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Polymeric Micelles for Drug Delivery

  • 1st Edition - August 18, 2022
  • Latest edition
  • Editors: Prashant Kesharwani, Khaled Greish
  • Language: English

Polymeric Micelles for Drug Delivery provides a comprehensive overview on the synthesis, characterization and application of polymeric micelles in drug delivery applicati… Read more

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Description

Polymeric Micelles for Drug Delivery provides a comprehensive overview on the synthesis, characterization and application of polymeric micelles in drug delivery applications. The use of nanomedicines and carriers, such as polymeric micelles, has made it possible to deliver drugs, genes and therapeutic agents to localized disease sites to maximize clinical benefit while limiting unwanted side effects. This book thoroughly reviews the development and application of polymeric micelles for drug delivery, covering various polymer types and the synthesis, characterization and pharmacokinetics of different micelles.

Subsequent chapters go on to look at the range of drug delivery applications of polymeric micelles – such as mucosal and transdermal – and the assorted stimuli-responsive micelles available. The book concludes with an important analysis of the environmental and regulatory aspects associated with micelle development and clinical translation.

Key features

  • Explores how polymeric micelles can be utilized in a range of different drug delivery approaches, from traditional oral delivery to ocular and dermal delivery
  • Describes the various polymer types used in the synthesis and characterization of polymeric micelles
  • Covers recent advances in polymeric micelles, such as drug co-delivery, triblock polymeric micelles, delivery of genetic materials, and more

Readership

Academics and researchers in materials science, engineering and biomedical engineering. Pharmaceutical scientists

Table of contents

Part A: Synthesis and characterization of polymeric micelles for drug delivery

1. Polymeric micelles: pre´ cis for past, present, and future

2. Various polymers in the development of polymeric micelles

3. Solubility enhancement and drug release mechanism of polymeric micelles

4. Polymeric micellar nanomedicine for enhanced permeability and retention effect

5. Polymeric micelles for oral drug delivery

6. Polymeric micellar nanocarriers: topical treatment of inflammatory diseases

Part B: Application of polymeric micelles in drug delivery

7. Polymeric micelles in dermal and transdermal drug delivery

8. Polymeric micelles as delivery systems for anticancer immunotherapy

9. Polymeric micelles for drug delivery in oncology

10. Surface engineering of polymeric micelles for imparting multifunctionality

11. Cellular interaction of polymeric micelles in targeted drug delivery systems: the road from tissue to cell

Part C: Stimuli-responsive polymeric micelles for drug delivery

12. pH-responsive polymeric micelles for drug delivery

13. Enzyme-responsive polymeric micelles for drug delivery applications

14. Light- and temperature-responsive polymeric micelles for drug delivery

15. Exogenous stimuli

16. Dual-responsive polymeric micelles for drug delivery

Part D: Recent advances in polymeric micelles

17. Polymeric micelles for drug codelivery

18. Nose-to-brain delivery

19. The application of a drug

20. Polymeric micelles with cleavable links for drug delivery

21. Block copolymer micelles as long-circulating drug delivery vehicles

22. Triblock polymeric micelles as an emerging nanocarrier for drug delivery

Part E: Environmental and regulatory aspects

23. Biological toxicity and environmental hazards associated with polymeric micelles

24. Clinical translation of polymeric micelles into market

25. Regulatory pathways and prospects for polymeric micelles

Product details

  • Edition: 1
  • Latest edition
  • Published: August 18, 2022
  • Language: English

About the editors

PK

Prashant Kesharwani

Dr. Prashant Kesharwani is an Assistant Professor of Pharmaceutics at Dr. Harisingh Gour Vishwavidyalaya (A Central University), Sagar, India. His work focuses on translational nanomedicine, polymeric biomaterials, targeted drug delivery, nanoengineered drug delivery systems, and translational pharmaceutical research. He has contributed extensively to the scientific literature and has served as an editor of scholarly books. Dr. Kesharwani has received research funding from national agencies and has been recognized with awards and fellowships for his contributions to the field. His research interests include nanomedicine, targeted and stimuli-responsive drug delivery, polymeric nanocarriers, and related pharmaceutical applications. He is actively involved in scientific research, academic mentoring, and scholarly publishing.

Affiliations and expertise
Dr. Harisingh Gour Vishwavidyalaya University, India

KG

Khaled Greish

Dr. Khaled Greish is Professor of Molecular Medicine, and head of the Nano-research unit, at Princes Al-Jawhara Center, Arabian Gulf University, Kingdom of Bahrain. His previous appointments included Senior lecturer of Pharmacology at the University of Otago, New Zealand, and Assistant Professor of Pharmaceutical Chemistry at University of Utah (UT, USA). He has published > 70 peer reviewed papers, and 10 book chapters in the field of targeted anticancer drug delivery. Controlled Release Society (CRS) awarded him the CRS Postdoctoral Achievement Award in 2008 and in 2010; he was elected as member of the CRS College of Fellows. In recognition of his research, University of Otago awarded him “Early Career Awards for Distinction in Research” in 2014. His research focuses on Nanomedicine, tumor vascular biology, and anticancer drug discovery/development.
Affiliations and expertise
Professor of Molecular Medicine, Princes Al-Jawhara Center, Arabian Gulf University, Kingdom of Bahrain

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