Phytochemicals as Lead Compounds for New Drug Discovery

1st Edition - September 7, 2019
Editors: Chukwuebuka Egbuna, Shashank Kumar, Jonathan C. Ifemeje, Shahira M. Ezzat, Saravanan Kaliyaperumal
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 1 7 8 9 0 - 4
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 1 7 8 9 1 - 1

Phytochemicals as Lead Compounds for New Drug Discovery presents complete coverage of the recent advances in the discovery of phytochemicals from medicinal plants as models to the… Read more

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Phytochemicals as Lead Compounds for New Drug Discovery presents complete coverage of the recent advances in the discovery of phytochemicals from medicinal plants as models to the development of new drugs and chemical entities. Functional bioactive compounds of plant origin have been an invaluable source for many human therapeutic drugs and have played a major role in the treatment of diseases around the world. These compounds possess enormous structural and chemical diversity and have led to many important discoveries. This book presents fundament concepts and factors affecting the choice for plant-based products, as well as recent advances in computer-aided drug discovery and FDA drug candidacy acceptance criteria. It also details the various bioactive lead compounds and molecular targets for a range of life-threatening diseases including cancer, diabetes, and neurodegenerative diseases.

Written by a global team of experts, Phytochemicals as Lead Compounds for New Drug Discovery is an ideal resource for drug developers, phytochemists, plant biochemists, food and medicinal chemists, nutritionists and toxicologists, chemical ecologists, taxonomists, analytical chemists, and other researchers in those fields. It will also be very valuable to professors, students, and researchers in this domain.

Cover image
Title page
Table of Contents
Copyright
List of contributors
Biography
Part I. Plants as natural sources of drugs
Chapter 1. Plant secondary metabolites as lead compounds for the production of potent drugs
1.1. Medicinal plants and phytochemicals
1.2. Conclusion
Chapter 2. Factors affecting the choice for plant-based products in drug discoveries
2.1. Introduction
2.2. Conclusion
Chapter 3. Advances in computer-aided drug discovery
3.1. Introduction
Chapter 4. FDA drug candidacy acceptance criteria and steps: problems and way forward
4.1. Introduction
Part II. Biofunctional leads for drug development
Chapter 5. Bioactive lead compounds and molecular targets for the treatment of heart diseases
5.1. Introduction
5.2. Natural products targeting autophagy and cardiovascular disorders
5.3. Natural products targeting endoplasmic reticulum (ER) and cardiovascular diseases
5.4. Atherosclerosis and chronic inflammation
5.5. Selected classes of natural products used in the prevention of hypertension and ischaemic heart diseases by various mechanisms
5.6. Natural products in preclinical/clinical studies
Chapter 6. Natural bioactive lead compounds effective against haematological malignancies
6.1. Introduction
Chapter 7. Adjunct therapeutic potential of phytochemicals against cancer
7.1. Introduction
Chapter 8. Antidiabetic lead compounds and targets for drug development
8.1. Introduction
8.2. Molecular targets of antidiabetic drugs
8.3. Phytochemicals in diabetes management
8.4. Classes of antidiabetic drugs currently used
8.5. Antidiabetic drugs on clinical trial
8.6. Future directions
8.7. Conclusion
Chapter 9. Antiobesity functional leads and targets for drug development
9.1. Introduction
Chapter 10. Phytochemicals as therapeutic interventions in neurodegenerative diseases
10.1. Introduction
Chapter 11. Organosulfur phytochemicals against metabolic and neurodegenerative diseases: benefits and risks
11.1. Introduction to phytochemicals: chemistry and classification
Chapter 12. Lead compounds with the potentials for the treatment of chronic liver diseases
12.1. Introduction
Chapter 13. Bioactive lead compounds effective against skin diseases
13.1. Introduction
Chapter 14. Phytochemicals as emerging therapeutic agents for alopecia treatment
14.1. Introduction
Chapter 15. Antiviral phytocompounds for drug development: a data mining studies
15.1. Introduction
Chapter 16. Shikimic acid as intermediary model for the production of drugs effective against influenza virus
16.1. Introduction
16.2. Influenza and its various forms
Chapter 17. Antimicrobial lead compounds from marine plants
17.1. Introduction
Chapter 18. Antibacterial lead compounds and their targets for drug development
18.1. Introduction
Chapter 19. Awareness and current therapeutic strategies of malaria
19.1. Introduction
Chapter 20. Bioactive lead compounds and targets for the development of antimalarial drugs
20.1. Introduction
20.2. Conclusion
Chapter 21. Bioactive lead compounds and molecular targets for the development of antiinflammatory drugs
21.1. Introduction
Chapter 22. Functional lead compounds and targets for the development of drugs for the treatment of male infertility
22.1. Introduction
Chapter 23. Prenylated flavonoids as a promising drug discovery candidate: a pharmacological update
23.1. Introduction
Index

Chukwuebuka Egbuna

Chukwuebuka Egbuna (PhD) is a chartered chemist and academic researcher. He is a member of the Institute of Chartered Chemists of Nigeria (ICCON), the Nigerian Society of Biochemistry and Molecular Biology (NSBMB), and the Royal Society of Chemistry (RSC) (United Kingdom). Dr. Egbuna is the founder and editor of the Elsevier book series on Drug Discovery Update. The series includes books, monographs, and edited collections from all areas of drug discovery including emerging therapeutic claims for the treatment of diseases. He has published research articles in many international journals of repute and is ranked among the top 500 Nigerian scientists in SciVal/SCOPUS. He has edited more than 25 books with Elsevier, Springer, Wiley, and Taylor & Francis. His most recent book is the three volume Coronavirus Drug Discovery, published by Elsevier. Dr. Egbuna is the founder and the publishing director of IPS Intelligentsia Publishing Services.

