Population Neuroimaging
- 1st Edition - March 2, 2026
- Editors: Ryan Muetzel, Tonya White, Henning Tiemeier
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 5 1 9 6 - 5
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 5 1 9 7 - 2
Population Neuroimaging is an emerging field with the goal to understand brain structure, function, development, and ageing within the general population, including the inhere… Read more
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Population Neuroimaging is an emerging field with the goal to understand brain structure, function, development, and ageing within the general population, including the inherent variety and diversity of health or illness within the population. Unlike studies that recruit patients with specific illnesses, population neuroimaging encompasses epidemiological approaches to better understand genetic and environmental factors that contribute to both brain health and brain disorders in the population at large. This book covers important themes within population neuroimaging and provides the reader with the tools to understand and engage in population-based neuroimaging studies.
- Highlights the importance of epidemiological concepts in neuroimaging and gives an overview of population neuroscience
- Provides hands-on self-learning tutorials such as the effect of confounding bias on neuroimaging data, multiple imputations of missing covariates, etc.
- Shows the steps and considerations for designing large-scale neuromaging studies and outlines the neuroinformatic, statistical and methodological challenges associated with large samples of neuroimaging data
- Examines the important considerations and opportunities for reproducibility and replication
- Discusses ethical issues such as incidental findings, data sharing, while providing details on the public health relevance of neuroimaging research, including striving for better generalizability and representativeness
- Gives a detailed review of the current population neuro-imaging/science literature on key topics, including prenatal exposures, psychiatry/neurology, imaging genetics and more
- Provides a detailed cohort profiles for several population neuroimaging datasets (e.g., ABCD and UKBB)
Upper level undergraduates, Graduate students, researchers in neuroscience, biomedical engineering, electronic engineering, clinicians, epidemiology, genetics
Part I Overview and Design Considerations
1. Overview and introduction
1.1. Overview of population neuroscience
1.2. Introduction to epidemiologic principles
1.3. Neuroimaging primer
1.4. Introduction to population neuroimaging
2. Population Neuroimaging Study design, Setup, and Quality
2.1. Study designs
2.2. Protocol Considerations
Imaging sequences
Multisite Considerations
2.3. Protocol Stability and Quality Control (perhaps split into 2 chapters)
Phantom, Human, Scanner Stability, Protocol Stability
3. Infrastructure for Large Scale Population Neuroimaging Studies
3.1. Data storage and management
3.2. Image analysis
3.3. high performance computing
4. Image Processing
4.1. Structural
4.2. Diffusion Tensor Imaging
4.3. Resting State Functional MRI
4.4. Task-based Functional MRI
4.5. Other sequences
4.6. Quality Control
5. Incidental Findings
5.1. General (protocol options, sequence selection)
5.2. Ethical considerations
Part II Methodological and Statistical Considerations
6. Statistical challenges in Population Neuroimaging
6.1. Statistical inference and multiple testing correction
6.2. effect sizes, confidence intervals
6.3. multivariate methods
6.4. novel population methods
7. Methodological challenges
7.1. Confounding
7.2. Other bias
7.3. Epidemiological Methods
7.4. Causal Inference
8. Replication, Reproducibility, Reliability
8.1. General
8.2. State of the Art
Part III Applications
9. Public Health Relevance
9.1. World Health Organization / OHBM initiative
9.2. Under-represented countries in brain mapping
9.3. Opportunities for population neuroimaging in public health
10. Population Neuroimaging Domains
10.1. Prenatal Exposures
10.2. Neurology
10.3. Radiology
10.4. Psychiatry
10.5. Family/Early Environment
10.6. Stress and brain development
10.7. Air pollution
10.8. Public Health
10.9. Imaging Genetics
11. Data Sharing
11.1. General
11.2. Open Cohort Profiles
12. Future Directions
12.1. Discovering transdiagnostic stratifications
12.2. Normative Modelling
12.3. Multimodal integration
12.4. Multi-organ systems interactions
12.5. Role in Precision Medicine
- Edition: 1
- Published: March 2, 2026
- Language: English
RM
Ryan Muetzel
Ryan Muetzel, PhD, is an Assistant Professor in the Department of Child and Adolescent Psychiatry/Psychology at the Erasmus MC University Medical Center in Rotterdam. Ryan completed his undergraduate training in psychology and biology at the University of Minnesota, and his Master of Science degree in Epidemiology at the Netherlands Institute for Health Sciences. His PhD focused on population neuroscience and neuroimaging at the Erasmus University in Rotterdam. He Co-Directs one of the world’s largest neuroimaging studies of neurodevelopment, the Generation R Study. His group, the Integrative and Precision Neuroimaging Lab focuses on studying typical and atypical brain development using longitudinal neuroimaging data across four domains: i.) understanding the bidirectional relationship between psychiatric problems and brain over time, ii.) using statistical learning techniques to identify complex patterns in neuroimaging data which are predictive of mental illness, iii.) understanding how various risk and resilience factors shape the brain in the context of mental illness, and iv.) development of open source population neuroimaging tools which enable neuroimaging researchers to incorporate epidemiological concepts into their work.
