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Pituitary Tumors

A Comprehensive and Interdisciplinary Approach

1st Edition - April 11, 2021

Editors: Jürgen Honegger, Martin Reincke, Stephan Petersenn

Hardback ISBN:

9 7 8 - 0 - 1 2 - 8 1 9 9 4 9 - 7

eBook ISBN:

9 7 8 - 0 - 1 2 - 8 1 9 9 5 0 - 3

Pituitary Tumors: A Comprehensive and Interdisciplinary Approach provides the latest information on preclinical issues, diagnostic procedures, treatment options and post-treatment… Read more

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Pituitary Tumors: A Comprehensive and Interdisciplinary Approach provides the latest information on preclinical issues, diagnostic procedures, treatment options and post-treatment care for patients with pituitary tumors. The book includes basic and advanced knowledge for a broad audience, including physicians, endocrinologists, neurosurgeons, neuro-radiologists, neuro-ophthalmologists, neuro-pathologists, oncologists, radiotherapists and researchers who are investigating pituitary tumors. Readers will find the latest research surrounding progress on uncoding the molecular mechanisms involved in tumor genesis. In addition, standard treatment modalities, including surgery, medical treatment and radiosurgery are explored.

I. Preclinical essentials

1. Physiology of pituitary hormones

2. Principles of laboratory investigation for pituitary hormones

3. Pathophysiology and genetics in pituitary tumors

4. Pathophysiology and genetics in craniopharyngioma

5. Anatomy of the pituitary region

II. Neuroradiological and ophthalmological diagnosis in pituitary tumors

6. Morphological imaging including imaging anatomy

7. Functional imaging

8. Neuroophthalmological diagnosis

III. Endocrinological diagnosis and replacement therapy for hypopituitarism and diabetes insipidus in pituitary tumors

9. Endocrinological diagnosis and replacement therapy for hypopituitarism

10. Endocrinological diagnosis and replacement therapy for diabetes insipidus

11. The role of nurses in supporting selfmanagement for patients with hypopituitarism

IV. Endocrinological diagnosis and medical treatment in functioning pituitary adenomas

12. Prolactinomas: Diagnosis and medical treatment

13. Endocrinological diagnosis in acromegaly

14. Medical treatment in acromegaly

15. The diagnosis of Cushing’s disease

16. Medical management of Cushing’s disease

17. Endocrinological diagnosis and treatment

V. Surgical treatment of pituitary tumors

18. Microscopic transsphenoidal surgery

19. Endoscopic transsphenoidal surgery: Including a brief history of transsphenoidal surgery

20. Risks of transsphenoidal surgery

21. Ophthalmologic outcome of transsphenoidal surgery

22. Endocrinological outcome of transsphenoidal surgery in pituitary adenomas

23. Extended transsphenoidal surgery

24. Transcranial surgery

25. Video presentations of pituitary surgery

VI. Histo-pathological classification of pituitary tumors

26. Pathology of pituitary adenoma

27. Pathology of nonadenomatous pituitary tumors and tumor-like lesions

VII. Perioperative and postoperative management in patients with pituitary adenomas

28. Perioperative neurosurgical management

29. Perioperative endocrinological management in patients with pituitary adenomas

30. Perioperative and postoperative nursing care

31. Postoperative endocrinological follow-up

32. Pituitary magnetic resonance imaging use in the posttreatment follow-up of secreting pituitary adenomas

VIII. Radiotherapy for pituitary adenomas

33. Fractionated radiotherapy for pituitary adenomas

34. Pituitary adenomas: Radiosurgery

IX. Aggressive pituitary adenomas and carcinomas

35. Management of aggressive pituitary tumors

36. Medical treatment of aggressive pituitary tumors

X. Diagnosis, treatment and outcome in nonfunctioning pituitary tumors and lesions

37. Clinically nonfunctioning pituitary tumors

38. Childhood-onset craniopharyngiomas

39. Adult craniopharyngiomas

40. Rathke’s cleft cysts and arachnoid cysts

41. Perisellar solid tumors

42. Inflammatory pituitary lesions

43. Vascular lesions and aneurysms

XI. Diagnosis and treatment of co-morbidities in pituitary tumors

44. Psychiatric disorders

45. Metabolic disorders

46. Osteoporosis and arthropathy in functioning pituitary tumors

XII. Special issues

47. Pituitary incidentaloma

48. Pituitary apoplexy

49. Management of pituitary tumors in pregnancy

50. Quality of life in pituitary tumors

51. Multidisciplinary team perspective: A model of care for patients with pituitary tumors

Jürgen Honegger