Affiliations and expertise

Africa Centre of Excellence in Public Health and Toxicological Research, University of Port Harcourt, Nigeria

Shashank Kumar

Shashank Kumar, PhD, obtained his BSc, MSc, and PhD degrees in biochemistry from the University of Allahabad. He has worked as a postdoctoral fellow at the Department of Biochemistry in King George’s Medical University. Dr. Kumar has about 60 published scientific papers, reviews, editorial articles, and book chapters in various national and international peer-reviewed journals and has been cited more than 1,200 times. His expertise is in the areas of free radical biology, cancer biology, characterization of plant products, xenobiotic metabolism, and microbiology. He is familiar with many biochemical techniques such as spectrophotometry, ELISA, electrophoresis, PCR, RT-PCR, flow cytometry, TLC, HPLC, LC-MS, cell culture, and microbiological techniques. He has presented his research findings at more than 25 national and international conferences and has attended about 30 workshops at many major universities and medical colleges throughout the India. Dr. Kumar is a life-time member of the Italo-Latin American Society of Ethnomedicine and the Indian Sciences Congress Association, and a member of the Asian Council of Science Editors in Dubai and Publication Integrity & Ethics in London. He has been awarded junior, senior, and research associate fellowships formulated and funded by various Indian agencies, such as the Indian Council of Medical Research, University Grants Commission, and the Council of Scientific and Industrial Research India.

Affiliations and expertise

Center for Biochemistry and Microbial Sciences, Central University of Punjab, Bathinda, India

Jonathan C. Ifemeje

Dr. Jonathan Chinenye Ifemeje, PhD, is an Associate Professor (Reader) in the Department of Biochemistry, Faculty of Natural Sciences, Chukwuemeka Odumegwu Ojukwu University, Nigeria. He has published over 40 articles with international publishers and has attended series of workshops and conferences. He has also served as an external examiner for various institutions. He is the managing editor of the Tropical Journal of Applied Natural Sciences and a reviewer and an editorial board member for various reputable journals. He has worked extensively in the areas of phytochemistry, environment, and nutritional toxicology. He is a member of various institutes, including the Institute of Chartered Chemists of Nigeria, the Nigerian Society of Biochemistry and Molecular Biology, and Society of Quality Assurance. Dr. Ifemeje is presently the Director of Student Industrial Work Experience Scheme (SIWES), COOU and the Department of Biochemistry Postgraduate Coordinator, COOU. He has also served as the department and faculty staff adviser. He obtained his PhD in applied biochemistry from Nnamdi Azikiwe University, Awka, Nigeria, and his MSc degree in nutrition and toxicology from the University of Port-Harcourt, Nigeria.

Affiliations and expertise

Associate Professor, Department of Biochemistry, Faculty of Natural Sciences, Chukwuemeka Odumegwu Ojukwu University, Nigeria

Shahira M. Ezzat

Professor Shahira M. Ezzat holds a Ph.D in pharmacognosy from the College of Pharmacy, Cairo University (CU) since 2007. She is a frequent speaker in conferences around the world, in which she won several prizes for excellent presentations. She has published over 60 articles including research articles, reviews, books, and book chapters in the field of chemistry and biological activity of natural products. She is positioned as a professor and head of Department of Pharmacognosy, College of Pharmacy, MSA University, Egypt. Her main field of research includes the isolation of bioactive plant constituents using advanced chromatographic techniques and the elucidation of their structures using different chemical and spectral methods. She has also performed work using in vitro enzymes-based assays for biological evaluation of plant extracts and the standardization of biologically active extracts using HPLC and other advanced techniques. In addition to identification of chemical constituents in plant extracts using HPLC-MS/MS and UPLC-MS/MS, Professor Ezzat currently works on the deep mechanism of anticancer activity of pure compounds in collaboration with National Cancer Institute (NCI) and searches for the effectiveness of Egyptian herbs as antiaging agents.

Affiliations and expertise

Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Egypt

Saravanan Kaliyaperumal

Dr. Saravanan Kaliyaperumal has been engaged in teaching and research for over 16 years. He obtained MSc Wildlife Biology and PhD degrees at A.V.C. College, Mayiladuthurai, and obtained his MSc, Bioinformatics degree at Annamalai University, India. He has been awarded Har Gobind Kohorana Best Scientist Award (2016-17). He has published 55 research papers and a book and has contributed chapters to four other books. He has completed one major research project and has organized one national and two international conferences, as well as three state-level workshops. He has been engaged in a number of academic roles at Nehru Memorial College, including his most recent appointment as Dean of Academic Affairs. He is a reviewer and editorial board member of various journals. He is a member of Indian Society of Systems for Science and Engineering and OISCA-International in Tokyo, Japan.

Affiliations and expertise

Department of Zoology, Nehru Memorial College, Tamil Nadu, India

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Phytochemicals as Lead Compounds for New Drug Discovery

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Chukwuebuka Egbuna

Shashank Kumar

Jonathan C. Ifemeje

Shahira M. Ezzat

Saravanan Kaliyaperumal