Polymeric Micelles for Drug Delivery

1st Edition - August 18, 2022
Editors: Prashant Kesharwani, Khaled Greish
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 8 9 8 6 8 - 3
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 8 6 2 9 - 1

Polymeric Micelles for Drug Delivery provides a comprehensive overview on the synthesis, characterization and application of polymeric micelles in drug delivery applicati… Read more

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Polymeric Micelles for Drug Delivery provides a comprehensive overview on the synthesis, characterization and application of polymeric micelles in drug delivery applications. The use of nanomedicines and carriers, such as polymeric micelles, has made it possible to deliver drugs, genes and therapeutic agents to localized disease sites to maximize clinical benefit while limiting unwanted side effects. This book thoroughly reviews the development and application of polymeric micelles for drug delivery, covering various polymer types and the synthesis, characterization and pharmacokinetics of different micelles.

Subsequent chapters go on to look at the range of drug delivery applications of polymeric micelles – such as mucosal and transdermal – and the assorted stimuli-responsive micelles available. The book concludes with an important analysis of the environmental and regulatory aspects associated with micelle development and clinical translation.

Cover image
Title page
Table of Contents
Copyright
Dedication
List of contributors
About the editors
Preface
Acknowledgments
Part A: Synthesis and characterization of polymeric micelles for drug delivery
Chapter 1. Polymeric micelles: précis for past, present and future
Abstract
Conflict of interest
1.1 History and general features
1.2 Structure
1.3 Properties
1.4 Characterization of polymeric micelles
1.5 Conclusions and perspective
Acknowledgments
References
Chapter 2. Various polymers in the development of polymeric micelles
Abstract
2.1 Introduction
2.2 The structure of polymeric micelles
2.3 Key features of polymeric micelles
2.4 Various polymers used in polymeric micelles
2.5 Various types of polymeric micelles
2.6 Preparation method of drug-loaded polymeric micelles
2.7 Characterization of polymeric micelles
2.8 Applications of polymeric micelles
2.9 Conclusion and prospects
References
Further reading
Chapter 3. Solubility enhancement and drug release mechanism of polymeric micelles
Abstract
3.1 Introduction
3.2 Polymeric micelles as a drug delivery system
3.3 Polymeric micelle applications in treating cancer
3.4 Drug release enhancement by polymeric micelle
3.5 Conclusion and future prospects
Disclosures
References
Chapter 4. Polymeric micellar nanomedicine for enhanced permeability and retention effect–based tumor-targeted delivery
Abstract
4.1 Introduction
4.2 Pharmacokinetics and in vitro, in vivo evaluation of polymeric micelles
4.3 The enhanced permeability and retention effect, a novel principle of anticancer drug design
4.4 Challenges and factors in enhanced permeability and retention effect–based drug delivery
4.5 Strategies to improve the therapeutic effect of nanomedicines with regard to the enhanced permeability and retention effect
4.6 Conclusion
References
Chapter 5. Polymeric micelles for oral drug delivery
Abstract
5.1 Motivation of oral delivery
5.2 Anatomy and physiology of the gastrointestinal tract
5.3 Challenges of oral delivery
5.4 Polymeric micelles
5.5 Polymeric micelle applications
5.6 Mucoadhesion as a strategy for oral delivery
5.7 Conclusion
References
Chapter 6. Polymeric micellar nanocarriers: topical treatment of inflammatory diseases
Abstract
6.1 Introduction
6.2 Inflammatory diseases
6.3 Topical drug delivery and its obstacles
6.4 Nanocarrier-based drug delivery
6.5 Polymeric micelles
6.6 Topical polymeric micelles in the treatment of inflammatory diseases
6.7 Future directions and conclusion
References
Further reading
Part B: Application of polymeric micelles in drug delivery
Chapter 7. Polymeric micelles in dermal and transdermal drug delivery
Abstract
7.1 Introduction
7.2 The essentials of polymeric micelles
7.3 Types of polymeric micelles used in skin drug delivery
7.4 Nanocarrier-facilitated cutaneous drug delivery
7.5 Skin barrier properties in skin disease and disorders
7.6 Polymeric micelle fate after topical application
7.7 Conclusion
References
Chapter 8. Polymeric micelles as delivery systems for anticancer immunotherapy
Abstract
8.1 Introduction
8.2 Polymeric micelles as agents for immunotherapy
8.3 Conclusion and prospects
References
Chapter 9. Polymeric micelles for drug delivery in oncology with an emphasis on siRNA conveyance
Abstract
Graphical abstract
9.1 Introduction
9.2 Toward selective release of small interfering RNA to tumors
9.3 Polymeric micelles as small interfering RNA delivery carriers
9.4 Conclusions and perspective
Acknowledgments
References
Chapter 10. Surface engineering of polymeric micelles for imparting multifunctionality
Abstract
10.1 Introduction
10.2 Hyaluronic acid–coated or functionalized polymeric micelles
10.3 Folic acid–coated or functionalized polymeric micelles
10.4 Glycyrrhetinic acid– or phenylboronic acid–coated polymeric micelles
10.5 Biotin-coated polymeric micelles
10.6 Antibody-coated polymeric micelles
10.7 Peptide-coated polymeric micelles
10.8 Aptamer-coated polymeric micelles
10.9 Conclusion
References
Chapter 11. Cellular interaction of polymeric micelles in targeted drug delivery systems: the road from tissue to cell
