histiocytoma, superficial pleomorphic sarcoma, pleomorphic dermal sarcoma)
27.13: Fibrosarcoma
27.14: Epithelioid sarcoma
27.15: Fibromatosis
27.16: Calcifying aponeurotic fibroma
27.17: Myxoma (cutaneous myxoma, superficial angiomyxoma)
27.18: Plexiform fibrohistiocytic tumor (PFT)
27.19: Fibrous hamartoma of infancy
27.20: Solitary fibrous tumor (SFT)
27.21: Cutaneous PEComa
Chapter 28: Metastatic Neoplasms to Skin
28.1: Metastatic squamous cell carcinoma
28.2: Metastatic adenocarcinoma
28.3: Metastatic breast carcinoma
28.4: Metastatic renal cell carcinoma
28.5: Metastatic small cell carcinoma
28.6: Metastatic sarcoma
Chapter 29: Miscellaneous Remnants and Neoplasms
29.1: Nevus lipomatosus
29.2: Lipoma
29.3: Benign lipoblastoma
29.4: Hibernoma
29.5: Liposarcoma
29.6: Leiomyoma
29.7: Leiomyosarcoma
29.8: Osteoma cutis
29.9: Cutaneous endometriosis
29.10: Accessory tragus
29.11: Omphalomesenteric duct polyp
29.12: Accessory nipple (supernumerary nipple, polythelia)
Chapter 30: Special Stains
References and Further Reading
Index
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Ronald P. Rapini