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Pharmacology of Cholinergic and Adrenergic Transmission
Proceedings of the Second International Pharmacological Meeting, August 20—23, 1963
- 1st Edition - February 14, 2014
- Editors: G. B. Koelle, W. W. Douglas, A. Carlsson
- Language: English
- Paperback ISBN:9 7 8 - 1 - 4 8 3 1 - 6 9 5 8 - 3
- eBook ISBN:9 7 8 - 1 - 4 8 3 1 - 8 5 3 9 - 2
Section on Pharmacology of the International Union of Physiological Sciences (SEPHAR), Proceedings of the Second International Pharmacological Meeting, August 20-23, 1963, Volume… Read more
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Request a sales quoteSection on Pharmacology of the International Union of Physiological Sciences (SEPHAR), Proceedings of the Second International Pharmacological Meeting, August 20-23, 1963, Volume 3: Pharmacology of Cholinergic and Adrenergic Transmission focuses on the effects of drugs on muscles, nerve fibers, and the central nervous system. The selection first offers information on the role of sodium ions in the release of acetylcholine and the distribution and release of acetylcholine in muscles. Discussions focus on the effects of sodium deficiency on ACh release in perfused ganglia; effects of sodium pump inhibitors on ganglionic and myoneural transmission; distribution of ACh and choline acetylase in muscle; and ACh release after denervation. The text then ponders on the roles of acetylcholine and acetylcholinesterase in junctional transmission and correlated studies of monoamines and acetylcholinesterase in sympathetic ganglia, manifesting the distribution of adrenergic and cholinergic neurons. The publication examines the action of acetylcholine and related drugs on mammalian nonmyelinated nerve fibers; possible mechanisms of acetylcholine action in muscles; and electrophysiological analysis of cholinergic transmission in sympathetic ganglia. The text then reviews the interactions of cholinomimetic and cholinergic blocking drugs at sympathetic ganglia; evolution of cholinoreceptive sites of locomotor muscle; and pharmacological blocking of central cholinoreactive systems and the possibilities of its therapeutic application. The selection is a dependable source of data for readers interested in the pharmacology of cholinergic and adrenergic transmission.
List of Authors and Participants
Cholinergic Transmission
Section One
The Role of Sodium Ions in the Release of Acetylcholine
Distribution and Release of Acetylcholine in Muscle
The Roles of Acetylcholine and Acetylcholinesterase in Junctional Transmission
Correlated Studies of Monoamines and Acetylcholinesterase in Sympathetic Ganglia, Illustrating the Distribution of Adrenergic and Cholinergic Neurons
The Action of Acetylcholine and Related Drugs on Mammalian Non-Myelinated Nerve Fibers
Possible Mechanisms of Acetylcholine Action in Muscle
Chairman's Summing Up
Section Two
Electrophysiological Analysis of Cholinergic Transmission in Sympathetic Ganglia
Interactions of Cholinomimetic and Cholinergic Blocking Drugs at Sympathetic Ganglia
Acetylcholine as a Secretogogue: Calcium-Dependent Links in "Stimulus-Secretion Coupling" at the Adrenal Medulla and Submaxillary Gland
On the Evolution of Cholinoreceptive Sites of Locomotor Muscle
The Molecular Distribution of 14C-Decamethonium in and around the Motor Endplate and its Metabolism in Cats and Mice
Cholinergic Transmission in the Mammalian Central Nervous System
Pharmacological Blocking of Central Cholinoreactive Systems and the Possibilities of its Therapeutic Application
Chairman's Summing Up
Adrenergic Transmission
Section One
Introductory Remarks
Localization of Neuronal Monoamines at the Cellular Level
Drugs Interfering with the Formation of Adrenergic Transmitters
Metabolism and Inactivation of Noradrenaline and Adrenaline and the Effect of Drugs
Biochemical and Pharmacological Aspects of a New Series of Substances Interfering with Biosynthesis and Interaction of Catecholamines
The Role of the Membrane of Chromaffin Granules Isolated from the Adrenal Medulla
The Biphasic Effect of Phenothiazines on the Release of Adrenaline from Adrenomedullary Granules and its Dependence on pH
Chairman's Summing Up
Section Two
Effect of Drugs on the Storage Granules of Adrenergic Nerves
Effect of Drugs on Monoamine Uptake in Isolated Tissues
Effect of Drugs and Sympathetic Denervation on Noradrenaline Uptake and Binding in Animal Tissues
Drugs Interfering with the Storage and Release of Adrenergic Transmitters
Adrenergic Receptor Mechanisms
Adenyl Cyclase and Hormone Action
Functional Significance of Noradrenaline Depletion by α-Methyl Metatyrosine, Metaraminol and Dextro-Adrenaline
Chairman's Summing Up
Index
- No. of pages: 358
- Language: English
- Edition: 1
- Published: February 14, 2014
- Imprint: Pergamon
- Paperback ISBN: 9781483169583
- eBook ISBN: 9781483185392
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