Abstract
11.1 Introduction
11.2 The cell membrane
11.3 Cellular uptake
11.4 Physiochemical characteristics of polymer micelles and internalization into the cell
11.5 Lipid membrane alterations and polymer micelles
11.6 Polymeric micelle targeting of and internalization to cells
11.7 Conclusion
References
Part C: Stimuli-responsive polymeric micelles for drug delivery
Chapter 12. pH-responsive polymeric micelles for drug delivery
Abstract
12.1 Introduction
12.2 Polymeric micelles
12.3 pH-responsive polymeric micelles
12.4 Polymeric excipients for pH-responsive micelle preparation
12.5 Conclusion and future direction
References
Chapter 13. Enzyme-responsive polymeric micelles for drug delivery applications
Abstract
13.1 Introduction
13.2 Enzyme-responsive polymeric micelles for drug delivery applications
13.3 Conclusions
Acknowledgment
References
Chapter 14. Light- and temperature-responsive polymeric micelles for drug delivery
Abstract
14.1 Introduction
14.2 Polymeric micelles and their types
14.3 Stimuli-responsive micelles
14.4 Conclusions
References
Chapter 15. Exogenous stimuli–responsive polymeric micelles for drug delivery
Abstract
15.1 Introduction
15.2 Various exogenous stimuli
15.3 Exogenous stimuli–responsive polymeric systems
15.4 Conclusion
Acknowledgment
Conflict of interest
References
Chapter 16. Dual-responsive polymeric micelles for drug delivery
Abstract
16.1 Overview
16.2 Drug delivery systems for dual polymeric micelles
16.3 Polymeric drug delivery systems
16.4 Dual-responsive polymeric micelles for drug delivery
16.5 Conclusion
References
Part D: Recent advances in polymeric micelles
Chapter 17. Polymeric micelles for drug codelivery
Abstract
17.1 Introduction
17.2 RNA-mediated codelivery of drugs using polymeric micelles
17.3 Cellular uptake of polymeric micelles for the codelivery of drugs
17.4 Passive and active targeting of polymeric micelles for the codelivery of drugs
17.5 Conclusions and perspectives
References
Chapter 18. Nose-to-brain delivery
Abstract
18.1 Introduction
18.2 Polymeric micelles for nose-to-brain delivery
18.3 Cell-penetrating peptide–modified polymer micelles for nose-to-brain delivery
18.4 Glioma-specific ligand/cell-penetrating peptide–comodified polymer micelles for nose-to-brain delivery
18.5 Conclusions and prospects
References
Chapter 19. The application of a drug–poly(lactic-co-glycolic acid) hybrid micellar system for drug delivery
Abstract
19.1 Introduction
19.2 Preparation of drug–poly(lactic-co-glycolic acid) hybrid
19.3 Small interfering RNA delivery into the tumor cells using small interfering RNA–poly(lactic-co-glycolic acid) hybrid micelles in a murine ovarian cancer model
19.4 Targeting micellar system using small interfering RNA–poly(lactic-co-glycolic acid)/Fab′–poly(lactic-co-glycolic acid) mixed micelles in vitro
19.5 Peptide delivery system using CKR12–poly(lactic-co-glycolic acid) hybrid micelles in four types of cancer cells
19.6 Conclusion
Acknowledgments
References
Chapter 20. Polymeric micelles with cleavable links for drug delivery
Abstract
20.1 Introduction
20.2 Conclusion
References
Chapter 21. Block copolymer micelles as long-circulating drug delivery vehicles
Abstract
21.1 Introduction
21.2 Block copolymer micelles for drug delivery
21.3 Strategies to promote micellar stability and circulation time
21.4 Functionalization with targeting ligands
21.5 Stimuli responsiveness
21.6 Conclusion
References
Chapter 22. Triblock polymeric micelles as an emerging nanocarrier for drug delivery
Abstract
22.1 Introduction
22.2 Preparations of various types of triblock polymeric micelles
22.3 Triblock polymeric micelles for oral drug delivery
22.4 Triblock polymeric micelles for ocular drug delivery
22.5 Triblock polymeric micelles for pulmonary drug delivery
22.6 Applications of triblock polymeric micelles for anticancer drug therapy and other disease treatment
22.7 Conclusion and prospects
Acknowledgment
Disclosures
References
Part E: Environmental and regulatory aspects
Chapter 23. Biological toxicity and environmental hazards associated with polymeric micelles
Abstract
23.1 Introduction
23.2 Route of exposure and toxicity
23.3 Mechanisms of nanoparticle toxicity
23.4 Studies of nanoparticle toxicity
23.5 Effects of nanoparticles on plants
23.6 Effects of nanoparticles on terrestrial species
23.7 Effects of nanoparticles on Amphibia (semiaquatic animals)
23.8 Effects of nanoparticles on aquatic animals
23.9 Conclusion
References
Chapter 24. Clinical translation of polymeric micelles into market
Abstract
24.1 Introduction
24.2 Polymeric micelles in sustained-release profiles
24.3 Stimulus-responsive drug release micelles (pH-sensitive polymeric micelles)
24.4 Micelles in photodynamic therapy
24.5 Diagnostic and imaging application of polymeric micelles
24.6 Evolution of polymeric micelles into multifunctional nanocarriers
24.7 Polymeric micelles in mucosal drug delivery
24.8 Clinical application of polymeric micelles for the treatment of cancer
24.9 Polymeric micelles: recent advancements in the delivery of anticancer drugs
24.10 Use of micelles in COVID-19 therapies
References
Chapter 25. Regulatory pathways and prospects for polymeric micelles
Abstract
25.1 Introduction
25.2 The importance of regulation
25.3 Current regulatory pathways
25.4 Nanomedicine regulatory approaches
25.5 Major gaps and challenges in nanomicelle regulation
25.6 Nanomicelles in the pharmaceutical market
25.7 Conclusion and prospects
References
Index