Affiliations and expertise
Assistant Professor, Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC University Medical Center, Rotterdam, The NetherlandsTW
Tonya White
Tonya White, MD, PhD is an associate professor in the Department of Child and Adolescent Psychiatry at Erasmus MC University Medical Center in Rotterdam. She received Bachelors (Magna Cum Laude from the University of Utah) and Masters (University of Illinois) degrees in Electrical Engineering prior to completing medical school at the University of Illinois and later a Ph.D. from Erasmus University in Rotterdam, the Netherlands. Her residency involved a combined pediatrics, psychiatry, and child and adolescent psychiatry program (Triple Board Program) at the University of Utah, after which she completed a research fellowship in neuroimaging under the mentorship of Nancy C. Andreasen. Following a junior faculty position at the University of Minnesota, she joined the faculty at Erasmus University Medical Center in 2009 to set up and direct the neuroimaging program in the Generation R study, which has become the largest neuroimaging birth cohort in the world. Her primary focus is in pediatric population neuroimaging. Her primary research goals are to apply neuroimaging techniques to obtaining a better understanding of genetic and environmental factors associated with typical and atypical brain development in hopes that this will translate into either preventing or decreasing the morbidity of severe psychiatric disorders.
Affiliations and expertise
Associate Professor, Department of Child and Adolescent Psychiatry, Erasmus MC University Medical Center, Rotterdam, The NetherlandsHT
Henning Tiemeier
Henning Tiemeier is a Professor of Social and Behavioral Science and the Sumner and Esther Feldberg Chair in Maternal and Child Health at the Harvard T.H. Chan School of Public Health, Boston, where he directs the Harvard Center of Excellence in Maternal and Child Health. He received both his medical and sociological degrees from the University of Bonn, Germany, and his PhD from the Erasmus University in Rotterdam, Netherlands.
Tiemeier is a psychiatric epidemiologist who studies child development in population-based cohort studies. His work has a focus on prenatal exposures such as maternal depression and substance use. Much of his work takes a neurodevelopmental approach and his group conducted large scale brain imaging studies in children and adolescents. Recent work shows how parenting and environmental risk factors relate to brain development in childhood and pre-adolescence. Other studies highlight methodological problems in child and adolescent psychiatric research using multi-informant assessments. His multidisciplinary work combining epidemiology, genetics, brain imaging, and child development bridges historically separate disciplines and forms Population Neuroscience. He has conducted large scale population-based birth cohorts from fetal life onwards as well as follow-up studies of international adoptees with exposure to early life trauma and abuse.
At the Harvard TH Chan School of Public Health, he mainly focusses on Population Neuroscience, he has received NIH funding to establish the Mississippi Delta Center of Excellence in Maternal Health to conduct observational studies and trials to improve maternal morbidity, and also works on a longitudinal study of children of incarcerated mothers. Tiemeier has received several honors among which the 2017 Dutch VICI prize, the 2019 Leon Eisenberg Award, and the 2023 Alzheimer Award.
Affiliations and expertise
Department of Child and Adolescent Psychiatry, The Netherlands