Jürgen Honegger is Professor of Neurosurgery and Vice-Chairman of the Department of Neurosurgery at the Eberhard-Karls University in Tübingen, Germany. He worked as a resident in the ophthalmological department in Tübingen (1986) and as a resident (1986-1989), senior resident (1991-1994), and consulting neurosurgeon (1994-1997) in neurosurgery at the University of Erlangen-Nürnberg, where he was trained in pituitary surgery by Professor Rudolf Fahlbusch. He spent 1990 at St. Bartholomew’s hospital in London, UK, as a Clinical and Research Fellow to Professors Michael Besser, John Wass, and Ashley Grossman. From 1998 to 2004, he was consultant at the Department of Neurosurgery, University of Fribourg. Since 2005, he has been Vice-Chairman at the Department of Neurosurgery, University of Tübingen, where his main neurosurgical specialities are pituitary surgery, vascular surgery, and epilepsy surgery. Jürgen Honegger was licensed as neurosurgeon in 1987. He was appointed Associate Professor (with a thesis on “Biochemical characterization and surgical treatment of craniopharyngiomas”) in 1997 and Professor in Neurosurgery in 2006. His main clinical and scientific area of activity is in pituitary tumors. In Tübingen, he has built up a Pituitary Surgery Unit that today ranks among the largest units in Germany. Prof. Honegger performs more than 150 operations for pituitary tumors per year. He has organized and hosted pituitary surgery training courses of the German Society of Neurosurgery. He has directed several national studies and surveys on pituitary disorders. Since 2014, he has been the head of the Pituitary Tumor Working Group of the German Society of Endocrinology, which holds the patronage for the German Acromegaly Registry, the German Craniopharyngioma Registry for Adults, and the German Pituitary Tumor Registry.

Affiliations and expertise

Department of Neurosurgery, University of Tübingen, Tübingen, Germany

Martin Reincke

Martin Reincke is Professor of Endocrinology and Chair of Medical Department IV of the Ludwig-Maximilians University in Munich, a leading institution in German academic medicine. His research specialties include endocrine hypertension, mineralocorticoid and glucocorticoid action, and stress research. Professor Reincke is a clinician-scientist at heart. He heads a research team that specifically explores the prevalence and relevance of glucocorticoid and mineralocorticoid excess on the epidemiological, clinical, genetic, and molecular levels. He is co-founder of the European Network for the Study of Adrenal Tumors (ENSAT), established in 2000. In 2009, he founded the German Primary Aldosteronism Registry, and in 2012, the German Cushing Registry. Professor Reincke is a member of many national and international societies, including the Endocrine Society and the European Society of Endocrinology. He has served on the Executive Board of the German Endocrine Society and European Society of Endocrinology, is on the editorial boards of several international journals, and has served as Teaching Dean of the Faculty from 2006 to 2012 and as president of the German Endocrine Society (2014–2017). Prof. Reincke won the prestigious European Research Council Advanced Grant Award (2.5 million €) in 2016. He is currently President-Elect of the European Society of Endocrinology. His publications include more than 490 MEDLINE-listed manuscripts, which have been cited >12,500 times, and his h-index is 61 (ISI Web of Science).

Affiliations and expertise

Chairman of Medicine, Department of Medicine IV, University Hospital Munich, Ludwig-Maximilians-University Munich, Germany

Stephan Petersenn

Stephan Petersenn, MD, ENDOC Center for Endocrine Tumors, Hamburg, Germany. Prof. Stephan Petersenn studied medicine at the University of Kiel, Germany (1984–1987 and 1988–1990) and the University of Vienna, Austria (1987–1988). He is qualified in Internal Medicine (1999), Diabetology (1999), Endocrinology (2000), and Andrology (2007). Previously, he worked in an internship (1991–1992) in the Department of Medicine, University of Kiel, as a Research Fellow (1992–1994) to Professor S Melmed at Cedars-Sinai Medical Center, Los Angeles, USA, as a Resident and Fellow (1995–2000) in the Department of Medicine, University of Hamburg, and as a Senior Physician (2001–2009) in the Division of Endocrinology, University of Duisburg-Essen. In 2009, he founded the ENDOC Center for Endocrine Tumors in Hamburg, while remaining a member of the faculty of the University of Duisburg-Essen. In 2003, he became Associate Professor, and in 2008 Professor of Medicine, at the University of Duisburg-Essen. His research is focused on the diagnosis and treatment of pituitary and adrenal tumors, as well as neuroendocrine tumors. Furthermore, his clinical and basic studies aim for a better understanding of the physiology and pathophysiology of somatostatin receptors. Throughout his career, Prof Petersenn has published more than 160 articles in peer-reviewed journals of high reputation, and he has presented at many international conferences. He is a member of several societies, including the Endocrine society, the European Society of Endocrinology, and the International Pituitary Society.

Affiliations and expertise

ENDOC Center for Endocrine Tumors, Hamburg, Germany