Prashant Kesharwani

Dr. Prashant Kesharwani is an assistant professor of pharmaceutics at School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India. He has more than 12 years of teaching, research, and industrial experience at international levels from various countries, including the United States, Malaysia, and India. An overarching goal of his current research is the development of nanoengineered drug delivery systems for various diseases. He has more than 300 international publications in well-reputed journals and more than 25 international books (Elsevier). He is a recipient of many research grants from various funding bodies. He is also the recipient of several internationally acclaimed awards, such as “USERN Laureate award”, most prestigious “Ramanujan Fellowship Award”. He actively participates in outreach and scientific dissemination for the service of the wider community.

Affiliations and expertise

Assistant Professor, Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India

Khaled Greish

Dr. Khaled Greish is Professor of Molecular Medicine, and head of the Nano-research unit, at Princes Al-Jawhara Center, Arabian Gulf University, Kingdom of Bahrain. His previous appointments included Senior lecturer of Pharmacology at the University of Otago, New Zealand, and Assistant Professor of Pharmaceutical Chemistry at University of Utah (UT, USA). He has published > 70 peer reviewed papers, and 10 book chapters in the field of targeted anticancer drug delivery. Controlled Release Society (CRS) awarded him the CRS Postdoctoral Achievement Award in 2008 and in 2010; he was elected as member of the CRS College of Fellows. In recognition of his research, University of Otago awarded him “Early Career Awards for Distinction in Research” in 2014. His research focuses on Nanomedicine, tumor vascular biology, and anticancer drug discovery/development.

Affiliations and expertise

Professor of Molecular Medicine, Princes Al-Jawhara Center, Arabian Gulf University, Kingdom of Bahrain

Life Sciences

Physical Sciences & Engineering

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