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Phytoconstituents and Antifungals
1st Edition - August 20, 2022
Editor: Awanish Kumar
Paperback ISBN:9780323917926
9 7 8 - 0 - 3 2 3 - 9 1 7 9 2 - 6
eBook ISBN:9780323986175
9 7 8 - 0 - 3 2 3 - 9 8 6 1 7 - 5
Phytoconstituents and Antifungals covers a wide range of specific information on various phytoconstituents, their antifungal mode and the diagnosis and management of fungal… Read more
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Phytoconstituents and Antifungals covers a wide range of specific information on various phytoconstituents, their antifungal mode and the diagnosis and management of fungal infections. The book offers encouragement and empowers readers to re-embrace their knowledge of phytoconstituents and their various antifungal activities against most opportunistic pathogenic fungi as fungal diseases cause an estimated 1.5+ million deaths annually and over one billion people suffer from severe fungal disease. In this complex scenario, it is now clear that global warming and accompanying climate changes have resulted in increased incidence of many fungal infections.
On the basis of all these factors, concerns on the occurrence of a pandemic fungal origin in the near future have been raised. In this context, to stop forgetting and underestimating fungal diseases is mandatory.
Provides readers with up-to-date information on different phytoconstituents over fungal strain
Collectively addresses important and updated material on fungal diseases
Conveys the knowledge needed to understand and improve success in managing and combating fungal diseases worldwide
Researchers and investigators working in the area of pathogenic human fungal infections. Researchers in applied microbiology, molecular biology, mycology, biotechnology, biochemistry, Pharmaceutical industry, Medicinal Chemistry, Drug Discovery etc; Basic and applied scientists of different disciplines (microbiologist, molecular biologists, medicinal chemists, mycologist) specialists in different sub-disciplines of phytomedicines, and students in postgraduate and PhD programs
Cover image
Title page
Table of Contents
Copyright
List of contributors
Acknowledgment
1. Major diseases caused by fungal infections
Introduction
2. Antifungal discovery from plant sources
Introduction
Plant selection for the discovery of antifungal
Importance of medicinal plants
Extraction and characterization of plant extract
Plant materials
Solvent selection
Techniques of extraction
Methods of antifungal susceptibility testing
Screening of antifungals through bioautographic techniques
3. Phytoconstituents as antifungals
Searching for phytochemicals from medicinal plants
Phytochemicals for antimicrobial activity
Action of phytoconstituents over microorganisms
Phytoconstituents classification
Types of terpenes
Biosynthesis of phytoconstituents
4. Plant alkaloids
Introduction
Biology and bioactivity of alkaloids
Elicitor signal transduction for plant alkaloids biosynthesis
Extraction and evaluation of plant alkaloids
Antifungal activities of alkaloids from natural sources
5. Plant phenolics
Introduction
6. Plant terpenes
Introduction
Chemical structure
Classification of terpenes
Terpenes as an antifungal agent
General properties of terpenoids
Terpenes as agents of biotransformation
Terpene's chemistry and biosynthesis
Regulation of plant terpenoid biosynthesis
Transgenic plants and future research
Conclusion
7. Glycosides and polysaccharides
Introduction
Two important plant glycosides that behave as antifungals
Therapeutic properties of glycones (polysaccharides) and glycosides against pathogens
Mechanism of antifungal sensitivity of glycosides
8. Peptides and polypeptides
Introduction
Molecular structure composition of peptide molecules
Therapeutic role of bioactive AMPs on pathogenic fungus
Natural AFPs
Synthetic AFPs
Antifungal peptides with synergistic effects
Delivery of therapeutic peptides and polypeptides
9. Oils and resins
Introduction
Natural architecture of plant oils
Biosynthesis of major components of essential oil
Action mechanism of essential oils over fungal cells
Antifungal action against opportunistic mycoses
10. Conclusions
Summary
References
Index
No. of pages: 166
Language: English
Published: August 20, 2022
Imprint: Academic Press
Paperback ISBN: 9780323917926
eBook ISBN: 9780323986175
AK
Awanish Kumar
Dr. Awanish Kumar is currently an Associate Professor in the Department of Biotechnology at the National Institute of Technology, Raipur (CG), India. He is working in the area of infection biology, drug targeting, and drug discovery. He has more than 13 years of research experience. He received his PhD in molecular parasitology from the CSIR-Central Drug Research Institute-Lucknow, India and Jawaharlal Nehru University-Delhi, India. He did his post-doctoral study at McGill University, Montreal, Canada. Dr. Kumar has served various national and international organizations in different academic and research capacities. He has authored several monographs, books, and book chapters. He has served on many national committees, scientific society and advisory panels, is a member of many international professional research societies and as a reviewer and editorial board member of reputed and refereed journals.
Affiliations and expertise
Associate Professor, Department of Biotechnology, National Institute of Technology Raipur, India